scholarly journals Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2076
Author(s):  
Gust Nuytten ◽  
Susan Ríos Revatta ◽  
Pieter-Jan Van Bockstal ◽  
Ashish Kumar ◽  
Joris Lammens ◽  
...  
Keyword(s):  
Freeze Drying ◽  
Gas Flow ◽  
Prediction Interval ◽  
Mechanistic Model ◽  
Longitudinal Axis ◽  
Drug Formulation ◽  
Gas Temperature ◽  
Uncertainty Interval ◽  
Model Input ◽  
Spin Freezing

During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis. The aqueous drug formulation subsequently spreads over the inner vial wall, while a cold gas flow is used for cooling and freezing the product. In this work, a mechanistic model was developed describing the energy transfer during each phase of spin freezing in order to predict the vial and product temperature change over time. The uncertainty in the model input parameters was included via uncertainty analysis, while global sensitivity analysis was used to assign the uncertainty in the model output to the different sources of uncertainty in the model input. The model was verified, and the prediction interval corresponded to the vial temperature profiles obtained from experimental data, within the limits of the uncertainty interval. The uncertainty in the model prediction was mainly explained (>96% of uncertainty) by the uncertainty in the heat transfer coefficient, the gas temperature measurement, and the equilibrium temperature. The developed model was also applied in order to set and control a desired vial temperature profile during spin freezing. Applying this model in-line to a continuous freeze-drying process may alleviate some of the disadvantages related to batch freeze-drying, where control over the freezing step is generally poor.

scholarly journals A Mechanistic Model of a Passive Autocatalytic Hydrogen Recombiner

2015 ◽  
Vol 36 (1) ◽  
pp. 3-19 ◽  
Author(s):  
Antoni Rożeń
Keyword(s):  
Nuclear Power ◽  
Power Plants ◽  
Gas Flow ◽  
Nuclear Reactor ◽  
Catalyst Surface ◽  
Mechanistic Model ◽  
Power Input ◽  
Heat Radiation ◽  
Recombination Reaction ◽  
Gas Temperature

Abstract : A passive autocatalytic hydrogen recombiner (PAR) is a self-starting device, without operator action or external power input, installed in nuclear power plants to remove hydrogen from the containment building of a nuclear reactor. A new mechanistic model of PAR has been presented and validated by experimental data and results of Computational Fluid Dynamics (CFD) simulations. The model allows to quickly and accurately predict gas temperature and composition, catalyst temperature and hydrogen recombination rate. It is assumed in the model that an exothermic recombination reaction of hydrogen and oxygen proceeds at the catalyst surface only, while processes of heat and mass transport occur by assisted natural and forced convection in non-isothermal and laminar gas flow conditions in vertical channels between catalyst plates. The model accounts for heat radiation from a hot catalyst surface and has no adjustable parameters. It can be combined with an equation of chimney draft and become a useful engineering tool for selection and optimisation of catalytic recombiner geometry.

Frequency response of the chest: modeling and parameter estimation

1975 ◽  
Vol 39 (4) ◽  
pp. 523-534 ◽  
Author(s):  
R. Peslin ◽  
J. Papon ◽  
C. Duviver ◽  
J. Richalet
Keyword(s):  
Frequency Response ◽  
Gas Flow ◽  
Airway Resistance ◽  
Mechanistic Model ◽  
Normal Subjects ◽  
Order Equation ◽  
Mean Values ◽  
Tissue Compliance ◽  
Linear Differential ◽  
Gas Compressibility

The frequency response of the respiratory system was studied in the range from 3 to 70 Hz in 15 normal subjects by applying sinusoidal pressure variations around the chest and measuring gas flow at the mouth. The observed input-output relationships were systematically compared to those predicted on the basis of linear differential equations of increasing order. From 3 to 20 Hz the behavior of the system was best described by a 3rd-order equation, and from 3 to 50 Hz by a 4th-order one. A mechanistic model of the 4th order, featuring tissue compliance (Ct), resistance (Rt) and inertance (It), alveolar gas compressibility (Cg) and airway resistance (Raw), and inertance (Iaw) was developed. Using that model, the following mean values were found: Ct = 2.08–10(-2)1-hPa-1 (1 hPa congruent to 1 cm of water); Rt = 1.10-hPa-1(-1)-s; It = 0.21–10(-2)hPa-1(-1)-s2; Raw = 1.35-hPa-1(-1)-s; Iaw = 2.55–10(-2)hPa-1(-1)-s2. Additional experiments devised to validate the model were reasonably successful, suggesting that the physical meaning attributed to the coefficients was correct. The validity of the assumptions and the physiological meaning of the coefficients are discussed.

scholarly journals Numerical Simulations of Molten Breakup Behaviors of a de Laval-Type Nozzle, and the Effects of Atomization Parameters on Particle Size Distribution

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1027
Author(s):  
Lianghui Xu ◽  
Xianglin Zhou ◽  
Jinghao Li ◽  
Yunfei Hu ◽  
Hang Qi ◽  
...  
Keyword(s):  
Particle Size ◽  
Particle Size Distribution ◽  
Size Distribution ◽  
Gas Flow ◽  
Nozzle Geometry ◽  
Particle Model ◽  
Process Conditions ◽  
Operating Pressure ◽  
Gas Temperature ◽  
Tracking Model

In this work, an atomizer with a de Laval-type nozzle is designed and studied by commercial computational fluid dynamics (CFD) software, and the secondary breakup process during atomization is simulated by two-way coupling and the discrete particle model (DPM) using the Euler-Lagrange method. The simulation result demonstrates that the gas flow patterns greatly change with the introduction of liquid droplets, which clearly indicates that the mass loading effect is quite significant as a result of the gas-droplet interactions. An hourglass shape of the cloud of disintegrating molten metal particles is observed by using a stochastic tracking model. Finally, this simulation approach is used for the quantitative evaluation of the effects of altering the atomizing process conditions (gas-to-melt ratio, operating pressure P, and operating gas temperature T) and nozzle geometry (protrusion length h, half-taper angle α, and gas slit nozzle diameter D) on the particle size distribution of the powders produced.

scholarly journals Experimental and Numerical Study of a Thermal Expansion Gyroscope for Different Gases

Sensors ◽  
2019 ◽  
Vol 19 (2) ◽  
pp. 360 ◽  
Author(s):  
Guillaume Kock ◽  
Philippe Combette ◽  
Marwan Tedjini ◽  
Markus Schneider ◽  
Caroline Gauthier-Blum ◽  
...  
Keyword(s):  
Thermal Expansion ◽  
Gas Flow ◽  
Numerical Study ◽  
Rotational Velocity ◽  
Measurement Range ◽  
Gas Temperature ◽  
Hot Air ◽  
Working Principle ◽  
Set Up ◽  
Different Gases

A new single-axis gas thermal gyroscope without proof mass is presented in this paper. The device was designed, manufactured and experimentally characterized. The obtained results were compared to numerical simulation. The working principle of the gyroscope is based on the deflection of a laminar gas flow caused by the Coriolis effect. A bidirectional hot air flow is generated by alternating activation of two suspended resistive micro-heaters. The heated gas is encapsulated in a semi-open cavity and the gas expands primarily inside the cavity. The thermal expansion gyroscope has a simple structure. Indeed, the device is composed of a micromachined cavity on which three bridges are suspended. The central bridge is electrically separated into two segments enabling to set up two heaters which may be supplied independently from each other. The two other bridges, placed symmetrically on each side of the central bridge, are equipped with temperature detectors which measure variations in gas temperature. The differential temperature depends on the rotational velocity applied to the system. Various parameters such as the heating duty cycle, the type of the gas and the power injected into the heaters have been studied to define the optimal working conditions required to obtain the highest level of sensitivity over a measurement range of around 1000°/s. The robustness of the device has also been tested and validated for a shock resistance of 10,000 g for a duration of 400 µs.

scholarly journals Numerical Analysis on Effect of Additional Gas Injection on Characteristics around Raceway in Melter Gasifier

2019 ◽  
Vol 38 (2019) ◽  
pp. 837-848
Author(s):  
Du Kaiping ◽  
Gao Xiangzhou ◽  
Sun Haibo
Keyword(s):  
High Speed ◽  
Gas Flow ◽  
Gas Injection ◽  
Coke Oven ◽  
Pure Oxygen ◽  
Small Scale ◽  
Gas Temperature ◽  
Fuel Gas ◽  
Hot Air ◽  
Flow Circulation

AbstractThe raceway plays an important role in the mass and heat transportation inside a melter gasifier. Considering that pure oxygen at room temperature instead of hot air is injected into the melter gasifier, a two-dimensional mathematical model at steady state is developed in the current work to describe the effect of the additional gas injection on the characteristics around the raceway in melter gasifier. The results show that a high-speed jet with a highest temperature above 3500 K could be found in front of tuyere. Furthermore, a small scale of gas flow circulation occurs in front of tuyere that results in a more serious thermal damage to tuyere. In order to decrease the gas temperature in the raceway to prevent the blowing-down caused by tuyere damage, the additional gas, including N2, natural gas (NG) and coke oven gas (COG) should be injected through the tuyere. Compared with N2, additional fuel gas injection gives full play to the high temperature reduction advantage of hydrogen. In addition, considering the insufficient hearth heat after injecting NG and the effective utilization of secondary resource, an appropriate amount of COG is recommended to be injected for optimizing blast system.

Part II. Research on the Performance of a Type of Internally Air-cooled Turbine Blade

1953 ◽  
Vol 167 (1) ◽  
pp. 351-370 ◽  
Author(s):  
D. G. Ainley
Keyword(s):  
Gas Flow ◽  
Thermal Stresses ◽  
Turbine Blades ◽  
Small Diameter ◽  
Rotor Blades ◽  
Air Cooling ◽  
Gas Temperature ◽  
Flow Through ◽  
Cooling Air ◽  
Practical Feasibility

A comprehensive series of tests have been made on an experimental single-stage turbine to determine the cooling characteristics and the overall stage performance of a set of air-cooled turbine blades. These blades, which are described fully in Part I of this paper had, internally, a multiplicity of passages of small diameter along which cool air was passed through the whole length of the blade. Analysis of the, test data indicated that, when a quantity of cooling air amounting to 2 per cent, by weight, of the total gas-flow through the turbine is fed to the row of rotor blades, an increase in gas temperature of about 270 deg. C. (518 deg. F.) should be permissible above the maximum allowable value for a row of uncooled blades made from the same material. The degree of cooling achieved throughout each blade was far from uniform and large thermal stresses must result. It appears, however, that the consequences of this are not highly detrimental to the performance of the present type of blading, it being demonstrated that the main effect of the induced thermal stress is apparently to transfer the major tensile stresses to the cooler (and hence stronger) regions of the blade. The results obtained from the present investigations do not represent a limit to the potentialities of internal air-cooling, but form merely a first exploratory step. At the same time the practical feasibility of air cooling is made apparent, and advances up to the present are undoubtedly encouraging.

Assessment of a Syngas-Diesel Dual Fuelled Compression Ignition Engine

2010 ◽  
Author(s):  
Bibhuti B. Sahoo ◽  
Niranjan Sahoo ◽  
Ujjwal K. Saha
Keyword(s):  
Diesel Engine ◽  
Thermal Efficiency ◽  
Gas Flow ◽  
Direct Injection ◽  
Dual Fuel ◽  
Exhaust Gas ◽  
Compression Ignition ◽  
Gas Temperature ◽  
Compression Ignition Engine ◽  
Exhaust Gas Temperature

Synthesis gas (Syngas), a mixture of hydrogen and carbon monoxide, can be manufactured from natural gas, coal, petroleum, biomass, and even from organic wastes. It can substitute fossil diesel as an alternative gaseous fuel in compression ignition engines under dual fuel operation route. Experiments were conducted in a single cylinder, constant speed and direct injection diesel engine fuelled with syngas-diesel in dual fuel mode. The engine is designed to develop a power output of 5.2 kW at its rated speed of 1500 rpm under variable loads with inducted syngas fuel having H2 to CO ratio of 1:1 by volume. Diesel fuel as a pilot was injected into the engine in the conventional manner. The diesel engine was run at varying loads of 20, 40, 60, 80 and 100%. The performance of dual fuel engine is assessed by parameters such as thermal efficiency, exhaust gas temperature, diesel replacement rate, gas flow rate, peak cylinder pressure, exhaust O2 and emissions like NOx, CO and HC. Dual fuel operation showed a decrease in brake thermal efficiency from 16.1% to a maximum of 20.92% at 80% load. The maximum diesel substitution by syngas was found 58.77% at minimum exhaust O2 availability condition of 80% engine load. The NOx level was reduced from 144 ppm to 103 ppm for syngas-diesel mode at the best efficiency point. Due to poor combustion efficiency of dual fuel operation, there were increases in CO and HC emissions throughout the range of engine test loads. The decrease in peak pressure causes the exhaust gas temperature to rise at all loads of dual fuel operation. The present investigation provides some useful indications of using syngas fuel in a diesel engine under dual fuel operation.

Exposure Test Results of Lu2Si2O7 in Combustion Gas Flow at High Temperature and High Speed

2004 ◽  
Author(s):  
Isao Yuri ◽  
Tohru Hisamatsu ◽  
Shunkichi Ueno ◽  
Tatsuki Ohji
Keyword(s):  
Weight Loss ◽  
Water Vapor ◽  
Partial Pressure ◽  
Gas Flow ◽  
Loss Rate ◽  
Gas Temperature ◽  
Weight Loss Rate ◽  
Combustion Gas ◽  
Vapor Partial Pressure ◽  
Water Vapor Partial Pressure

In order to understand recession behavior and the amount of recession of Lu2Si2O7 in the combustion gas flow, sintered Lu2Si2O7 specimens were manufactured by hot pressing and exposed under various combustion gas flow conditions (T = 1300–1500 °C, P = 0.3 MPa, V = 150 m/s, PH2O = 27–69 kPa, t = 10h). After the exposure tests, etch pits, which are assumed to form due to volatilization of SiO2 in the grain boundary phase, were observed at the surface of specimen. The amount of Lu2SiO5 phase at the surface of specimen increased with the increase of gas temperature or water vapor partial pressure. A corresponding decrease in the amount of Lu2Si2O7 phase was observed. Furthermore, by using the average weight loss rate for exposure times of ten hours, the influence of gas temperature and water vapor partial pressure on weight loss rate was examined, and the amount of recession under gas turbine conditions was calculated.

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