scholarly journals Understanding the Ethnobotany, Chemistry, Pharmacology, and Distribution of Genus Hydnora (Aristolochiaceae)

Plants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 494
Author(s):  
Elijah Mbandi Mkala ◽  
Moses Mutuse Mutungi ◽  
Elizabeth Syowai Mutinda ◽  
Millicent Akinyi Oulo ◽  
Vincent Okelo Wanga ◽  
...  
Keyword(s):  
Arid Regions ◽  
Arabian Peninsula ◽  
Biological Activities ◽  
Phytochemical Screening ◽  
Research Gaps ◽  
Pharmacological Activities ◽  
Nutritional Values ◽  
The World ◽  
Available Information ◽  
Species Being

The genus Hydnora (Hydnoraceae) is one of the basal angiosperms in the order Piperales, found in the semi-arid regions of Africa, and the Southern Arabian Peninsula. Plants in this genus play essential roles in communities around the world as revealed by various studies. Currently, there are eight species of the genus Hydnora; seven in Africa and one in the Arabian Peninsula. Notably, Hydnora abyssinica A.Br. and Hydnora africana Thunb. are widely distributed compared to other species. They are widely used for their medicinal and nutritional values. The information on ethnobotany, chemistry, pharmacology, and distribution of genus Hydnora was gathered using phytochemical and ethnobotanical books, electronic sources, and published articles. Preliminary phytochemical screening shows that flavonoids, phenolics, proanthocyanidins, and tannins are the main compounds in H. abyssinica and H. africana. Furthermore, 11 compounds have been isolated from H. abyssinica. The biological activities of H. abyssinica and H. africana have been reported. They include antibacterial, antiproliferative, antioxidant, antidiarrhea, and antifungal potentials. Despite the Hydnora species being practiced in ancient folkloric medicine, their traditional uses and pharmacological value are poorly documented. Based on the available information on ethnobotany, phytochemistry, pharmacology, and distribution, we aim to provide research gaps and challenges for a better understanding of this genus. This may be resourceful in the development of effective phytomedicines, and aid in conservation. The available studies on this genus on some aspects such as phytochemistry, pharmacological activities, and distribution are under-reported hence the need for further research.

scholarly journals A REVIEW ON MARINE ALGAE AND ITS APPLICATIONS

2020 ◽  
pp. 21-27
Author(s):  
CHANDRA VELUCHAMY ◽  
RADHA PALANISWAMY
Keyword(s):  
Bioactive Compounds ◽  
Marine Algae ◽  
Biological Activities ◽  
Therapeutic Agents ◽  
The Novel ◽  
Marine Microbes ◽  
Pharmacological Activities ◽  
Nutritional Values ◽  
Other Substances ◽  
Living Organisms

The ocean is the major essential source of structurally unique natural products that are mainly present in living organisms. The essential products extracted from marine microbes and marine algae are highly analyzed areas in instinctive product research. Marine algae are the novel food with potential nutritional values used for multiple purposes in industry and medicine. They show pharmacological activities which are helpful for the invention of bioactive compounds. Furthermore, marine algae have shown to provide an abundant source of natural bioactive compounds with antidiabetic, anti-inflammatory, antiviral, antifungal, hypolipidemic, antioxidant, anti-hypercholesterolemia, antibacterial, and antineoplastic properties. They produce new secondary metabolites that possess biological activities and have the potential to be developed as therapeutic agents. Macroalgal lectins, fucoidans, kainoids, and other substances have been routinely used in the research of biomedical and also have biological activities. The potential pharmaceutical, medicinal, and research applications of these compounds are discussed.

scholarly journals Recent Advances in the Semisynthesis, Modifications and Biological Activities of Ocotillol-Type Triterpenoids

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5562
Author(s):  
Yucheng Cao ◽  
Kaiyi Wang ◽  
Si Xu ◽  
Lingtan Kong ◽  
Yi Bi ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Pharmacological Activities ◽  
Structure Activity ◽  
Recent Advances ◽  
The World ◽  
Anti Inflammatory ◽  
Active Substances

Ginseng is one of the most widely consumed herbs in the world and plays an important role in counteracting fatigue and alleviating stress. The main active substances of ginseng are its ginsenosides. Ocotillol-type triterpenoid is a remarkably effective ginsenoside from Vietnamese ginseng that has received attention because of its potential antibacterial, anticancer and anti-inflammatory properties, among others. The semisynthesis, modification and biological activities of ocotillol-type compounds have been extensively studied in recent years. The aim of this review is to summarize semisynthesis, modification and pharmacological activities of ocotillol-type compounds. The structure–activity relationship studies of these compounds were reported. This summary should prove useful information for drug exploration of ocotillol-type derivatives.

scholarly journals Opuntia ficus-indica (L.) Mill.: A Multi-Benefit Potential to Be Exploited

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 951
Author(s):  
Mafalda Alexandra Silva ◽  
Tânia Gonçalves Albuquerque ◽  
Paula Pereira ◽  
Renata Ramalho ◽  
Filipa Vicente ◽  
...  
Keyword(s):  
Food Security ◽  
Bioactive Compounds ◽  
Arid Regions ◽  
Biological Activities ◽  
Food Products ◽  
Prickly Pear ◽  
Opuntia Ficus Indica ◽  
Antioxidant Power ◽  
The World ◽  
Semi Arid

Consumer interest in foods with enhanced nutritional quality has increased in recent years. The nutritional and bioactive characterization of fruits and their byproducts, as well as their use in the formulation of new food products, is advisable, contributing to decrease the global concerns related to food waste and food security. Moreover, the compounds present in these raw materials and the study of their biological properties can promote health and help to prevent some chronic diseases. Opuntia ficus-indica (L.) Mill. (prickly pear) is a plant that grows wild in the arid and semi-arid regions of the world, being a food source for ones and a potential for others, but not properly valued. This paper carries out an exhaustive review of the scientific literature on the nutritional composition and bioactive compounds of prickly pear and its constituents, as well as its main biological activities and applications. It is a good source of dietary fiber, vitamins and bioactive compounds. Many of its natural compounds have interesting biological activities such as anti-inflammatory, hypoglycemic and antimicrobial. The antioxidant power of prickly pear makes it a good candidate as an ingredient of new food products with fascinating properties for health promotion and/or to be used as natural extracts for food, pharmaceutic or cosmetic applications. In addition, it could be a key player in food security in many arid and semi-arid regions of the world, where there are often no more plants.

scholarly journals Review: Pharmacological Activity, Chemical Composition and Medical Importance of Leonotis nepetifolia R.Br.

2021 ◽  
pp. 29-43
Author(s):  
Pranjal C. Tidke ◽  
Nikhita Chambhare ◽  
Milind J. Umekar ◽  
R. T. Lohiya
Keyword(s):  
Biological Activities ◽  
Physiological Effects ◽  
Huge Number ◽  
Pharmacological Activities ◽  
Important Species ◽  
Medicinal Uses ◽  
The World ◽  
History Of ◽  
Medical Importance ◽  
Allenic Acid

India is perhaps the most unique country in the world, with the richest tradition of indigenous and health care medical practices. Most of these practices are unique and known to very few individuals or communities. Leonotis nepetifolia Family (Lamiaceae) commonly known as ‘Klip dagga’ which has a long history of several traditional medicinal uses in many countries in the world. A huge number of phytoconstituents have been reported from the plant are allenic acid, iridoids, glycosides, terpenoids, and many more. This plant exhibited various biological activities and has been attributed to a variety of physiological effects like antifungal, antidiabetic, anxiolytic, arthritic, and many more activities. This literature review presents important species covering phytochemistry and pharmacological activities aspects systematically.

A Gift of Good Health from Mother Nature: Presenting Moringa oleifera, a Plant with Multiple Anticancer Activities

2021 ◽  
Vol 6 (4) ◽  
pp. 284-291
Author(s):  
Madhushree Das Sarma
Keyword(s):  
Moringa Oleifera ◽  
Biological Activities ◽  
Good Health ◽  
Anticancer Activities ◽  
Nutritional Values ◽  
Low Concentrations ◽  
The World ◽  
Low Toxicity ◽  
Different Parts ◽  
Moringa Oleifera Lam

Moringa oleifera Lam. (Moringaceae) is a multifarious beneficial tree and widely cultivated in the tropical and subtropical regions all over the world. All parts of this plants are edible and used as a plentiful source of phytochemicals with high nutritional values. Since antiquity, this plant was recognized as a panacea for the treatment of several ailments in ethnomedicinal system. In last few decades, this fact is further reconfirmed by various scientific research works in which the plant was found to show broad spectrum of biological activities including antioxidant, anti-inammatory, antiurolithic, antimicrobial, anangesic, antidiabetic, antihypertensive, antiproliferative, hepatoprotective, cardioprotective, etc. Different parts of this plant exhibited significant inhibitory activity against a variety of cancer cells at moderate to low concentrations and also possess low toxicity in normal cells. This review mainly focuses a brief overview on the anticancer profile of this wonderful tree.

Phytochemical Contents, Biological Activities, and Therapeutic Applications of Hedera Helix (Ivy Leaf) Extracts: A Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Aya Shokry ◽  
Riham El-Shiekh ◽  
Gehan Kamel ◽  
Amer Ramadan
Keyword(s):  
Biological Activities ◽  
Phytochemical Screening ◽  
Bioactive Constituents ◽  
Leaf Extracts ◽  
Hedera Helix ◽  
Pharmacological Activities ◽  
Chemical Screening ◽  
Therapeutic Uses

Background: Herbs have long been used as natural therapeutics, and recent controlled clinical studies have confirmed some of the presumed benefits. Hedera helix (ivy leaves) is a valuable common from related to the family Araliaceae. Many herbal preparations include extracts from their leaves as the principle active ingredient. Objective: The objective of this article is to summarize the pharmacological activities and phytochemical screening of H. helix. Methods: The objective of this article is to summarize the pharmacological activities and phytochemical screening of H. helix. Results: The all-published studies depend on isolation, identification and characterization of different active constituents of H. helix leaves followed by determination of biological activities in vivo and in vitro. Chemical screening has shown that H. helix leaves are a rich source of phytochemicals with demonstrated therapeutic activities, such as sterols, tannins, terpenoids, glycosides, phenols, emetine alkaloids, flavonoids, saponins, volatile and fixed oils, vitamins, carbohydrates, reducing sugars, and minerals. Further, studies of disease models and clinical trials have demonstrated anti-inflammatory, analgesic, cough suppressant, expectorant, anticancer, antimicrobial, anticoagulant, and smooth muscle relaxant activities. Conclusion: This review summarizes the bioactive constituents of H. helix leaves and their underlying pharmacological mechanisms, clinical efficacies, and safety profiles. We also suggest potential therapeutic uses for Covid-19.

Biodiversity of the aculeate wasps (Hymenoptera: Aculeata) of the Arabian Peninsula: Preface

Zootaxa ◽  
2020 ◽  
Vol 4754 (1) ◽  
pp. 5-7
Author(s):  
NEVEEN S. GADALLAH ◽  
DENIS J. BROTHERS
Keyword(s):  
Arabian Peninsula ◽  
Focused Attention ◽  
Diverse Group ◽  
Ecological Studies ◽  
The Past ◽  
Additional Work ◽  
The World ◽  
Opportune Time ◽  
Taxonomic Changes ◽  
Available Information

During the past 20 decades, many taxonomic and ecological studies were undertaken on different taxa of a fascinating, biologically diverse group of insects, the aculeate wasps, in different areas of the Arabian Peninsula. These wasps comprise all Aculeata, except for the ants (Formicidae) and bees (Anthophila) which are specialized monophyletic groups that have attracted more focused attention across the world. The Arabian studies have been published in the form of scattered articles in various journals, newsletters, book chapters, etc., many being rather obscure and difficult to trace. Recently, the number of such studies has increased as a result of targeted collecting projects. The results of most of these have now been published, making this an opportune time to collect all the available information into a single volume that makes it more accessible to researchers interested in this group of insects. In the process, this provides us an opportunity to estimate the diversity and distributions of aculeate wasps in the Arabian countries. This is also important for the development of the Arabian national collections, especially in aggregating taxonomic changes with their subsequent synonymous forms and pointing out the very many gaps in sampling, so indicating where additional work is needed. 

Potential Triazole-based Molecules for the Treatment of Neglected Diseases

2019 ◽  
Vol 26 (23) ◽  
pp. 4403-4434 ◽  
Author(s):  
Susimaire Pedersoli Mantoani ◽  
Peterson de Andrade ◽  
Talita Perez Cantuaria Chierrito ◽  
Andreza Silva Figueredo ◽  
Ivone Carvalho
Keyword(s):  
Effective Treatment ◽  
Chagas Disease ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Neglected Diseases ◽  
Triazole Derivatives ◽  
Wide Range ◽  
The World ◽  
Great Relevance ◽  
The Moment

Neglected Diseases (NDs) affect million of people, especially the poorest population around the world. Several efforts to an effective treatment have proved insufficient at the moment. In this context, triazole derivatives have shown great relevance in medicinal chemistry due to a wide range of biological activities. This review aims to describe some of the most relevant and recent research focused on 1,2,3- and 1,2,4-triazolebased molecules targeting four expressive NDs: Chagas disease, Malaria, Tuberculosis and Leishmaniasis.

Tetrazoloquinolines: Synthesis, Reactions, and Applications

2020 ◽  
Vol 24 (4) ◽  
pp. 439-464 ◽  
Author(s):  
Rizk E. Khidre ◽  
Tahah A. Ameen ◽  
Mounir A. I. Salem
Keyword(s):  
Carboxylic Acid ◽  
Chemical Reactions ◽  
Sodium Azide ◽  
Biological Activities ◽  
Quinoline Derivatives ◽  
Pharmacological Activities ◽  
Synthesis Reactions ◽  
Intramolecular Cyclocondensation

This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[ 1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.

scholarly journals Cyanobacteria—From the Oceans to the Potential Biotechnological and Biomedical Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 241
Author(s):  
Shaden A. M. Khalifa ◽  
Eslam S. Shedid ◽  
Essa M. Saied ◽  
Amir Reza Jassbi ◽  
Fatemeh H. Jamebozorgi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Biomedical Applications ◽  
Large Scale ◽  
Biological Activities ◽  
Scale Production ◽  
Pharmacological Activities ◽  
Large Scale Production ◽  
Marine Products ◽  
Hiv 1 ◽  
Successful Phase

Cyanobacteria are photosynthetic prokaryotic organisms which represent a significant source of novel, bioactive, secondary metabolites, and they are also considered an abundant source of bioactive compounds/drugs, such as dolastatin, cryptophycin 1, curacin toyocamycin, phytoalexin, cyanovirin-N and phycocyanin. Some of these compounds have displayed promising results in successful Phase I, II, III and IV clinical trials. Additionally, the cyanobacterial compounds applied to medical research have demonstrated an exciting future with great potential to be developed into new medicines. Most of these compounds have exhibited strong pharmacological activities, including neurotoxicity, cytotoxicity and antiviral activity against HCMV, HSV-1, HHV-6 and HIV-1, so these metabolites could be promising candidates for COVID-19 treatment. Therefore, the effective large-scale production of natural marine products through synthesis is important for resolving the existing issues associated with chemical isolation, including small yields, and may be necessary to better investigate their biological activities. Herein, we highlight the total synthesized and stereochemical determinations of the cyanobacterial bioactive compounds. Furthermore, this review primarily focuses on the biotechnological applications of cyanobacteria, including applications as cosmetics, food supplements, and the nanobiotechnological applications of cyanobacterial bioactive compounds in potential medicinal applications for various human diseases are discussed.

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