scholarly journals The Unique Substance, Lidocaine and Biological Activityof the Dioscorea Species for Potential Application as a Cancer Treatment, Natural Pesticide and Product

Plants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1551
Author(s):  
Warin Wonok ◽  
Arunrat Chaveerach ◽  
Pornnarong Siripiyasing ◽  
Runglawan Sudmoon ◽  
Tawatchai Tanee
Keyword(s):  
Biological Activity ◽  
Comet Assay ◽  
Cancer Treatment ◽  
High Efficiency ◽  
Brassica Chinensis ◽  
Hct 116 ◽  
Dioscorea Species ◽  
Product Creation ◽  
Ethanol Extracts ◽  
Natural Pesticide

The six Dioscorea species, D. brevipetiolata, D. bulbifera, D. depauperata (Dd), D. glabra (Dg), D. pyrifolia and D. hamiltonii were analyzed for phytochemicals, toxicity in PBMCs, and biological activity in two cancer cell lines by MTT and comet assays, and pesticide efficiency. Via GC-MS, lidocaine was found to be the predominant compound in two of the studied species. To confirm the systematics, lidocaine was also found in lower amounts in 11 species. The MTT assay showed no toxicity in all six of the studied species. The comet assay showed the key result that the ethanol extracts of Dd and Dg violently broke DNA into pieces. Biological activity of these two species’ extracts showed toxicity on HepG2 and no effects on HCT-116. The water extracts of Dd and Dg, applied to Brassica chinensis showed high efficiency as a bioprotectant. In summary, lidocaine seems to be the predominant identifying compound of the genus Dioscorea in Thailand, which is useful in systematics. At least the two species, Dd and Dg, may be used for human hepatocyte cancer treatment and as an alternative pesticide for economically important vegetables. Dioscorea species containing lidocaine or extracted lidocaine have promise for natural product creation.

scholarly journals The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

2018 ◽  
Vol 5 (6) ◽  
pp. 172317 ◽  
Author(s):  
Chang K. Zhao ◽  
Chan Li ◽  
Xian H. Wang ◽  
Yu J. Bao ◽  
Fu H. Yang ◽  
...  
Keyword(s):  
Biological Activity ◽  
Cell Growth ◽  
Cancer Treatment ◽  
Cancer Cell ◽  
Therapeutic Potential ◽  
Selective Synthesis ◽  
Cancer Cell Growth ◽  
Activity Evaluation ◽  
Moderate Yield

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro . These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.

scholarly journals Preparation of crotalus venom radiolabeled with technetium-99m as a tool for biodistribution study

2005 ◽  
Vol 48 (spe2) ◽  
pp. 9-12 ◽  
Author(s):  
Priscilla Brunelli Pujatti ◽  
Carlos Jorge Rodrigues Simal ◽  
Raquel Gouvêa dos Santos
Keyword(s):  
Biological Activity ◽  
High Efficiency ◽  
High Yield ◽  
Clinical Use ◽  
Crude Venom ◽  
Technetium 99M ◽  
Biodistribution Studies ◽  
Nuclear Medicine Procedures ◽  
Distribution Studies ◽  
Exogenous Source

Technetium-99m (99mTc) has been the radionuclide of choice for nuclear medicine procedures and experimental research. Because of its optimal nuclear properties, 99mTc is suitable for high efficiency detection with the advantage of reduced radiological waste. Crotalus venom (CV) has been shown to reduce tumors in clinical studies and tissue distribution studies are very important for clinical use. The goal of this work was to obtain CV labeled with 99mTc which preserves its biological activity. After labeling, biological activity was assessed by hemolytic activity evaluation. Labeled and crude venom caused indirect hemolysis provided that the incubation medium contained an exogenous source of lecithin. High yield radiolabeled-CV was obtained and biological activity was preserved. The results suggest that 99mTc-CV can be a useful tool for biodistribution studies.

scholarly journals Biological Activity of Ethanol Extracts from Amelanchier asiatica Fruits

2011 ◽  
Vol 54 (4) ◽  
pp. 238-243 ◽  
Author(s):  
Jung-Woo Chae ◽  
Jin-Sung Kim ◽  
Bun-Sung Jo ◽  
Sun-Ae Kang ◽  
Hye-Jin Park ◽  
...  
Keyword(s):  
Biological Activity ◽  
Ethanol Extracts

scholarly journals Creation of New Analogues of Natural Phytogormons for Increasing the Yield of Agricultural Crops

2018 ◽  
Vol 7 (3.32) ◽  
pp. 59
Author(s):  
Zhylkybaev Oral ◽  
Alimzhanova Mereke ◽  
Ashimuly Kazhybek ◽  
Shoinbekova Sabina ◽  
Tukenova Zulfia
Keyword(s):  
Biological Activity ◽  
Growth Regulator ◽  
High Efficiency ◽  
Field Tests ◽  
Dry Mass ◽  
Water Soluble ◽  
High Yield ◽  
Small Scale ◽  
Wide Range ◽  
Reference Preparation

Synthesis of new potential plant growth regulators (analogues of natural phytohormones) is accomplished by mixing an equimolar mixture of aryloxypropin and 1-methylpiperidin-4-one under the conditions of Favorsky's reactions. New derivatives of acetylene aminoalcohols - the ZhOT series - have been obtained. The structure of the synthesized compounds was established by IR and NMR 1H spectroscopy. Screening of their water-soluble forms, on wheat and barley seeds, two preparations (ZhOT-4 and ZhOT-7) were selected, which exceed both the control and standards of known phytohormones, such as heteroauxin (indolyl-3-acetic acid), 6-BAP (6-benzylaminopurine) for further testing. Conducted in-depth laboratory and demonstration field tests on cereals (wheat and barley) showed high efficiency of ZhOT-4 and ZhOT-7, the indicators of which exceeded the well-known reference preparation - Agrostimulin (Ukraine). The growth regulating activity of synthesized compounds was determined. Processing of wheat seeds ZhOT-4 and ZhOT-7 increased the field germination of seeds, plant height, leaf area, the mass of the aerial part and the total area. The conducted studies showed that the biological activity of the tested compounds largely depends on the concentration and the best growth regulator is ZhOT-4. The activity of the synthesized growth regulatory compounds has been determined. Treatment of seeds of with ZhOT-4 and ZhOT-7 increased seed germination, height of plants, leave areas, weight of an elevated part and the total area, weight of an elevated part and the total area. Studies have shown that the biological activity of tested compounds is largely dependent on the concentration and the best growth regulator is ZhОТ-4. Thus, the advanced laboratory and demonstration (small-scale) comparative tests of ZhOT-4 and ZhOT-7 and the well-known reference preparation "Agrostimulin" (Ukraine) for cereals (wheat and barley) showed high efficiency of new synthesized preparations. The use of ZhOT preparations increases the germination and germination energy, the number of spikelets, the mass of grains, the bushiness and the yield of wheat and barley, leads to the accumulation of dry mass in both the ground and underground parts of plants. The advantages of ZhOT-4 and ZhOT-7 are: high efficiency, a wide range of cultures, good solubility in water, low application dose of 0.0001% by active ingredient (1g per 1t of water) or 13-50 mg per hectare, comparable to natural phytohormones, long shelf life, safety, high yield of target products, sequential 3-stage reaction in one reactor. 

Synthesis and biological activity of new 2,4,6-trisubstituted triazines as potential phosphoinositide 3-kinase inhibitors

2020 ◽  
Vol 44 (7-8) ◽  
pp. 393-402
Author(s):  
Minhang Xin ◽  
Hui-Yan Wang ◽  
Hao Zhang ◽  
Ying Shen ◽  
San-Qi Zhang
Keyword(s):  
Biological Activity ◽  
Anticancer Drugs ◽  
Antiproliferative Activity ◽  
Kinase Inhibitors ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Hct 116 ◽  
Phosphoinositide 3 Kinase ◽  
New Anticancer Drugs ◽  
Mcf 7

Twenty-five novel 2,4,6-trisubstituted triazines were synthesized and biologically evaluated. Most of the compounds synthesized showed good antiproliferative activity against HCT-116 and MCF-7. Compounds B18 and B19 showed the best antiproliferative activity. Further study showed B18 and B19 inhibited four phosphoinositide 3-kinase isoforms and mammalian target of rapamycin with good potency. These results demonstrate that 2,4,6-trisubstituted triazines are potentially useful phosphoinositide 3-kinase inhibitors for the development of new anticancer drugs.

scholarly journals Novel Surface Modification of ZnO QDs for Paclitaxel-Targeted Drug Delivery for Lung Cancer Treatment

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582092673
Author(s):  
Chuan Xie ◽  
Yan Zhan ◽  
Peng Wang ◽  
Bo Zhang ◽  
Yukun Zhang
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Cancer Treatment ◽  
Drug Delivery System ◽  
Delivery System ◽  
High Efficiency ◽  
A549 Cells ◽  
Cytotoxicity Studies

Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.

Psychosocial Analysis of Cancer Deaths

1975 ◽  
Vol 6 (1) ◽  
pp. 61-75 ◽  
Author(s):  
Avery D. Weisman ◽  
J. William Worden
Keyword(s):  
Biological Activity ◽  
Cancer Treatment ◽  
Personal Life ◽  
Death Wishes

In addition to biological activity and cancer treatment, psychosocial considerations may influence both the quality of survival and its length. The investigators used information from psychological autopsies of cancer deaths, and correlated observed survival (measured in months beyond expected survival) with psychosocial findings. Patients who lived significantly longer tended to maintain cooperative and mutually responsive relationships, especially towards the end of their lives. Patients with death wishes, depression, apathy, and long-standing mutually destructive relationships survived for shorter periods than expectable. Why longevity occurs in some patients, but not in others, may be related to different traits which create alienation in personal life and in caretaking staff as life draws to a close. More assertive patients ask for and get better attention and services, and as a result, may live longer and die better deaths.

scholarly journals Spectroscopic Characterization of an Oxovanadium(IV) Complex of Oxodiacetic Acid and 2,2’-Bipyridine. Bioactivity on Osteoblast-Like Cells in Culture

2017 ◽  
Vol 57 (3) ◽  
Author(s):  
Ignacio E. León ◽  
Susana B. Etcheverry ◽  
Beatriz S. Parajón-Costa ◽  
Enrique J. Baran
Keyword(s):  
Cell Proliferation ◽  
Biological Activity ◽  
Cancer Treatment ◽  
Cellular Proliferation ◽  
Spectroscopic Characterization ◽  
Cells In Culture ◽  
Mouse Calvaria ◽  
Tumoral Cells

The oxovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and 2,2’-bipyridine (bipy) of stoichiometry [VO(ODA)(bipy)]⋅H<sub>2</sub>O, was thoroughly characterized by infrared, Raman and electronic spectroscopies. The biological activity of the complex on the cell proliferation was tested on osteoblast-like cells (MC3T3E1 osteoblastic mouse calvaria-derived cells and UMR106 rat osteosarcoma-derived cells) in culture. The complex caused inhibition of cellular proliferation in both osteoblast-like cells in culture, but its action was statistically stronger in the tumoral cells. This effect was specially marked with increasing concentrations of the complex. Based on these preliminary biological results, [VO(ODA)(bipy)]⋅H<sub>2</sub>O can be considered as a good candidate to be further investigated in relation to cancer treatment.

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