scholarly journals Porous Polymers from High Internal Phase Emulsions as Scaffolds for Biological Applications

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1786
Author(s):  
Stanko Kramer ◽  
Neil R. Cameron ◽  
Peter Krajnc
Keyword(s):  
Cell Growth ◽  
Biomedical Applications ◽  
Wide Spectrum ◽  
Continuous Phase ◽  
Porous Polymer ◽  
Porous Polymers ◽  
Biological Cell ◽  
Biological Applications ◽  
Internal Phase ◽  
Advanced Applications

High internal phase emulsions (HIPEs), with densely packed droplets of internal phase and monomers dispersed in the continuous phase, are now an established medium for porous polymer preparation (polyHIPEs). The ability to influence the pore size and interconnectivity, together with the process scalability and a wide spectrum of possible chemistries are important advantages of polyHIPEs. In this review, the focus on the biomedical applications of polyHIPEs is emphasised, in particular the applications of polyHIPEs as scaffolds/supports for biological cell growth, proliferation and tissue (re)generation. An overview of the polyHIPE preparation methodology is given and possibilities of morphology tuning are outlined. In the continuation, polyHIPEs with different chemistries and their interaction with biological systems are described. A further focus is given to combined techniques and advanced applications.

scholarly journals Bio-Compatible Ca-BDC/Polymer Monolithic Composites Templated from Bio-Active Ca-BDC Co-Stabilized CO2-in-Water High Internal Phase Emulsions

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 931
Author(s):  
Xule Yang ◽  
Youwei Hao ◽  
Liqin Cao
Keyword(s):  
Polymer Composites ◽  
Continuous Phase ◽  
Porous Polymer ◽  
Porous Composite ◽  
Open Cell ◽  
E Coli ◽  
Internal Phase ◽  
Carbon Dioxide Pressure ◽  
Bio Compatibility ◽  
Porous Composites

Because of the nontoxic solvents contained in CO2-in-water emulsions, porous polymer composites templated from these emulsions are conducive for bio-applications. Herein, bio-active rod-like calcium-organic framworks (Ca-BDC MOFs, BDC= 1,4-benzenedicarboxylate anion) particles co-stabilized CO2-in-water high internal phase emulsion (C/W HIPE) in the presence of polyvinyl alcohol (PVA) is first presented. After curing of the continuous phase, followed by releasing CO2, integral 3D macro-porous Ca-BDC monolith and Ca-BDC/Poly(2-hydroxyethyl methacrylate-co-acrylamide) HIPEs monolithic composites [Ca-BDC/P(AM-co-HEMA)HIPEs] with open-cell macro-porous structures were successfully prepared. The pore structure of these porous composite can be tuned by means of tailoring the Ca-BDC dosage, carbon dioxide pressure, and continuous phase volume fractions in corresponding C/W HIPEs. Results of bio-compatibility tests show that these Ca-BDC/P(AM-co-HEMA)HIPEs monoliths have non-cytotoxicity on HepG2 cells; also, the E. coli can grow either on the surfaces or inside these monoliths. Furthermore, immobilization of β-amylase on these porous composite presents that β-amylase can be well-anchored into the porous polymer composites, its catalytic activity can be maintained even after 10 cycles. This work combined bio-active MOFs Ca-BDC, bio-compatible open-cell macroporous polymer PAM-co-HEMA and green C/W HIPEs to present a novel and facile way to prepare interconnected macro-porous MOFs/polymer composites. Compared with the existing other well-known materials such as hydrogels, these porous composites possess well-defined tunable pore structures and superior bio-activity, thereby have promising applications in bio-tissue engineering, food, and pharmaceutical.

scholarly journals Morphology Control and Metallization of Porous Polymers Synthesized by Michael Addition Reactions of a Multi-Functional Acrylamide with a Diamine

Materials ◽  
2021 ◽  
Vol 14 (4) ◽  
pp. 800
Author(s):  
Naofumi Naga ◽  
Minako Ito ◽  
Aya Mezaki ◽  
Hao-Chun Tang ◽  
Tso-Fu Mark Chang ◽  
...  
Keyword(s):  
Phase Separation ◽  
Michael Addition ◽  
Phenylboronic Acid ◽  
Monomer Concentration ◽  
Coupling Reaction ◽  
Porous Polymer ◽  
Porous Polymers ◽  
Cross Coupling Reaction ◽  
Internal Phase ◽  
Polymerization Induced Phase Separation

Porous polymers have been synthesized by an aza-Michael addition reaction of a multi-functional acrylamide, N,N′,N″,N‴-tetraacryloyltriethylenetetramine (AM4), and hexamethylene diamine (HDA) in H2O without catalyst. Reaction conditions, such as monomer concentration and reaction temperature, affected the morphology of the resulting porous structures. Connected spheres, co-continuous monolithic structures and/or isolated holes were observed on the surface of the porous polymers. These structures were formed by polymerization-induced phase separation via spinodal decomposition or highly internal phase separation. The obtained porous polymers were soft and flexible and not breakable by compression. The porous polymers adsorbed various solvents. An AM4-HDA porous polymer could be plated by Ni using an electroless plating process via catalyzation by palladium (II) acetylacetonate following reduction of Ni ions in a plating solution. The intermediate Pd-catalyzed porous polymer promoted the Suzuki-Miyaura cross coupling reaction of 4-bromoanisole and phenylboronic acid.

How SIMS microscopy can be used in medicine

1992 ◽  
Vol 50 (2) ◽  
pp. 1602-1603
Author(s):  
Philippe Fragu
Keyword(s):  
Mass Spectrometry ◽  
Biomedical Applications ◽  
Secondary Ion Mass Spectrometry ◽  
Chemical Elements ◽  
Biological Applications ◽  
The Past ◽  
Potential Source ◽  
Secondary Ion ◽  
Chemical Integrity ◽  
Scientific Endeavour

The identification, localization and quantification of intracellular chemical elements is an area of scientific endeavour which has not ceased to develop over the past 30 years. Secondary Ion Mass Spectrometry (SIMS) microscopy is widely used for elemental localization problems in geochemistry, metallurgy and electronics. Although the first commercial instruments were available in 1968, biological applications have been gradual as investigators have systematically examined the potential source of artefacts inherent in the method and sought to develop strategies for the analysis of soft biological material with a lateral resolution equivalent to that of the light microscope. In 1992, the prospects offered by this technique are even more encouraging as prototypes of new ion probes appear capable of achieving the ultimate goal, namely the quantitative analysis of micron and submicron regions. The purpose of this review is to underline the requirements for biomedical applications of SIMS microscopy.Sample preparation methodology should preserve both the structural and the chemical integrity of the tissue.

scholarly journals Porous scaffolds with the structure of an interpenetrating polymer network made by gelatin methacrylated nanoparticle-stabilized high internal phase emulsion polymerization targeted for tissue engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (37) ◽  
pp. 22544-22555
Author(s):  
Atefeh Safaei-Yaraziz ◽  
Shiva Akbari-Birgani ◽  
Nasser Nikfarjam
Keyword(s):  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Cell Growth ◽  
Polymer Network ◽  
Synthetic Polymers ◽  
Tissue Scaffolds ◽  
Interpenetrating Polymer Network ◽  
Porous Scaffolds ◽  
Promising Strategy ◽  
Internal Phase

The interlacing of biopolymers and synthetic polymers is a promising strategy to fabricate hydrogel-based tissue scaffolds to biomimic a natural extracellular matrix for cell growth.

scholarly journals Hypercrosslinked porous polymers hybridized with graphene oxide for water treatment: dye adsorption and degradation

RSC Advances ◽  
2018 ◽  
Vol 8 (24) ◽  
pp. 13417-13422 ◽  
Author(s):  
Yipeng Huang ◽  
Guihua Ruan ◽  
Yuji Ruan ◽  
Wenjuan Zhang ◽  
Xianxian Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Water Treatment ◽  
Dye Adsorption ◽  
Porous Polymers ◽  
Internal Phase

We report the synthesis of graphene oxide hybridized polymeric high internal phase emulsions and their applications in adsorption and photocatalysis.

Improved dispersibility of nano-graphene oxide by amphiphilic polymer coatings for biomedical applications

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77818-77829 ◽  
Author(s):  
Rana Imani ◽  
Wei Shao ◽  
Shahriar Hojjati Emami ◽  
Shahab Faghihi ◽  
Satya Prakash
Keyword(s):  
Graphene Oxide ◽  
Biomedical Applications ◽  
Aqueous Media ◽  
Polymer Coatings ◽  
Amphiphilic Polymer ◽  
Nano Materials ◽  
Biological Applications ◽  
The Poor ◽  
Nano Graphene

The poor dispersibility of graphene-based nano-materials in aqueous media is a crucial limitation in their biological applications.

Preparation of Core-Shell Particles Consisted of Polysiloxane and Styrene-Butyl Methacrylate by High Internal Phase Emulsion

2014 ◽  
Vol 1033-1034 ◽  
pp. 996-1001
Author(s):  
Shao Jin Jia ◽  
Zhen Qi Zhang ◽  
Zhen Gang Ding ◽  
Xiao Tian Hou ◽  
Ping Kai Jiang
Keyword(s):  
Weight Ratio ◽  
Continuous Phase ◽  
Butyl Methacrylate ◽  
Core Shell ◽  
Water Contact ◽  
High Internal Phase Emulsion ◽  
Transmission Electron ◽  
Internal Phase ◽  
Shell Particles ◽  
Shell Composite

A core-shell composite polymer was produced by the method of high internal phase emulsion polymerization. The continuous phase of emulsion contained styrene(St), butyl methacrylate(BMA), octamethylcylotetrasiloxane(D4), and azobisisobutyronitrile (AIBN) which worked as an initiator. The block copolymers with St, BMA, D4 units are particularly promising for surface modification and hydrophobicity. The core-shell structure is proved by the use of Transmission electron microscopy (TEM). In addition, the water contact angle increased with the increasing weight ratio of D4. The results show that the concentrated emulsion system has good stability and the water resistance of the polymer has been improved greatly.

scholarly journals Stimuli Responsive, Programmable DNA Nanodevices for Biomedical Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Udisha Singh ◽  
Vinod Morya ◽  
Bhaskar Datta ◽  
Chinmay Ghoroi ◽  
Dhiraj Bhatia
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Dna Nanotechnology ◽  
Research Area ◽  
Biological Applications ◽  
Stimuli Responsive ◽  
Future Prospects ◽  
Dna Structures ◽  
Challenges And Opportunities

Of the multiple areas of applications of DNA nanotechnology, stimuli-responsive nanodevices have emerged as an elite branch of research owing to the advantages of molecular programmability of DNA structures and stimuli-responsiveness of motifs and DNA itself. These classes of devices present multiples areas to explore for basic and applied science using dynamic DNA nanotechnology. Herein, we take the stake in the recent progress of this fast-growing sub-area of DNA nanotechnology. We discuss different stimuli, motifs, scaffolds, and mechanisms of stimuli-responsive behaviours of DNA nanodevices with appropriate examples. Similarly, we present a multitude of biological applications that have been explored using DNA nanodevices, such as biosensing, in vivo pH-mapping, drug delivery, and therapy. We conclude by discussing the challenges and opportunities as well as future prospects of this emerging research area within DNA nanotechnology.

scholarly journals Synthesis and characterizations of nano-silica for biomedical applications

2021 ◽  
Vol 10 (2) ◽  
pp. 114-118
Author(s):  
Huyen Nguyen Thi ◽  
Tam Lai Thi Thanh ◽  
Yudy Paola Monreno Gonzalez ◽  
Thinh Nguyen Ngoc ◽  
Mai Nguyen Thi Tuyet ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Biomedical Applications ◽  
Cetyltrimethylammonium Bromide ◽  
Average Length ◽  
Biological Applications ◽  
Nano Silica ◽  
Facile Synthesis ◽  
Structure Morphology ◽  
Ft Ir

This paper presents a facile synthesis of nano-silica by hydrothermal treatment assisted by cetyltrimethylammonium bromide (CTAB). The effect of CTAB on the morphology of the material was also investigated. Structure, morphology, and composition of the material were studied byvarious methods such as XRD, SEM, FT-IR, and EDX.The results showed that a sample of nanosilica with amount of 1,0 g CTAB at pH 10-11 reached the most appropriate size, with the average length and width are 231,34±48,98 nm và 113,05±16,45 nm, respectively. In addition, the results indicated that the nanoparticles are completely pure, with many silanol groups on the surface, suitable for applications in bone tissue engineering and other biological applications.

Biocompatible succinic acid-based polyesters for potential biomedical applications: fungal biofilm inhibition and mesenchymal stem cell growth

RSC Advances ◽  
2015 ◽  
Vol 5 (104) ◽  
pp. 85756-85766 ◽  
Author(s):  
E. Jäger ◽  
R. K. Donato ◽  
M. Perchacz ◽  
A. Jäger ◽  
F. Surman ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Growth ◽  
Mesenchymal Stem Cell ◽  
Medical Devices ◽  
Biomedical Applications ◽  
Growth Promotion ◽  
Intrinsic Properties ◽  
Biofilm Inhibition

Poly(alkene succinates) are promising materials for specialized medical devices and tissue engineering, presenting intrinsic properties, such as; fungal biofilm inhibition, biocompatibility and stem cells controlled growth promotion.

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