scholarly journals Techno-Economic Analysis of a Hyaluronic Acid Production Process Utilizing Streptococcal Fermentation

Processes ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 241
Author(s):  
Rafael G. Ferreira ◽  
Adriano R. Azzoni ◽  
Maria Helena Andrade Santana ◽  
Demetri Petrides
Keyword(s):  
Hyaluronic Acid ◽  
Economic Analysis ◽  
Lower Cost ◽  
Value Added ◽  
Production Costs ◽  
Selling Price ◽  
Baseline Scenario ◽  
Adhesive Properties ◽  
Fed Batch Culture ◽  
Economic Analyses

Hyaluronic acid (HA) is a polysaccharide of alternating d-glucuronic acid and N-acetyl-d-glucosamine residues present in the extracellular matrix of connective, epithelial, and nervous tissues. Due to its singular hydrating, rheological and adhesive properties, HA has found numerous cosmetic and medical applications. However, techno-economic analyses of high value-added bioproducts such as HA are scarce in the literature. Here, we present a techno-economic analysis of a process for producing HA using Streptococcus zooepidemicus, simulated in SuperPro Designer. In the baseline scenario, HA is produced by batch fermentation, reaching 2.5 g/L after 24 h. It is then centrifuged, diafiltered, treated with activated carbon and precipitated with isopropanol. The product is suitable for topical formulations and its production cost was estimated as 1115 $/kg. A similar scenario, based on fed-batch culture and assuming a titer of 5.0 g/L, led to a lower cost of 946 $/kg. Moreover, in two additional scenarios, 10% of the precipitated HA is diverted to the production of a highly pure and high-molecular weight HA, suitable for injectable applications. These scenarios resulted in higher capital and operating costs, but also in higher profits, because HA for injectable use has a higher selling price that more than compensates for its higher production costs.

scholarly journals Economic analysis of up-to-date sour cherry or in Hungary

2008 ◽  
Vol 14 (1-2.) ◽  
Author(s):  
F. Apáti
Keyword(s):  
Economic Analysis ◽  
Sour Cherry ◽  
High Standard ◽  
Production Costs ◽  
Major Portion ◽  
Selling Price ◽  
Average Yield ◽  
Direct Production ◽  
Personal Cost ◽  
Profit Analysis

In this study cost-profit analysis is carried out to up-to-date Hungarian sour cherry orchards. These orchards cover only 1 to 3 thousand hectares from the sour cherry territory of 16 thousand hectares. In a many-year-average a yield of 15 tons per hectare may be reached in up-to-date sour cherry orchards cultivated under high standard conditions. Per hectare direct production costs take up of approximately 1000 thousand HUF, from which the major portion (60%) is accounted for the personal cost of harvesting. Regarding the above mentioned average yield and a selling price of 100 HUF per kilogram a revenue of 1 500 thousand HUF may be realized, which results in a per hectare contribution of 500 thousand HUF. To sum up, regarding the present extremely unfavourable selling price only reaching an average yield of 15 to 20 tons per hectare may lead to appropriate profit.

scholarly journals Techno-Economic Assessment for the Production of Algal Fuels and Value-Added Products: Opportunities for High-Protein Microalgae Conversion

2021 ◽  
Author(s):  
Matthew Wiatrowski ◽  
Bruno C Klein ◽  
Ryan W Davis ◽  
Carlos Quiroz-Arita ◽  
Eric C D Tan ◽  
...  
Keyword(s):  
Unsaturated Fatty Acids ◽  
Strong Dependence ◽  
Value Added ◽  
Hydrocarbon Fuels ◽  
High Protein ◽  
Production Costs ◽  
Selling Price ◽  
Economic Potential ◽  
Oxygenated Fuels ◽  
Mixed Alcohols

Abstract BackgroundMicroalgae possess numerous advantages for use as a feedstock in producing renewable fuels and products, with techno-economic analysis (TEA) frequently used to highlight the economic potential and technical challenges of utilizing this biomass in a biorefinery context. However, many historical TEA studies have focused on the conversion of biomass with elevated levels of carbohydrates and lipids and lower levels of protein, incurring substantial burdens on the ability to achieve high cultivation productivity rates relative to nutrient-replete, high-protein biomass. Given a strong dependence of algal biomass production costs on cultivation productivity, further TEA assessment is needed to understand the economic potential for utilizing potentially lower-cost but lower-quality, high-protein microalgae for biorefinery conversion. ResultsIn this work, we conduct rigorous TEA modeling to assess the economic viability of two conceptual technology pathways for processing proteinaceous algae into a suite of fuels and products. One approach, termed mild oxidative treatment and upgrading (MOTU), makes use of a series of thermo-catalytic operations to upgrade solubilized proteins and carbohydrates to hydrocarbon fuels, while another alternative focuses on the biological conversion of those substrates to oxygenated fuels in the form of mixed alcohols (MA). Both pathways rely on the production of polyurethanes from unsaturated fatty acids and valorization of unconverted solids for use as a material for synthesizing bioplastics. The assessment found similar, albeit slightly higher fuel yields and lower costs for the MA pathway, translating to a residual solids selling price of $899/ton for MA versus $1,033/ton for MOTU as would be required to support a $2.50/gallon gasoline equivalent (GGE) fuel selling price. A variation of the MA pathway including subsequent upgrading of the mixed alcohols to hydrocarbon fuels (MAU) reflected a required solids selling price of $975/ton.ConclusionThe slight advantages observed for the MA pathway are partially attributed to a boundary that stops at oxygenated fuels versus fungible drop-in hydrocarbon fuels through a more complex MOTU configuration, with more comparable results obtained for the MAU scenario. In either case, it was shown that an integrated algal biorefinery can be economical through optimal strategies to utilize and valorize all fractions of the biomass.

scholarly journals Identification of Rent Relations Results in the Accounting System

2020 ◽  
pp. 5-11
Author(s):  
Serhiy Bardash ◽  
◽  
Tetyana Osadcha ◽  
Keyword(s):  
Natural Resources ◽  
Information Disclosure ◽  
Balance Sheet ◽  
Value Added ◽  
Production Costs ◽  
Practical Significance ◽  
Selling Price ◽  
Accounting System ◽  
Environmental Measures ◽  
Economic Nature

In the context of the implementation of the concept of sustainable development of individual countries of the post-Soviet space, the study of the problems of accounting for the results of rent relations becomes relevant given the solution of a number of strategic tasks facing businesses today. It is offered to solve the specified problem on the basis of definition in system of concepts of accounting of the economic nature of results of rent relations arising as a result of involvement in economic process of rent-forming factors. The purpose of the article is to formulate proposals for accounting for the results of rental relationships. The methodological basis of the research is the historical and logical method, which is used to study the evolution of rent and approaches to the disclosure of its economic content. The dialectical method and comparative analysis are used to identify significant differences in the definition of rent, formed at different stages and forms of economic relations. Methods of analysis, synthesis, induction, deduction, abstraction, idealization and generalization are used to identify the results of rent relations in the system of accounting concepts and formulate proposals for rent accounting and rent payments. Based on a critical assessment of a certain pluralism of researchers' opinions on the disclosure of the economic content of rent, it is established that: rent is a component of value added, but value added is not taken into account in the accounting system; rent is a component of income from operating activities carried out with the use or exploitation of limited natural resources; the complication of the preliminary valuation of rent makes it impossible to reflect it in income; the amount of rent depends on the demand for the product. Given the above, rent as income from the extraction / use of natural resources, as well as the use of other rent-forming factors, it is proposed to reflect on the off-balance sheet account “Rent” with the allocation of sub-accounts by type of economic rent. It is proposed to attribute rent payments to operating costs, as their inclusion in production costs contradicts the economic nature of such costs, unreasonably increases the cost and contradicts the principle of fair distribution of rent. The practical significance of the study is to increase the level of information disclosure for management decisions, in particular: determining the maximum allowable reduction in the selling price of finished products while maintaining an acceptable level of profitability to increase demand, expand market and, consequently, increase profits; directing all or part of the rent to the implementation of environmental measures, modernization of material and technical base, intensification of innovation.

scholarly journals Energetic and Economic Analyses for Agricultural Management Models: The Calabria PGI Clementine Case Study

Energies ◽  
2020 ◽  
Vol 13 (5) ◽  
pp. 1289 ◽  
Author(s):  
Giacomo Falcone ◽  
Teodora Stillitano ◽  
Anna Irene De Luca ◽  
Giuseppe Di Vita ◽  
Nathalie Iofrida ◽  
...  
Keyword(s):  
Economic Analysis ◽  
Organic Farming ◽  
Energy Use ◽  
Average Energy ◽  
Farming Systems ◽  
The Other ◽  
Selling Price ◽  
South Italy ◽  
Average Energy Consumption ◽  
Economic Analyses

Farming systems need to be planned to provide suitable levels of economic profitability and, at the same time, ensure an effective energy use, in order to perform environmentally friendly production strategies. The herein present work aims to assess the efficiency of energy use and economic impacts of the main farming methods (conventional, organic and integrated) of Clementine’s crops in Calabria (South Italy), through a combined use of Life Cycle Energy Assessment (LCEA) approach and economic analysis. For this purpose, data were collected from clementine producers by using face-to-face interviews. The results revealed that average energy consumption in the organic farming systems was 72,739 MJ, lower than conventional and integrated systems equal to 95,848 MJ and 94,060 MJ, respectively. This is mainly due to the ban of chemicals. Economic analysis showed that organic farms were more profitable compared with the other farming methods, because of the greater selling price and the EU economic support, reaching an average net profit of 4255 € ha−1 against 3134 € ha−1 of integrated farms and 2788 € ha−1 of conventional ones. The economic efficiency of energy from clementine production was 0.058 € MJ−1 in the organic farming, higher compared to the other two farming systems equal to 0.033 € MJ−1 on average.

PROFITABILITAS USAHA PETERNAKAN AYAM BROILER DENGAN TIPE KANDANG YANG BERBEDA

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
Nurul Mukminah ◽  
Rita Purwasih
Keyword(s):  
Economic Analysis ◽  
Production Cost ◽  
Broiler Chicken ◽  
Production Costs ◽  
Different Types

This study aims to determine and compare the profitability of different types of broiler chicken farms (open and cloused houses) in Subang Regency. This study involved 9 farmers consisting of 5 farmers with closed house and 4 farmers with open house who partnered with PT. Surya Unggas Mandiri (PT. SUM). Production costs taken are 2 production periods from May-August 2018. Data are analyzed using economic analysis and descriptive methods. The results showed that the production cost per period per 1000 birds closed house was higher (Rp. 27.656.768,-) compared to open house (Rp. 24.975.671,-). The revenue per period per 1000 birds of closed house is higher (Rp. 30.606.931,-) compared to open house (Rp. 25.788.618,-). The profit of farmers who use closed house is higher (Rp. 2.621/period/bird) than open house (Rp.417,-). The profitability in close house s is 9.48% and is very feasible to develop

scholarly journals Investigation of Changes in Saliva in Radiotherapy-Induced Head Neck Cancer Patients

2021 ◽  
Vol 18 (4) ◽  
pp. 1629
Author(s):  
Christina Winter ◽  
Roman Keimel ◽  
Markus Gugatschka ◽  
Dagmar Kolb ◽  
Gerd Leitinger ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Salivary Glands ◽  
Treatment Options ◽  
Chemical Properties ◽  
Head Neck Cancer ◽  
Potential Candidate ◽  
Adhesive Properties ◽  
Whole Saliva ◽  
Radiation Induced ◽  
Unstimulated Whole Saliva

The intact function of the salivary glands is of utmost importance for oral health. During radiotherapy in patients with head and neck tumors, the salivary glands can be damaged, causing the composition of saliva to change. This leads to xerostomia, which is a primary contributor to oral mucositis. Medications used for protective or palliative treatment often show poor efficacy as radiation-induced changes in the physico-chemical properties of saliva are not well understood. To improve treatment options, this study aimed to carefully examine unstimulated whole saliva of patients receiving radiation therapy and compare it with healthy unstimulated whole saliva. To this end, the pH, osmolality, electrical conductivity, buffer capacity, the whole protein and mucin concentrations, and the viscoelastic and adhesive properties were investigated. Moreover, hyaluronic acid was examined as a potential candidate for a saliva replacement fluid. The results showed that the pH of radiation-induced saliva shifted from neutral to acidic, the osmolality increased and the viscoelastic properties changed due to a disruption of the mucin network and a change in water secretion from the salivary glands. By adopting an aqueous 0.25% hyaluronic acid formulation regarding the lost properties, similar adhesion characteristics as in healthy, unstimulated saliva could be achieved.

Design and Techno-Economic Analysis of a Process for Transforming Pig Manure into a Value-Added Product

2008 ◽  
Vol 85 (3) ◽  
pp. 360-368 ◽  
Author(s):  
Mylène Fugère ◽  
Patrice Farand ◽  
Rock Chabot ◽  
Paul Stuart
Keyword(s):  
Economic Analysis ◽  
Value Added ◽  
Pig Manure ◽  
A Value

A Methodology to Conduct a Combined Heating and Power System Assessment and Feasibility Study for Industrial Manufacturing Facilities

2011 ◽  
Author(s):  
Chad Wheeley ◽  
Pedro J. Mago
Keyword(s):  
Economic Analysis ◽  
Feasibility Study ◽  
Prime Mover ◽  
Viable Option ◽  
Industrial Manufacturing ◽  
System Assessment ◽  
Manufacturing Facilities ◽  
Economic Analyses ◽  
Chp System ◽  
Topping Cycle

This paper considers combined heat and power (CHP) systems based on topping cycles only, in which electricity is generated by a prime mover and heat is then recovered from the exhaust and utilized to offset all or a portion of the facility’s process and/or space heating requirements.. The objective of this paper is to develop a methodology to perform a topping cycle CHP assessment and feasibility study for industrial manufacturing facilities. In order to determine the best and most viable option for the facility in question, the proposed methodology can be used to size different systems which utilize diverse technologies and fuel sources, perform an economic analysis of each proposed option, and then compare the benefits and setbacks of each type of CHP system considered. The calculations performed in the economic analysis will then provide a broad insight as to which proposed system will show the best payback if installed. Examples are presented in this paper that describe in detail the application of this methodology, from equipment selection and sizing through economic analyses and proposed system comparisons, which is recommended for use in order to determine the most economically feasible CHP system for an industrial manufacturing facility.

Economic Analysis of Tank Coatings for Tankers in Clean Service

1965 ◽  
Vol 2 (04) ◽  
pp. 380-389
Author(s):  
E. Lee Purlee ◽  
Walter A. Leyland ◽  
W. E. McPherson
Keyword(s):  
Economic Analysis ◽  
Zinc Silicate ◽  
Silicate Coating ◽  
Economic Analyses ◽  
Two Alternatives

An economic analysis has been made of a hypothetical 30,000-dwt tanker operated in continuous, clean service. Under the premise that the ship will continue to operate throughout her remaining book-life in predominantly clean service, two alternatives are considered. Alternative I: Conventional corrosion policy is continued. Annual shipyard repair, including steel renewals and maintenance are performed to the extent required. Alternative II: The required steel renewals are made at the end of the fifth year of service and all tanks are coated with a zinc silicate coating. Annual shipyard repairs and maintenance are subsequently performed to the extent required. In general, the methods consisted of (a) generating steel-renewal requirements by appropriate simulations for the 20 years' book-life of the vessel, and (b) conducting economic analyses of alternatives I and II for comparison. The results of this study indicate that coating the tanks in accordance with alternative II represents a net saving of $998,301 by the end of the vessel's book-life. The payout time on the coating investment was found to be 6.6 years with an average, annual return on the coating investment of 21.9 percent.

NILAI TAMBAH PENGOLAHAN KANGKUNG HIDROPONIK MENJADI KANGKUNG RENDANG

2020 ◽  
Vol 2 (2) ◽  
pp. 95-106
Author(s):  
Indrawaty Sitepu ◽  
Nurmely Violeta Sitorus
Keyword(s):  
Raw Materials ◽  
Value Added ◽  
Data Retrieval ◽  
Rice Flour ◽  
Production Costs ◽  
Added Value ◽  
Water Spinach ◽  
A Value ◽  
Chicken Eggs

Kangkung hidroponik menjadi kangkung rendang merupakan kegiatan yang dapat meningkatkan nilai tambah, menghasilkan produk yang dapat dikonsumsi, serta menambah pendapatan dan keuntungan produsen.Tujuan penelitian untuk menguraikan apa saja tahapan pengolahan kangkung hidroponik menjadi kangukung rendang, menganalisis biaya produksi, penerimaan, dan pendapatan, menganalisis nilai tambah pengolahan kangkung hidroponik menjadi kangkung rendang, menganalisis apakah usaha pengolahan kangkung hidroponik menjadi kangkung rendang layak diusahakan. Penelitian ini dilakukan di Jalan Bromo lorong Amal Medan Denai Kota Medan. Penentuan daerah penelitian dilakukan secara purposive, Metode pengambilan sampel secara sensus yaitu usaha Syifa Hidroponik dengan pengambilan data ulangan selama 2,5 bualan sebanyak 10 kali ulangan. Hasil penelitian: 1) Tahapan  pengolahan kangkung hidroponik menjadi kangkung rendang yaitu:  Penyediaan bahan baku kangkung hidroponik, kangkung dihaluskan, pengadonan kangkung, telur ayam, tepung beras dan garam, kangkung dikukus, kangkung didinginkan, dipotong-potong, digoreng, pemasakan bumbu rendang, pencampuran kangkung yang digoreng dengan bumbu rendang dan pemasaran. Total biaya pengolahan kangkung hidroponik menjadi kangkung rendang untuk sekali produksi sebesar Rp 545.291,83, penerimaan sebesar Rp 1.500.000,00, per sekali produksi dan pendapatan sebesar Rp 954.708,17 per sekali produksi. Nilai tambah yang dihasilkan dari pengolahan kangkung hidroponik menjadi kangkung rendang tergolong tinggi dengan rasio nilai tambah 75,31% > 50%.Usaha pengolahan kangkung hidroponik menjadi kangkung rendang layak untuk diusahakan dengan nilai R/C rasio 2,75 > 1.  Abstract  Hydroponic water spinach into rendang water spinach is an activity that can increase added value, produce edible products, as well as increase producer income and profits. The purpose of the research is to describe what are the stages of processing hydroponic water spinach into rendang kangukung, analyze production costs, revenue, and income, analyze added value of processing hydroponic water spinach into rendang water spinach, analyzing whether the business of processing hydroponic water spinach into rendang water spinach is worth the effort. This research was conducted in Jalan Bromo Amal Medan Denai alley Medan City. Determination of the study area was done purposively, census sampling method that is Syifa Hydroponic business with retrieval data retrieval for 2.5 boasting as many as 10 replications. The results of the study: 1) The stages of processing hydroponic water spinach into rendang water spinach, namely: Provision of raw materials for hydroponic water spinach, crushed water spinach, stirring water spinach, chicken eggs, rice flour and salt, steamed water spinach, water spinach water spinach, cut into pieces, fried, fried spicy water spinach, cooking water spinach kale, chicken egg, rice flour and salt, steamed water spinach, water spinach kangkung cooled, cut, fried, cooking spices, rendang, mixing fried kale with spicy rendang and marketing. The total cost of processing hydroponic water spinach into rendang water spinach for one production is Rp. 545,291.83, revenue is Rp. 1,500,000.00, per production and income is Rp. 954,708.17 per production. The added value generated from the processing of hydroponic water spinach into rendang water spinach is classified as high with a value added ratio of 75.31%> 50%. The business of processing hydroponic water spinach into rendang water spinach is feasible to be cultivated with an R / C ratio of 2.75> 1.  

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