Increased Radiation Dose Exposure in Thoracic Computed Tomography in Patients with Covid-19

The CT manifestation of COVID-19 patients is now well known and essentially reflects pathological changes in the lungs. Actually, there is insufficient knowledge on the long-term outcomes of this new disease, and several chest CTs might be necessary to evaluate the outcomes. The aim of this study is to evaluate the radiation dose for chest CT scans in COVID-19 patients compared to a cohort with pulmonary infectious diseases at the same time of the previous year to value if there is any modification of exposure dose. The analysis of our data shows an increase in the overall mean dose in COVID-19 patients compared with non-COVID-19 patients. In our results, the higher dose increase occurs in the younger age groups (+86% range 21–30 years and +67% range 31–40 years). Our results show that COVID-19 patients are exposed to a significantly higher dose of ionizing radiation than other patients without COVID infectious lung disease, and especially in younger age groups, although some authors have proposed the use of radiotherapy in these patients, which is yet to be validated. Our study has limitations: the use of one CT machine in a single institute and a limited number of patients.

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Survival Associations between Patient Age and Treatment Modality in Olfactory Neuroblastoma: A Retrospective Population-Based Study

Journal of Clinical Medicine ◽

10.3390/jcm10122685 ◽

2021 ◽

Vol 10 (12) ◽

pp. 2685

Author(s):

Andre J. Burnham ◽

Phillip A. Burnham ◽

Edwin M. Horwitz

Keyword(s):

Treatment Modality ◽

Age Groups ◽

Olfactory Neuroblastoma ◽

Population Based ◽

Treatment Modalities ◽

Long Term Outcomes ◽

Patient Age ◽

Population Based Study ◽

Patient Âgé

Olfactory neuroblastoma (ONB) is a rare neuroepithelial-derived malignancy that usually presents in the nasal cavity. The rarity of ONB has led to conflicting reports regarding associations of patient age and ONB survival and outcome. Moreover, long-term outcomes of chemotherapy and other treatment modalities are speculated. Here, we aimed to compare survival outcomes across age groups through time and determine associations between treatment modality and survival. In this retrospective population-based study, we analyzed the SEER 2000–2016 Database for patients with ONB tumors. Using Kaplan–Meier survival analysis, a significant effect of age and cancer-specific survival (CSS) was observed; geriatric ONB patients had the lowest CSS overall. Generalized linear models and survival analyses demonstrated that CSS of the pediatric patient population was similar to the geriatric group through 100 months but plateaued thereafter and was the highest of all age groups. Radiation and surgery were associated with increased CSS, while chemotherapy was associated with decreased CSS. GLM results showed that tumor grade, stage and lymph node involvement had no CSS associations with age or treatment modality. Our results provide insight for future investigations of long-term outcomes associated with ONB patient age and treatment modality, and we conclude that survival statistics of ONB patients should be analyzed in terms of trends through time rather than fixed in time.

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Is Age the New Class? Economic Crisis and Demographics in European Politics

Critical Sociology ◽

10.1177/0896920515603109 ◽

2016 ◽

Vol 43 (1) ◽

pp. 59-71 ◽

Cited By ~ 4

Author(s):

Jan Erk

Keyword(s):

Age Groups ◽

The Political ◽

Economic Downturn ◽

New Class ◽

Political Landscape ◽

Younger Age ◽

Material Interests ◽

Post War ◽

The Welfare State

As the crisis turns into long-term economic downturn, younger age-groups in Europe seem to be hit with higher levels of unemployment while the welfare state is steadily shrinking. The young have suddenly become a social group united by collective material interests, but does this translate into a sense of a collective political interest? The paper examines to what extent the dominant class-based social science of the post-war years can help us understand the politics of age-groups. The analysis highlights four changes since post-war years: the workplace has changed, impacting socialization; modern media has changed, impacting mobilization; the political landscape is fairly institutionalized, tempering the possibilities for new political concerns to find voice; and those who would define and articulate the political priorities of the young are leaving the Old Continent.

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Investigational Immunotherapeutics for B-Cell Malignancies

Journal of Clinical Oncology ◽

10.1200/jco.2009.22.8254 ◽

2010 ◽

Vol 28 (5) ◽

pp. 884-892 ◽

Cited By ~ 14

Author(s):

Alfonso Quintás-Cardama ◽

William Wierda ◽

Susan O'Brien

Keyword(s):

Monoclonal Antibodies ◽

B Cell ◽

Acquired Resistance ◽

Long Term Outcomes ◽

Clinical Value ◽

B Cell Malignancies ◽

Therapeutic Algorithms ◽

Number Of Patients

The use of rituximab-based chemoimmunotherapy regimens has remarkably improved the response rates, long-term outcomes, and quality of life of patients with B-cell malignancies. However, a substantial number of patients exhibit either primary or acquired resistance to rituximab, which suggests that novel immunotherapeutics with distinct mechanisms of action are necessary. A series of monoclonal antibodies with specificity against different surface antigens expressed on malignant B cells (eg, CD22, CD23, CD40, CD70) and novel immunotherapeutics (eg, bispecific monoclonal antibodies, small-modular immunopharmaceuticals, T-cell engagers) are currently in clinical or final preclinical stages of development. Although these agents offer reason for optimism, considerable challenges lie ahead in establishing their real clinical value, as well as in integrating them into current therapeutic algorithms for patients with B-cell malignancies. This review describes some of the most promising investigational immunotherapeutics for the treatment of B-cell malignancies.

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Predictive Value of Technical Throwing Skills on Nomination Status in Youth and Long-Term Career Attainment in Handball

Sports Medicine - Open ◽

10.1186/s40798-021-00397-5 ◽

2022 ◽

Vol 8 (1) ◽

Author(s):

Till Koopmann ◽

Franziska Lath ◽

Dirk Büsch ◽

Jörg Schorer

Keyword(s):

Logistic Regression ◽

National Level ◽

Age Groups ◽

Age Group ◽

Regression Analyses ◽

Chi Square ◽

Career Attainment ◽

Future Performance ◽

Younger Age

Abstract Background Research on talent in sports aims to identify predictors of future performance. This study retrospectively investigated 1) relationships between young handball field players’ technical throwing skills and (a) their potential nomination to youth national teams and (b) their long-term career attainment 10 years later, and 2) associations between nomination status and career attainment. Results Results from retrospectively predicting nomination status and career attainment using logistic regression analyses show that technical throwing skills were partly able to explain players’ nomination status (Nagelkerke R2: females 9.2%, males 13.1%) and career attainment (Nagelkerke R2: 9.8% for female players). Here, variables throwing velocity and time on exercise showed statistically significant effects. In addition, nomination status and career attainment were shown to be associated using chi-square tests (w of .37 and .23 for female and male players, respectively) and nomination status as a predictor increased the prediction of career attainment remarkably (Nagelkerke R2: females 20.3%, males 12.7%). Conclusions Given these results, basic technical throwing skills may serve rather as a prerequisite in this age group on national level, emphasizing its importance already on lower levels and in younger age groups. Furthermore, advantages from entering the national TID system early especially for females are discussed.

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71. Long-term Outcomes of Standard Discectomy for Lumbar Disc Herniation in Different Age Groups

The Spine Journal ◽

10.1016/j.spinee.2007.07.086 ◽

2007 ◽

Vol 7 (5) ◽

pp. 35S

Author(s):

Etsuro Yorimitsu ◽

Kazuhiro Chiba ◽

Yoshiaki Toyama ◽

Yosio Shinozaki

Keyword(s):

Lumbar Disc Herniation ◽

Disc Herniation ◽

Lumbar Disc ◽

Age Groups ◽

Long Term Outcomes

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Transsphenoidal surgery for prolactinomas: results and prognosis

Medicina ◽

10.3390/medicina43090089 ◽

2007 ◽

Vol 43 (9) ◽

pp. 691 ◽

Cited By ~ 2

Author(s):

Kęstutis Šinkūnas ◽

Daiva Rastenytė ◽

Vytenis Deltuva ◽

Robertas Knispelis ◽

Arimantas Tamašauskas

Keyword(s):

Surgical Treatment ◽

Dopamine Agonist ◽

Remission Rate ◽

Visual Field Defects ◽

Plasma Prolactin ◽

Long Term Outcomes ◽

Agonist Therapy ◽

Dopamine Agonist Therapy ◽

Younger Age

Objective. The aim of this study was to explore the long-term outcomes of surgery for transsphenoidal prolactinomas and the factors that influence them. Material and methods. Transsphenoidal approach for pituitary adenomas has been applied to 329 patients in the Department of Neurosurgery of Kaunas University of Medicine Hospital in the period of 1995 to 2006. Of these, 85 patients were operated for prolactinomas. Results. Of the 85 patients operated on for prolactinomas, 68 (80%) were females and 17 (20%) were males. Thirty-two microprolactinomas and 36 macroprolactinomas were diagnosed in women and 16 and 1, respectively, in men. Twenty (23.5%) patients (16 women and 4 men) had visual field defects before the operation. Dopamine agonist therapy was administered in 50 patients (38 women and 12 men) before the operation. Of 10 women, in whom microadenoma was diagnosed and no dopamine agonist therapy was prescribed, remission was achieved in 9 (90%) patients after the operation, while of 22 women, who was treated with dopamine agonists before the operation, remission was achieved only in 10 (45.5%) (P=0.01). Each year of age decreased the chance of remission by 8%. Conclusions. Remission after the surgical treatment was achieved in 11.8% of men and 47.1% of women hyperprowith prolactinomas. Remission rate was very high (90%) among women with microprolactinoma not treated with dopamine agonist before the surgical treatment. The probability of a good outcome of surgery among women with prolactinoma was related to younger age of the patient, noninvasive tumor growth, plasma prolactin level less than 2309 mU/L, and no use of dopamine agonist before the surgical treatment.

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Postoperative atrial fibrillation: Target for stroke prevention?

European Stroke Journal ◽

10.1177/2396987317719363 ◽

2017 ◽

Vol 2 (3) ◽

pp. 222-228 ◽

Cited By ~ 6

Author(s):

Vincent Thijs ◽

Robin Lemmens ◽

Omar Farouque ◽

Geoffrey Donnan ◽

Hein Heidbuchel

Keyword(s):

Atrial Fibrillation ◽

Lifestyle Changes ◽

Adverse Outcomes ◽

Postoperative Atrial Fibrillation ◽

Long Term Outcomes ◽

Number Of Patients ◽

History Of ◽

Long Term Mortality

Purpose A substantial number of patients without a history of atrial fibrillation who undergo surgery develop one or more episodes of atrial fibrillation in the first few days after the operation. We studied whether postoperative transient atrial fibrillation is a risk factor for future atrial fibrillation, stroke and death. Method We performed a narrative review of the literature on epidemiology, mechanisms, risk of atrial fibrillation, stroke and death after postoperative atrial fibrillation. We reviewed antithrombotic guidelines on this topic and identified gaps in current management. Findings Patients with postoperative atrial fibrillation are at high risk of developing atrial fibrillation in the long term. Mortality is also increased. Most, but not all observational studies report a higher risk of stroke. The optimal antithrombotic regimen for patients with postoperative atrial fibrillation has not been defined. The role of lifestyle changes and of surgical occlusion of the left atrial appendage in preventing adverse outcomes after postoperative atrial fibrillation is not established. Conclusion Further studies are warranted to establish the optimal strategy to prevent adverse long-term outcomes after transient, postoperative atrial fibrillation.

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Should we vaccinate the better seroconverters or the most vulnerable? Game changing insights for COVID-19 vaccine prioritization policies

Egyptian Pediatric Association Gazette ◽

10.1186/s43054-021-00086-8 ◽

2021 ◽

Vol 69 (1) ◽

Author(s):

Antoine AbdelMassih ◽

Meryam El Shershaby ◽

Hanya Gaber ◽

Menna Habib ◽

Nada Gamal ◽

...

Keyword(s):

Ethical Dilemma ◽

Seroconversion Rate ◽

Age Groups ◽

Main Body ◽

Rapid Rise ◽

Long Term Effects ◽

Fast Tracking ◽

Younger Age ◽

Cellular Mediated Immunity

Abstract Background With the rapid rise in COVID 19 cases incomparable to the number of vaccinations available, there has been a demand to prioritize the older age groups receiving the vaccine as they have more risk of morbidity and mortality and thus better outcome from vaccination. Main body Some studies showed a lower seroconversion rate in older group patients; thus, we discuss the necessity to reprioritize vaccinations to younger age groups who have better seroconversion rates, but we may face some ethical dilemma that could hinder our hypothesis. Decreased seroconversion rates in adults are attributable to immuno-senescence which involves a decrease in humoral and cellular-mediated immunity with age. Despite this fact, there remains some ethical dilemma that can hinder widespread vaccination of younger generations, the most important of which is the unknown long-term effects of COVID-19 vaccines due their fast-tracking under the pressure of the pandemic. Short conclusion Prioritizing children vaccination against COVID-19 seems an interesting strategy that can help in containing the pandemic. Resolving some ethical dilemma needs to be done before implementing such strategy.

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The Role of Destination Experience in the Sustainability of the Image of the Tourist Destination

10.20944/preprints202106.0730.v1 ◽

2021 ◽

Author(s):

Olimpia Ban ◽

Adrian Hatos ◽

Laurențiu Droj ◽

Carmen Toderascu

Keyword(s):

Brand Image ◽

Age Groups ◽

Destination Image ◽

Tourist Destination ◽

Good Image ◽

Remarkable Increase ◽

Dangerous Situation ◽

Younger Age

The concept of destination image is closely related to the brand image of the destination. A good image is a step in branding the destination. The image of the destination can be a primary, sec-ondary or global one, the latter incorporating the first two. The sustainability of a positive image of the destination is based on both a positive secondary image and a positive global image. The purpose of this research is to analyze separately the two types of images for a given tourist des-tination that has registered in recent years a remarkable increase in the number of visitors. The research is based on a questionnaire-based survey of a sample of 607 people. The collected data were processed with SPSS and the results show significant differences between the two types of images (secondary image and global image), a dangerous situation in the medium and long term for destination management. The nuances in the perception of the image of the destination on the two types of respondents (who experienced respectively who did not experience the destination) can be explained by the aggressive strategy of promoting the tourist destination, but inefficient strategy for younger age groups. The study allows the formulation of conclusions and measures to correct the situation.

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Experiencing Eight Psychotherapy Approaches Devoted to Eating Disorders in a Single Day Workshop Increases Insight and Motivation to Engage in Care

10.21203/rs.3.rs-1028999/v1 ◽

2021 ◽

Author(s):

Elisabetta Scanferla ◽

Bernard Pachoud ◽

Philip Gorwood

Keyword(s):

Eating Disorders ◽

Newly Diagnosed ◽

Motivation To Change ◽

Long Term Outcomes ◽

Commitment To Change ◽

Outcomes Evaluation ◽

Number Of Patients ◽

Almost All ◽

Action Stage

Abstract PurposeFor patients with eating disorders (EDs), early engagement in care is usually considered as a positive prognostic factor. The aim of the present study is to investigate how a single-day intervention devoted to an early experiential exposure to a variety of psychotherapy approaches, supports transition to specialised care and commitment to change in patients with EDs.MethodsOne hundred and sixty-nine outpatients newly diagnosed with an ED took part in a single-day workshop for groups of up to 10 patients, where they discovered and experienced eight psychotherapeutic approaches. Motivation to change care, and level of insight were assessed at baseline and 10 days after the intervention.ResultsMotivation and commitment to take active steps toward change (expressed by the “Committed Action” composite score) significantly improved after intervention (p<0.001), and a significant number of patients specifically moved from “contemplation” to “action” stage (p<0.001). The improvement of motivation to change is significantly associated to an increase of insight capacity (p<0.001), and this for almost all dimensions.ConclusionA single-day session devoted to experiencing a range of group psychotherapies increased patients’ insight and motivation to actively engage in care. Further studies including different factors and long-term outcomes evaluation may be necessary to better establish which aspects are specifically involved in patients' increased motivation for care and confirm potential longer-term benefits of this intervention.Level of evidenceLevel V: Opinions of respected authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.

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