scholarly journals Identification of the Profile of the Patients with Hemophilia B Eligible for Treatment with Nonacog Alfa Once-Weekly

Reports ◽  
2020 ◽  
Vol 3 (1) ◽  
pp. 3
Author(s):  
Dorina Cultrera ◽  
Raimondo De Cristofaro ◽  
Paola Giordano ◽  
Silvia Linari ◽  
Silvia Macchi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Age Groups ◽  
Treatment Compliance ◽  
Venous Access ◽  
Hemophilia B ◽  
Age Group ◽  
On Demand ◽  
Weekly Treatment ◽  
Age Range

This study aimed to identify the characteristics of patients with hemophilia B eligible for once-weekly treatment with Nonacog alfa. Methods: A survey was conducted in 14 Hemophilia (HCs) of Italy. These centers were given a questionnaire consisting of ten closed multiple-choice questions. The centers were asked: (a) the percentages of their hemophilia B (HB) patients undergoing replacement therapy, “On-demand”, or weekly prophylaxis, (b) the criteria guiding the monitoring of patients, the advantages according to the age of patients, and (c) the obstacles to prophylaxis. The percentage of patients receiving “On-demand” (OD) treatment or continuous prophylaxis (prophy) differed depending on patient age and the severity of the disease. Only 57% of HCs provided “On-demand” therapy to the mild HB patients, about 93% to moderate ones, of whom 43% on prophylaxis. About 78% of patients <6 years old, were on treatment in 9 out of 14 HCs, by prophylaxis 66.7% and 33.3% by On-demand. In the 6–18 age group, 90.1% of HCs treated HB patients with prophylaxis, 42.8% in the 18–30 age range. On-demand treatment was the therapy of choice in 61.5% of HCs for patients aged 30–65 years. In total, 64% of the HCs assigned the maximum score to bleeding frequency, especially in the <6 and 6–18 age groups. Bleeding severity was also taken into significant consideration, particularly in subjects up to 30 years old. The scores regarding venous access were distributed relatively evenly throughout all age groups. The majority of the centers attributed a medium-high score to treatment compliance, especially in the 6–65 age range. In actuality, 55% of HCs attributed pro-thrombotic comorbidity a low score in the 18–30 age group, whereas 81% gave pro-hemorrhagic comorbidity a high rating in patients aged >65 years old. Many centers assigned a medium-high score to the baseline concentration of FIX level at diagnosis in all age groups. Most HCs attributed a medium-high score to type of genetic mutation in the younger age groups. As for socio-cultural barriers and quality of life, the majority of respondents gave a medium-high score in all age groups. For periodic monitoring of patients receiving continuous prophylaxis, 59% of the centers reported using clinical assessment. With regard to prophylaxis administration method, the majority of hemophiliacs were given infusions twice weekly, while as regards to the dose of FIX concentrate delivered, 50% of the centers reported administering prophylaxis once-weekly at a dose ranging from 5–100 IU/kg in 10–50% of HB patients. Thus, 93% of the centers reported using a dose of 25–50 IU/kg for twice-weekly prophylaxis in 6–100% of the patients. The majority of centers (86%) believe that, in a program of early primary prevention, once-weekly treatment with nonacog alfa may represent an alternative strategy to dose escalation. The results show that patients with mild hemophilia, with functional musculoskeletal status and difficulties with venous access, are candidates for once-weekly prophylaxis with nonacog alfa. For such patients, this regimen can improve treatment compliance and quality of life.

scholarly journals Video-Based Communication and its Association with Loneliness, Mental Health and Quality of Life among Older People during the COVID-19 Outbreak

2021 ◽  
Author(s):  
Tore Bonsaksen ◽  
Hilde Thygesen ◽  
Janni Leung ◽  
Mary C. Ruffolo ◽  
Mariyana Schoultz ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Older People ◽  
Online Survey ◽  
Age Groups ◽  
Psychological Outcomes ◽  
Age Group ◽  
Communication Tools ◽  
Study Results

The aim of the study was to examine the use of video-based communication and its association with loneliness, mental health and quality of life in older adults (60-69 years versus 70+ years) during the COVID-19 pandemic. A cross-sectional online survey was conducted in Norway, UK, USA and Australia during April/May 2020, and 836 participants in the relevant age groups were included in the analysis. Multiple regression analyses were conducted to examine associations between use of video-based communication tools and loneliness, mental health and quality of life within age groups, while adjusting by sociodemographic variables. Video-based communication tools were found to be more often used among participants aged 60-69 years (60.1%), compared to participants aged 70 or above (51.8%, p &lt; 0.05). Adjusting for all variables, use of video-based communication was associated with less loneliness (&beta; = -0.12, p &lt; 0.01) and higher quality of life (&beta; = 0.14, p &lt; 0.01) among participants aged 60-69 years, while no associations occurred for participants in the oldest age group. The use of video-based communication tools was therefore associated with favorable psychological outcomes among participants in their sixties, but not among participants in the oldest age group. The study results support the notion that age may influence the association between use of video-based communication tools and psychological outcomes amongst older people.

scholarly journals Major depressive disorder in different age groups and quality of life

2017 ◽  
Vol 28 (2) ◽  
pp. 58-61 ◽  
Author(s):  
Umme Salma Talukder ◽  
MM Jalal Uddin ◽  
Niaz Mohammad Khan ◽  
Md Mostarshid Billah ◽  
Tufayel Ahmed Chowdhury ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Age Groups ◽  
World Health ◽  
Age Group ◽  
Major Depressive ◽  
World Health Organization Quality ◽  
Quality Of Life Scale

Major Depressive Disorder (MDD) is a significant public health problem due to its impact on the quality of life. The aim of the study was to determine the presentation of depression in different age group and quality of life among the respondents. This was a descriptive cross sectional study conducted from May, 2012 to February, 2013 among 65 patients aged 18 to 65 years with major depressive disorder in both outpatient and inpatient departments of National Institute of Mental Health (NIMH), Dhaka by using convenient sampling technique. Diagnostic and Statistical Manual of Mental Disorders- Text version (DSM-IV-TR), Beck Depression Inventory and World Health Organization Quality of Life Scale, Brief version (WHOQOL-BREF) were used to diagnose depressive disorder, to measure severity of depressive illness and Quality of Life (QOL) respectively. Level of depression was compared with the QOL. Quality of life deteriorated in patients with depression. Presence and level of depression was compared in different age groups of depressed patients. The results showed that most of the depressed people (17) were found in the age group of 21-25 years and most of the patients were severely depressed which was thirty nine (39). The study revealed that young people were mostly depressed and their quality of life was decreasing. lt needs further study to explore more information about pattern of presentation of depression and its effect on the quality of life.Bang J Psychiatry Dec 2014; 28(2): 58-61

Quality of life in young men after radical prostatectomy: Results from the CaPSURE registry

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 4576-4576 ◽  
Author(s):  
J. L. Wright ◽  
D. W. Lin ◽  
J. E. Cowan ◽  
J. Duchane ◽  
P. R. Carroll ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Age Groups ◽  
Older Men ◽  
Multivariate Model ◽  
Age Group ◽  
Younger Men ◽  
One Year

4576 Background: Over the past two decades, the age at diagnosis and treatment of men with prostate cancer (CaP) has steadily declined. Previous work suggests that younger men have similar or improved pathologic and clinical outcomes compared to older men. The literature on quality of life (QOL) following local treatment for CaP has primarily focused on comparing treatment modalities rather than specific age groups. This analysis explored QOL outcomes in younger men following primary curative treatment for localized prostate cancer. Methods: This was a secondary analysis of a prospectively collected cohort from the CaPSURE (Cancer of the Prostate Strategic Urologic Endeavor) registry. Men who underwent radical prostatectomy (RP) for localized disease and completed the UCLA Prostate Cancer Index (PCI) pre- and one-year post-surgery were identified. Men were grouped based on age (< 55, 55–64, ≥ 65 years). A severe decline in PCI domains from pre- to post-RP was defined as a decrease of one standard deviation from the pre-RP score. PCI scores were compared across age groups, and a multivariate model created to analyze the predictors of severe declines in PCI domains. Results: 1,143 men were identified, with 190, 526 and 427 men in the three age groups, respectively. Younger men had significantly higher mean scores one-year after RP in the urinary function (UF), urinary bother (UB) and sexual function (SF) domains of the PCI. The proportion of men with a severe decline in UF, UB and SF was not significantly different in the age groups (range 49–54%, 32–38%, 58–51% respectively). However, a severe decline in SB was more common in the youngest age group than in the oldest (54% vs. 36%, p < 0.01). With the youngest men as the reference group in the multivariate model, the oldest age group was 40% less likely to have a severe decline of SB (OR = 0.60, 95% CI 0.41–0.90, p = 0.04) but trended toward a higher risk of severe decline in UB (OR = 1.27, 95% CI 0.85–1.89, p = 0.08). Conclusions: Age predicts disease-specific QOL changes at one-year following RP. Younger men had significantly better mean UF, UB, and SF domain scores one-year after RP than did their older counterparts. Men < 55 years old are more likely than older men to experience a severe decline of sexual bother but trend toward a lower risk of a severe urinary bother. No significant financial relationships to disclose.

scholarly journals Is age group a predictive factor for satisfaction among patients undergoing sympathectomy to treat hyperhidrosis?

2011 ◽  
Vol 10 (4) ◽  
pp. 284-288 ◽  
Author(s):  
José Ribas Milanez de Campos ◽  
Nelson Wolosker ◽  
Marco Antonio Soares Munia ◽  
Guilherme Yazbek ◽  
Paulo Kauffman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Mass Index ◽  
Body Mass ◽  
Age Groups ◽  
Age Group ◽  
Compensatory Hyperhidrosis ◽  
Thoracic Sympathectomy ◽  
Video Assisted ◽  
Primary Hyperhidrosis

OBJECTIVE: Video-assisted thoracic sympathectomy is currently the procedure of choice for the definitive treatment of primary hyperhidrosis, because it is an effective, safe, and minimally invasive method. In the search for better quality of life indexes, all researchers look for predictive factors indicating better surgical outcomes. Failure in the primary treatment, postoperative compensatory hyperhidrosis, body mass index over 25, level of resection of the sympathetic chain, and extent of resection are some of the factors that may negatively influence the results. The objective of this study was to compare, according to the age group, the quality of life after bilateral thoracic sympathectomy for treatment of primary hyperhidrosis in a cohort of 1,644 patients. METHODS: From February 2000 to October 2008, data were collected from 1,644 patients with palmar (71%) or axillary (29%) hyperhidrosis who underwent video-assisted thoracic sympathectomy. The patients were divided into three groups according to their ages. The first group consisted of patients up to 17 years-old, the second from 18 to 30 years-old, and the third of over 30 years-old. All patients had a body mass index of less than 25. RESULTS: In the evaluation 30 days after surgery, improvement of the quality of life in the three groups was observed. There was no significant difference between the age groups. In the present study, 91.9% of the patients presented compensatory hyperhidrosis, with no difference between the age groups. CONCLUSIONS: Patients with primary hyperhidrosis experience quality of life improvement after thoracic sympathectomy regardless of their age.

scholarly journals PREVALENCE OF OBSTRUCTIVE SLEEP APNEA IN AN INDIAN POPULATION: USING STOPBANG QUESTIONNAIRE

2018 ◽  
Vol 11 (11) ◽  
pp. 100 ◽  
Author(s):  
Snigdha Pattanaik ◽  
Rajagopal R ◽  
Neeta Mohanty ◽  
Swati Pattanaik
Keyword(s):  
Quality Of Life ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Clinical Symptoms ◽  
Age Groups ◽  
Age Group ◽  
Prime Concern ◽  
Obstructive Sleep ◽  
Significant Difference

Objective: Obstructive sleep apnea (OSA) is a condition characterized by complete/partial obstruction of the upper airway that disrupts normal sleep pattern. It has become highly prevalent and negatively affects the quality of life. Reports show ≥4% of men and ≥2% of women, and mostly, the obese individuals are affected by OSA. OSA is independently associated with an increased likelihood of hypertension, cardiovascular disease, and diminished quality of life. Hence, it becomes a prime concern for health-care personnel to diagnose it at earliest. A screening tool is necessary to stratify patients based on their clinical symptoms, their physical examinations, and their risk factors. Thus, this study was taken up to assess the prevalence of OSA using the STOP-Bang questionnaire.Methods: A total number of 1012 participants were selected using random sampling technique from various community health camps for the study. The participants were asked to fill in the STOP-Bang questionnaire. All questionnaire respondents were precisely briefed about this study in a face-to-face interview. Data obtained from the survey were subjected to statistics, and descriptive analysis was done.Results: The prevalence of OSA was found to be 13.7% by using the Stop Bang questionnaire. It was found that the prevalence of OSA was highest in the age group of 50–59 (21.7%) and least in the age group of 18–29 (12.0%). Gender-wise distribution of OSA based on the scoring was seen to be more, among males (14.8%) and females showed a prevalence of 12.9%.Conclusion: This study concludes that the STOP-Bang method of screening showed a prevalence of 13.7%. However, the prevalence of OSA did not show any significant difference in various age groups; it was found that males had a higher prevalence of OSA compared to females.

scholarly journals The quality of life of children suffering from oncologic diseases in Lithuania

Medicina ◽  
2007 ◽  
Vol 43 (9) ◽  
pp. 726 ◽  
Author(s):  
Joana Makari ◽  
Apolinaras Zaborskis ◽  
Liutauras Labanauskas ◽  
Lina Ragelienė
Keyword(s):  
Quality Of Life ◽  
Pediatric Cancer ◽  
Cognitive Activity ◽  
Age Groups ◽  
Psychosocial Health ◽  
Close Relative ◽  
Age Group ◽  
Older Children ◽  
Oncologic Diseases

Nearly 80 new cases of pediatric cancer are diagnosed in Lithuania each year. Since 2005, we have been conducting a study evaluating the quality of life of children suffering from cancer in Lithuania. The participants were children between the ages of 2 and 18 years, diagnosed with oncologic diseases during the period from March 2005 to March 2006, and their parents. The PedsQLTM (Pediatric Quality of Life InventoryTM) was used. This questionnaire is specifically designed for investigating the quality of life in children between the ages of 2 and 18 years. The PedsQL questionnaire is designed according to the level of cognitive activity of children and applied to children of four age groups: 2–4, 5–7, 8–12, and 13–18 years of age. The questionnaires were completed by children between the ages of 8 and 18 years in addition to parents of children from all age groups. The families of 63 children suffering from cancer participated in the study. A total of 44 children and teenagers between the ages of 5 and 18 years and 53 parents (mother, father, close relative) filled out the questionnaire. Data from the study showed that children suffering from cancer (irrespective of their age) in addition to their parents evaluated their physical health as being worse than their psychosocial health. The parents had the opinion that children from all age groups experienced negative emotions: the younger children were afraid of giving blood for tests, whereas the older children were worried about the future. In the oldest age group of participants (13–18 years), children felt disease-related fatigue more often than their younger counterparts.

scholarly journals Assessment of Biological Parameters that (Influence) Affect the Quality of Life in a Group of Patients with Metabolic Syndrome

2021 ◽  
Vol 26 (3) ◽  
pp. 18-23
Author(s):  
Ovidiu Boitor ◽  
Laura Ștef ◽  
Gabriela Boţa ◽  
Romeo Mihăilă
Keyword(s):  
Quality Of Life ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Age Groups ◽  
Hdl Cholesterol ◽  
Biological Data ◽  
Age Group ◽  
Low Hdl ◽  
The Impact

Abstract The study included a group of 42 patients with metabolic syndrome and 32 patients without metabolic syndrome. The following biological data: BMI, blood pressure, type 2 diabetes, low HDL cholesterol levels were statistically compared using the ANOVA test. To assess the impact on quality of life, patients in both groups completed the EQ-5D-3L questionnaire. To verify the statistical confirmation of the results we used the Chi 2 test. In order to correlate the results with the gender and age of the patients, we formed the following age groups 45-54 years, 55-64 years, 65-74 years and over 75 years. We found that the dimensions that affect the quality of life differ depending on the age group as follows: in the 55-64 age group pain / discomfort predominates p = 0.009 and in the 65-74 age group the mobility and self-care dimensions p = 0.043 predominate. We did not obtain statistical confirmation by the Chi 2 test in patients with metabolic syndrome and the variable blood pressure Chi 2 = 5.27 and p = 0.072

scholarly journals Quality of life and comorbid status in persons of the older age group with chronic sensorineural hearing loss

2020 ◽  
Vol 19 (5) ◽  
pp. 36-43
Author(s):  
T. Yu. Vladimirova ◽  
◽  
A. B. Martynova ◽  
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Age Groups ◽  
Inverse Correlation ◽  
Older Age ◽  
Sensorineural Hearing ◽  
World Health ◽  
Age Group

A study was conducted of 300 patients with chronic sensorineural hearing loss (SNHL) in four age groups, allocated according to the age classification of the World Health Organization (WHO). For patients of the older age group, a high comorbidity index is noted, while among concomitant diseases, chronic non-infectious diseases that are likely to affect hearing (arterial hypertension, cardiovascular disease (CVDs), diabetes mellitus) are more often observed with age. A direct correlation was found between diseases that probably affect the auditory function and quality of life (QoL) of patients. It was noted that the proportion of people with moderate and severe hearing impairment increases with age, while the total QoL indicator correlated with age (inverse correlation in the elderly, direct correlation in senile people and long-livers) and the degree of SNHL (inverse correlation). Self-assessment of QOL level by the physical component in patients of the older age group corresponded to the pre-critical level.

scholarly journals Gender Differences in Nutritional Quality of Life of Young and Old Adults.

2018 ◽  
Vol 24 (S) ◽  
pp. 872-878
Author(s):  
Fatima Javed Saleem ◽  
Farhat Jamil ◽  
Ruhi Khalid
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Nutritional Quality ◽  
Nutritional Value ◽  
Social Impact ◽  
Age Groups ◽  
Younger Adults ◽  
Gender And Age ◽  
Age Range

Background: Healthy eating is essential for individuals’ physical as well as psychological wellbeing. Women’s focus on achieving thin ideal physique and men’s aspiration for muscular body is likely to impact their food intake and consequently Nutritional Quality of Life (NQoL). Moreover, NQoL varies across different age groups owing to the varying nutritional needs with increasing age. Investigating NQoL across gender and age has useful implications for health counseling and practice. Objectives| To investigate differences in nutritional quality of life among gender and different age groups. To investigate gender and age group differences in knowledge of nutritional value of food. Methodology| A descriptive cross-sectional research was conducted. The sample consisted of 200 participants i.e., 100 younger adults between age range of 18-23 years and 100 older adults between age range of 40-60 years. Gender of participants was equally represented in both age groups. Nutritional Quality of Life (NQoL) Instrument and a self-developed Nutritional Knowledge Questionnaire were administered on the sample to collect data. Results| Mean age of younger adults was 19.17 ± 1.18 and for older adults it was 48.17 ± 5.20. Findings showed that women scored significantly higher on psychological factor and social impact whereas men scored significantly higher on food impact and self-efficacy impact of NQoL. Moreover younger adults scored higher on self-efficacy than older adults and older adults scored higher on food impact, social impact, psychological factor and physical functioning than younger adults. Also interaction of gender and age was significant regarding knowledge of nutritional value of food; older women and younger men had more knowledge of nutritional value of food than younger women and older men. Conclusions| There were significant differences in nutritional quality of life. Also knowledge of nutritional value of food varied across gender and age groups.

scholarly journals Quality of life of institutionalized elderly in an urban area of North India

2020 ◽  
Vol 7 (12) ◽  
pp. 4986
Author(s):  
Rameela Sanya ◽  
Jayasree Anandabhavan Kumaran
Keyword(s):  
Quality Of Life ◽  
Urban Area ◽  
Age Groups ◽  
Care Facility ◽  
North India ◽  
Age Group ◽  
Physical And Mental Health ◽  
Institutionalized Elderly ◽  
Environmental Domain

Background: Being transferred from home to nursing care facility is great challenge for elderly as they have to face a radical change in their lifestyle. However, not much is known about the response of its residents to institutionalization and its impact on their physical and mental health. Objective is to assess quality of life (QOL) of institutionalized elderly in an urban area of North Kerala and its association with sociodemographic factors.Methods: A cross- sectional study was conducted among 202 elderly residing in old age homes (OAH). Data was collected using WHO QOL BREF. Data analysed using SPSS version 16.0. Results expressed terms of mean, SD, frequencies, percentages. Kruskal Wallis and Mann Whitney U test used to find association between domain-wise (physical, psychological, social relationships, environmental) QOL and sociodemographic factors.Results: Out of 202 elderly residing in OAH, majority were females (60.4%), belonged to 60-69 years age-group (39.6%), Hindus (59.9%) and widowed (49.5%). Majority had ‘moderately poor QOL in all domains, except environmental domain where majority had ‘moderately good’ QOL. Highest mean scores were found in environmental domain. Statistically significant association was found between physical domain and age- groups, gender, marital and educational status; and between psychological domain and gender, current occupational status. Environmental domain was associated with age-groups, religion, financial dependency, current occupational status.Conclusions: Elderly belonging to younger age- group (60-69 years), male gender, educated, retired group and those without morbidity had better QOL.

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