scholarly journals Global Collaboration Research Strategies for Sustainability in the Post COVID-19 Era: Analyzing Virology-Related National-Funded Projects

2020 ◽  
Vol 12 (16) ◽  
pp. 6561 ◽  
Author(s):  
Doyeon Lee ◽  
Jongseok Kang ◽  
Keunhwan Kim
Keyword(s):  
Scientific Evidence ◽  
Research Strategies ◽  
Policy And Practice ◽  
Related Research ◽  
Competitive Edge ◽  
Research Areas ◽  
Research Fields ◽  
The Us ◽  
The Status ◽  
Developed Nations

In the post-COVID-19 era, virology-related research, which not only depends on the governments as its main source of funding but also requires international and interdisciplinary collaborations, is recognized as an essential defense for sustainability. Few published studies have examined the trend, but only for certain viruses before the mid-2010s. Moreover, it is challenging to define generally accepted virology-related research fields due to its broad spectrum. Thus, it is time that we confront the unprecedented pandemic to understand the status of nationally supported projects in developed nations to establish international collaborative research strategies from an interdisciplinary perspective. In this study, 32,365 national-funded projects were collected from the US, EU, and Japan and assigned to five scientific fields to conduct a cluster analysis. Then, an expert-based approach was utilized to define an individual cluster. Moreover, a comparative analysis between nations was carried out to determine if there was a competitive edge for collaboration. As a result, a framework for virology-related research areas was constructed to provide the status quo and differences between nations’ research capabilities, thereby eliciting practical global research and development (R&D) cooperation to achieve a common agenda and a direction for goals in the post-COVID-19 era. These findings have implications for viral response R&D, policy, and practice for future pandemics. A systematic approach based on scientific evidence and an R&D collaboration strategy between industry and academia is essential to resolve the interdisciplinary barriers between countries and promote sustainable virus R&D collaboration.

scholarly journals Research Strategies for Biomedical and Health Informatics

2017 ◽  
Vol 56 (S 01) ◽  
pp. e1-e10 ◽  
Author(s):  
Reinhold Haux ◽  
Casimir Kulikowski ◽  
Suzanne Bakken ◽  
Simon de Lusignan ◽  
Michio Kimura ◽  
...  
Keyword(s):  
Health Care ◽  
Health Informatics ◽  
Scientific Discipline ◽  
Academic Community ◽  
Care Practice ◽  
Research Strategies ◽  
Health Care Outcomes ◽  
Research Areas ◽  
Research Fields ◽  
The One

SummaryBackground: Medical informatics, or biomedical and health informatics (BMHI), has become an established scientific discipline. In all such disciplines there is a certain inertia to persist in focusing on well-established research areas and to hold on to well-known research methodologies rather than adopting new ones, which may be more appropriate.Objectives: To search for answers to the following questions: What are research fields in informatics, which are not being currently adequately addressed, and which methodological approaches might be insufficiently used? Do we know about reasons? What could be consequences of change for research and for education?Methods: Outstanding informatics scientists were invited to three panel sessions on this topic in leading international conferences (MIE 2015, Medinfo 2015, HEC 2016) in order to get their answers to these questions.Results: A variety of themes emerged in the set of answers provided by the panellists. Some panellists took the theoretical foundations of the field for granted, while several questioned whether the field was actually grounded in a strong theoretical foundation. Panellists proposed a range of suggestions for new or improved approaches, methodologies, and techniques to enhance the BMHI research agenda.Conclusions: The field of BMHI is on the one hand maturing as an academic community and intellectual endeavour. On the other hand vendor-supplied solutions may be too readily and uncritically accepted in health care practice. There is a high chance that BMHI will continue to flourish as an important discipline; its innovative interventions might then reach the original objectives of advancing science and improving health care outcomes.

scholarly journals A Strategy for International Cooperation in the COVID-19 Pandemic Era: Focusing on National Scientific Funding Data

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 204 ◽  
Author(s):  
Doyeon Lee ◽  
Yoseob Heo ◽  
Keunhwan Kim
Keyword(s):  
South Korea ◽  
The United States ◽  
The European Union ◽  
Future Health ◽  
Health Security ◽  
Health Crisis ◽  
Related Research ◽  
Research Fields ◽  
The Status ◽  
The Government

The coronavirus crisis may lead to a deeper understanding of international collaborations for developing antivirals and vaccines that are essential to protect us from current and future health security threats. Beyond technical solutions, the government of South Korea needs to establish a timely strategic investment in coronavirus-related research and development (R&D) in order to enhance the capabilities for managing this new uncertainty in regard to the domestic health crisis. Thus, this study aims to provide useful information about the status of global coronavirus-related research from the South Korean government’s perspective. National funded projects stemmed from leading nations such as the United States, countries of the European Union, and Japan between 2012 and 2018. Six research fields were derived by clustering analysis and an expert-based approach, and then matched to those of South Korea. The comparative analysis among them allowed for the identification of the nations’ strengths and weaknesses, thereby laying the groundwork for strategic international research collaborations.

The Tragedy of Lebanon

1984 ◽  
Vol 1 (1) ◽  
pp. 27-52
Author(s):  
Mahmud A. Faksh
Keyword(s):  
Civil War ◽  
Status Quo ◽  
World War ◽  
Land Area ◽  
Henry Kissinger ◽  
The North ◽  
Northern Cyprus ◽  
The Us ◽  
The Status ◽  
New States

I.Since the end of World War 11, approximately eighty new states havebeen established. Only two, Pakistan and Cyprus, have undergone theagony of dismemberment when Bangladesh broke off in 1973 and theTurkish Republic of Northern Cyprus was declared in 1983. The worldmay now be witnessing the possible breakup of yet a third state:Lebanon, whose disintegration has been accelerated since the June 1982Israeli invasion.Shortly after the invasion began, Henry Kissinger assessed itsconsequence for Lebanon’s future, concluding, “It is neither desirablenor possible to return to the status quo ante in Lebanon.” One possibleoutcome was that some Syrian and Israeli forces would remain in thenorthern and southern ends, respectively, and the central government’sauthority would ostensibly cover the rest of the country. Implicit in theKissinger diagnosis is the possibility of eventual partition.Though the gloomy assessment by the “wizard” of US. foreign policyshould by no means be construed as a portent of an official shift awayfrom the publicly stated US. support of “Lebanon’s sovereignty andterritorial integrity,” a shadow was cast on the country’s prospects.Subsequent developments have seemed to indicate that Lebanon’sdemise looms larger than at any time since the beginning of the civil warin 1975-76.For over a year and a half national fragmentation has proceededinexorably. What many people once could imagine only with difficulty,they now acknowledge: in reality, Lebanon is facing possible death. TheSouth (35 percent of the land area) is occupied by Israel; the North andthe Biqa’ (45 percent) are controlled by Syria; Kasrawan (15 percent) iscontrolled by the Christian Maronite forces (the Lebanese Front forces),which are not subject to the government’s authority. The rest of thecountry-beleaguered Beirut and environs-was until the February1984 breakdown under the government’s shaky control supported bysymbolic US., French, Italian, and British units. The Multi-NationalForce (MNF) was subject to increasing attacks by Muslim leftist factions,as witnessed in the October 23 bombing of the quarters of U.S.Marines and French troops. Thus, instead of keeping peace, the MNFbecame ,a partisan force trying to protect itself. The US. and Frenchforces in particular seemed to have outlived their usefulness as“peacekeepers.” Recurrent fighting in southern Beirut and in theadjacent Chouf mountains, that pitted Christian Maronites and armyunits against Shi‘ite and Druse Muslims constantly threatened theexistence of President Amin Gemayel’s government and consequently arenewal of the civil war. This situation culminated in February 1984 inthe resignation of the Shafiq al-Wazzan’s cabinet, the loss ofgovernment’s control of West Beirut to Muslim-leftist militias, and theimminent collapse of Amin Gemayel’s presidency ...

Scripturalizing and the Second Amendment

2018 ◽  
Author(s):  
Rosamond C. Rodman
Keyword(s):  
White Women ◽  
White Children ◽  
The Bible ◽  
Second Amendment ◽  
The Us ◽  
The Status ◽  
Us Constitution ◽  
Half Decade

Expanding beyond the text of the Bible, this chapter explores instead a piece of political scripture, namely the Second Amendment of the US Constitution. Over the last half-decade, the Second Amendment has come to enjoy the status of a kind of scripture-within-scripture. Vaulted to a much more prominent status than it had held in the first 150 years or so of its existence, and having undergone a remarkable shift in what most Americans think it means, the Second Amendment provides an opportunity to examine the linguistic, racial, and gendered modes by which these changes were effected, paying particular attention to the ways in which white children and white women were conscripted into the role of the masculine, frontier-defending US citizen.

The Crisis of the Ryukyus (1877–82)

2018 ◽  
Author(s):  
Patrick Sze-lok Leung ◽  
Anthony Carty
Keyword(s):  
International Law ◽  
Colonial Power ◽  
Independent State ◽  
The People ◽  
The Us ◽  
The Status ◽  
Historical Viewpoint

Okinawa is now considered as Japanese territory, without challenge from most world powers. However, this is debatable from a historical viewpoint. The Ryukyu Kingdom which dominated the islands was integrated into Japan in 1879. The transformation is seen by Wang Hui as a process of modernization. This chapter argues the issue from an international law perspective. It shows that Ryukyu was an independent State as demonstrated by the 1854 Ryukyu–US Treaty, although it sent regular tributes to China. The Japanese integration by coercion is not justifiable. The people of Ryukyu were willing to continue being a tributary State rather than part of Japan. Britain, as the greatest colonial power, did not object. China and the US attempted to intervene in this affair, but no treaty has so far been concluded. Therefore, the status of Ryukyu/Okinawa remains unresolved and may need to be revisited, while putting the history context into consideration.

scholarly journals Animal and Human Vaccines against West Nile Virus

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1073
Author(s):  
Juan-Carlos Saiz
Keyword(s):  
Clinical Trials ◽  
West Nile Virus ◽  
Vaccine Development ◽  
Phase Iii ◽  
West Nile ◽  
Specific Therapy ◽  
Phase Iii Clinical Trials ◽  
Neuroinvasive Disease ◽  
The Us ◽  
The Status

West Nile virus (WNV) is a widely distributed enveloped flavivirus transmitted by mosquitoes, which main hosts are birds. The virus sporadically infects equids and humans with serious economic and health consequences, as infected individuals can develop a severe neuroinvasive disease that can even lead to death. Nowadays, no WNV-specific therapy is available and vaccines are only licensed for use in horses but not for humans. While several methodologies for WNV vaccine development have been successfully applied and have contributed to significantly reducing its incidence in horses in the US, none have progressed to phase III clinical trials in humans. This review addresses the status of WNV vaccines for horses, birds, and humans, summarizing and discussing the challenges they face for their clinical advance and their introduction to the market.

scholarly journals Basing Information on Comprehensive, Critically Appraised, and Up-to-Date Syntheses of the Scientific Evidence: An Update from the International Patient Decision Aid Standards

2021 ◽  
pp. 0272989X2199662
Author(s):  
Tammy C. Hoffmann ◽  
Mina Bakhit ◽  
Marie-Anne Durand ◽  
Lilisbeth Perestelo-Pérez ◽  
Catherine Saunders ◽  
...  
Keyword(s):  
Decision Aid ◽  
Scientific Evidence ◽  
Decision Aids ◽  
Future Research ◽  
Patient Decision Aid ◽  
Patient Decision Aids ◽  
Research Areas ◽  
Patient Decision ◽  
Evidence Quality ◽  
Emerging Issues

Background Patients and clinicians expect the information in patient decision aids to be based on the best available research evidence. The objectives of this International Patient Decision Aid Standards (IPDAS) review were to 1) check the currency of, and where needed, update evidence for the domain of “basing the information in decision aids on comprehensive, critically appraised, and up-to-date syntheses of the evidence”; 2) analyze the evidence characteristics of decision aids; and 3) propose updates to relevant IPDAS criteria. Methods We searched MEDLINE and PubMed to inform updates of this domain’s definitions, justifications, and components. We also searched 5 sources to identify all publicly available decision aids ( N = 471). Two assessors independently extracted each aid’s evidence characteristics. Results Minor updates to the definitions and theoretical justifications of this IPDAS domain are provided and changes to relevant IPDAS criteria proposed. Nearly all aids (97%) provided a year of creation/update, but most (81%) did not report an explicit update or expiration policy. No scientific references were cited in 33% of aids. Of the 314 that cited at least 1 reference, 39% cited at least 1 guideline, 44% cited at least 1 systematic review, and 23% cited at least 1 randomized trial. In 35%, it was unclear what statement in the aid the citations referred to. Only 14% reported any of the processes used to find and decide on evidence inclusion. Only 14% reported the evidence quality. Many emerging issues and future research areas were identified. Conclusions Although many emerging issues need to be addressed, this IPDAS domain is validated and criteria refined. High-quality patient decision aids should be based on comprehensive and up-to-date syntheses of critically appraised evidence.

scholarly journals Weeding through the haze: a survey on cannabis use among people living with Parkinson’s disease in the US

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Megan P. Feeney ◽  
Danny Bega ◽  
Benzi M. Kluger ◽  
A. Jon Stoessl ◽  
Christiana M. Evers ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Scientific Evidence ◽  
Symptom Control ◽  
Cannabis Use ◽  
Symptom Improvement ◽  
Motor Symptoms ◽  
The Us ◽  
Alternative Means ◽  
Non Motor Symptoms

AbstractSymptomatic management of Parkinson’s disease (PD) is complex and many symptoms, especially non-motor symptoms, are not effectively addressed with current medications. In the US, cannabis has become more widely available for medical and recreational use, permitting those in the PD community to try alternative means of symptom control. However, little is known about the attitudes towards, and experiences with, cannabis use among those living with PD. To address this shortcoming, we distributed an anonymous survey to 7,607 people with PD in January 2020 and received 1339 responses (17.6%). 1064 complete responses were available for analysis. Respondents represented 49 states with a mean age of 71.2 years (±8.3) and mean PD duration of 7.4 years (±6.2). About a quarter of respondents (24.5%) reported cannabis use within the previous six months. Age and gender were found to be predictors of cannabis use in this sample (Age OR = 0.95, 95% CI 0.93 to 0.97; Male OR = 1.44, 95% CI 1.03 to 2.03). Users reported learning about cannabis use from the internet/news (30.5%) and friends or other people with PD (26.0%). Cannabis users were more likely to report insufficient control of their non-motor symptoms with prescription medications than non-users (p = 0.03). Cannabis was primarily used for PD (63.6%) and was most often used to treat nonmotor symptoms of anxiety (45.5%), pain (44.0%), and sleep disorders (44.0%). However, nearly a quarter of users (23.0%) also reported they had stopped cannabis use in the previous six months, primarily due to a lack of symptom improvement (35.5%). Three quarters of respondents (75.5%) did not use cannabis, primarily because there was a lack of scientific evidence supporting efficacy (59.9%). Our results suggest that the lack of formal guidance or research evidence about cannabis for PD may in part underlie inconsistencies in both use and reported effectiveness.

scholarly journals High Prevalence of Three Potyviruses Infecting Cucurbits in Oklahoma and Phylogenetic Analysis of Cucurbit Aphid-Borne Yellows Virus Isolated from Pumpkins

Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 53
Author(s):  
Vivek Khanal ◽  
Harrington Wells ◽  
Akhtar Ali
Keyword(s):  
Phylogenetic Analysis ◽  
Mosaic Virus ◽  
Zucchini Yellow Mosaic Virus ◽  
Yellow Mosaic Virus ◽  
Watermelon Mosaic Virus ◽  
High Prevalence ◽  
The Us ◽  
Close Relationship ◽  
The Status ◽  
Low Incidence

Field information about viruses infecting crops is fundamental for understanding the severity of the effects they cause in plants. To determine the status of cucurbit viruses, surveys were conducted for three consecutive years (2016–2018) in different agricultural districts of Oklahoma. A total of 1331 leaf samples from >90 fields were randomly collected from both symptomatic and asymptomatic cucurbit plants across 11 counties. All samples were tested with the dot-immunobinding assay (DIBA) against the antisera of 10 known viruses. Samples infected with papaya ringspot virus (PRSV-W), watermelon mosaic virus (WMV), zucchini yellow mosaic virus (ZYMV), and cucurbit aphid-borne-yellows virus (CABYV) were also tested by RT-PCR. Of the 10 viruses, PRSV-W was the most widespread, with an overall prevalence of 59.1%, present in all 11 counties, followed by ZYMV (27.6%), in 10 counties, and WMV (20.7%), in seven counties, while the remaining viruses were present sporadically with low incidence. Approximately 42% of the infected samples were positive, with more than one virus indicating a high proportion of mixed infections. CABYV was detected for the first time in Oklahoma, and the phylogenetic analysis of the first complete genome sequence of a CABYV isolate (BL-4) from the US showed a close relationship with Asian isolates.

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