scholarly journals The Effect of Vaccination with Live Attenuated Neethling Lumpy Skin Disease Vaccine on Milk Production and Mortality—An Analysis of 77 Dairy Farms in Israel

Vaccines ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 324 ◽  
Author(s):  
Michal Morgenstern ◽  
Eyal Klement
Keyword(s):  
Adverse Effects ◽  
Milk Production ◽  
Skin Disease ◽  
Linear Models ◽  
Viral Disease ◽  
Lumpy Skin Disease ◽  
Post Vaccination ◽  
Efficient Measure ◽  
Daily Milk Production ◽  
Cattle Farms

Lumpy skin disease (LSD) is an economically important, arthropod borne viral disease of cattle. Vaccination by the live attenuated homologous Neethling vaccine was shown as the most efficient measure for controlling LSD. However, adverse effects due to vaccination were never quantified in a controlled field study. The aim of this study was to quantify the milk production loss and mortality due to vaccination against LSD. Daily milk production, as well as culling and mortality, were retrieved for 21,844 cows accommodated in 77 dairy cattle farms in Israel. Adjusted milk production was calculated for each day during the 30 days post vaccination. This was compared to the preceding month by fitting mixed effects linear models. Culling and mortality rates were compared between the 60 days periods prior and post vaccination, by survival analysis. The results of the models indicate no significant change in milk production during the 30 days post vaccination period. No difference was observed between the pre- and post-vaccination periods in routine culling, as well as in immediate culling and in-farm mortality. We conclude that adverse effects due to Neethling vaccination are negligible.

scholarly journals The First Lumpy Skin Disease Outbreak in Thailand (2021): Epidemiological Features and Spatio-Temporal Analysis

2022 ◽  
Vol 8 ◽  
Author(s):  
Orapun Arjkumpa ◽  
Minta Suwannaboon ◽  
Manoch Boonrod ◽  
Issara Punyawan ◽  
Supawadee Liangchaisiri ◽  
...  
Keyword(s):  
Skin Disease ◽  
Temporal Analysis ◽  
Space Time ◽  
Effective Control ◽  
Outbreak Response ◽  
Lumpy Skin Disease ◽  
Epidemiological Features ◽  
Spatio Temporal ◽  
Epidemiological Characteristics ◽  
Cattle Farms

The first outbreak of lumpy skin disease (LSD) in Thailand was reported in March 2021, but information on the epidemiological characteristics of the outbreak is very limited. The objectives of this study were to describe the epidemiological features of LSD outbreaks and to identify the outbreak spatio-temporal clusters. The LSD-affected farms located in Roi Et province were investigated by veterinary authorities under the outbreak response program. A designed questionnaire was used to obtain the data. Space-time permutation (STP) and Poisson space-time (Poisson ST) models were used to detect areas of high LSD incidence. The authorities identified 293 LSD outbreak farms located in four different districts during the period of March and the first week of April 2021. The overall morbidity and mortality of the affected cattle were 40.5 and 1.2%, respectively. The STP defined seven statistically significant clusters whereas only one cluster was identified by the Poisson ST model. Most of the clusters (n = 6) from the STP had a radius <7 km, and the number of LSD cases in those clusters varied in range of 3–51. On the other hand, the most likely cluster from the Poisson ST included LSD cases (n = 361) from 198 cattle farms with a radius of 17.07 km. This is the first report to provide an epidemiological overview and determine spatio-temporal clusters of the first LSD outbreak in cattle farms in Thailand. The findings from this study may serve as a baseline information for future epidemiological studies and support authorities to establish effective control programs for LSD in Thailand.

scholarly journals Associations between milking technology, herd size and milk production parameters on commercial dairy cattle farms

2020 ◽  
Vol 70 (2) ◽  
pp. 103-111
Author(s):  
Dorottya Ivanyos ◽  
László Ózsvári ◽  
István Fodor ◽  
Csaba Németh ◽  
Attila Monostori
Keyword(s):  
Dairy Cattle ◽  
Milk Production ◽  
Milk Yield ◽  
Linear Models ◽  
Herd Size ◽  
Exact Test ◽  
Production Parameters ◽  
Daily Milk Yield ◽  
Cattle Farms ◽  
Daily Milk

The aim of the study was to survey the milking technology and to analyse the associations between milking parlour type, herd size, and milk production parameters on dairy cattle farms. The milking technology was surveyed by using a questionnaire in 417 Hungarian dairy herds with 177,514 cows in 2017, and it was compared with their official farm milk production data. The surveyed farms were categorized according to their size (1-50, 51-300, 301-600, and >600 cows) and to their milking parlour types (herringbone, parallel, carousel, and others). The relationships were analysed by multivariate linear models, one-way ANOVA, and Fisher’s exact test. Pairwise comparisons were performed by Tukey’s post hoc tests. The prevailing type of milking parlour was herringbone (71.0 %), but on larger farms the occurrence of parallel and carousel parlours increased (p<0.001). The number of milking stalls per farm increased with herd size (p<0.001). Farms with herringbone parlour had significantly smaller number of milking stalls than that of parallel (p=0.022) and carousel (p<0.001) parlours, and the cows were mostly milked two times, while in carousel milking parlours mostly three times a day. As the herd size increased, so did daily milk yield (p<0.001) and daily milk production per cow (p<0.001). Herd size was associated with somatic cell count (p<0.001). The type of milking parlour showed significant association with daily milk yield (p=0.039) and dairy units with herringbone milking system had the lowest milk quality. Our findings show that herd size has greater impact on milk production parameters than milking technologies.

scholarly journals Hematological and serum biochemical findings in clinical cases of cattle naturally infected with lumpy skin disease

2015 ◽  
Vol 9 (03) ◽  
pp. 283-288 ◽  
Author(s):  
Sameeh M Abutarbush
Keyword(s):  
Skin Disease ◽  
Venous Blood ◽  
Hemoglobin Concentration ◽  
Viral Disease ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Creatinine Concentration ◽  
Blood Profile ◽  
Lumpy Skin Disease ◽  
Serum Biochemical

Introduction: Lumpy skin disease (LSD) is an acute viral disease of cattle that is currently emerging in the Middle East region and poses a serious threat to Europe and the rest of the world. The objective of this study was to describe hematological and serum biochemical findings associated with natural clinical infection of LSD in cattle. Methodology: A total of 129 animals clinically infected with LSD were enrolled in the study. Venous blood sample were collected from study animals, and hematological and serum biochemical parameters were measured. Results: Leukocytopenia was found in 8.7%, while leucocytosis was found in 18.2% of affected cattle. Decreased hematocrit concentration was seen in 18.3%. Most affected cattle had reduced mean corpuscular volume (43.7%), mean corpuscular hemoglobin (14.3%), and mean corpuscular hemoglobin concentration (11.5%). All cattle with abnormal platelets count had thrombocytopenia. Hyperfibrinogenemia, hyperproteinemia, and hyperalbuminemia were found in 69%, 59.6%, and 37.2% of affected cattle, respectively. Decreased creatinine concentration was seen in 65.8%. Hyperkalemia and hyperchloremia was found in 9.6% and 10.4% of the affected cattle, respectively. Conclusions: LSD appears to be associated with inflammatory leukogram, anemia, thrombocytopenia, hyperfibrinogenemia, hyperproteinemia, decreased creatinine concentration, hyperchloramia, and hyperkalemia. These are likely due to the associated severe inflammatory process and disease complications such as anorexia and reduced muscle mass. This is the first study that documents hematological and serum biochemical findings associated with LSD infection. Understanding the blood profile picture may give further insight to the pathogenesis of the disease and help in treatment of individual cattle.

scholarly journals Occurrences of Lumpy Skin Disease (LSD) in Cattle in Dinajpur Sadar of Bangladesh

2020 ◽  
Vol 7 (3) ◽  
pp. 445-455
Author(s):  
Sumon Sarkar ◽  
Mirza Mienur Meher ◽  
Mst Misrat Masuma Parvez ◽  
Mahfuza Akther
Keyword(s):  
Skin Disease ◽  
Viral Disease ◽  
Skin Lesions ◽  
Young Female ◽  
Whole Body ◽  
Economic Losses ◽  
Local Breed ◽  
Lumpy Skin Disease ◽  
Herd Level ◽  
Level Information

Lumpy skin disease (LSD) is an acute viral disease infectious of cattle and recently emerged very common in Bangladesh causing economic losses. Hence, this study was design to investigate the prevalence of LSD in considering the herd level and some of management status. Thus, a total of 453 sick animals were subjected to study during the period of April 2020 to July 2020 in Dinajpur. LSD was confirmed according to the clinical inspection and microscopic study of skin scraping. The results indicated that the overall prevalence of LSD was 41.06% in cattle. Moreover, the local breed (75%) and young cattle less than one year (64%) were significantly (p<0.001) higher for LSD with the significant (p<0.001) skin lesions in whole body (44%). In addition, the animal grazed in flock (61%), non-dewormed (58%), non-vaccinated (61%) was significantly (p<0.05) higher for LSD. In the same way, 75% prevalence was in without fly repellent (p<0.001). Afterward, the univariate logistic regression in herd level information had the odd ratio of local breed (95% CI: 0.244-0.553), skin lesions in abdominal regions (95% CI: 1.620-5.923) and pregnant cattle (95% CI: 1.057-3.386) was 0.367, 3.098 and 1.892 respectively indicated the likelihood of no LSD outbreaks. Besides this, the odd ratio of dewormed cattle, vaccinated, individually grazed, regular use of disinfectant and fly repellent farm animal was 1.493 (95% CI:1.024-2.177), 1.491 (95% CI:1.020-2.180), 1.656 (95% CI:1.133-2.421), 1.516 (95% CI:0.952-2.414) and 1.660 (95% CI:1.097-2.513), respectively indicated the likelihood of no LSD. Therefore, LSD infection can be greatly reduced by practicing regular vaccination, deworming, and disinfection, vector controlling and allowing grazing individually, especially with great concern to young female cattle of local breed. Res. Agric., Livest. Fish.7(3): 445-455,  December 2020

scholarly journals Risk Factors for Outbreaks of Lumpy Skin Disease and the Economic Impact in Cattle Farms of Nakuru County, Kenya

2020 ◽  
Vol 7 ◽  
Author(s):  
Samuel Kipruto Kiplagat ◽  
Philip Mwanzia Kitala ◽  
Joshua Orungo Onono ◽  
Philippa M. Beard ◽  
Nicholas A. Lyons
Keyword(s):  
Risk Factors ◽  
Economic Impact ◽  
Skin Disease ◽  
Lumpy Skin Disease ◽  
Cattle Farms

scholarly journals Emergence of the First Lumpy Skin Disease Outbreak Among Livestock in the Republic of Kazakhstan in 2016.

2020 ◽  
Author(s):  
Arman Issimov ◽  
Nurkuisa Rametov ◽  
Kuandyk Zhugunissov ◽  
Lespek Kutumbetov ◽  
Assylbek Zhanabayev ◽  
...  
Keyword(s):  
Skin Disease ◽  
Preliminary Investigation ◽  
Viral Disease ◽  
Control Measures ◽  
Disease Spread ◽  
African Continent ◽  
Cattle Farm ◽  
Lumpy Skin Disease ◽  
The Republic ◽  
West Kazakhstan

Lumpy skin disease (LSD) is an emerging transboundary viral disease of cattle originating from the African continent. Here we describe the first LSD outbreak reported in the Republic of Kazakhstan, in July 2016. Initially, LSD was reported in a cattle farm located 49 km from Kazakh &ndash;Russian border in, Atyrau Oblast in West Kazakhstan. Subsequently, the disease spread to neighbouring farms situated within the same district. Following a preliminary investigation, the local State Veterinary Service declared a strict quarantine according to the State Contingency Plan, along with immediate total stamping out and cattle movement restrictions. During the outbreak, the number of affected cattle within an epidemiological unit reached 459 cattle out of registered 3557 susceptible cattle with 12.90% morbidity and 0.96%, mortality. This manuscript presents the epidemiological situation, the diagnosis, the control measures including mass vaccination and the stamping out campaign.s

scholarly journals Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 621
Author(s):  
Zahra Bamouh ◽  
Jihane Hamdi ◽  
Siham Fellahi ◽  
Slimane Khayi ◽  
Mohammed Jazouli ◽  
...  
Keyword(s):  
Skin Disease ◽  
Vaccine Dose ◽  
Neutralizing Antibody ◽  
Skin Lesions ◽  
Whole Body ◽  
Lumpy Skin Disease ◽  
Post Vaccination ◽  
Live Vaccines ◽  
Skin Nodules ◽  
Successful Control

Lumpy skin disease virus (LSDV) causes an economically important disease in cattle. The only method for successful control is early diagnosis and efficient vaccination. Adverse effects of vaccination such as local inflammation at the injection site and localized or generalized skin lesions in some vaccinated animals have been reported with live vaccines. The aim of this work was to compare the safety of two lumpy skin disease (LSD) vaccine strains, Kenyan (Kn) Sheep and Goat Pox (KSGP O-240) and LSDV Neethling (Nt) strain, and to determine the etiology of the post-vaccination (pv) reactions observed in cattle. Experimental cattle were vaccinated under controlled conditions with Nt- and KSGP O-240-based vaccines, using two different doses, and animals were observed for 3 months for any adverse reactions. Three out of 45 cattle vaccinated with LSDV Nt strain (6.7%) and three out of 24 cattle vaccinated with Kn strain (12.5%) presented LSD-like skin nodules, providing evidence that the post-vaccination lesions may not be strain-dependent. Lesions appeared 1–3 weeks after vaccination and were localized in the neck or covering the whole body. Animals recovered after 3 weeks. There is a positive correlation between the vaccine dose and the appearance of skin lesions in vaccinated animals; at the 105 dose, 12% of the animals reacted versus 3.7% at the 104 dose. Both strains induced solid immunity when protection was measured by neutralizing antibody seroconversion.

scholarly journals Safety of Pfizer-BioNTech COVID-19 mRNA Vaccine in the Elderly

2021 ◽  
Author(s):  
Katarzyna Korzeniowska ◽  
Artur Cieślewicz ◽  
Katarzyna Grabańska-Martyńska ◽  
Anna Jabłecka
Keyword(s):  
Statistical Analysis ◽  
Adverse Effects ◽  
Older People ◽  
The Elderly ◽  
Viral Disease ◽  
Potential Effect ◽  
Common Phenomenon ◽  
Post Vaccination ◽  
The Past ◽  
Initial Results

Abstract Background. COVID-19 is an infectious viral disease that has affected more than 234 million people and has caused almost 4.8 million deaths worldwide. A patient's age is the most important factor influencing the risk of severe course of the disease. The elderly usually suffer from many ailments, and therefore, polypharmacy is a common phenomenon among them. Our paper presents the initial results of the analysis of adverse effects in the group of older people in the context of participants' pharmacotherapy. Methods. The information concerning post-vaccination adverse effects, COVID-19 in the past and current pharmacotherapy was collected from 200 people aged 60 years or older. Statistical analysis was performed using StatSoft Statistica 13.1 software. Results. Twenty-three participants reported adverse effects after vaccination. Statistical analysis of groups with and without adverse effects revealed significant differences in age, cardiovascular drugs, neurological and psychiatric drugs, analgesics, gastrointestinal drugs, supplements, and vitamins. Conclusions. Obtained results suggest the need to study the potential effect of ongoing pharmacotherapy on the safety and effectiveness of vaccination.

scholarly journals Prevalence and Management Practices of Lumpy Skin Disease (LSD) in Cattle at Natore District of Bangladesh

2021 ◽  
Vol 3 (6) ◽  
pp. 76-81
Author(s):  
Md Hakimul Haque ◽  
Rahul Krishna Roy ◽  
Farhana Yeasmin ◽  
Md. Fakhruzzaman ◽  
Tanjina Yeasmin ◽  
...  
Keyword(s):  
Skin Disease ◽  
Management Practices ◽  
Case Fatality ◽  
Viral Disease ◽  
Molecular Characteristics ◽  
Critical Determinant ◽  
Clinical Indicators ◽  
Lumpy Skin Disease ◽  
The North ◽  
Import Restrictions

Lumpy skin disease (LSD) is a potentially contagious viral disease in cattle, caused by the Lumpy skin disease virus (LSDV), which belongs to the family Poxviridae. The virus is suspected to spread via biological vectors such as mosquitoes, flies, ticks, and direct contact. It is a significant economic disease caused by a virus that causes significant losses in milk production, fertility, abortions, import restrictions, and, in some cases, death in the livestock animals. This study aimed to assess the current state of LSD and its management on several farms in the north-western region of Bangladesh. Data were obtained from two Upazilas in the Natore district (Natore Sadar and Baraigram) using a structured questionnaire. During the study period of 1 June to 20 December 2020, a total of 34 small farms and 87 animals were monitored. The OIE guidelines directed the diagnosis of LSD based on current clinical indicators. MS Excel and SPSS statistical software were used to evaluate all of the data. Morbidity, mortality, and case-fatality rates were found to be 64.70%, 2.94 %, and 4.53 % in Natore Sadar and 83.02 %, 3.77 %, and 4.55 % in Baraigram Upazilas, respectively. Female animals that were newly matured (2-4 years) were a larger prone to LSD infection (43.1%) than animals of other ages. A total of 34.43% illness was found in young bull cattle aged (2-4). Bull and heifer calves are also vulnerable populations, with reports of LSD infection leading to mortality. Limb swelling is a common clinical symptom, and LSD-positive young mature (2-4 year) cattle had the most significant rate (18.39%) of limb swelling. The farm hygiene practice is a critical determinant in the spread of LSDV, and a large proportion of cattle (48.27 %) infected with LSD were on farms with poor hygienic management, compared to good (01.14 %) and medium (01.14 %) hygienic management practices (26.43 %). Despite the fact that mosquito nets help prevent mosquitoes, most owners (91.17 %) did not use one in their cattle barn at night. More study is needed in Bangladesh to improve the clinical management of LSD, identify risk factors, and understand the molecular characteristics of diseases.

scholarly journals Mechanical transmission of lumpy skin disease virus by Rhipicephalus appendiculatus male ticks

2012 ◽  
Vol 141 (2) ◽  
pp. 425-430 ◽  
Author(s):  
E. S. M. TUPPURAINEN ◽  
J. C. LUBINGA ◽  
W. H. STOLTSZ ◽  
M. TROSKIE ◽  
S. T. CARPENTER ◽  
...  
Keyword(s):  
Disease Virus ◽  
Skin Disease ◽  
Clinical Signs ◽  
Viral Disease ◽  
Rhipicephalus Appendiculatus ◽  
Mechanical Transmission ◽  
Lumpy Skin Disease ◽  
Lumpy Skin Disease Virus ◽  
Feeding Site ◽  
Source Of Infection

SUMMARYLumpy skin disease (LSD) is an economically important, acute or sub-acute, viral disease of cattle that occurs across Africa and in the Middle East. The aim of this study was to investigate if lumpy skin disease virus (LSDV) can be transmitted mechanically by African brown ear ticks (Rhipicephalus appendiculatus Neum.). Laboratory-bred R. appendiculatus males were fed on experimentally infected viraemic ‘donor’ cattle. Partially fed male ticks were then transferred to feed on an uninfected ‘recipient’ cow. The recipient animal became viraemic, showed mild clinical signs of LSD and seroconverted. Additionally, R. appendiculatus males were found to transmit LSDV through feeding on skin lacking visible lesions, demonstrating that viraemic animals without lesions at the feeding site of ticks may be a source of infection. This is the first time that transmission of poxviruses by a tick species has been demonstrated and the importance of this mode of transmission in the spread of LSDV in endemic settings is discussed.

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