scholarly journals Pneumococcal Disease Prevention: Are We on the Right Track?

Vaccines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 305
Author(s):  
Nicola Principi ◽  
Susanna Esposito

The history of Streptococcus pneumoniae diseases dramatically changed with the introduction into the immunization schedule of infants and children of the first pneumococcal conjugate vaccine, the one containing 7 (PCV7) of the most common pneumococcal serotypes (STs) causing invasive pneumococcal diseases (IPDs). Where PCV7 was largely used, incidence of both IPDs and non-invasive pneumococcal diseases (nIPDs) in vaccinated children and in unvaccinated subjects of any age, mainly the elderly, significantly decreased. Unfortunately, the impact of PCV7 administration was slightly lower than expected, as the reduction in infections due to vaccine serotypes (STs) was accompanied by a significant increase in the number of IPDs and nIPDs due to STs not included in the vaccine. To overcome this problem, two PCVs containing 10 (PCV10) and 13 (PCV13) STs, chosen among those emerging, were developed and licensed. However, ST replacement occurred again. Moreover, the new PCVs showed little effectiveness in the prevention of infection due to non-encapsulated STs and to ST3. Next-generation S. pneumoniae vaccines able to prevent pneumococcal infections regardless of infecting ST are urgently needed. For the moment, the use of available PCVs remains fundamental because their benefits far outweigh any concerns for emerging STs.

Author(s):  
Monique A. Bedasse

When Rastafarians began to petition the Tanzanian government for the “right of entry” in 1976, they benefitted from a history of linkages between Jamaica and Tanzania, facilitated largely by the personal and political friendship between Julius Nyerere and Prime Minister of Jamaica, Michael Manley. This is the subject of the third chapter, which provides essential context for the repatriation. The chapter begins by unearthing the pan-African politics of Michael Manley, which he constructed after appropriating Rastafarian symbols and consciousness into his political campaigns. It also puts a spotlight on the extent to which African leaders of newly independent states helped to define the pan-Africanism of this period by detailing the impact of Julius Nyerere on Manley’s thinking. Finally, it juxtaposes Manley’s acceptance in pan-African circles across Africa with his personal struggle over his own perceived distance from blackness, as a member of Jamaica’s “brown’ elite. In the end, Rastafari was absolutely central to generating the brand of politics surrounding race, color and class in the moment of decolonization. The history of repatriation transgresses analytical boundaries between state and nonstate actors.


Author(s):  
Dirk Voorhoof

The normative perspective of this chapter is how to guarantee respect for the fundamental values of freedom of expression and journalistic reporting on matters of public interest in cases where a (public) person claims protection of his or her right to reputation. First it explains why there is an increasing number and expanding potential of conflicts between the right to freedom of expression and media freedom (Article 10 ECHR), on the one hand, and the right of privacy and the right to protection of reputation (Article 8 ECHR), on the other. In addressing and analysing the European Court’s balancing approach in this domain, the characteristics and the impact of the seminal 2012 Grand Chamber judgment in Axel Springer AG v. Germany (no. 1) are identified and explained. On the basis of the analysis of the Court’s subsequent jurisprudence in defamation cases it evaluates whether this case law preserves the public watchdog-function of media, investigative journalism and NGOs reporting on matters of public interest, but tarnishing the reputation of public figures.


2019 ◽  
Author(s):  
Hanna Gekle

The history of mental development on the one and the history of his writings on the other hand form the two separate but essentially intertwined strands of an archeology of Ernst Bloch´s thought undertaken in this book. Bloch as a philosopher is peculiar in that his initial access to thought rose from the depths of early, painful experience. To give expression to this experience, he not only needed to develop new categories, but first and foremost had to find words for it: the experience of the uncanny and the abysmal, of which he tells in Spuren, is on the level of philosophical theory juxtaposed by the “Dunkel des gerade gelebten Augenblicks” (darkness of the moment just lived) and his discovery of a “Noch-nicht-Bewusstes” (not-yet-conscious), thus metaphysically undermining the classical Oedipus complex in the succession of Freud. In this book, psyche, work and the history of the 20th century appear concentrated in Ernst Bloch the philosopher and contemporary witness, who paid tribute to these supra-individual powers in his work as much as he hoped to transgress them.


2018 ◽  
Vol 10 (9) ◽  
pp. 3245 ◽  
Author(s):  
Tianxing Wu ◽  
Guilin Qi ◽  
Cheng Li ◽  
Meng Wang

With the continuous development of intelligent technologies, knowledge graph, the backbone of artificial intelligence, has attracted much attention from both academic and industrial communities due to its powerful capability of knowledge representation and reasoning. In recent years, knowledge graph has been widely applied in different kinds of applications, such as semantic search, question answering, knowledge management and so on. Techniques for building Chinese knowledge graphs are also developing rapidly and different Chinese knowledge graphs have been constructed to support various applications. Under the background of the “One Belt One Road (OBOR)” initiative, cooperating with the countries along OBOR on studying knowledge graph techniques and applications will greatly promote the development of artificial intelligence. At the same time, the accumulated experience of China in developing knowledge graphs is also a good reference to develop non-English knowledge graphs. In this paper, we aim to introduce the techniques of constructing Chinese knowledge graphs and their applications, as well as analyse the impact of knowledge graph on OBOR. We first describe the background of OBOR, and then introduce the concept and development history of knowledge graph and typical Chinese knowledge graphs. Afterwards, we present the details of techniques for constructing Chinese knowledge graphs, and demonstrate several applications of Chinese knowledge graphs. Finally, we list some examples to explain the potential impacts of knowledge graph on OBOR.


2014 ◽  
Vol 11 ◽  
pp. 72-81
Author(s):  
Peter Wood

In April, 1845, the Rev. Richard Taylor passed through the area of the North Island now marked by the town of Levin. At this time, he described Lake Horowhenua as being of singular appearance for the small storehouses built over the water on poles. As was his predilection, Taylor made a drawing of the lake huts, a version of which was belatedly included in the second edition of his most important literary contribution, Te Ika-a-Māui (1870). This image would have remained as little more than a questionable curiosity was it not for Messrs Black Bros who, in the course of exploring the lake bed for Māori artefacts in 1932, legitimised Taylor's observation with their discovery of the submerged architectural remains of an aquatic hut. Nonetheless, almost a century after Taylor's original diary entry, GL Adkin, writing for The Journal of the Polynesian Society, lamented the neglect shown toward these remarkable structures, and which he cited as just one example of the "tantalising gaps" in the recorded history of Māori custom and culture. Sadly, it is well beyond the scope of this research to properly redress the historical neglect shown toward lake pātaka. What I do wish to do is to link these structures to an event on the shores of the Lake of Zurich, Switzerland, when Dr Ferdinand Keller noticed some half-submerged piles in 1854. Upon these remains Keller made a great, if erroneous, case for primitive "pile-work habitations" in the Swiss lakes. The impact of this argument cannot be understated. It became the privileged model for architectural origins in the German and French parts of Switzerland, and by the 1890s it was a part of standard teaching texts in Swiss schools, where it was firmly inculcated into the curriculum at the time that Charles Edouard Jeanneret was a child. This in turn has led Vogt to suggest that, in Keller's "dwellings on the water," Le Corbusier found a Primitive Hut typology that underpinned all his architectural thinking, and which is made most explicit in his principled use of piloti. What makes this all the more involved is that Keller, in searching for examples to visualise the construction of the Swiss lake dwellings, turned to the Pacific (which he categorised as at a developmental stage of architectural evolution akin to early Europe). In this paper I identify the exact etching by Louis Auguste de Sainson that Keller took for direct influence. The problem, however, is that de Sainson depicted a conventional whare built on land, and Keller transposed it to the water. So we have on the one side of this paper an authentic lake whare that is all but forgotten, and a famed European lake-hut that is all but Māori, and between the two is the figure of Le Corbusier who may or may not have unknowingly based one on his major innovations on influences found in the pātaka of Lake Horowhenua.


2019 ◽  
Vol 9 (1) ◽  
pp. 85-97
Author(s):  
Béla Mester

Abstract The role of the diaries and memoirs in the process of the conscious self-reflection and their contribution to the emergence of modern individual personalities are well-known facts of the intellectual history. The present paper intends to analyze a special form of the creation of modern individual character; it is the self-creation of the writer as a conscious personality, often with a clearly formulated opinion about her/his own social role. There will be offered several examples from the 19th-century history of the Hungarian intelligentsia. This period is more or less identical with the modernization of the “cultural industry” in Hungary, dominated by the periodicals with their deadlines, fixed lengths of the articles, and professional editing houses on the one hand and the cultural nation building on the other. Concerning the possible social and cultural role of the intelligentsia, it is the moment of the birth of a new type, so-called public intellectual. I will focus on three written sources, a diary of a Calvinist student of theology, Péter (Litkei) Tóth, the memoirs of an influential public intellectual, Gusztáv Szontagh, and a belletristic printed diary of a young intellectual, János Asbóth.


2018 ◽  
Vol 7 (3) ◽  
pp. e000088 ◽  
Author(s):  
Muge Capan ◽  
Stephen Hoover ◽  
Kristen E Miller ◽  
Carmen Pal ◽  
Justin M Glasgow ◽  
...  

BackgroundIncreasing adoption of electronic health records (EHRs) with integrated alerting systems is a key initiative for improving patient safety. Considering the variety of dynamically changing clinical information, it remains a challenge to design EHR-driven alerting systems that notify the right providers for the right patient at the right time while managing alert burden. The objective of this study is to proactively develop and evaluate a systematic alert-generating approach as part of the implementation of an Early Warning Score (EWS) at the study hospitals.MethodsWe quantified the impact of an EWS-based clinical alert system on quantity and frequency of alerts using three different alert algorithms consisting of a set of criteria for triggering and muting alerts when certain criteria are satisfied. We used retrospectively collected EHRs data from December 2015 to July 2016 in three units at the study hospitals including general medical, acute care for the elderly and patients with heart failure.ResultsWe compared the alert-generating algorithms by opportunity of early recognition of clinical deterioration while proactively estimating alert burden at a unit and patient level. Results highlighted the dependency of the number and frequency of alerts generated on the care location severity and patient characteristics.ConclusionEWS-based alert algorithms have the potential to facilitate appropriate alert management prior to integration into clinical practice. By comparing different algorithms with regard to the alert frequency and potential early detection of physiological deterioration as key patient safety opportunities, findings from this study highlight the need for alert systems tailored to patient and care location needs, and inform alternative EWS-based alert deployment strategies to enhance patient safety.


Author(s):  
Haydar Darıcı ◽  
Serra Hakyemez

What kind of work does the categorical distinction between combatant and civilian do in the interplay of the necropolitics and biopower of the Turkish state? This paper focuses on a time period (2015-2016) in the history of the Kurdish conflict when that distinction was no longer operable as the war tactics of the Kurdish movement shifted from guerrilla attacks of hit and run in the mountains to the self-defence of residents in urban centres. It reveals the limit of inciting compassion through the figure of civilian who is assumed to entertain a pre-political life that is directed towards mere survival. It also shows how the government reconstructs the dead bodies using forensics and technoscience in order to portray what is considered by Kurdish human rights organizations civilians as combatants exercising necroresistance. As long as the civilian-combatant distinction remains and serves as the only episteme of war to defend the right to life, the state is enabled to entertain not only the right to kill, but also to turn the dead into the perpetrators of their own killing. Finally, this paper argues that law and violence, on the one hand, and the right to life and the act of killing on the other, are not two polar opposites but are mutually constitutive of each other in the remaking of state sovereignty put in crisis by the Kurdish movement's self-defence practices.


Author(s):  
Peter Mitchell

Over 50,000 years ago a Neanderthal hunter approached a wild ass on the plains of northeastern Syria. Taking aim from the right as the animal nervously assessed the threat, he launched his stone-tipped spear into its neck, penetrating the third cervical vertebra and paralyzing it immediately. Butchered at the kill site, this bone and most of the rest of the animal were taken back to the hunter’s camp at Umm el Tlel, a short distance away. Closely modelled on archaeological observations of that vertebra and the Levallois stone point still embedded within it, this incident helps define the framework for this chapter. At the start of the period it covers, human interactions with the donkey’s ancestors were purely a matter of hunting wild prey, but by its end the donkey had been transformed into a domesticated animal. Chapter 2 thus looks at how this process came about, where it did so, and what the evolutionary history of the donkey’s forebears had been until that point. Donkeys and the wild asses that are their closest relatives form part of the equid family to which zebras and horses also belong. Collectively, equids, like rhinoceroses and tapirs, fall within the Perissodactyla, the odd-toed division of hoofed mammals or ungulates. Though this might suggest a close connection with the much larger order known as the Artiodactyla, the even-toed antelopes (including deer, cattle, sheep, and goats), their superficial resemblances may actually reflect evolutionary convergence; some genetic studies hint that perissodactyls are more closely related to carnivores. Like tapirs and rhinoceroses, the earliest equids had three toes, not the one that has characterized them for the past 40 million years. That single toe, the third, now bears all their weight in the form of a single, enlarged hoof with the adjacent toes reduced to mere splints. This switch, and the associated elongation of the third (or central) metapodial linking the toe to the wrist or ankle, is one of the key evolutionary transformations through which equids have passed. A second involves diet since the earliest perissodactyls were all browsers, not grazers like the equids of today.


2018 ◽  
Vol 16 (4) ◽  
pp. 429-452 ◽  
Author(s):  
Daniel Hedinger ◽  
Nadin Heέ

Transimperial History – Connectivity, Cooperation and Competition This Forum article argues that a turn in empire history is needed, one which we label «transimperial». Whereas national history has been transnationalized in recent decades, the history of empires has, by and large, remained nationalized. Since transnational history, global history, postcolonial studies and new imperial history all offer an abundance of tools to tear down imperial borders and deconstruct nationalized narratives, the moment seems to have come for a shift, namely for what we call a transimperial approach to imperial history. We seek to show how such an approach makes it possible to dynamize and decentralize the history of empires both on the level of empirical research and historiographical narratives. By including marginalized empires we offer a way to overcome British centrism of empire studies. On the methodological level, this contribution seeks to discuss imperial competition, cooperation and connectivity not as separate phenomena but as entangled processes. The point is not to analytically isolate cooperation or competition but to shed light on how they reinforced each other and how connectivity plays into this. The article shows that a key to establishing a transimperial approach is to consider time and space together by focusing on the transformative aspect of competition, cooperation and connectivity in spaces in-between empires. In this article, we highlight transimperial histories avant la lettre, on which such an approach can rely. Finally, we discuss how this approach helps challenge essentializing master narratives in empire studies, be it the one in which the British Empire serves as a model for other empires or the one where the Japanese empire is seen as a mimicry of European imperialism.


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