scholarly journals Delivery Routes for COVID-19 Vaccines

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 524
Author(s):  
Jang Hyun Park ◽  
Heung Kyu Lee
Keyword(s):  
Immune Responses ◽  
Viral Vector ◽  
Future Research ◽  
The Novel ◽  
Subunit Vaccines ◽  
Mucosal Vaccination ◽  
The Status ◽  
Delivery Routes ◽  
History Of ◽  
Novel Coronavirus

The novel coronavirus, SARS-CoV-2, which causes COVID-19, has resulted in a pandemic with millions of deaths. To eradicate SARS-CoV-2 and prevent further infections, many vaccine candidates have been developed. These vaccines include not only traditional subunit vaccines and attenuated or inactivated viral vaccines but also nucleic acid and viral vector vaccines. In contrast to the diversity in the platform technology, the delivery of vaccines is limited to intramuscular vaccination. Although intramuscular vaccination is safe and effective, mucosal vaccination could improve the local immune responses that block the spread of pathogens. However, a lack of understanding of mucosal immunity combined with the urgent need for a COVID-19 vaccine has resulted in only intramuscular vaccinations. In this review, we summarize the history of vaccines, current progress in COVID-19 vaccine technology, and the status of intranasal COVID-19 vaccines. Future research should determine the most effective route for vaccine delivery based on the platform and determine the mechanisms that underlie the efficacy of different delivery routes.

scholarly journals Genrens tøven

2007 ◽  
Vol 35 (103) ◽  
pp. 108-137
Author(s):  
Carsten Sestoft
Keyword(s):  
Seventeenth Century ◽  
The Novel ◽  
Book Market ◽  
English Novel ◽  
The Social ◽  
The Status ◽  
Historical Semantics ◽  
History Of ◽  
Insight Into ◽  
Or History

Romanens status i det 17. århundredes Frankrig The hesitations of a genre: The status of the novel in seventeenth-century FranceIn answering the question: What was the novel in seventeenth-century France? – this article provides insight into some important points of the early history of the genre. The contradiction between its non-existence in official (Aristotelian) poetics and its existence as a popular commodity on the book market was, in the course of the seventeenth century, reconciled in the emergent category of belles lettres as a plurality of genres mainly defined by their public of honnêtes gens, while attempts at legitimizing the novel as belonging to such Aristotelian genres as epic or history generally failed; and at the end of the century a number of convergences – between epic and novel, between the designations roman and nouvelle, and between the ‘high’ and ‘low’ forms of the novel – seem to point to the fact that the social existence of the genre had been strengthened, even if it was the English novel of the eighteenth century that could be said to reap the profits of this stronger position. Using historical semantics and cultural sociology to study the status of the novel in seventeenth-century France thus leads to a clearer understanding of the specificity of the novel as a literary and cultural genre.

scholarly journals Respiratory Care in Corona

2021 ◽  
Vol 58 (2) ◽  
pp. 613-620
Author(s):  
Mustafa Amdani, Dr. Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Human Life ◽  
The Body ◽  
Respiratory Care ◽  
The Novel ◽  
Specific Therapy ◽  
History Of ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

BACKGROUND The expanse of the coronavirus disease 2019 or COVID-19 is huge. The impact is multispectral and affected almost all aspects of human life. SUMMARY Respiratory impact of the COVID-19 is the most felt and widely reported impact. As the novel coronavirus maintained its history of affecting lungs as seen previously in severe acute respiratory syndrome (SARS) outbreak. Ventilators and oxygen support system are required mostly in comorbid patients particularly amongpatientsbearing illnesses like asthma, bronchial impairment and so on. CONCLUSION More study needs to be done in order to assess the impact on the respiratory functioning of the body. Respiratory care must be including proper instruments so that more efficient result can be obtained. Research is needed to promote the invention of specific therapy for targeted action for respiratory functioning improvement.

A Roadmap for Development, Implementation, and Evaluation of Virtual Practicums in Teacher Education

2021 ◽  
pp. 163-182
Author(s):  
Jennifer L. Gallup ◽  
Beverly Ray ◽  
Cory A. Bennett
Keyword(s):  
Teacher Preparation ◽  
Online Education ◽  
Future Research ◽  
The Novel ◽  
Preparation Programs ◽  
Partnership Development ◽  
Online Setting ◽  
Novel Coronavirus ◽  
Pre Service Teacher ◽  
And Training

Education for students in the P-12 setting has been subject to significant changes due to access to the internet and online education availability and most recently, the novel coronavirus (COVID-2019) pandemic; therefore, teacher preparation must meet the demands of this new reality through efficacious preparation programs that reflect this reality. Teachers must meet students' unique needs across virtual platforms, which requires mentoring, practice, and training. Today, there are very few programs that prepare teachers to work in an online P-12 setting. Additionally, there is limited research on how to supervise pre-service teachers in an online setting; therefore, the purpose of this chapter is to present a theoretical framework for virtual observations of a pre-service teacher learning to teach in an online P-12 setting. Along with recommendations for partnership development, implementation, and evaluation, a protocol is offered, and recommendations for future research and conclusions are offered.

scholarly journals Why Companion Animals Are Beneficial During COVID-19 Pandemic

2020 ◽  
Vol 7 (4) ◽  
pp. 430-432
Author(s):  
Unnati G Hunjan ◽  
Jayasankara Reddy
Keyword(s):  
Immune System ◽  
Companion Animals ◽  
Well Being ◽  
Physical Contact ◽  
The Novel ◽  
Psychological Benefits ◽  
The Status ◽  
Novel Coronavirus ◽  
Health And Well Being

Companion animals and pets can be helpful during the novel coronavirus-19 pandemic. Interactions with them and positive physical contact lead to a variety of physiological and psychological benefits. It also releases biochemicals which can further boost the immune system and enhance health and well-being. This perspective discusses the benefits of these interactions, the modes of interactions and the activities that can be used. It also highlights the individuals that should avoid this approach and the status of the animal’s health before engaging with them.

scholarly journals Situation analysis of novel Coronavirus (2019-nCoV) cases in Nepal

2020 ◽  
Vol 1 (1) ◽  
pp. 9-14
Author(s):  
Kiran Paudel ◽  
Prashamsa Bhandari ◽  
Yadav Prasad Joshi
Keyword(s):  
South Asian ◽  
Case Fatality ◽  
Cumulative Number ◽  
The Novel ◽  
Asian Countries ◽  
Primary Case ◽  
The Status ◽  
Exponential Trend ◽  
Using Data ◽  
Novel Coronavirus

The Novel Coronavirus (2019-nCoV) is currently a major threat to global health in an unprecedented manner. The global pandemic of COVID-19 has affected 215 countries and territories including Nepal. Until 1st June 2020, altogether 1,811 COVID-19 positive cases were diagnosed using RT-PCR. This study aimed to analyze the status of COVID-19 cases in Nepal and South Asian countries. A retrospective study from 23rd January to 1st June 2020 was conducted using data of the Ministry of Home Affairs, Nepal and Worldometer homepages. The primary case records during the pre and post lockdown periods were examined. Spatial distribution was observed. An exponential trend line was plotted and COVID-19 situation in South Asian countries was assessed. Of 1,811 COVID-19 cases, the highest number (38.3%) was reported in Province 2. Out of 77 districts, 59 were affected. In Fifty-eight districts, primary cases appeared during the lockdown period. The cumulative number of COVID-19 cases showed the exponential pattern of distribution in Nepal. In South Asian countries, India had the highest number of cases and case fatality rate (CFR). There were no cases of CFR in Bhutan. The Novel Coronavirus emergence in Nepal has become a serious challenge to the various sectors including public health. The emergence of primary cases even in the lockdown period needs a detailed study in the future.

scholarly journals Emergence of the first manic episode in recovered COVID-19 patients: A case series from Egypt

2021 ◽  
Author(s):  
Hayam M. Elgohary ◽  
Mohammad G. Sehlo ◽  
Usama M. Youssef ◽  
Mohamed Abdelghani
Keyword(s):  
Neuropsychiatric Symptoms ◽  
Gastrointestinal Symptoms ◽  
Case Series ◽  
Manic Episode ◽  
Behavioral Changes ◽  
Future Research ◽  
The Novel ◽  
Manic Symptoms ◽  
Global Pandemic ◽  
Novel Coronavirus

Abstract Objective In December 2019, the novel coronavirus (COVID-19) infection was first reported in Wuhan city, China, which had rapidly spread as a global pandemic. This infection was commonly presented by respiratory and /or gastrointestinal symptoms. However, it is still unclear whether COVID-19 infection could be associated with central nervous system (CNS) damage which would result in development of neuropsychiatric symptoms. Method A total of five cases of suddenly emerged manic episodes during the pandemic of COVID-19 were extensively described. We presented the symptoms and described the diagnosis, clinical course, and treatment of each case. Results All patients had positive findings of ribonucleic acid (RNA) tests for COVID-19 in specimens of their sputum. The patients later developed manic symptoms during and after the recovering period of their illness. Conclusions The case series of newly emerged manic symptoms associated with COVID-19 infection highlights the essential need for evaluation of mental health status and would contribute to our understanding of the potential risk of CNS affection by COVID-19 infection. The limited number of cases would limit the generalizability of association. Future research should investigate the behavioral changes accompanying and following COVID-19 infection.

scholarly journals Revealing Findings in Youth Sport Parenting Research

2019 ◽  
Vol 8 (3) ◽  
pp. 252-259 ◽  
Author(s):  
Camilla J. Knight
Keyword(s):  
Parental Involvement ◽  
Best Practice ◽  
Youth Sport ◽  
Future Research ◽  
Research Directions ◽  
Factors Affecting ◽  
The Status ◽  
History Of ◽  
Future Research Directions ◽  
Future Work

It is widely accepted that parents are a pivotal part of young people’s sporting journey, and over the last 4 decades there has been a substantial growth in research pertaining to youth sport parenting. The aim of this paper is to review the status of the literature pertaining to parenting in youth sport and suggest areas for future work. Specifically, the author provides a very brief history of sport parenting research before turning attention to the 3 areas of study that are currently attracting the majority of researchers’ attention: the influence of parental involvement in youth sport, factors affecting parental involvement in youth sport, and strategies to promote high-quality parental involvement. Future research directions pertaining to the sport parenting questions that are asked, the populations that are sampled, and the interventions that are developed and evaluated are subsequently provided. Finally, the paper concludes with some considerations for best practice in sport clubs and organizations that seek to foster more adaptive youth sport parenting.

scholarly journals Development of a Recombinant RBD Subunit Vaccine for SARS-CoV-2

Viruses ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1936
Author(s):  
Yi-Sheng Sun ◽  
Jing-Jing Zhou ◽  
Han-Ping Zhu ◽  
Fang Xu ◽  
Wen-Bin Zhao ◽  
...  
Keyword(s):  
Subunit Vaccine ◽  
Neutralizing Antibody ◽  
Human Society ◽  
The Novel ◽  
Subunit Vaccines ◽  
Cellular Immune Responses ◽  
Human Igg1 ◽  
Ifn Γ ◽  
Novel Coronavirus ◽  
Cellular Immune

The novel coronavirus pneumonia (COVID-19) pandemic is a great threat to human society and now is still spreading. Although several vaccines have been authorized for emergency use, only one recombinant subunit vaccine has been permitted for widespread use. More subunit vaccines for COVID-19 should be developed in the future. The receptor binding domain (RBD), located at the S protein of SARS-CoV-2, contains most of the neutralizing epitopes. However, the immunogenicity of RBD monomers is not strong enough. In this study, we fused the RBD-monomer with a modified Fc fragment of human IgG1 to form an RBD-Fc fusion protein. The recombinant vaccine candidate based on the RBD-Fc protein could induce high levels of IgG and neutralizing antibody in mice, and these could last for at least three months. The secretion of IFN-γ, IL-2 and IL-10 in the RBD-stimulated splenocytes of immunized mice also increased significantly. Our results first showed that the RBD-Fc vaccine could induce both humoral and cellular immune responses and might be an optional strategy to control COVID-19.

scholarly journals The history of the F. Erisman Institute of Public Health and its directions of activity during the COVID-19 pandemic

2021 ◽  
Vol 2 (1) ◽  
pp. 41-50
Author(s):  
N. I. Briko ◽  
A. Ya. Mindlina ◽  
R. V. Polibin ◽  
P. D. Lopukhov
Keyword(s):  
Public Health ◽  
Preventive Medicine ◽  
Research Work ◽  
Community Research ◽  
Medical Institute ◽  
The Novel ◽  
Current State ◽  
History Of ◽  
Novel Coronavirus ◽  
Public Health Epidemiology

In 2020, exactly 90 years have passed since the first sanitary faculty in the history of medical education (F. ErismannInstitute of Public Health, nowadays) was found in the 1st Moscow Medical Institute (Sechenov University, nowadays).The history of the faculty unites the names of prominent scientists in the field of preventive medicine: F. Erismann, N.A. Semashko, A.V. Molkov, A.N. Sysin, E.M. Tareev and many, many others. New challenges to public health continueto appear in our time. The direction of “preventive medicine” has become more important than ever in the context of a pandemic of infection caused by the novel coronavirus (COronaVIrus Disease-19, COVID-19). The issues of epidemiologyand hygiene have become extremely relevant for doctors of any profile, not only for preventive ones (epidemiologists and hygienists). The strategic task today is to increase the “preventive medicine” specialty’s authority. It is also important to preserve and enhance the domestic experience of studying the disciplines of preventive medicine, harmonizing the content of educational programs with the world community. Research work at the Institute is carried out in 4 main areas of preventive medicine and public health: epidemiology, public health, microbiology, and hygiene.This review presents the main historical milestones in the development of teaching the specialty “preventive medicine” at the Sechenov University, the current state, and prospects for further development.

scholarly journals Protective Immunity against COVID-19

2021 ◽  
Author(s):  
Anjali Priyadarshini ◽  
Archana Gupta ◽  
Manoj Kumar Yadav ◽  
Arpana Vibhuti ◽  
Ramendra Pati Pandey ◽  
...  
Keyword(s):  
United States ◽  
Immune Responses ◽  
Drug Administration ◽  
United States Of America ◽  
Protective Immunity ◽  
The United States ◽  
The Novel ◽  
Infectious Agents ◽  
Novel Coronavirus ◽  
Target Effects

Tuberculosis and Covid-19 infection measure two quite different diseases- TB is caused by a sort of bacterium whereas Covid-19 is caused by a virus. However, the BCG immunizing agent would possibly facilitate individuals build immune responses to things aside from TB, inflicting "off-target effects," In different words, in run format, individuals started learning positive in obtaining the immunizing agent that had nothing to try and do with TB, several studies showed however the BCG immunizing agent affects individuals with kind one although the precise mechanism for these off-target effects of the BCG immunizing agent is not clear, it's believed that the immunizing agent will cause a nonspecific boost of the reaction. There is presently no immunizing agent or treatments approved by the United States of America Food and Drug Administration for the novel coronavirus. BCG is usually innocuous with the most facet impact the event of inflammation at the positioning of injection. Supported by these observations BCG so emerges as a possible candidate for the development of innate and adjustive reactions which can be non-specifically taking care of mycobacterium and different infectious agents against that vaccine remains not on the market.

Sign in / Sign up

Export Citation Format

Share Document