scholarly journals mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship

Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1503
Author(s):  
Girolamo Giannotta ◽  
Nicola Giannotta
Keyword(s):  
Plasma Cells ◽  
Late Phase ◽  
Immunological Memory ◽  
World Market ◽  
Point Of View ◽  
Humoral Immune ◽  
Specific Memory ◽  
Immunological Mechanisms ◽  
Waning Immunity ◽  
Almost All

mRNA COVID-19 vaccines have hegemonized the world market, and their administration to the population promises to stop the pandemic. However, the waning of the humoral immune response, which does not seem to last so many months after the completion of the vaccination program, has led us to study the molecular immunological mechanisms of waning immunity in the case of mRNA COVID-19 vaccines. We consulted the published scientific literature and from the few articles we found, we were convinced that there is an immunological memory problem after vaccination. Although mRNA vaccines have been demonstrated to induce antigen-specific memory B cells (MBCs) in the human population, there is no evidence that these vaccines induce the production of long-lived plasma cells (LLPCs), in a SARS-CoV-2 virus naïve population. This obstacle, in our point of view, is caused by the presence, in almost all subjects, of a cellular T and B cross-reactive memory produced during past exposures to the common cold coronaviruses. Due to this interference, it is difficult for a vaccination with the Spike protein alone, without adjuvants capable of prolonging the late phase of the generation of the immunological memory, to be able to determine the production of protective LLPCs. This would explain the possibility of previously and completely vaccinated subjects to become infected, already 4–6 months after the completion of the vaccination cycle.

scholarly journals SARS-CoV-2 specific memory B cells frequency in recovered patient remains stable while antibodies decay over time

2020 ◽  
Author(s):  
Anna Vaisman-Mentesh ◽  
Yael Dror ◽  
Ran Tur-Kaspa ◽  
Dana Markovitch ◽  
Tatiana Kournos ◽  
...  
Keyword(s):  
B Cells ◽  
Antibody Response ◽  
B Cell ◽  
Cell Response ◽  
Plasma Cells ◽  
Memory B Cells ◽  
Humoral Immune ◽  
Specific Memory ◽  
Over Time ◽  
B Cell Response

The breadth of the humoral immune response following SARS-CoV-2 infection was indicated to be important for recovery from COVID-19. Recent studies have provided valuable insights regarding the dynamics of the antibody response in symptomatic COVID-19 patients. However, the information regarding the dynamics of the serological and cellular memory in COVID-19 recovered patients in scarce. It is imperative to determine the persistence of humoral memory in COVID-19 recovered patients as it will help to evaluate the susceptibility of recovered patients to re-infection. Here, we describe the dynamics of both the SARS-CoV-2 specific serological and B cell response in COVID-19 recovered patients. We found that symptomatic SARS-CoV-2 patients mount a robust antibody response following infection however, the serological memory decays in recovered patients over the period of 6 months. On the other hand, the B cell response as observed in the SARS-CoV-2 specific memory B cell compartment, was found to be stable over time. Moreover, the frequency of SARS-CoV-2 specific B cell plasmablasts was found to be associated with the SARS-CoV-2 specific antibody levels. These data, suggests that the differentiation of short-lived plasmablasts to become long-lived plasma cells is impaired and the main contributor of antibody production are the short-lived plasmablasts. Overall, our data provides insights regarding the humoral memory persistence in recovered COVID-19 patients. Notwithstanding the insights from this study, it is still to be determined if the persistence of SARS-CoV-2 memory B cells can be considered as a correlate of protection in the absence of serological memory.

Nonwovens: Global Trends in World Economy, European Foreign Trade, and Selected Case Studies from Poland and Asian Brics Countries

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Zofia Wysokińska ◽  
Tomasz Czajkowski ◽  
Katarzyna Grabowska
Keyword(s):  
Case Studies ◽  
World Economy ◽  
World Market ◽  
Global Trends ◽  
Textile Materials ◽  
Brics Countries ◽  
Recent Trends ◽  
Almost All ◽  
Special Case

AbstractNonwovens are one of the most versatile textile materials and have become increasingly popular in almost all sectors of the economy due to their low manufacturing costs and unique properties. In the next few years, the world market of nonwovens is predicted to grow by 7%–8% annually (International Nonwovens & Disposables Association [INDA], European Disposables and Nonwovens Association [EDANA], and Markets and Markets). This article aims to analyze the most recent trends in the global export and import of nonwovens, to present two case studies of Polish companies that produce them, and to present one special case study of the market of nonwoven geotextiles in China and India, which are the Asian transition economies among the BRICS countries (Brazil, Russia, India, China, and South Africa).

scholarly journals How ethical challenges of covert observations can be met in practice

2021 ◽  
pp. 174701612110082
Author(s):  
Nicole Podschuweit
Keyword(s):  
Social Research ◽  
Role Playing ◽  
Great Distance ◽  
Point Of View ◽  
Ethical Challenges ◽  
Research Subjects ◽  
Written Information ◽  
Ethical Debate ◽  
The People ◽  
Almost All

This paper aims to bring into the ethical debate on covert research two aspects that are neglected to date: the perspective of the research subjects and the special responsibility of investigators towards their observers. Both aspects are falling behind, especially in quantitative social research. From a methodological point of view, quantitative forms of covert observation involve a great distance between the researcher and the research subjects. When human observers are involved, the focus is usually on the reliable application of the measuring instrument. Therefore, herein, a quantitative study is used as an example to show how the protection needs of both the observed persons and the observers can be met in practice. The study involved 40 student observers who covertly captured everyday conversations in real-world settings (e.g. in cafés or trains) by a highly standardised observation scheme. The study suggests that the anonymity of the research subjects and their trust in the observers are crucial for their subsequent consent. However, many participants showed only little or even no interest in the written information they were provided. Further, this study strongly emphasises how mentally stressful covert observations are to the observers. Almost all observers were worried in advance that the people they were observing would prematurely blow their cover and confront them. Role-playing and in-depth discussions in teams are good strategies to alleviate such and other fears and to prepare student assistants well for their demanding work in the field.

Assessment of the positions of the exporting countries of agri-food products on the world market according to their role in global value chains

2021 ◽  
pp. 8-14
Author(s):  
Elena Yu. Frolova ◽  
Keyword(s):  
Raw Materials ◽  
Action Plan ◽  
Value Added ◽  
Global Value Chains ◽  
World Market ◽  
Point Of View ◽  
Value Chains ◽  
Agricultural Exports ◽  
Export Policy ◽  
The World

The place in the rankings of agricultural exporting countries in world trade is estimated in terms of the volume of imports and exports of raw materials and food. However, to assess the efficiency of agricultural exports, it is important to analyze the value added of exported goods produced in the country. The position of the exporting country in global value chains is derived from the type of agricultural production, which in turn depends on the level of development of the national economy, the availability and breadth of use of modern high technologies. The article examines the concept of the development of world agriculture from the point of view of the formation of global value chains, set out in the report of the UN World Food Organization [1] in comparison with the political decisions of such countries as India and the People’s Republic of China in the development of agricultural and food exports. The paper analyzes the risks associated with the consolidation of developing countries as suppliers of agricultural raw materials, as well as the conditions and action plan that allow the country-exporter of agricultural raw materials to move to higher levels in the global value chains on the world market. This experience should be considered to make comprehensive and effective decisions on the formation of the export policy of agricultural products and food of the Russian Federation, considering the food security of the country.

Bernhard Riemann’s legacy of 1859

2009 ◽  
Vol 93 (528) ◽  
pp. 468-475
Author(s):  
Graham Hoare
Keyword(s):  
Number Theory ◽  
Mathematical Physics ◽  
Point Of View ◽  
German Version ◽  
Profound Impact ◽  
Almost All ◽  
University Of Göttingen ◽  
The University ◽  
Modern Mathematics ◽  
Mathematics And Physics

The German version of Riemann’s Collected Works is confined to a single volume of 690 pages. Even so, this volume has had an abiding and profound impact on modern mathematics and physics, as we shall see. In fifteen years of activity, from 1851, when he gained his doctorate at the University of Göttingen, to his death in 1866, two months short of his fortieth birthday, Riemann contributed to almost all areas of mathematics. He perceived mathematics from the analytic point of view and used analysis to illuminate subjects as diverse as number theory and geometry. Although regarded principally as a mathematician Riemann had an abiding interest in physics and researched significantly in the methods of mathematical physics, particularly in the area of partial differential equations.

scholarly journals Social Order and Practical Wisdom of Walking in a Crowd

2018 ◽  
Vol 24 (4) ◽  
pp. 8-29
Author(s):  
Andrei M. Korbut
Keyword(s):  
Social Order ◽  
Practical Wisdom ◽  
Point Of View ◽  
Joint Production ◽  
Social Phenomena ◽  
Social Transformations ◽  
Sociological Approach ◽  
Everyday Practices ◽  
Phenomenal Field ◽  
Almost All

The article suggests returning to the “crowd” as an object of sociological analysis. Crowds have attracted early sociologists because crowds were visual embodiments of social forces that surpass individuals and also served as a symbol of the profound social transformations which were taking place in the late 19th and early 20th centuries. Analyzing crowds allowed for the first sociologists (G. Simmel, R. Park, M. Weber, E. Durkheim) to oppose the psychological interpretation of mass social phenomena with a purely sociological approach. However, in the second half of the 20th century sociologists had lost almost all interest in the crowd, as it did not meet the interests of researchers of “large” social structures, nor the interests of the proponents of interactionist approaches. This article shows that the crowd can again be made interesting for sociology if we were to consider it from the point of view of the everyday practices of the participants. In these everyday practices a specific form of phronesis, i.e. practical wisdom, technical skill coupled with moral judgment about which action is good and which is not, is implemented. It is shown here that the study of the practical wisdom of walking in a crowd requires special concepts and methods that can be found in phenomenology and ethnomethodology. The article suggests using three such concepts for the analysis of crowds: phenomenal field, oriented object, and figuration of details. With the help of these concepts, the methods of the crowd’s situated social order production are analyzed in relation to the management of speed and trajectories of movement, following one another, walkers’ stopping and slowing down, and joining the crowd. This analysis shows that the joint production of the crowd’s social order by its participants is a situated practice, i.e. it consists of making the local scenes of everyday life familiar and accountable, and of assessing the local adequacy of the actions performed.

scholarly journals SISI NEGATIF GAME ONLINE PERSPEKTIF ISLAM DAN PSIKOLOGI ISLAM

2021 ◽  
Vol 5 (2) ◽  
pp. 153
Author(s):  
Khotibul Umam ◽  
Abdul Muhid
Keyword(s):  
Literature Review ◽  
Life Style ◽  
Negative Impact ◽  
Technological Development ◽  
Human Life ◽  
Online Games ◽  
Point Of View ◽  
Technological Advances ◽  
Islamic Psychology ◽  
Almost All

Technological development has changed human life style. Child's world that was once filled with traditional games has now been eroded by technological advances. Nowadays online games that replace traditional games are not only favored by children, almost all levels of human age like playing online games. But behind it all there is a negative impact that haunts its users. This study aims to reveal the negative side of using online games from the point of view of Islam and Islamic Psychology. The technique used is literature review by compiling some previous articles. The results showed that excessive use of online games will give a bad impact on the physical and psychological users, such as visual impairment, sleep disturbance, addiction, violence and stress. The use of online games is also considered more disadvantage than the benefits and it’s seen as an activity that wastes time, and it is prohibited in Islam.

scholarly journals Complexes for continuous monitoring of drilling fluid parameters during drilling

2021 ◽  
Vol 6 (3) ◽  
pp. 144-151
Author(s):  
Sergey V. Lakhtionov ◽  
Ivan S. Chumakov ◽  
Sergey G. Filinkov ◽  
Dmitry M. Chukin ◽  
Evgeny N. Ishmetyev
Keyword(s):  
Continuous Monitoring ◽  
Drilling Fluid ◽  
Point Of View ◽  
Complete Analysis ◽  
Drilling Fluids ◽  
Automatic Mode ◽  
Design Values ◽  
Drilling Rigs ◽  
Almost All ◽  
Fluid Parameters

Background. The article provides an overview of existing complexes (units) for continuous monitoring of drilling fluid parameters in automatic mode. Aim. To justify the need to develop a complex (module) that will allow combining existing technologies and making a step forward in the field of process automation in terms of monitoring the parameters of drilling fluids. Materials and methods. In the current realities of well construction, the control of drilling fluid parameters on almost all drilling rigs operating on the territory of Russia (possibly with the exception of a few off shore projects) is carried out by the work of a solution engineer, usually a representative of a service company. The analysis of the parameters, depending on the number of personnel, the speed of penetration, the complexity or importance of the well, can be carried out from 2 to 6 times a day [1, 2]. This means a complete analysis, rather than monitoring the density and conditional viscosity, which can be measured by a representative of the drilling crew, for rapid response, and with greater frequency. Due to such a low measurement discreteness, there is a high probability of a significant deviation of the drilling fluid parameters from the design values. As a result, the probability of various complications, both geological and technological, increase significantly. Results. During the analysis of information from open sources, the most promising complexes (modules) from the point of view of application in the current conditions were identified, their positive and negative sides were evaluated. As a result of the conducted review of open sources, the most promising complexes (modules) in terms of application in the current conditions are identified, the positive and negative sides of the systems under consideration are displayed, and the need to develop a complex (module) that will combine all the best that is available today and make a qualitative step forward in the field of “peopleless” technologies used during drilling wells in terms of monitoring the parameters of drilling fluids is justified. Conclusions. The necessity of developing a complex (module) for automating processes in terms of monitoring the parameters of drilling fluids is justified.

scholarly journals THE STATE AND PROGRESS OF OILSEEDS MARKET AND FOODS OF THEIR PROCESSING TRENDS ARE IN UKRAINE

2018 ◽  
Vol 20 (1(66)) ◽  
pp. 44-52 ◽  
Author(s):  
P.O ANTONYUK ◽  
V.M. LISYUK
Keyword(s):  
Structural Changes ◽  
Export Price ◽  
Processing Condition ◽  
World Market ◽  
Point Of View ◽  
Raw Material ◽  
Home Production ◽  
Yield Production ◽  
Production Capacities ◽  
Practical Recommendations

Topicality. Actuality of problem of oilseeds market and foods of their processing development increases inconnection with the necessity of maintenance of existent volumes and leading positions of Ukraine in the world market, and also increases of efficiency of functioning component the integrated market. Aim and tasks. The aim of the article is an estimation of existent oilseeds market and foods of their processing condition, development of practical recommendations, both on the height of production and sales volumes and to efficiency in the conditions of action of the free trading with European Union. Research results. A oilseed market and foods of their processing analysis is conducted from the point of view of volume and structure as oilseeds raw material so vegetable oil. Measures are offered on the improvement of structure at the market of vegetable oils, meaning the heightof stake of soy-bean and rape oil. These measures areaimed at limitation of export of oilseeds raw material, especially soy and rape, and also all types of cake. Therow of measures of the custom adjusting is offered with the purpose of increase of home production and export of products with a greater valueadded. Conclusions. Strategic directions of oilseeds market and foods of their processing development include measures on limitation of export of raw material and on the increase of export of products with a greater valueadded. Keywords: world export, crop rotation, profitability, middle export price, export profit yield, production capacities, unrefined oil, structural changes

scholarly journals WORLD ADVERTISING MARKET: MAIN DEVELOPMENT TRENDS

2021 ◽  
Author(s):  
Larysa Chernyshova
Keyword(s):  
Digital Technologies ◽  
World Market ◽  
Target Market ◽  
Outdoor Advertising ◽  
Economic Relations ◽  
International Advertising ◽  
The World ◽  
Almost All ◽  
Integrated Or ◽  
Advertising Activity

The article defines international advertising as a process of communication and sales organization in foreign markets. The reasons for the intensive development of modern international advertising, including increased production and globalization of markets, reduced costs for packaging and labeling caused by standard approaches, the emergence of a global consumer segment, interpenetration of different cultures, introduction of common cultural standards, accelerated development of global media. The characteristics of evolutionary models of the advertising market are given. The advertising market is defined as a target market of marketing communications, which develops independently, with a system of economic relations between the participants of advertising activity and target consumers and functions in constant connection with the tendencies of the commodity market. It was found that the advertising market is developing in almost all directions, and new types of advertising (Internet, online technology) are characterized by a sharp rise in advertising, which led to the creation of a new type of advertising market - integrated or global advertising space. The modern tendencies of development of the world advertising market are analyzed, the structure of expenses for advertising all over the world is resulted. The strategic directions of development of advertising activity of the leading advertisers in the world market are analyzed. The influence of digital technologies, which continue to stimulate global growth of investment in advertising and transform traditional mass media, is substantiated. Promising directions of development of the main segments of the world advertising market are outlined, among them increase of expenses for digital advertising in the world, growth of a role of social networks and online video as a segment in the field of digital technologies, growth of expenses for mobile advertising, saving on TV and radio advertising. advertising market, the development of outdoor advertising based on the transition from addressing opportunities to expand the customer experience through technologies such as VR and face recognition, the outflow of advertising budgets for print media.

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