Age-related readjustments of caucasian men’s functional reserves in the North

Author(s):  
И.В. Аверьянова ◽  
Е.А. Луговая

Цель работы - определение доли лиц, характеризующихся отклонениями физиологических параметров от нормативных диапазонов, и формирование паттернов функциональных резервов у подростков, юношей, мужчин среднего возраста и лиц пожилого возраста. Впервые проведена оценка динамики функциональных резервов на основе отклонений от нормативных референсов некоторых показателей физического развития, сердечно-сосудистой системы, биохимического и микроэлементного профиля, а также характеристик основного обмена и дыхания в онтогенетическом аспекте на основе построения паттернов степени напряжения анализируемых систем у лиц мужского пола, постоянно проживающих на Севере. Дан прогноз возрастного изменения изученных морфофизиологических параметров у лиц пожилого возраста. Результаты исследования показали, что паттерны отклонения анализируемых параметров свидетельствуют о нарастании напряжения функций систем в возрастном аспекте. Это проявляется в кумуляции отклонений в виде возрастных изменений показателей физического развития (увеличение ИМТ), сердечно-сосудистой системы (увеличение доли лиц с высоким нормальным АД и артериальной гипертензией по САД и ДАД), нарастания степени нарушений углеводного обмена (увеличение индекса инсулинорезистентности и гипергликемии натощак), возрастания степени дислипидемии относительно липидного обмена, трансформации нарушений микроэлементного профиля (усилении степени дефицита и возрастного избытка химических элементов). Это наблюдали на фоне снижения основного обмена веществ и показателей функции внешнего дыхания у современных жителей-северян старшего возраста. This study determined proportion of males whose physiological parameters were out of standard ranges and made patterns of their functional reserves to see dynamics in the row of teenagers, young adults, middle-aged adults, older adults. For the first time, dynamics of functional reserves was evaluated based on deviations from standard values existing for physical development, cardiovascular system, biochemical and trace element pictures, as well as characteristics of basic metabolism and breathing in ontogenetic aspect. The evaluation was performed by creating patterns of tension in subjective body systems under the North extremes to make predictive age-related changes older adults morphophysiological indicators. The results the patterns exhibited increasingly dysregulated functioning in the age aspect. That could be seen in age-related stress observed in physical development variables (accelerated body mass index), cardiovascular system (higher proportion of people with high normal blood pressure and arterial hypertension in systolic and diastolic blood pressure), carbohydrate metabolism disorders (higher index of insulin resistance and fasting hyperglycemia), more pronounced dyslipidemia, microelement disorders such as more severe age-related deficiency or excess. Those deviations existed together with worsening in basic metabolism and external respiration function in modern northerners of working age.

2015 ◽  
Vol 4 (2) ◽  
pp. 47-54
Author(s):  
Проворова ◽  
O. Provorova ◽  
Соколова ◽  
A. Sokolova ◽  
Филатова ◽  
...  

Revealing the regularities of human cardiovascular system’s parameters in the North can significantly affect the ongoing efforts to increase the working age and duration of life of inhabitants of Ugra. The work addresses important aspects of the state of cardiovascular system in different age groups. An increase in activity of the sympathetic autonomic system status with age in aboriginal and alien population, but individual components (cardiointervals) in the two groups behave differently. If quasiattractors demonstrate exponential type of dynamics of their size (area) in Khanty, then the non-indigenous population observed parabolic type of changes of the area of quasiattractors.


2020 ◽  
Vol 5 (4) ◽  
pp. 6-11
Author(s):  
O. Filatova ◽  
Yuliya Bashkatova ◽  
E. Mel'nikova ◽  
L. Chempalova

The study of the effect of physical activity on the parameters of the human cardiovascular system in the North of the Russian Federation is an urgent problem of age-related physiology. The purpose of this research is to study the parameters of the pseudoattractors of the cardiointervals of the subjects at rest and after exercise. Object and methods: a group of 15 women in a calm state (sitting) and after 30 squats were examined using the «Elox-01C» instrument. 15 samples of cardio-intervals for each subject were recorded (in 5 minutes), and then 225 phase portraits of the subjects before the load and 225 phase portraits after the load were calculated. The mezhattraktorny distances Ri were calculated for each subject (before and after the load). Significant differences were found across the entire group of area parameters S for pseudoattractors of cardiointervals and for parameters of mezhattraktorny distances R. It is shown that the areas of pseudoattractors S and mezhattraktorny distances can be used to identify individual characteristics of the parameters of the cardiovascular system of the subjects (for example, before and after the load) and for group comparison. At the same time, traditional statistics practically do not give results due to the Eskov-Zinchenko effect.


2002 ◽  
Vol 283 (5) ◽  
pp. R1027-R1032 ◽  
Author(s):  
Kevin D. Monahan ◽  
Chester A. Ray

Aging attenuates the increase in muscle sympathetic nerve activity (MSNA) and elicits hypotension during otolith organ engagement in humans. The purpose of the present study was to determine the neural and cardiovascular responses to otolithic engagement during orthostatic stress in older adults. We hypothesized that age-related impairments in the vestibulosympathetic reflex would persist during orthostatic challenge in older subjects and might compromise arterial blood pressure regulation. MSNA, arterial blood pressure, and heart rate responses to head-down rotation (HDR) performed with and without lower body negative pressure (LBNP) in prone subjects were measured. Ten young (27 ± 1 yr) and 11 older subjects (64 ± 1 yr) were studied prospectively. HDR performed alone elicited an attenuated increase in MSNA in older subjects (Δ106 ± 28 vs. Δ20 ± 7% for young and older subjects). HDR performed during simultaneous orthostatic stress increased total MSNA further in young (Δ53 ± 15%; P < 0.05) but not older subjects (Δ−5 ± 4%). Older subjects demonstrated consistent significant hypotension during HDR performed both alone (Δ−6 ± 2 mmHg) and during LBNP (Δ−7 ± 2 mmHg). These data provide experimental support for the concept that age-related impairments in the vestibulosympathetic reflex persist during orthostatic challenge in older adults. Furthermore, these findings are consistent with the concept that age-related alterations in vestibular function might contribute to altered orthostatic blood pressure regulation with age in humans.


Author(s):  
M. V. Osin ◽  
V. P. Maltsev

The study focused on the physical development indicators in younger teens aged 11–12 (Group 1) and 13–14 (Group 2) living in northern conditions (Surgut, Russia). The data was collected and processed in spring from February through March 2020. The physical development, the functional state of the cardiovascular system and the functional body reserves were assessed by anthropometric and hemodynamic indicators. It was found that the physical development was harmonious in the majority of examined teenagers. Among elder teenagers, more boys had good physical development, while more elder girls showed signs of asthenization. Hemodynamic parameters reflected the improved functioning of the cardiovascular system in relation to age. The integrative indicators of heart rate hemodynamics and arterial blood pressure were above the age-sex norm, which indicates stress on the vital systems. The adaptation reserves in teenagers of both groups were reduced during the spring period: 47–66 % of teenagers in Group 1 and 57–68 % of teenagers in Group 2 demonstrated unsatisfactory adaptation indicators.


1992 ◽  
Vol 35 (4) ◽  
pp. 892-902 ◽  
Author(s):  
Robert Allen Fox ◽  
Lida G. Wall ◽  
Jeanne Gokcen

This study examined age-related differences in the use of dynamic acoustic information (in the form of formant transitions) to identify vowel quality in CVCs. Two versions of 61 naturally produced, commonly occurring, monosyllabic English words were created: a control version (the unmodified whole word) and a silent-center version (in which approximately 62% of the medial vowel was replaced by silence). A group of normal-hearing young adults (19–25 years old) and older adults (61–75 years old) identified these tokens. The older subjects were found to be significantly worse than the younger subjects at identifying the medial vowel and the initial and final consonants in the silent-center condition. These results support the hypothesis of an age-related decrement in the ability to process dynamic perceptual cues in the perception of vowel quality.


Author(s):  
Yvonne Rogalski ◽  
Muriel Quintana

The population of older adults is rapidly increasing, as is the number and type of products and interventions proposed to prevent or reduce the risk of age-related cognitive decline. Advocacy and prevention are part of the American Speech-Language-Hearing Association’s (ASHA’s) scope of practice documents, and speech-language pathologists must have basic awareness of the evidence contributing to healthy cognitive aging. In this article, we provide a brief overview outlining the evidence on activity engagement and its effects on cognition in older adults. We explore the current evidence around the activities of eating and drinking with a discussion on the potential benefits of omega-3 fatty acids, polyphenols, alcohol, and coffee. We investigate the evidence on the hypothesized neuroprotective effects of social activity, the evidence on computerized cognitive training, and the emerging behavioral and neuroimaging evidence on physical activity. We conclude that actively aging using a combination of several strategies may be our best line of defense against cognitive decline.


2014 ◽  
Vol 28 (3) ◽  
pp. 148-161 ◽  
Author(s):  
David Friedman ◽  
Ray Johnson

A cardinal feature of aging is a decline in episodic memory (EM). Nevertheless, there is evidence that some older adults may be able to “compensate” for failures in recollection-based processing by recruiting brain regions and cognitive processes not normally recruited by the young. We review the evidence suggesting that age-related declines in EM performance and recollection-related brain activity (left-parietal EM effect; LPEM) are due to altered processing at encoding. We describe results from our laboratory on differences in encoding- and retrieval-related activity between young and older adults. We then show that, relative to the young, in older adults brain activity at encoding is reduced over a brain region believed to be crucial for successful semantic elaboration in a 400–1,400-ms interval (left inferior prefrontal cortex, LIPFC; Johnson, Nessler, & Friedman, 2013 ; Nessler, Friedman, Johnson, & Bersick, 2007 ; Nessler, Johnson, Bersick, & Friedman, 2006 ). This reduced brain activity is associated with diminished subsequent recognition-memory performance and the LPEM at retrieval. We provide evidence for this premise by demonstrating that disrupting encoding-related processes during this 400–1,400-ms interval in young adults affords causal support for the hypothesis that the reduction over LIPFC during encoding produces the hallmarks of an age-related EM deficit: normal semantic retrieval at encoding, reduced subsequent episodic recognition accuracy, free recall, and the LPEM. Finally, we show that the reduced LPEM in young adults is associated with “additional” brain activity over similar brain areas as those activated when older adults show deficient retrieval. Hence, rather than supporting the compensation hypothesis, these data are more consistent with the scaffolding hypothesis, in which the recruitment of additional cognitive processes is an adaptive response across the life span in the face of momentary increases in task demand due to poorly-encoded episodic memories.


Author(s):  
Rachel L. C. Mitchell ◽  
Rachel A. Kingston

It is now accepted that older adults have difficulty recognizing prosodic emotion cues, but it is not clear at what processing stage this ability breaks down. We manipulated the acoustic characteristics of tones in pitch, amplitude, and duration discrimination tasks to assess whether impaired basic auditory perception coexisted with our previously demonstrated age-related prosodic emotion perception impairment. It was found that pitch perception was particularly impaired in older adults, and that it displayed the strongest correlation with prosodic emotion discrimination. We conclude that an important cause of age-related impairment in prosodic emotion comprehension exists at the fundamental sensory level of processing.


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