HUBUNGAN KADAR ALBUMIN PLASMA DAN GULA DARAH DENGAN SEPSIS NEONATORUM

Abstract. Sepsis is the most leading cause of morbidity and mortality in neonates. In sepsis, the proinflammatory cytokines realeasing leads to disruption of plasma albumin and blood glucose levels. This study aim to analyze the relationship of plasma albumin and blood sugar levels with neonatal sepsis. Prospective observational analytic studies conducted on suspected sepsis neonates at Pediatrics Department Sub Division Neonatology RSUP Prof.Kandou Manado. Diagnosis of sepsis based on clinical symptoms and laboratory tests. Subjects are grouped into two groups of neonatal sepsis and non-neonatal sepsis group (control group). Plasma albumin and blood glucose level examined, then statistically analyzed. The statistical analysis used was Pearson Chi-Square correlation and Fisher Exact. The data were processed using SPSS 21. The results of this study indicate that hypoalbuminemia was found in 12 (75%) of 16 neonatal sepsis subject, whereas in non-neonatal sepsis only found 5 (22,7%) of 22 non-sepsis subjects. Statistically there is a highly significant difference (p=0,001). For the impaired blood glucose (both hypoglycemia or hyperglycemia) there is no significant difference between the two groups (p=0,466).Conclusion: There is a highly significant relationship between hypoalbuminemia with neonatal sepsis. There was no significant correlation between abnormal blood glucose levels with neonatal sepsis. Keywords: neonatal sepsis, plasma albumin levels, blood glucose levels Abstrak.Sepsis merupakan penyebab morbiditas dan mortalitas terbanyak pada neonatus. Pada sepsis terjadi pelepasan sitokin proinflamasi yang memicu terjadinya gangguan kadar albumin plasma dan kadar glukosa darah.Menganalisis hubungan kadar albumin plasma dan kadar gula darah dengan sepsis neonatorum.Penelitian analitik observasional prospektif dilakukanpada tersangka sepsis neonatorum yang dirawat di bagian Ilmu Kesehatan Anak Sub Bagian Neonati RSUP Prof. Dr. R.D. Kandou Manado. Diagnosis sepsis berdasarkan gejala klinik dan pemeriksaan laboratorium. Subyek penelitian dikelompokkan menjadi kelompok sepsis neonatorum dan kelompok non sepsis neonatorum (kelompok kontrol). Dilakukan pemeriksaan kadar albumin plasma dan glukosa darah, kemudian dianalasis secara statistik. Analisis statistik yang digunakan adalah uji korelasi Pearson Chi-Square dan uji Fisher Exact. Data diolah dengan menggunakan program SPSS 21.Hasil penelitian menunjukkan bahwa hipoalbuminemia ditemukan pada 12 (75%) dari 16 penderita sepsis neonatorum, sedangkan pada penderita non sepsis hanya ditemukan 5 (22,7%) dari 22 penderita non sepsis. Secara statistik terdapat perbedaan yang sangat bermakna (p=0,001). sedangkan gangguan glukosa darah (baik hipoglikemia maupun hiperglikemia) tidak terdapat perbedaan yang bermaknsa antara kedua kelompok (p=0,466).Simpulan:Terdapat hubungan yang sangat bermakna antara hipoalbuminemia dengan sepsis neonatorum. Tidak terdapat hubungan yang bermakna antara kadar gula darah abnormal dengan sepsis neonatorum. Kata Kunci:sepsis neonatorum, kadar albumin plasma, kadar glukosa darah

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UJI AKTIVITAS ANTIDIABETES EKSTRAK ETANOL BUAH CABAI MERAH ( Capsicum annuum L. ) TERHADAP MENCIT PUTIH JANTAN

SCIENTIA : Jurnal Farmasi dan Kesehatan ◽

10.36434/scientia.v9i1.221 ◽

2019 ◽

Vol 9 (1) ◽

pp. 86 ◽

Cited By ~ 1

Author(s):

Zulkarni Zulkarni

Keyword(s):

Blood Glucose ◽

Capsicum Annuum ◽

Fasting Blood Glucose ◽

Ethanol Extract ◽

Negative Control ◽

Control Group ◽

Glucose Levels ◽

Capsicum Annuum L ◽

Blood Glucose Levels ◽

Significant Difference

This Research was conducted to determine the effect of ethanol extract from red chilli (Capsicum annuum L)in lowering blood glucose levels of hyperglycemic male white mices. This study used 30 malewhitemices and divided into 6 groups: negative control group, the positive control group, the treatmentgroup withdosage of 200 mg / kgweight, 400 mg / kgwieght, 600 mg / kg weight and a comparison group with glibenclamide with dosage of 5 mg / kgweightadministered orally for 21 days. The level of fasting blood glucose was checked 6 days after dexamethasone induced, and after the ethanol extract of red chilies on day 7th, 14th, and 21st. The data was analyzed statistically with one –way and two-way Anova by usingSPSS16 program and proceed with the test Duncan to look the significant difference between treatments. The results showed that the ethanol extract from red chilies with a dosage of 200mg / kgweight, 400mg / kgweight, 600 mg / kgweight showed the effect in lowering blood sugar levels in male white mices hyperglycemia significantly (p <0.05). The duration ethanol extract of red chili affected blood glucose levels. The most effective duration in lowering blood glucose levels is the administration of a preparation within 21 days.

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Red dragon fruit (Hylocereus spp.) peel marmalade effectively improve blood glucose and lipid profile of hypercholesterolemic wistar rats

JURNAL GIZI INDONESIA ◽

10.14710/jgi.9.1.61-67 ◽

2020 ◽

Vol 9 (1) ◽

pp. 61-67

Author(s):

Natalia Desy Putriningtyas ◽

Intan Permatasari ◽

Dita Oktaviani ◽

Anastasia Servia Raha ◽

Siti Wahyuningsih

Keyword(s):

Blood Glucose ◽

Functional Food ◽

Wistar Rats ◽

Fasting Blood Glucose ◽

Control Group ◽

Fruit Peel ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Dragon Fruit ◽

Significant Difference

Background: Polyphenols, antioxidants, dietary fiber, and vitamin contained in the red dragon fruit peel. Red dragon fruit peel can be processed into marmalade. Red dragon fruit peel marmalade has the potential to be a functional food. Functional food is food that has a physiological function based on scientific studies.Objectives: The objective of this study is to analyze the effect of red dragon fruit peel marmalade on fasting blood glucose levels, HDL, LDL, and triglycerides levels of hypercholesterolemic Wistar rats.Methods: This study used a pre-&post-test control group design. Hypercholesterolemic male Wistar rats were randomly assigned into five groups. Hypercholesterolemia was induced by 1% cholesterol powder and 0.5% cholic acid for two weeks. All groups received standard chow. Samples were grouped into five groups: K-; K+; K1 (0.94 g/kg b.wt/day); K2 (1.41 g/kg b.wt/day); K3 (1.88 g/kg b.wt/day). The intervention was carried out for 28 days. GDP level was measured using the GOD-PAP. HDL, LDL, and triglyceride were analyzed with spectrophotometry. GDP, HDL, LDL, and triglyceride levels were measured twice before fasting. A paired t-test and one-way ANOVA were used to analyze the data.Results: The result showed that K-; K1; K2; K3 had a significant difference between groups before and after the intervention (p<0.05). Red dragon fruit peel Marmalade was able to reduce the levels of GDP, LDL, triglycerides, and increase HDL (p <0.05).Conclusion: Red dragon fruit peel marmalade reduced fasting blood glucose levels, LDL, triglyceride levels, and increased HDL levels of hypercholesterolemic Wistar rats.

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Decreased Blood Glucose and Histopathology Improvement in Hyperbaric Hyperoxic Conditions Alloxan-induced rats(Laboratory Experimental Study)

International Journal of PharmTech Research ◽

10.20902/ijptr.2019.120408 ◽

2019 ◽

Vol 12 (4) ◽

pp. 54-62

Author(s):

Retno Budiarti

Keyword(s):

Blood Glucose ◽

Treatment Group ◽

Hyperbaric Oxygen ◽

Control Group ◽

Glucose Levels ◽

Oxygen Exposure ◽

White Rats ◽

Blood Glucose Levels ◽

Significant Difference ◽

Hyperbaric Oxygen Exposure

Background: Diabetes mellitus is still a problem in Indonesia, related to the number of organs involved. This disease has relatively high morbidity and mortality rates. Adjuvant therapy is needed considering the long-term therapy that must be consumed by patients. Objective: To explain the effect of hyperbaric oxygen in reducing blood glucose levels, and repairing histopathological damage to the pancreas and liver. Method : this study was an experimental laboratory study using whistar strain rats (Rattus Norvegicus) which were given a normal diet then induced alloxan to create a hyperglycemia condition. After that, 12 rats from the treatment group were given 3 x 30’ hyperbaric oxygen exposure for 6 days. Blood glucose levels, histopathological changes in the pancreas and liver was measured between the treatment group and the control group were not given hyperbaric oxygen exposure. Results: There was a significant difference (α< 0,05) in decreasing blood glucose and repairing histopathological damage in pancreatic and liver tissue between treated group and control group. Conclusion: hyperbaric oxygen treatment as much as 3 x 30'for days at 2.4 ATA O2 100% reduce blood glucose levels and repair histopathological damage to pancreatic tissue and liver of alloxan- induced white rats.

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Effect of The Sweet Potato Against Mice on Blood Glucose of Diabetes Mellitus

Nutri-Sains Jurnal Gizi Pangan dan Aplikasinya ◽

10.21580/ns.2018.2.1.2812 ◽

2018 ◽

Vol 2 (1) ◽

pp. 1

Author(s):

Ai Kustiani ◽

Wilda Raziq

Keyword(s):

Blood Glucose ◽

Treatment Group ◽

Sweet Potato ◽

Control Group ◽

Diabetic Mellitus ◽

Glucose Levels ◽

Positive Effects ◽

Blood Glucose Levels ◽

Significant Difference ◽

Average Blood Glucose

The aim of this study was to analyze the effects of the sweet potato to the levels of blood glucose on diabetic mellitus mice. This study had been carried out with a sample of 25 mice which were divided into 5 groups. The levels of blood glucose on mice before treating with rice flour and sweet potato flour on the negative control group (KN) was 76.2 ± SD, on the positive control group (KP) was 159.4 ± SD, on the 1st treatment group (P1) was 159.4 ± SD, on the 2nd treatment group (P2) was 166.6 ± SD and 3rd treatment group (P3) was 161.2 ± SD. The average blood glucose levels on the 2nd treatment group (P2) before treatment was 166.6 ± SD and after treatment was 109.0 ± SD. The result showed a significant difference based on the statistical data (p < 0.05) between 4 test groups of mice. There was a big difference on the average blood glucose levels before and after treatment o P2 and P3. It is concluded that the treatment of sweet potatoes gives a positive effects on the blood glucose levels of diabetic mellitus mice.

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PSYCHONEUROIMMUNOLOGY APPROACH TO IMPROVE RECOVERY MOTIVATION, DECREASE CORTISOL AND BLOOD GLUCOSE OF DM TYPE 2 PATIENTS WITH DHIKR THERAPY

Jurnal NERS ◽

10.20473/jn.v12i1.2315 ◽

2017 ◽

Vol 12 (1) ◽

pp. 60

Author(s):

Rifka Pahlevi ◽

Suhartono Taat Putra ◽

Sriyono Sriyono

Keyword(s):

Type 2 Diabetes ◽

Blood Glucose ◽

T Test ◽

Control Group ◽

Stress Perception ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference ◽

Cortisol Levels

Introduction: Blood glucose levels are controlled when the management of diabetes success. Positive perception of the strength of the spiritual aspect will improve the motivation of patients with type 2 diabetes to control it. The purpose of this study was to determine the effect of dhikr based on psychoneuroimmunology (PNI) on blood glucose levels of patients with type 2 diabetes. Methods: This study used quasi-experiment with pre-test and post-test control group design. Samples were taken from the population of patients with type 2 diabetes who were hospitalized in the Internal Medicine Rumkital Dr. Ramelan Surabaya with purposive sampling techniques. Data taken include the general characteristics of respondents, cures motivation, cortisol levels and fasting blood glucose levels. Collecting data using questionnaires and laboratory test, then analyzed using paired t-test and independent t-test, with α value <0.05. Results: Statistical test showed that the motivation to recover increased (p = 0.001), cortisol levels fall (p = 0.058) and a drop in blood glucose levels (p = 0.028) after administration of dhikr therapy in patients with diabetes mellitus type 2. There was a significant difference in increased of recovery motivation between patient conduct zikr therapy and patient cared (p = 0,000). Conclusion: Dhikr therapy increases the motivation of patients with type 2 diabetes by strengthening awareness and spirituality belief in Allah make positive stress perception. Positive stress perception will affect the stress response and improved regulation of blood glucose through the HPA axis to suppress the secretion of CRH, ACTH, and cortisol.

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Daya Antihiperglikemia Yoghurt Pada Mencit Putih Jantan

Jurnal Katalisator ◽

10.22216/jk.v4i2.4607 ◽

2019 ◽

Vol 4 (2) ◽

pp. 72

Author(s):

Irene Puspa Dewi ◽

Roza Septriani ◽

Verawaty Verawaty ◽

Dwi Mulyani

Keyword(s):

Diabetes Mellitus ◽

Blood Glucose ◽

Positive Control ◽

Negative Control ◽

Positive Control Group ◽

Control Group ◽

Percentage Increase ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference

Research has been conducted on the antihyperglycemic of yogurt in male white mice. Yogurt contains probiotics that have a positive effect on both type 1 and types 2 diabetes mellitus. Yogurt is given for 3 weeks at a dose of 200 grams / Kg BW / day and 400 grams / Kg BW / day to mice that have been alloxan-induced. As a comparison, a positive control group was created, the alloxan-induced mice group, but not given yogurt and a negative control group, the mice group without any treatment. After 3 weeks of treatment with yogurt, it was found that there was a significant difference between the average blood glucose levels in the mice of the 200 grams/ Kg BW group and the 400 grams / Kg BW dose with the positive control group. From the data on the percentage increase in blood glucose levels of mice, it is known that by giving yogurt for 3 weeks, reducing the high percentage of increase in blood glucose levels in mice. From these data, it can be concluded that the administration of yogurt with a dose of 200 grams / Kg / day and 400 grams / Kg / day can help reduce blood glucose levels in alloxan-induced mice. Telah dilakukan penelitian mengenai daya antihiperglikemia yogurt pada mencit putih jantan. Yogurt mengandung probiotik yang memberikan pengaruh positif terhadap diabetes mellitus baik tipe 1 maupun tipe 2. Yogurt diberikan selama 3 minggu dengan dosis 200/Kg BB/hari dan 400 gram/Kg BB/hari kepada mencit yang telah diinduksi aloksan. Sebagai pembanding dibuat kelompok kontrol positif yaitu kelompok mencit yang diinduksi aloksan, namun tidak diberi yogurt dan kelompok kontrol negatif, yaitu kelompok mencit tanpa perlakuan apapun. Setelah 3 minggu perlakuan dengan yogurt, didapatkan hasil bahwa terdapat perbedaan bermakna antara rata-rata kadar glukosa darah mencit kelompok dosis 200 gram/Kg BB dan dosis 400 gram/Kg BB dengan kelompok kontrol postif. Dari data persentase kenaikan kadar glukosa darah mencit, diketahui bahwa dengan pemberian yogurt selama 3 minggu, mengurangi tingginya persentase kenaikan kadar glukosa darah mencit.dari data-data tersebut, dapat disimpulkan bahwa pemberian yogurt dengan dosis 200 gram/Kg BB/hari dan 400 gram/Kg BB/hari dapat membantu menurunkan kadar glukosa darah mencit yang diinduksi aloksan.

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Effect of Honey Variation on Blood Glucose Level in Pregnant Wistar Rats (Rattus norvegicus)

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2020.5200 ◽

2020 ◽

Vol 8 (T2) ◽

pp. 98-103

Author(s):

Syarifuddin Syarifuddin ◽

Veny Hadju ◽

Rahayu Inriasari

Keyword(s):

Blood Glucose ◽

Quantitative Research ◽

Control Group ◽

Pregnant Rats ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Wistar Strain ◽

Significant Difference ◽

Post Test ◽

Research Type

BACKGROUND: In addition to Moringa one of the food products that are often used as supplements is honey. Honey contains carbohydrates and content of antioxidants and other active substances needed during pregnancy. AIM: This study aimed to look at the effect of the intervention on the blood glucose levels of normal white pregnant Wistar strain of Moringa honey, honey plus Moringa or natural honey interventions. METHODS: This research method uses a quantitative research with experimental lab research type. With a completely randomized pre-test-post-test controlled completely randomized research design. The samples in this study were 24 white Wistar pregnant rats, divided into four groups, the control group, the honey group, the honey plus Moringa group, and the Moringa honey group, each consisting of six animals. The intervention was carried out for 20 days with initial BB measurements pregnancy (pre) and end of pregnancy (post). Data analysis used paired t-test and one-way ANOVA test. RESULTS: GD levels showed a significant decrease in GD levels in all groups at the end of pregnancy with a p < 0.05, but a decrease in GD levels between groups did not show a significant difference at the end of the study, the control group (82.33 ± 8.98), honey (83.83 ± 6.67), plus honey (73.17 ± 10.92), and Moringa honey (73.00 ± 6.45) with a p = 0.065 > 0.05. CONCLUSION: It shows that honey variation has the effect of controlling blood glucose levels during pregnancy.

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Pengaruh pemberian susu almond terhadap glukosa darah puasa pada tikus diabetes

JURNAL GIZI INDONESIA ◽

10.14710/jgi.7.2.86-91 ◽

2019 ◽

Vol 7 (2) ◽

pp. 86-91

Author(s):

Ryta Ristantia Ningsih ◽

Enny Probosari ◽

Binar Panunggal

Keyword(s):

Blood Glucose ◽

Treatment Group ◽

Metabolic Diseases ◽

Fasting Blood Glucose ◽

Glucose Measurement ◽

Control Group ◽

Control Group Design ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference

Background: Type 2 Diabetes Mellitus is a group of metabolic diseases with characteristic hyperglycemia that occurs due to abnormalities in insulin secretion and insulin action. Diet plus high fiber can help control glucose levels. Almond contains fiber, vitamin E, and magnesium that contributes to the fasting blood glucose levels. This study aimed to analyze the effect of almond milk to the fasting blood glucose diabetic rats.Method: This study used an experimental design with pre-post test control group design. The sample were Rattus norvegicus Wistar which were divided into 4 groups: K (-), K (+), A1 and A2. Almond milk was given in the group treatmeant for 14 days with a dose of 4.32 ml and 8.64 ml. Fasting blood glucose measurement taken before and after treatment used Oxidase Glucose - Peroxidase Aminoantypirin (GOD PAP). Analysis of data used paired t-test, ANOVA and Post Hoc.Results: The fasting blood glucose levels decreased significantly (p = 0.01) in the treatment group which were intervened with almond milk. A decrease in fasting blood glucose levels in a dose treatment group 1 for 116.96 ± 4.45 (p = 0:01), whereas in the group treated at a dose of 2 for 155.53 ± 3.15 (p = 0.01). There were a significant difference in decreased of the fasting blood glucose levels between the two treatment groups (p = 0.01).Conclusion: Giving a dose almond milk 4.32 ml and 8.64 ml for 14 days can lower the fasting blood glucose levels significantly.

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effects of Orally Administered Monosodium Glutamate (MSG) on the Metabolic Syndrome of Adult Albino Rats

NIGERIAN ANNALS OF PURE AND APPLIED SCIENCES ◽

10.46912/napas.185 ◽

2020 ◽

Vol 3 (3a) ◽

pp. 27-37

Author(s):

LN UTUME ◽

PM Ansha ◽

TA Gav

Keyword(s):

Blood Glucose ◽

Monosodium Glutamate ◽

Experimental Period ◽

The Body ◽

Control Group ◽

Albino Rats ◽

Glucose Levels ◽

The Metabolic Syndrome ◽

Blood Glucose Levels ◽

Significant Difference

Monosodium Glutamate (MSG) or glutamate is a commonly used flavour enhancer, naturally found in protein-rich foods; although produced commercially through the fermentation of molasses. MSG is essential in the metabolism of living bodies. The increase in MSG consumption has become a growing concern due to the lack of adequate data on its effects. This study investigates the effects of MSG on weight and blood glucose levels of adult albino rats for an experimental period of eight (8) weeks. Twenty-four (24) albino rats weighing between 48.7 g to 94.6 g were randomly divided into four (4) groups of six (6) rats each: 1 control group and 3 test groups. Test groups were fed and daily doses of MSG dissolved in water (8 g/L, 10 g/L and 15 g/L respectively) were administered orally. The control group were fed on plain water and rat chow (grower’s mash) only. Weekly weights, fasting blood glucose levels of rats were measured, and change in behaviour and exploratory tendencies observed, all through the experimental period. Glycosylated haemoglobin was tested at the end of the experimental period to confirm the weekly blood glucose levels. There was no significant difference in the average weights (P ˃ 0.05). Blood glucose levels maintained a normal range of 4.5 – 5.1 % (good glycemic control) over the experimental period. The study illustrates that Monosodium Glutamate has no adverse effects on weight and blood glucose levels when consumed daily, but not exceeding a 15 g dose. Further research to validate casual inference may be necessary. The consumption of MSG should be in moderation and individuals prone to hypoallergenic reactions should ensure to check product labels for MSG before the consumption of foods. Further research can be carried out using higher doses as well as other metabolic markers in the body to further consolidate empirical data.

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TEST OF THE EFFECTIVENESS ANTIHIPERGLIKEMIA OF COMBINATION CUCUMBER JUICE(Cucumis sativus) AND TOMATO (Solanum lycopersicum L) ON THE WISTAR MALE RAT

JURNAL BORNEO AKCAYA ◽

10.51266/borneoakcaya.v4i1.76 ◽

2017 ◽

Vol 4 (1) ◽

pp. 16-23

Author(s):

Suntoro ◽

Ressi Susanti ◽

Robiyanto

Keyword(s):

Blood Glucose ◽

Fasting Blood Glucose ◽

Tomato Juice ◽

Male Rat ◽

Control Group ◽

Glucose Levels ◽

Blood Glucose Levels ◽

Significant Difference ◽

Decrease Blood Glucose ◽

Tolerance Method

Diabetes mellitus is a metabolic disease with characteristics of hyperglycemia. Conventional treatments using oral medications such as glibenclamide and metformin have many side effects. Therefore, it is necessary to find an alternative drug that is more effective and safer. Some agents that are often used as anantihiperglikemia are cucumber and tomato.The purpose of this study was to determine the effectiveness of combination of cucumber and tomato juice to decrease blood glucose levels of male Wistar ratsusingglucose tolerance method. Male Wistar rats were fasted for 10 hours and then measured the levels of fasting blood glucose. Then animals test were given the juice (single and combination), 30 minutes later were given a dose of sucrose load of 6.75 g / KgBW orally. Blood glucose levels of animal testre-measured at 30th, 60th, 90th, and 120th minutes after loading sucrose using a glucometer.The measurement results showed that blood glucose levels of the combination of cucumber and tomato juice group with dose ratio of 28 g/KgBW:16.8 g/KgBW gave decrease blood glucose levels significantly compared to the negative control group (p≤0.05) and didn’t not provide a significant difference compared to the metformin group (p ≥0.05).

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