scholarly journals PERBANDINGAN KADAR MAGNESIUM SERUM SEBELUM DAN SESUDAH AKTIVITAS FISIK INTENSITAS BERAT

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Gladys R. Rompas ◽  
Stefana H. M. Kaligis ◽  
Murniati Tiho
Keyword(s):  
Random Sampling ◽  
Serum Magnesium ◽  
Simple Random Sampling ◽  
Magnesium Level ◽  
Male Students ◽  
Enzymatic Reactions ◽  
Serum Magnesium Level ◽  
Before And After ◽  
Post Test ◽  
Vigorous Intensity

Abstract: Magnesium is an important cation in catalyzing more than 300 enzymatic reactions in the human body. As a multifunction mineral, magnesium has some major implications in physical activity. This study aimed to compare the serum magnesium level before and after vigorous intensity exercise. This was an experimental study with pretest and post-test design. Sample was collected using simple random sampling method. Twenty one male students of Faculty of Medicine Sam Ratulangi University participated in this study. Samples were designated to play futsal for 2 x 20 minutes, with 10 minutes break and no substitution. The results showed that the mean serum magnesium level before vigorous intensity exercise was 2.2029 mg/dL and after exercise was 2.0067 mg/dL. Analysis using paired sample t-test showed significant result (p=0.000). Conclusion: There was a significant differencce between serum magnesium level before and after vigorous intensity exercise.Keywords: serum magnesium level, exercise, vigorous intensityAbstrak: Magnesium berperan penting dalam mengatalisis lebih dari 300 reaksi enzimatik di tubuh manusia. Magnesium merupakan mineral serbaguna yang memiliki beberapa implikasi besar berkaitan dengan aktivitas fisik. Pada saat suatu aktivitas fisik, dapat terjadi perubahan kadar mineral tubuh sesuai dengan intensitas dan durasi latihan. Penelitian ini bertujuan untuk mendapatkan perbandingan kadar magnesium serum sebelum dan sesudah aktivitas fisik intensitas berat. Penelitian ini menggunakan metode eksperimental dengan pendekatan pretest-posttest. Sampel diperoleh melalui cara simple random sampling. Sebanyak 21 orang mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi dipilih menjadi responden untuk diperiksa kadar magnesium serumnya. Sampel diinstruksikan untuk melakukan olahraga futsal dengan durasi 2 x 20 menit, waktu istirahat selama 10 menit tanpa pergantian pemain. Hasil pemeriksaan kadar magnesium menunjukkan rerata kadar magnesium serum sebelum aktivitas fisik 2,2029 mg/dL dan rerata sesudah aktivitas fisik 2,0067 mg/dL. Hasil uji t berpasangan, memperlihatkan nilai signifikansi sebesar 0,000. Simpulan: Terdapat perbedaan yang signifikan antara kadar magnesium serum sebelum dan sesudah aktivitas fisik intensitas berat.Kata kunci: kadar magnesium serum, aktivitas fisik, intensitas berat

scholarly journals PERBANDINGAN KADAR BESI DARAH SEBELUM DAN SESUDAH AKTIVITAS FISIK INTENSITAS BERAT

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Yunita P. Moniaga ◽  
Youla A. Assa ◽  
Stefana H. M. Kaligis
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
T Test ◽  
The Body ◽  
Iron Level ◽  
Paired Samples ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
Vigorous Intensity

Abstract: Human body needs various substances to function properly; one of which is micronutrient. Iron is one of the micronutrients required by the body that is involved in several body processes including hemoglobin formation, energy metabolism, and immune system. Iron can be excreted through feces, urine, and sweat which could increase as a result of doing vigorious physical activity. This study aimed to compare blood iron level before and after vigorous intensity exercise. This was a pre-experimental study with one group pre-test post-test approach. Respondents were chosen by using simple random sampling method. The vigorous intensity exercise was playing futsal for 2 x 20 minutes and a 10-minute rest without any subtitution. The results showed that the mean of blood iron levels before vigorous intensity exercise was 83.86 ug/dL and after the exercise was 84.95 ug/dL. The analysis using paired-samples t-test showed a P value = 0.595. Conclusion: There was no significant difference between blood iron level before and after vigorous physical activity.Keywords: blood iron level, exxercise, vigorous intensityAbstrak: Tubuh manusia memerlukan berbagai macam zat untuk berfungsi, salah satunya ialah mikronutrien. Besi merupakan salah satu mikronutrien penting yang dibutuhkan tubuh untuk pembentukan hemoglobin, metabolisme energi, dan sistem kekebalan tubuh. Besi dapat diekskresikan melalui tinja, urin, dan keringat yang dapat meningkat akibat aktivitas fisik intensitas berat. Penelitian ini bertujuan untuk mengetahui perbandingan kadar besi darah sebelum dan sesudah aktivitas fisik intensitas berat. Penelitian ini bersifat pre-ekperimental dengan pendekatan one group pre-test post-test. Responden dipilih menggunakan metode simple random sampling. Aktivitas fisik intensitas berat yang dilakukan ialah olahraga futsal dengan durasi permainan 2 x 20 menit dan jeda 10 menit tanpa adanya pergantian pemain. Hasil penelitian menunjukkan nilai rata-rata kadar besi darah sebelum aktivitas fisik 83,86 μg/dL dan sesudah 84,95 μg/dL. Hasil analisis menggunakan paired-samples t-test menunjukkan nilai P = 0,595. Simpulan: Tidak terdapat perbedaan bermakna antara kadar besi darah sebelum dan sesudah aktivitas fisik intensitas berat.Kata kunci: kadar besi darah, aktivitas fisik, intensitas berat

scholarly journals SERUM MAGNESIUM LEVEL

2010 ◽  
Vol 17 (02) ◽  
pp. 279-285
Author(s):  
SADIA ZAFAR ◽  
HINA AYESHA ◽  
ASGHAR BUTT ◽  
Bushra Abdul Malik
Keyword(s):  
Serum Albumin Level ◽  
Serum Magnesium ◽  
Simple Random Sampling ◽  
Albumin Level ◽  
Magnesium Level ◽  
Healthy Children ◽  
Persistent Diarrhea ◽  
Serum Magnesium Level ◽  
Cross Sectional ◽  
Study Setting

Objectives: To evaluate serum magnesium level in children with 3rd degree malnutrition and to compare these values with healthy children. Study Design: Cross sectional comparative study. Setting and Duration: Pediatric Department of Allied Hospital Faisalabad from Oct. 2003 to Nov. 2004. Subjects: Cases: 60 children of age six month to five year having weight < 60% of that for age. Control: 60 healthy children of age six month to five year having weight > 80% of that for age. Methods: Both cases & controls were selected from indoor & outdoor through simple random sampling. Detailed history & examination was done and S/Mg level were measured by atomic absorption spectrophotometer. Data was analyzed with the help of SPSS by applying T test and was presented by frequency tables. Results: The cases showed decreased S/Mg level (1.11+/- 0.24 mg/dl) as compared to controls (2.01+/- 0.78mg/dl).S/Mg levels were also decreased in cases with height < 80 % of that for age (0.98+/-0.5mg/dl) as compared to controls having height > 90 % of that for age. S/Mg levels were markedly low in cases who had low albumin level (0.98+/- 0.05 mg/dl) and those children who presented with persistent diarrhea (0.96+/-0.12mg/dl) Conclusion: S/Mg levels were decreased in children with PEM as compared to those with age and sex matched control. This decrease in S/Mglevels was marked in those cases who had decrease serum albumin level and persistent diarrhea.

scholarly journals Evaluation of C-reactive protein and magnesium level in migraine patients on pre and post prophylactic treatment

2022 ◽  
Vol 7 (4) ◽  
pp. 295-300
Author(s):  
Aliya khaleel ◽  
A Shyam Sunder ◽  
G Meghana
Keyword(s):  
Prophylactic Treatment ◽  
Serum Magnesium ◽  
Pain Scale ◽  
Cerebrovascular Diseases ◽  
Magnesium Level ◽  
Serum Magnesium Level ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Before And After

Migraine affects the day to day life of the sufferers with the symptoms of photophobia and phonophobia with pulsatile or non-pulsatile headache lasting from 1 to 4 hours. Prophylactic treatment or anti-migraine drugs were given to migraineurs to overcome the complications. C-reactive protein (CRP) and Magnesium level of symptomatic migraineurs, which act as biomarkers for the inflammatory cerebrovascular diseases before and after the treatment with Sodium Divalproex, Flunarizine and Propranolol. The evaluation of C-reactive protein and magnesium levels are noted along with symptoms when they first walk into the clinic. Treatment provided with Sodium Divalproex, Flunarizine and Propranolol for one month. After 1 month, the same tests are being performed. During the test at first instance, the values of pain scale were 31%, CRP value for negative were 20% and positive were 80% and pre-test of Serum magnesium level was 8.8% and at the second visit the pain scale reduced to 10.25%; CRP level was negative 25% and positive was 75%; Serum Magnesium was 9.35%. So, the significant values are being measured by the statistics, which we applied and found P=0.05. The patients who visited first didn’t come for the second visit. So, the results might vary and the patients who visited for the second time after one-month treatment, some got effective results while others remained ineffective. The reason for being ineffective is that they might have adapted to their current regimen.

scholarly journals Perbedaan Motivasi Wanita PUS Usia 35-49 Tahun untuk Menggunakan Implant Sebelum dan Setelah Diberi Penyuluhan di Dusun Mojolegi Desa Bendo Kec. Pare.

2017 ◽  
Vol 3 (2) ◽  
pp. 68
Author(s):  
Triatmi Andri Yanuarini ◽  
Susanti Pratamaningtyas ◽  
Rika Aprilia Susanti
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
Test Design ◽  
Childbearing Age ◽  
Exclusion Criteria ◽  
Before And After ◽  
Post Test ◽  
The Difference ◽  
Removal Technique

Women who have age 35 these group will get increased morbidity and mortality experience if they pregnant. Implant is one method of effective an safety long-term contraception. Bendo Health Center have the lowest acceptor implants in Kediri that is 0%. The purpose of this research to know the difference motivation of childbearing age couples women in age  35-49 years to use implant before and after giving information. The design used a pre-experiment design with one group pre-test post-test design, the population was all childbearing age couples women in age  35-49 years at Mojolegi Hamlet Bendo Village Pare District who have children, not use contraception or still use non-Long Term contraception Method which total 72 people. The samplehave a lot 61 people according to inclusion and exclusion criteria. The sample removal technique used simple random sampling. The result of this research, from 61 respondents get average of respondent motivation before give information is 65 and after give information is 69, show that respondent’s motivation get increase after got information. And after going through the data analysis it was found z calculate ; z table, so in this case have difference motivation of childbearing age couples women in age  35-49 years to use implants before and after giving information.; Keywords: Counseling, Motivation, Implants

scholarly journals Hipnoterapi dapat Mengurangi Derajat Emesis pada Ibu Hamil Trimester Pertama

2020 ◽  
Vol 3 (1) ◽  
pp. 33
Author(s):  
Bram Burmanajaya ◽  
Agustina Agustina
Keyword(s):  
Pregnant Women ◽  
Random Sampling ◽  
Intervention Group ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
First Trimester ◽  
Control Group ◽  
Work Area ◽  
Before And After ◽  
Post Test

Secara psikologis 80% wanita hamil yang mengalami emesis mempengaruhi kualitas hidup mereka. Selama trimester pertama wanita menjadi ambivalen. Sekitar 80% wanita mengalami kekecewaan, penolakan, kecemasan, depresi, dan kesedihan akibat ketidaknyamanan karena mengalami mual dan muntah pada trimester pertama. Penelitian ini bertujuan untuk mengetahui sejauhmana pengaruh hipnoterapi dalam mengurangi emesis pada wanita hamil trimester pertama di wilayah kerja Puskesmas Gang Kelor Bogor. Penelitian ini adalah penelitian kuantitatif dengan desain "Quasi eksperimental pre-post test dengan kelompok kontrol" dan intervensi "hipnoterapi". Penentuan sampel dengan teknik simple random sampling, sebanyak 60 orang terdiri dari 30 orang untuk kelompok intervensi dan 30 orang untuk kelompok kontrol selama 5 bulan. Emesis diukur dengan menggunakan skala Pregnancy-Unique Quantification of Emesis (PUQE-24) sebelum dan sesudah hipnoterapi. Data dianalisis menggunakan analisis univariat dan bivariat, yaitu T Dependent dan Independent T test.Hasil penelitian menunjukkan bahwa hipnoterapi memiliki efek yang signifikan pada penurunan tingkat emisisibu hamil pada trimester pertama (p = <0,05). Hipnoterapi sangat dianjurkan untuk wanita hamil yang mengalami emesis. Kata kunci: hipnoterapi, emesis gravidarum, ibuhamil, trimester pertama HYPNOTHERAPY CAN REDUCE THE DEGREE OF EMESIS IN FIRST TRIMESTER PREGNANT WOMEN ABSTRACTPsychologically 80% of pregnant women who experience emesis affect their quality of life. During the first trimester the woman becomes ambivalent. About 80% of women experience disappointment, rejection, anxiety, depression, and sadness due to discomfort due to nausea and vomiting in the first trimester. This study aims to determine the extent of the influence of hypnotherapy in reducing emesis in first trimester pregnant women in the work area of the Gang KelorHealth Center in Bogor. This research is a quantitative study with the design of "Quasi experimentalpre-post test with control group" and "hypnotherapy" intervention. Determination of the sample with simple random sampling technique, as many as 60 people consisting of 30 people for the intervention group and 30 people for the control group for 5 months. Emesis is measured using the Pregnancy-Unique Quantification of Emesis (PUQE-24) scale before and after hypnotherapy. Data wereanalyzedusingunivariate and bivariateanalysis, namely the T Dependent and Independent T tests. The results showed that hypnotherapy had a significant effect on reducing the level of emission of pregnant women in the first trimester (p = <0.05). Hypnotherapy is highly recommended for pregnant women who experience emesis. Keywords: hypnotherapy, emesisgravidarum, pregnantwomen, first trimester

scholarly journals Efektifitas Relaksasi Genggam Jari Terhadap Penurunan Nyeri Pada Pasien Post Op Appendiktomi di Ruang Bedah (Al-Muizz) RSUD Ratu Zalecha Martapura Tahun 2019

2020 ◽  
Vol 10 (1) ◽  
pp. 76-90
Author(s):  
Asni Hasaini
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
Pain Reduction ◽  
Daily Activities ◽  
Test Design ◽  
Pain Level ◽  
Neurogenic Shock ◽  
Before And After ◽  
Post Test ◽  
Grip Relaxation

Latar Belakang: Prevalensi apendesitis akut yang menjalani appendiktomysebanyak 75,2% dan keluhan yang sering dirasakan adalah nyeri yang sangat hebat, sedang sampai ringan. Nyeri akan berdampak pada aktivitas sehari-hari, dan apabila tidak ditangani dapat mengakibatkan syok neurogenik.  Sehingga diperlukan tindakan keperawatan mandiri dengan melakukan manajemen nyeri yang sederhana dan mudah untuk dilakukan yaitu relaksasi genggam jari.Tujuan: Untuk menganalisis efektifitas relaksasi genggam jari terhadap penurunan nyeri pada pasien post op appendiktomy di Ruang Bedah (Al-Muizz) RSUD Ratu Zalecha Martapura.Metode: Jenis desain penelitian adalah metode eksperimental dengan rancangan one-group pre-post test design. Populasi adalah seluruh klien yang terdiagnosa Post Op Appendictomy dan sampel sebanyak 15 orang responden dengan simple random sampling. Instrument menggunakan lembar observasi dan dianalisis bivariat dengan Wilcoxon.Hasil: Ada efek relaksasi genggam jari terhadap penurunan nyeri pada pasien post op appendiktomy di Ruang Bedah  (Al-Muizz) RSUD Ratu Zalecha Martapura p=0,000 (p 0,05).Kesimpulan: Tingkat nyeri sebelum diberikan relaksasi genggam jari didapatkan dikategori nyeri sedang, dan sesudah diberikan dikategorikan nyeri ringan. Hasil analisis sebelum dan sesudah dilakukan relaksasi genggam jari didapatkan p=0,000 (p 0,05) maka H0 ditolak yang artinya ada pengaruh (signifikan) Ada efek relaksasi genggam jari terhadap penurunan nyeri pada pasien post op appendiktomy di Ruang Bedah  (Al-Muizz) RSUD Ratu Zalecha Martapura. Kata kunci : Relaksasi Genggam Jari, Nyeri, Post Op Appendiktomy The Effectiveness of Finger Grip Relaxation Against the Pain Reduction of  Post Op Appendictomy Patients in the Surgical Room (Al-Muizz) RSUD Ratu Zalecha Martapura 2019Background: The prevalence of acute appendicitis undergoing appendictomy is 75.2% and complaints that are often felt are very severe, moderate to mild pain. Pain will have an impact on daily activities, and if left untreated can lead to neurogenic shock. So that independent nursing action is needed by doing pain management that is simple and easy to do, namely hand-held relaxation. Objective : To analyze the effectiveness of finger grip relaxation against the pain reduction on post op appendictomy patients in the Surgical Room (Al-Muizz) RSUD Ratu Zalecha Martapura.Method : The type of research design is an experimental method with a one-group pre-post test design. The population is all clients who are diagnosed with Post Op Appendictomy and sample is taken from 15 respondents with simple random sampling. The Instrumentuses observation sheets and will be analyzed by using bivariate with Wilcoxon. Results : There is an effect of the effectiveness of finger grip relaxation on the pain reduction of post op appendictomy patients in the Surgical Room (Al-Muizz) RSUD Ratu Zalecha Martapura p=0,000 (p 0,05).Conclusion : The pain level before the finger grip relaxationgiven was categorized medium pain, and after  it was given, the pain level turned into mild category. The results before and after the finger grip is p=0,000 (p 0,05) then H0 was rejected which means there is an influence (significant) of the finger grip relaxation on the pain reduction of the Post Op Appendictomypatients in the Surgical Room (Al-Muizz) RSUD Ratu Zalecha Martapura.Key words : Finger Grip Relaxation, Pain, Post Op Appendictomy. 

scholarly journals UPAYA MEWUJUDKAN KAMPUS SIAGA BENCANA MELALUI PENINGKATAN KESIAPSIAGAAN MAHASISWA KEPERAWATAN DENGAN PENERAPAN METODE TABLETOP DISASTER EXERCISE (TDE)

2019 ◽  
Vol 15 (1) ◽  
pp. 35
Author(s):  
Widya Addiarto
Keyword(s):  
Disaster Preparedness ◽  
Random Sampling ◽  
Design Research ◽  
Sampling Technique ◽  
Simple Random Sampling ◽  
Test Design ◽  
Before And After ◽  
Post Test ◽  
Disaster Education ◽  
Disaster Exercise

AbstrakPada saat ini, kesiapsiagaan masyarakat khususnya yang tinggal di kawasan rawan bencana masih tergolong rendah. Dari beberapa hasil studi menyatakan bahwa keadaan tersebut dikarenakan minimnya pendidikan bencana. Kampus dianggap sebagai tempat yang paling potensial untuk memulai pendidikan bencana. Salah satu media untuk mempermudah pendidikan bencana di lingkungan kampus adalah Tabletop Disaster Exercise (TDE). Tujuan penelitian ini adalah untuk menganalisa peningkataan kesiapsiagaan dalam menghadapi bencana melalui penerapan media Tabletop Disaster Exercise (TDE). Metode penelitian yang digunakan pada penelitian ini adalah pra-experiment dengan menggunakan desain penelitian one grup pre-post test design. Populasi dalam penelitian ini adalah semua mahasiswa tingkat IV STIKes Hafshawaty Pesantren Zainul Hasan Kabupaten Probolinggo sejumlah 60 responden. Teknik sampling yang digunakan pada penelitian ini adalah simple random sampling. Jumlah sampel yang akan digunakan disesuaikan dengan kriteria inklusi dan randomisasi adalah sejumlah 52 responden. Hasil yang didapatkan dari penelitian ini adalah terdapat perbedaan skor kesiapsiagaan sebelum dan sesudah diberikan intervensi TDE dengan nilai signifikansi (ρ = 0,000). Kata kunci: Kesiapsiagaan, Metode Tabletop Disaster Exercise (TDE), Kampus Siaga Bencana ABSTRACTToday, community preparedness, especially those living in disaster-prone areas is still relatively low. From the results of several studies stated that the situation was due to the lack of disaster education. Campus is considered as the most potential place to start disaster education. One of the media to facilitate disaster education in the campus environment is Tabletop Disaster Exercise (TDE). The purpose of this study was to analyze the improvement of preparedness in the face of disasters through the application of Tabletop Disaster Exercise (TDE) media. The research method used in this study was pre-experiment using the one group pre-post test design research design. The population in this study were all level IV students of STIKes, Hafshawaty, Pesantren Zainul Hasan, Probolinggo, with 60 respondents. The sampling technique used in this study was simple random sampling. The number of samples that will be used adjusted to the inclusion and randomization criteria were a number of 52 respondents. The results obtained from this study were that there were differences in preparedness scores before and after the TDE intervention was given with a significance value (ρ = 0,000). Keywords: Preparedness, Tabletop Disaster Exercise Method (TDE), Disaster Preparedness Campus

PENGGUNAAN MODEL PEMBELAJARAN STAD (STUDENT TEAMS-ACHIEVMENT DIVISIONS) DALAM PEMBELAJARAN MENULIS SURAT DINAS SISWA KELAS VIII DI SMP NEGERI SE-KECAMATAN PANYINGKIRAN KABUPATEN MAJALENGKA TAHUN AJARAN 2013/2014

2017 ◽  
Vol 3 (1) ◽  
pp. 447
Author(s):  
Iyay Robia Khoerudin ◽  
Neneng Titin ◽  
Eki Kiyamudin
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Student Teams ◽  
Post Test ◽  
Test Control

Penelitian ini bertujuan untuk mengetahui kemampuan menulis surat dinas siswa kelas VIII di SMP Negeri Se-Kecamatan Panyingkiran Kabupaten Majalengka, mengetahui kemampuan menulis surat dinas dengan menggunakan model pembelajaran STAD (Student Teams-Achievment Divisions) siswa kelas VIII di SMP Negeri Se-Kecamatan Panyingkiran Kabupaten Majalengka, serta menjelaskan efektifitas model pembelajaran STAD (Student Teams-Achievment Divisions) untuk meningkatkan  pengajaran menulis surat dinas siswa Kelas VIII di SMP Negeri Se-Kecamatan Panyingkiran Kabupaten Majalengka.Penelitian ini menggunakan pendekatan kuantitatif dan kualitatif dengan metode eksperimen Pre test-Post test Control Group Design, populasinya yaitu SMP Negeri Se-Kecamatan Panyingkiran Kabupaten Majalengka tahun ajaran 2013/2014, sedangkan  sampelnya ditentukan melalui teknik simple random sampling yaitu kelas VIII G SMP Negeri 2 Panyingkiran sebagai kelas eksperimen dan kelas VIII B SMP Negeri 1 Panyingkiran sebagai kelas kontrol. Instrumen pengumpulan data yang digunakan tes tertulis tes awal dan tes akhir, kuesioner, lembar observasi guru dan siswa, setelah data diperoleh maka dilakukan analisis data. Data kuesioner dan observasi dianalisis dalam bentuk uraian sedangkan data tes dianalisis dengan statistik dan di deskripsikan.Berdasarkan perhitungan statistik program SPSS 16.0 diperoleh hasil uji t pretes pada kedua kelas tersebut memiliki nilai t=5.429 derajat kebebasan (df)=n-1=38 nilai probability (sig 2-tailed) sebesar 0,000.  Hal ini berarti t hitung <0,005. Artinya 0,000<0,05, pada uji t ini bahwasanya pretes pada kedua kelas terdapat perbedaan yang signifikan antara kelas eksperimen dengan kelas kontrol.  Apabila ditinjau dari segi rata-rata pretes eksperimen lebih efektif daripada kelas kontrol. Hal ini terbukti dari rata-ratanya pretes kelas eksperimen 64,8 kelas kontrol 62,3 selisih rata-rata 2,5. Sedangkan rata-rata postes kelas eksperimen 81,2 dan kelas kontrol 69 terjadi selisih postes 12,2.

Ekstrak Ethanol Kulit Jeruk Purut (Citrus hystrix) Berpotensi sebagai Agen Penurun Kolesterol : Studi In Vivo

2020 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
Henas Deliara ◽  
Arum Kartikadewi ◽  
Dyah Mustika Nugraheni
Keyword(s):  
Random Sampling ◽  
Simple Random Sampling ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test

Latar Belakang: Hiperkolesterolemia dapat menyebabkan penyakit cerebrovaskuler bahkan kematian. Salah satu pencegahan hiperkolesterolemia adalah dengan pemberian suplemen contohnya menggunakan kulit jeruk purut (Citrus hystrix) yang mengandung saponin, tanin dan flavonoid. Tujuan penelitian ini adalah membuktikan adanya pengaruh pemberian ekstrak ethanol kulit jeruk purut terhadap kadar kolesterol total pada tikus wistar jantan yang diberi diet tinggi lemak. Metode: Penelitian eksperimental  ini menggunakan metode post test only control group design. Jumlah sampel 30 ekor tikus wistar jantan dikelompokkan secara simple random sampling menjadi kelompok kontrol negative (K-), kontrol positif (K+), perlakuan 1 (P1), perlakuan 2 (P2) dan perlakuan 3 (P3). Pada kelompok K+, P1,P2 dan P3 tikus diberi minyak babi sebanyak 3 mg/200grBB/hari selama 3 minggu. Kelompok P1, P2 dan P3 diberikan ekstrak ethanol kulit jeruk purut sebesar 35 mg/200grBB/hari, 70 mg/200grBB/hari, dan 140 mg/200grBB/hari selama 3 minggu. Kadar kolesterol total dihitung dengan metode CHOD-PAP lalu dianalisis secara statistic dengan uji One Way Annova dan uji beda dengan Pos Hoc. Hasil: Dari 25 sampel, rerata kadar kolesterol total (K-):73,90 mg/dl±19,11 mg/dl; (K+):80,00 mg/dl±4,72 mg/dl; (P1):69,94 mg/dl±6,52 mg/dl; (P2):59,10 mg/dl±11,70 mg/dl; (P3):59,74 mg/dl±7,52 mg/dl. (p=0,032). Hasil uji Pos Hoc kelompok yang berbeda signifikan adalah K- dengan P2 (p=0,049), K+ dengan P2 (p=0,008) dan K+ dengan P3 (p=0,010). Kesimpulan: Terdapat pengaruh pemberian ekstrak ethanol kulit jeruk purut terhadap kadar kolesterol total pada tikus wistar jantan yang diberi diet tinggi lemak. Dosis terendah ekstrak kulit jeruk purut yang dapat menurunkan kadar kolesterol total adalah 70 mg/200 grBB/hari.

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