CASE REPORT ON DENGUE ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS- A RARE PRESENTATION.

2021 ◽  
pp. 7-8
Author(s):  
K. Shivaraju ◽  
Manideepa Pogaku ◽  
Mandhala Saikrishna
Keyword(s):  
Dengue Fever ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Supportive Therapy ◽  
Hemorrhagic Fever ◽  
Severe Form ◽  
High Grade Fever ◽  
Rare Presentation ◽  
Life Threatening ◽  
The Common

Dengue fever in its severe form has signicant morbidity and mortality worldwide. Apart from the common complication of dengue fever, infection induced HLH is a rare and life-threatening complication associated with the viral infection. Here we are presenting a case of 28 years old male with no comorbidities and complains of high-grade fever, myalgia, nausea and vomiting, black stools from 5 days. Based on all investigations patient was diagnosed with hemophagocytic lymphohistiocytosis secondary to dengue hemorrhagic fever. Then treated with appropriate medications and supportive therapy, discharged, and advised follow-up on OPD basis.

scholarly journals Emphysematous pyelonephritis with Dengue hemorrhagic fever: A successful medical management of a fatal scenario

2017 ◽  
Vol 8 (5) ◽  
pp. 101-103
Author(s):  
Robin George Manappallil ◽  
Prathap Reddy Muthyala
Keyword(s):  
Dengue Fever ◽  
Hemorrhagic Fever ◽  
Severe Form ◽  
Medical Sciences ◽  
Emphysematous Pyelonephritis ◽  
Associated Gas ◽  
Acute Necrotizing ◽  
Life Threatening ◽  
History Of ◽  
Plasma Leakage

Emphysematous pyelonephritis is a life threatening acute necrotizing infection with associated gas formation involving the renal parenchyma and perinephric tissues. Dengue fever, according to the WHO, is the most rapidly spreading mosquito borne viral infection in the world. Dengue Hemorrgahic Fever is a more severe form of dengue fever and is characterized by fever, bleeding manifestations, plasma leakage and thrombocytopenia. This is a case of a 56 year old female, who presented with history of fever, headache, myalgia and dysuria; and was diagnosed to have emphysematous pyelonephritis with Dengue Hemorrgahic Fever. She was successfully managed with intravenous antibiotics and platelet transfusions, without any urological interventions. Asian Journal of Medical Sciences Vol.8(5) 2017 101-103

scholarly journals Haemophagocytic Lymphohistiocytosis Associated with Dengue Fever - A case series

2020 ◽  
Vol 21 (2) ◽  
pp. 123-126
Author(s):  
Quazi Tarikul Islam ◽  
Hirinmoy Barman Sagor ◽  
Tasmina Chowdhury Tuli
Keyword(s):  
Intravenous Immunoglobulin ◽  
Dengue Fever ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Medical Condition ◽  
Case Series ◽  
Supportive Therapy ◽  
Haemophagocytic Lymphohistiocytosis ◽  
Laboratory Findings ◽  
Good Outcome ◽  
Life Threatening

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening medical condition characterized by hyperphagocytosis secondary to an inappropriate over-activation of macrophages and lymphocytes that driven by excessive cytokines production which resulted in cellular destructions. Dengue induced hemophagocytic lymphohistiocytosis (HLH) is a serious condition and may prove fatal if not detected early and treated appropriately. Diagnosis of HLH is challenging and usually missed as clinical and laboratory findings are nonspecific. It should be suspected with prolonged fever beyond seven days associated with splenomegaly, hyperferritinemia, worsening cytopenias and development of multiorgan dysfunction. A proportion of patients recovered with supportive therapy, however most required interventions with corticosteroids, intravenous immunoglobulin or chemotherapy. We report 3 cases of dengue associated HLH . Among them 2 patients were treated with steroid with good outcome, and one died from MODS. J MEDICINE JUL 2020; 21 (2) : 123-126

scholarly journals Dengue Fever: An Overview

2020 ◽  
Author(s):  
Ramalingam Kothai ◽  
Balasubramanian Arul
Keyword(s):  
Dengue Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Severe Form ◽  
The Body ◽  
Immune Systems ◽  
Treatment And Prevention ◽  
The World ◽  
Viral Illness ◽  
Life Threatening

Dengue fever is a disease caused by a family of viruses transmitted by mosquitoes. Dengue virus (DENV), a member of the Flaviviridae family, causes the most widespread mosquito-borne viral infection in humans around the world today. Dengue can affect anyone but tends to be more severe in people with compromised immune systems. Dengue hemorrhagic fever is a more severe form of a viral illness. Symptoms include headache, fever, rash, and evidence of bleeding (hemorrhage) in the body. This form of dengue fever can be life-threatening and can progress to the most severe form of the illness, dengue shock syndrome. This chapter reviews the etiology, epidemiology, diagnosis, pathophysiology, transmissions, manifestations, diagnosis, treatment, and prevention of dengue.

scholarly journals Clinical profile of dengue fever in children: analysis of 2017 outbreak from Central Kerala, India

2018 ◽  
Vol 5 (6) ◽  
pp. 2265 ◽  
Author(s):  
Senthil Kumar K. ◽  
Rajendran N. K. ◽  
Ajith Brabhukumar C.
Keyword(s):  
Dengue Fever ◽  
Dengue Infection ◽  
Tertiary Care ◽  
Hemorrhagic Fever ◽  
Warning Signs ◽  
Clinical Profile ◽  
Severe Dengue ◽  
High Morbidity ◽  
Care Hospital ◽  
High Grade Fever

Background: In India, dengue epidemics are becoming more frequent (WHO, 2008). The majority of dengue viral infections are self-limiting, but complications may cause high morbidity and mortality. The objective of this study is to assess the clinical profile of the dengue infection in children less than 15 years of age and to evaluate the outcomes of dengue fever from March 2017 to July 2017 at the Pediatric Department of Karuna Medical College, the tertiary care hospital in Palakkad.Methods: In this retrospective study, medical records were reviewed and analyzed. Patients with suspected dengue infection were classified further into 2 groups, Dengue fever (probable dengue, dengue with warning signs) and ‘Severe Dengue’ (dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS) according to WHO.Results: A total of 77 cases were classified into 67 (87%) non-severe and 10 (13%) severe dengue cases. The most common age of presentation was above 10 yrs. The mean age of admission was 8.9 yrs. The most common presenting symptom was fever seen in 93% followed by vomiting in 68%. Elevation in Aspartate transaminase (SGOT) and thrombocytopenia were found in 32.4 %.Conclusions: High grade fever, vomiting, abdominal pain and skin rash with normal or low platelet count were the presenting features. Early diagnosis, monitoring and prompt supportive management can reduce mortality.

scholarly journals Panophthalmitis in a patient with dengue fever

2019 ◽  
Vol 12 (6) ◽  
pp. e229588
Author(s):  
Vimal Kumar ◽  
Vaibhav Deorari ◽  
Shekhar Swaroop ◽  
Ashutosh Biswas
Keyword(s):  
Dengue Fever ◽  
Staphylococcus Epidermidis ◽  
Early Stage ◽  
Supportive Therapy ◽  
Unusual Complication ◽  
Life Threatening ◽  
Brain Abscesses ◽  
Multiple Challenges ◽  
The Right ◽  
Spread Of Infection

Dengue fever is known for its life-threatening complications of bleeding and capillary leak syndrome. We report an unusual complication of dengue fever causing panophthalmitis, leading to rapidly progressive painful visual loss within days. Later on, the patient developed secondary bacterial infection of the eyeball and developed multiple brain abscesses due to spread of infection from the eyeball. Culture from pus swab of the right eye grew Staphylococcus epidermidis. The patient was promptly treated with broad spectrum antibiotics and after stabilisation, evisceration of the affected eye was done. Supportive therapy in the form of mechanical ventilation in view of poor sensorium, platelet transfusions for thrombocytopenia and guided fluid therapy was also provided. After multiple challenges in the management of the patient, fortunately, the patient survived but we failed to save his right eye. Therefore, it is necessary to carefully examine all vital organs at an early stage to prevent unfortunate outcome.

scholarly journals Dengue virus: A review

2022 ◽  
Vol 8 (4) ◽  
pp. 243-247
Author(s):  
Narinder Singh ◽  
Ajeet Pal Singh ◽  
Amar Pal Singh
Keyword(s):  
Public Health ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Rna Virus ◽  
Hemorrhagic Fever ◽  
Health Concern ◽  
Virus Infections ◽  
Public Health Concern ◽  
Viral Illness ◽  
Life Threatening

Dengue fever is a mosquito-borne viral illness that is quickly spreading over the globe, with significant death and morbidity rates. Dengue fever is an acute viral infection transmitted by Aedes mosquitos and caused by an RNA virus from the Flaviviridae family. The symptoms might vary from asymptomatic fever to life-threatening complications including hemorrhagic fever and shock. Although dengue virus infections are normally self-limiting, the disease has become a public health concern in tropical and subtropical countries. Dengue fever is a major public health concern owing to its rapid worldwide spread, and its burdens are now unmet due to a lack of accurate therapy and a simple diagnostic approach for the early stages of illness.

scholarly journals Prevalensi Dengue Pada Mahasiswa Universitas Surabaya

2018 ◽  
Vol 6 (1) ◽  
pp. 45
Author(s):  
Dina Chamidah
Keyword(s):  
Socioeconomic Status ◽  
Abdominal Pain ◽  
Dengue Fever ◽  
Muscle Pain ◽  
Clinical Signs ◽  
Virus Transmission ◽  
Hemorrhagic Fever ◽  
Age Group ◽  
Life Threatening ◽  
The University

In Indonesia, dengue fever is still common. This has caused many troubled people in Indonesia including Surabaya, East Java. Clinical signs of dengue start from mild illness to life-threatening shock syndrome. So it takes a development of a treatment to combat dengue fever. The purpose of this study is to see the prevalence of dengue fever in students. The prevalence of dengue fever at the University of Surabaya accounted for 17%, as we approached 81 people among them 14 were infected with dengue hemorrhagic fever. There were 42 (65%) people suffering from headaches, 19 (29%) joints, 26 (40%) muscle pain and 16 (25%) had abdominal pain, and from 64 among the 18-23 age group. The data obtained is helpful in determining the therapeutic approach to infections that appear. Furthermore, demographic factors such as age, gender, socioeconomic status with dengue virus transmission are also being considered.

scholarly journals Evaluation of biochemical and haematological changes in dengue fever and dengue hemorrhagic fever in Sri Lankan children: a prospective follow up study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Grace Angeline Malarnangai Kularatnam ◽  
Eresha Jasinge ◽  
Sunethra Gunasena ◽  
Dulani Samaranayake ◽  
Manouri Prasanta Senanayake ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Hemorrhagic Fever ◽  
Sri Lankan ◽  
Sri Lankan Children ◽  
Follow Up Study ◽  
Haematological Changes

scholarly journals Linfohistiocitose Hemofagocítica Secundária a Infeção por Epstein-Barr: Raridade e Gravidade num Adulto Imunocompetente

2019 ◽  
Vol 32 (1) ◽  
pp. 78
Author(s):  
Andreia Sofia Costa ◽  
Anusca Paixão ◽  
Henrique Santos ◽  
Fernando Salvador
Keyword(s):  
Disseminated Intravascular Coagulation ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Epstein Barr Virus ◽  
Clinical Case ◽  
Specific Treatment ◽  
Supportive Therapy ◽  
Intravascular Coagulation ◽  
Barr Virus ◽  
Life Threatening ◽  
Epstein Barr

Hemophagocytic lymphohistiocytosis is a rare, aggressive and life-threatening syndrome, characterized by an excessive immune activation. It is triggered by multiple stimuli, with infections having an important role. The most common infectious trigger is viral infection, particularly by Epstein-Barr virus. Coagulation disorders are common in hemophagocytic lymphohistiocytosis and disseminated intravascular coagulation can be present in severe cases. We report a clinical case of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis, complicated with disseminated intravascular coagulation which evolved favorably with only supportive therapy and without specific treatment.

Ifosfamide induced encephalopathy in a child with osteosarcoma

2020 ◽  
pp. 107815522096354
Author(s):  
Hakan Sarbay ◽  
Ülkü F. Demir ◽  
Güliz Yılmaz ◽  
Abdullah A. Atay ◽  
Barış Malbora
Keyword(s):  
Methylene Blue ◽  
Case Report ◽  
Treatment Protocol ◽  
Supportive Therapy ◽  
Neurological Findings ◽  
Electrolyte Disturbances ◽  
Before And After ◽  
Life Threatening ◽  
Reversible Encephalopathy

Background Ifosfamide (IFO) is an alkylating agent used to treat broad range of malignancies. One of the life-threatening toxic effects is reversible neurotoxicity. In this report; we presented a case report of ifosfamide induced encephalopathy (IIE) in a child with osteosarcoma in order to emphize that it is important to continue ifosfamide treatment as well as the importance of this potentially fatal complication. Case report Following the 20th week of ifosfamide treatment, the patient's follow-up with the diagnosis of osteosarcoma developed neurological findings. Laboratory analyzes before and after ifosfamide infusion were normal. No pathological findings were seen on MR imaging. Hypoglycemia, electrolyte disturbances, encephalitis, meningitis, metastasis and posterior reversible encephalopathy syndrome (PRES) were not considered. Electroencephalography was found compatible with neuronal hyperexcitability originating from the left hemisphere. With the diagnosis of ifosfamide induced encephalopathy, prophylaxis with methylene blue was received before the next infusion of ifosfamide. Neurological findings were not observed in the patient's follow-up. Conclusion Patients who develop IIE can continue their treatment protocol with methylene blue prophylaxis and supportive therapy.

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