scholarly journals SERUM C-REACTIVE PROTEIN (CRP) IN PATIENTS WITH SARS COV-2 IN KAMRUP (ASSAM)

2020 ◽  
pp. 18-20
Author(s):  
Malavika Barman ◽  
Sumi Deka ◽  
Elteza T. Jahir
Keyword(s):  
Early Stage ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Retrospective Case ◽  
Medical College ◽  
Reactive Protein ◽  
Initial Stage ◽  
Reflect Disease Severity ◽  
Novel Coronavirus

Background: The ongoing novel coronavirus (COVID-19) pandemic is shaping the world on an unprecedented scale affecting more than 10.3 million individuals across the globe . Various studies have found that C- reactive protein (CRP ) levels could reflect disease severity and should be used as a key indicator for disease monitoring . Objective: To assess the level of C reactive protein(CRP) in initial stage of COVID-19 cases and its correla-tion with clinical presentation of disease. Materials and method:This retrospective case-control study includes 60 RT- PCR (reverse tran-scriptase-polymerase chain reaction) confirmed positive cases above the age of 18 years who were subsequently admitted between May- June, 2020, at Mahendra Mohan Choudhury Hospi-tal(MMCH) –an annexe hospital of Gauhati Medical College and Hospital(GMCH), Kamrup, As-sam. Result:The mean CRP value in the case group was 6 ± 2.36 mg/L while in control group it was 3.03 ± 1.20 which was found to be significantly raised (p<0.005) Conclusion: CRP may be an important index for prognosis and assessment of early stage of COVID-19. CRP levels can also be used in the treatment and management of positive cases.

scholarly journals Serum C reactive Protein in Preeclamptic Women

2014 ◽  
Vol 31 (4) ◽  
pp. 194-198
Author(s):  
S Sultana ◽  
SR Dabee ◽  
S Akter ◽  
MR Khatun ◽  
P Akhter
Keyword(s):  
Pregnant Women ◽  
Early Stage ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Third Trimester ◽  
College Hospital ◽  
Medical College ◽  
Reactive Protein ◽  
Significant Difference

The incidence of preeclampsia is high in the developing countries. Since this condition is preventable if detected and treated at an early stage, it is essential to diagnose the disease at an early stage, and to institute proper medical care on time. The present study carried out in the Department of Obstetrics and Gynaecology, BIRDEM, and Dhaka Medical College Hospital during January 2009 and June 2010, was aimed to find out concentration of serum C reactive protein (CRP) in preeclamptic women. The study included 60 pregnant women; 30 normal (control) and 30 preeclamptic (case) pregnant women in their third trimester. Estimation of CRP was done by immunoprecipitation assay turbulometry method for both groups. The mean (±SD) age was 23.23±4.58 (control) and 23.90±3.20 (case) years (no significant difference). However, BMI, SBP and DBP were significantly (P<0.001) high in case compared to control group (BMI: 23.37±1.47 and 21.81±1.45 kg/m2; SBP: 148.33±13.41 and 108.00±7.14 mmHg; DBP: 106.67±6.99 and 69.67±5.56 mmHg). C reactive protein concentration (mg/dl) was significantly higher (P<0.001) in case group (10.57±6.71) compared to control group (0.63±0.49). In control and case group, respectively, CRP was normal (£0.8 mg/dl) in 25 (83.3%) and 2 (6.7%), and raised (>0.8 mg/dl) in 5 (16.7%) and 28 (93.3) (P<0.001). This study shows that maternal CRP concentration tends to be significantly high in women with preeclampsia. DOI: http://dx.doi.org/10.3329/jbcps.v31i4.21003 J Bangladesh Coll Phys Surg 2013; 31: 194-198

scholarly journals Serum High Sensitive C-Reactive Protein in Obese Persons with Normal Glucose Tolerance & Impaired Fasting Glucose

2018 ◽  
Vol 4 (1) ◽  
pp. 21-24
Author(s):  
Soniya Fahmi ◽  
Sunjida Shahriah ◽  
Omma Hafsa Any ◽  
Mahbuba Akter ◽  
Samia Afrin
Keyword(s):  
Fasting Glucose ◽  
Normal Glucose Tolerance ◽  
Control Group ◽  
Case Group ◽  
Obese Patients ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Normal Glucose ◽  
Obese Subjects ◽  
Hs Crp

Background: Obesity, characterized by increased fat mass and is currently regarded as a proinflammatory state and frequently associated with increased risk of cardiovascular diseases including Myocardial Infarction and also future risk for development of metabolic disorders such as T2DM. Highsensitivity C-reactive protein is a well-known inflammatory marker. Objective: In this study we aimed to determine the levels of serum high-sensitive C-reactive protein in obese parsons with normal glucose tolerance (NGT) and obese with impaired fasting glucose (IFG) individuals. Methodology: This was a case-control study which was conducted in the Department of Biochemistry, ZH Sikder Women’s Medical College, Dhaka during the period of July 2014 to June 2015. The age, sex and body mass index (BMI ≥ 30 kg / m²) matched 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. We measured levels of serum high sensitive Creactive protein in all groups. Subjects of both obese groups had significantly higher hs-CRP levels than the normal range. Results: A total number of 50 subjects were recruited for this study of which 25 obese subjects with NGT were selected as control group and 25 obese patients with IFG were selected as case group. The level of hs-CRP in obese with NGT and with IFG were found 2.91±1.56 mg/L & 3.42±1.72 mg/L, respectively. There are no significant difference between hs-CRP levels of obese subjects than the subjects with IFG (p>0.1). Conclusion: This study finding has concluded that obesity raises serum hsCRP level. IFG obese individuals are not at much higher cardiovascular and metabolic risk level than normal obese parsons. Bangladesh Journal of Infectious Diseases 2017;4(1):21-24

scholarly journals Evaluation of the role of CRP as an early predictor of chorioamnionitis in PPROM

2018 ◽  
Vol 7 (4) ◽  
pp. 1351 ◽  
Author(s):  
Amika Aggarwal ◽  
Sangeeta Pahwa
Keyword(s):  
Predictive Value ◽  
Early Stage ◽  
Control Group ◽  
Total Leucocyte Count ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
A Prospective Study ◽  
Early Predictor

Background: Preterm birth is one of the most important cause of perinatal morbidity and mortality. PROM is defined as spontaneous rupture of membranes before the onset of uterine contraction. Objective of present study was to evaluate the role of CRP as an early predictor of Chorioamnionitis in PPROM.Methods: A prospective study was done on 50 cases with PPROM and 50cases of control group without PPROM. All mothers and babies were observed from the time of admission to the time of discharge.Results: C-reactive protein appears to be the most sensitive acute phase protein; rising of less than 24 hours makes it suitable to serve as a marker for diagnosing an infective process in early stage. On comparing C-reactive protein levels with other laboratory tests and indicators of infection (e.g. total leucocyte count DLC, maternal fever, maternal tachycardia, fetal tachycardia) we found CRP level to be more sensitive (100%) but less specific (69.56%) in identifying clinical Chorioamnionitis. The positive predictive value was 22.22% and negative predictive value was 100%.Conclusions: In cases of PPROM, raised CRP is an early predictor of clinical Chorioamnionitis as well as histological Chorioamnionitis.

scholarly journals Analysis on the Clinical Characteristics of 36 Cases of Novel Coronavirus Pneumonia in Kunming

2020 ◽  
Author(s):  
Haiyan Fu ◽  
Hongjuan Li ◽  
Xiaoqing Tang ◽  
Xiang Li ◽  
Jie Shen ◽  
...  
Keyword(s):  
T Cells ◽  
Normal Control ◽  
Cd8 T Cells ◽  
Clinical Characteristics ◽  
Normal Control Group ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Novel Coronavirus

AbstractObjectiveTo analyze the clinical characteristics of patients with novel coronavirus pneumonia in Kunming City, and to study the correlation between nutritional status and immune function.MethodsClinical data of 36 patients with novel coronavirus pneumonia in isolation area of Kunming Third People’s Hospital from January 31 to February 15, 2020 were collected, and the basic situation, clinical characteristics, laboratory examination and CT imaging characteristics were analyzed. Serum albumin (ALB), prealbumin (PAB), hypersensitive c-reactive protein (hs-crp), CD3T cells, CD4T cells, CD8T cells and normal control group were analyzed. A simple linear regression analysis of the relationship between proalbumin and T cell subpopulation counts in the blood of patients.Results(1) The patients with new coronavirus pneumonia in Kunming were mainly of common type. (2) 50% of the patients’ first symptoms were fever and cough; (3) The total number of white blood cells in peripheral blood was normal or decreased in 23 cases (79%), and the lymphocyte count decreased in 5 cases (13.89%), without anemia. Hypersensitive c-reactive protein increased in 19 (52.78%) cases, and procalcitonin increased in 1 case. Albumin decreased in 5 cases (13.89%), proalbumin decreased in 15 cases (41.67%), alanine transaminase increased slightly in 4 cases (11.11%), alanine transaminase increased slightly in 4 cases (11.11%), total bilirubin increased slightly in 11 cases (30.56%), and renal function and blood coagulation were normal. Absolute value of CD3+T cells is with a decrease in 21 cases (58.3%), CD4+T in 28 cases (77.8%), CD8+T in 17 cases (47.2%), and CD4+/ CD8+ inverse in 6 cases (16.7%). (4) The prealbumin, CD3 T cells, CD4 T cells and CD8 T cells in the new coronavirus pneumonia group were significantly lower than those in the normal control group, and the hypersensitive c-reactive protein was higher than that in the normal control group. (5) The levels of PAB in the serum of the patients were linearly correlated with hs-crp, CD3 T cells, CD4 T cells and CD8 T cells, and the correlation coefficients were −0.474, 0.558, 0.467 and 0.613, respectively, showing statistical differences.ConclusionThe clinical characteristics of the novel coronavirus pneumonia in Kunming are different from those in Wuhan. The changes of serum proalbumin and T cell subsets are relatively obvious. Changes in serum proalbumin may contribute to the early warning of novel coronavirus pneumonia. The nutritional status of patients with common and mild pneumonia should be considered.

Correlation Between High Sensitivity C-Reactive Protein Level and Executive Function Disorders in Elderly Patients

2020 ◽  
Vol 17 (7) ◽  
pp. 3113-3116
Author(s):  
Dyah Anetta Afri Rukmi ◽  
Joseph Eko Wahono Rahardjo
Keyword(s):  
Executive Function ◽  
Elderly Patients ◽  
Complete Blood Count ◽  
High Sensitivity ◽  
High Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp

C-Reactive Protein is a marker of inflammation and vascular disease. The high serum of high-sensitivity C-Reactive Protein (hs-CRP) concentration was associated with interruption the integrity of the frontal-subcortical circuit. To determine the correlation between high serum concentration of hs-CRP and executive function disorder in elderly patients. Thirty six elderly patients was examined by using a case control study. The subjects were enrolled from the out-patient at Neurology Department Dr. Soetomo General Hospital, Surabaya, Indonesia. The time period was 4 months (April to July 2015). Executive function was measured with the Trail Making Test B (TMT B) and divided into two groups, case and control. Complete blood count and serum hs-CRP concentration were measured from nonfasting blood samples. Chi-square test was used for data analysis. Eighteen subjects were enrolled in the case group (3 men, 15 women) and the other 18 subjects were enrolled in the control group (4 men, 14 women). Executive function disorder was found in 17 (94,4%) subjects of case group and 11 (61,1%) subjects of control group. High levels of hs-CRP was not associated with executive function, with p = 0,149 and adjusted OR 5,629 (CI 95% 0, 538-58, 860). These data suggested that high levels of hs-CRP was not associated with executive function in elderly patients.

Highly sensitive C reactive protein (hsCRP) as a surrogate marker of head and neck cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e17034-e17034
Author(s):  
Preethi Bangalore Lakshmangowda ◽  
Adarsh K ◽  
T.R Arul Ponni
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Inflammatory Responses ◽  
Surrogate Marker ◽  
Cancer Case ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein

e17034 Background: High-sensitivity C-reactive protein (hsCRP) an acute phase inflamatory reactant protein, has been used to predict the risk of cardiovascular disease healthy individuals and to monitor treatment responses. Epidemiological evidence also points to link between inflammation and development of cancer, i.e. long-term inflammation and dysplasia. Worldwide ~ 15 % of the cancer incidence is associated with microbial infection. NSAIDs have been used for cancer preventionin familial adenomatous polyposis. The objective of study is to evaluate the association between hs-CRP and head and neck cancer (SCCHN). Methods: Prospective, cross sectional case-control study was under taken involving 36 SCCHN (cases) and 36 normal volunteers age matched (controls). Cases staged as per UICC TNM. The study subjects 4ml clotted blood, centrifuged, serum stored at -20°C. hsCRP (mg/L) determined using Quantitative Immunoturbidimetric method. Statistical analysis was performed using SPSS. Results: Evaluable subjects = 72, Cases (Cancer patients) = 36 & Control = 36. Age group range 18 to 80 yrs. Mean Age Cases 59.5+9.9 v/s Control 59+96. M: F Cases- 25:9 v/s Control 27:9. In Cases Oral Ca – 22(61.1%) & Oropharynx - 14 (38.9%).T4 – 20(55.6%), T3-8(22.2%) & T2-8(22.2%). N3-3(8.3%), N2-14(38.9%), N1-5(13.9%) & N0-14(38.9%). The hsCRP of Control group v/s Cancer Case group = 3.03 ± 2.61 v/s19.23 ± 19.003 respectively (P < 0.0001). hsCRP for Oral Cancer – 15.07+7.66 & OPX – 25.77+28.31. In the case group, the mean hsCRP levels with tumor size T2 was 119.36 ± 7.0, T3 was 21.32 ± 23.27 , T4 was 18.3350 ± 21.0915 and with Node size N0- 20.3 ± 35.07, N1- 13.8 ± 5.37, N2 -21.6 ± 25.022, N3 - 122.1 ± 1.7. Conclusions: Inflammatory responses play decisive roles at different stages of tumor development, initiation, promotion, malignant conversion, invasion, and metastasis. This study shows serum hsCRP levels were significantly elevated in SCCHN cases compared to age matched normal control subjects. hsCRP Can be used as a surrogate marker of SCCHN. Measuring and charting hsCRP values can prove useful in determining disease progress or the effectiveness of treatments, Furthers studies are contemplated.

Perfusion Index: A Noninvasive Tool for Clinical Decision in Neonates with Suspected Sepsis?

2018 ◽  
Vol 13 (03) ◽  
pp. 247-251
Author(s):  
Alessandro Perri ◽  
Giovanni Barone ◽  
Anthea Bottoni ◽  
Eloisa Tiberi ◽  
Enrico Zecca ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Clinical Signs ◽  
Perfusion Index ◽  
Control Group ◽  
P Value ◽  
Case Group ◽  
C Reactive Protein ◽  
Suspected Sepsis ◽  
Suspected Infection ◽  
Reactive Protein

Aim This article aims to assess whether perfusion index is significantly different in infants with positive C-reactive protein and/or positive cultures compared with a control group. Methods This was a prospective observational cohort study. Perfusion index was evaluated in 80 neonates at the start of antibiotic therapy for suspected sepsis. Antibiotic therapy was started based on the antenatal history or the presence of clinical signs of sepsis such as hypo/hyperthermia, feed intolerance, lethargy, hypotonia, irregular cardiac rhythms, bradycardia, cyanosis, apnea, respiratory distress, and metabolic acidosis. A case group of 23 neonates with abnormal C- reactive protein (> 10 mg/L) and/or positive cultures (blood, liquor, or bronchoalveolar lavage cultures) was compared with a control group of 23 neonates. Results Cases (mean gestational age [GA], 33 ± 5) and controls (mean GA, 33 ± 5) were matched according to the following criteria: GA (±2 weeks), postmenstrual age (±2 weeks), early (< 72 hours), or late (> 72 hours) onset of suspected infection. Mean perfusion index was 0.8 ± 0.3 in the case group and 1.2 ± 0.4 in the control group; p-value of < 0.001. Conclusions Perfusion index can be considered a noninvasive, reproducible, and easy-to-apply tool for early diagnosis of a neonatal acute inflammation in course of sepsis.

scholarly journals Association of Serum C-reactive Protein in Preeclampsia and its Effect on Fetal Birth Weight – A Case Control Study

2017 ◽  
Vol 31 (2) ◽  
pp. 75-80 ◽  
Author(s):  
Shahanaj Sharmin ◽  
Shahanara Chy ◽  
Diadrul Alam ◽  
Nasreen Banu ◽  
Fahmida Rashid ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Birth Weight ◽  
Pregnant Women ◽  
Case Control Study ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Mean ◽  
Control Study

Objective(s): The aim of this study was to evaluate the association of serum C-reactive protein (CRP) in preeclampsia (PE) and its effect on fetal birth weight.Materials and methods: This case control study was conducted in Chittagong Medical College Hospital, Bangladesh, from July 2013 to June 2014. Study population was pregnant women of third trimester with preeclampsia (case group) and normal blood pressure (control group). The maternal serum C-reactive protein (CRP) levels were measured by immune turbidometric assay between 32 weeks to term. The women were divided into three groups: mild PE, severe PE (according to ACOG criteria) and normal healthy group. The value of CRP and its correlation with birth weight was compared between groups.Results: One hundred and fifty (150) pregnant women were analyzed. Among them 50 were case and 100 control. There was no difference between age of the patients of both groups. The mean systolic blood pressure was 148.40 ± 12.35 mm Hg in case and 122.15 ± 6.44 mmHg in control group. The mean diastolic blood pressure was 100.00 ± 9.74 mmHg in case and 74.05 ± 5.97 mmHg for the control. The systolic and diastolic blood pressure was significantly higher in preeclamptic group (P < 0.000). C-reactive protein was 10.28 ± 7.25 mg/ mL in mild PE and 10.94 ± 6.32 mg/mL in severe PE and 3.45 ± 1.71 mg/mL in normotensive group, which was significantly higher in case than control group (P = 0.000). Preeclamptic women delivered at a significantly shorter gestational age than normal pregnant women. Mean gestational age during delivery for the case group and control group was 39.02 ± 1.6 and 39.58 ± 0.8 weeks respectively. Mean birth weight in PE (2.52 ± 0.42 kg) was significantly lower than normal pregnancies (2.88 ± 0.29 kg). The sensitivity and specificity of CRP were 68% and 98% respectively. Multiple regression analysis showed that there is a strong association between CRP levels and PE and birth weight.Conclusion: This small study showed that in case group CRP was raised in 68% cases which is much higher in comparison to healthy control group where CRP was high only in 2% cases. High CRP has association with low birth weight. Therefore, CRP may be used as cost effective investigation to identify the risk of preeclampsia and its effect on fetal birth weight.Bangladesh J Obstet Gynaecol, 2016; Vol. 31(2) : 75-80

scholarly journals Association between Serum C-reactive Protein and Pre-eclampsia

2021 ◽  
Vol 15 (2) ◽  
pp. 58-61
Author(s):  
Sanjoy Kumar Das ◽  
Shafeya Khanam ◽  
Rajib Kumar Roy ◽  
Samiya Alam ◽  
Tapan Kumar Roy ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Gestational Age ◽  
Maternal Serum ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Blood Pressures ◽  
Serum Crp

Among the common disorders of pregnancy, Pre-eclampsia is important one which causes significant maternal and perinatal morbidity and mortality. Its incidence is still high in the developing countries. The triad of high blood pressure, edema and albuminuria is neither specific nor sensitive enough; therefore, a reliable biochemical marker is needed to solve the problem. C-reactive protein(CRP), a marker of tissue damage and inflammation, is elevated in serum in overt preeclampsia. The present study is aimed to explore the association of high maternal serum C-reactive protein (CRP) level with preeclampsia and correlation with the severity of pre-eclamptic process. A total of 60 pregnant women constituting 30 pre-eclamptic (case) and 30 normal (control) pregnant women in the third trimester were enrolled in this study. Both the groups were matched for their age, parity and other baseline characteristics. More than three quarters (76.70%) of the case group exhibited raised serum CRP, which was 20% in control group (p=0.001). CRP was elevated about 13 fold higher than that in the normal pregnant women. The mean systolic and diastolic blood pressure were significantly higher in case group (154±12 mm of Hg) vs (107±7 mm of Hg) in control group (p<_0.001) and serum level of CRP bears linear relationship with both systolic and diastolic blood pressures. Preeclamptic women with higher serum CRP level were at a significantly (p<0.001) lower gestational age than control. Twenty two (73.30%) cases had gestational age <37 weeks (p=0.302) and 66.70% control group had gestational age > 37 weeks. The hypothesis of the study was supported by the study findings that maternal CRP concentration was higher in women with preeclampsia and was correlated with disease progression as evidenced by the investigative analysis. Faridpur Med. Coll. J. Jan 2020;15(2): 58-61

scholarly journals Body mass index, serum rheumatoid factor and c-reactive protein among individuals with rheumatoid arthritis in Kano Metropolis

2021 ◽  
Vol 1 (2) ◽  
pp. 59-67
Author(s):  
Isah Suleiman Yahaya
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Mass Index ◽  
Rheumatoid Factor ◽  
Body Mass ◽  
Control Group ◽  
Case Group ◽  
C Reactive Protein ◽  
Percentage Frequency ◽  
Reactive Protein ◽  
The Mean

Background: Rheumatoid arthritis (RA) is becoming a global health menace associated with joints swelling, pain, stiffness, and progressive loss of function of extremities etc. This study aimed at evaluating the Body Mass Index (BMI), Serum Rheumatoid Factor (RF) and C-Reactive Protein (CRP) among RA Patients in Kano Metropolis. Methods: A total of 111 participants comprising 74 Rheumatoid Arthritis patients and 37 apparently healthy controls were recruited for this study. Exactly 29 were males while 44 were females aged between 25 to 75 years. Using standard techniques, BMI was calculated using the weight and height taken from the participants. Blood samples were collected for serum RF and CRP and were analysed using Enzyme linked immunosorbent assay technique. Statistical Package for Social Sciences version 21 was used for the analysis of data. Results: Our findings reveal that, females recorded higher percentage frequency of 45 (60.8%) while males recorded a lower percentage frequency of 29(39.2%) of RA patients with the ratio of 1.55:1, the higher percentage frequencies of 35(47.3%) was observed in overweight BMI patients of between 25- 29.9 kg m-2. The mean serum value of RF was significantly (p = 0.00) higher in case group (4.4 ±1.5 ng/ml) compared with the control group (2.0 ±1.5 ng/ml) and also the mean serum value of CRP was significantly (p = 0.00) higher in case group (13.0 ±5.0 mg/L) compared with the control group (5.5±5.0 mg/L). A significant positive correlation was established between serum RF and CRP (r = 0.48, p=0.00). Conclusion: Our findings show increased RF and CRP in RA case group. Quantitative evaluation of immunological parameter such as RF, CRP and BMI monitoring may aid in proper management of RA patients.

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