High Incidence of Dengue Fever in Karachi and the Benefits of Ultrasound for Diagnosis of Complications

2020 ◽  
Author(s):  
Samia Perwaiz Khan
Keyword(s):  
Pericardial Effusion ◽  
Liver Injury ◽  
Dengue Fever ◽  
Joint Pain ◽  
High Grade ◽  
Ultrasound Scan ◽  
High Grade Fever ◽  
High Incidence ◽  
Laboratory Investigations ◽  
The Common

Background: Dengue fever presentations are from asymptomatic fever to most serious complications. Acute high-grade fever, muscle and joint pain, myalgia, skin rashes, hemorrhage and circulatory shock are the common symptoms. There has been reported increase in number of dengue fever and last few years. Urgent diagnosis is critical to avoid complications like liver injury, cardiomyopathy, pneumonia, orchitis, oophoritis, seizures and encephalopathies. This study aimed to determine the complication caused by dengue fever after the diagnosis by clinical and laboratory investigation by performing ultrasound abdomen and thorax. Methods: In this study one hundred and twenty one (121) patients diagnosed with dengue fever and laboratory investigations done from Jinnah Medical Hospital (JMH) and Pathological & Molecular Laboratories from August to November 2019. Ultrasound of abdomen and thorax was performed for diagnosing complications such as ascites, pleural and pericardial effusion through Xario-100 sonography machine. Results: Out of one hundred and twenty one (121) patients diagnosed with dengue fever forty-three (43) were found to have developed the complications such as ascites, pleural and pericardial effusion by performing ultrasound abdomen and chest. Conclusion: We found 35 % patients with dengue fever complications by ultrasound, which is most convenient diagnostic tool. Therefore, by performing early ultrasound scan of abdomen and thorax in these patients can reduce the risk of morbidity and mortality.

scholarly journals Chikungunya Outbreak from 1952-2019: A Prospective to Cope-Up with this Re-emerging Disease

2020 ◽  
Vol 11 (4) ◽  
pp. 11724-11736
Keyword(s):  
Dengue Fever ◽  
Human Population ◽  
Review Article ◽  
Emerging Disease ◽  
High Grade ◽  
High Grade Fever ◽  
Study Results ◽  
The Family ◽  
Heavy Burden ◽  
The Common

Chikungunya is a mosquito-borne disease caused by the alphavirus that belongs to the family Togaviridae. It was first identified in 1952 when the first outbreak of chikungunya occurred in the Tanganyika. From them, several outbreaks had been taken place around the globe, making a severe threat to the human population. High-grade fever, nausea, and body pain mislead the disease with Dengue fever. Disease effects are long-lasting; the disease is characterized by severe joint pains, which leads to arthralgia. To date, no direct treatment is available for the infection, which puts a heavy burden on society. In this review article, the authors focus on the outbreaks of chikungunya since1952 to 2019 worldwide. The mutations occurred in the proteome of chikungunya. The evolution occurred because of those mutations and their effects on human societies. The study results that the two mutations in the proteome made the species more vulnerable to society. The outbreak study suggests that numerous chikungunya cases had been identified worldwide with the common symptoms that turn severe with these mutations. This study result reveals that scientists and researchers must focus on the disease's intensity and work progressively to find the solution for this emerging disease.

scholarly journals COVID-19 and Dengue infection in Bangladesh: a case of coinfection where hemoptysis as first presentation

2021 ◽  
Author(s):  
Mohammad Ashraful Amin ◽  
Md. Taufiqul Islam ◽  
Ishtiakul Islam Khan ◽  
Zahid Hasan Khan ◽  
Firdausi Qadri ◽  
...  
Keyword(s):  
Dengue Fever ◽  
Sore Throat ◽  
Dengue Infection ◽  
High Grade ◽  
Rt Pcr ◽  
High Grade Fever

Bangladesh recently faced large outbreaks of both COVID-19 and Dengue fever. A 28-year-old woman suffered from symptoms including hemoptysis as first presentation followed by high-grade fever, sore throat, and fatigue. SARS-CoV-2 was confirmed by RT-PCR and also diagnosed dengue later on.COVID-19 and dengue fever could be a harmful combination.

CASE REPORT ON DENGUE ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS- A RARE PRESENTATION.

2021 ◽  
pp. 7-8
Author(s):  
K. Shivaraju ◽  
Manideepa Pogaku ◽  
Mandhala Saikrishna
Keyword(s):  
Dengue Fever ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Supportive Therapy ◽  
Hemorrhagic Fever ◽  
Severe Form ◽  
High Grade Fever ◽  
Rare Presentation ◽  
Life Threatening ◽  
The Common

Dengue fever in its severe form has signicant morbidity and mortality worldwide. Apart from the common complication of dengue fever, infection induced HLH is a rare and life-threatening complication associated with the viral infection. Here we are presenting a case of 28 years old male with no comorbidities and complains of high-grade fever, myalgia, nausea and vomiting, black stools from 5 days. Based on all investigations patient was diagnosed with hemophagocytic lymphohistiocytosis secondary to dengue hemorrhagic fever. Then treated with appropriate medications and supportive therapy, discharged, and advised follow-up on OPD basis.

scholarly journals Laboratory Approach to the Management of Clinical Emergencies: A Diagnostic Series

2009 ◽  
Vol 1 (01) ◽  
pp. 027-030
Author(s):  
Swati Gupta
Keyword(s):  
Abdominal Pain ◽  
Chest Pain ◽  
Occupational Exposure ◽  
Acute Abdominal Pain ◽  
Road Traffic ◽  
Acute Chest Pain ◽  
Loss Of Consciousness ◽  
High Grade ◽  
High Grade Fever ◽  
Laboratory Investigations

ABSTRACTThis article emphasizes on the laboratory investigations that may play a significant role in the prompt management of the patient. Hence, other conditions where laboratory investigations will not play a major role are not included in this article. An attempt has been made to highlight certain issues wherein we can prevent inadvertent ordering of tests to minimize the burden on the overworked emergency laboratory, without compromising patient care. The conditions that will be dealt here include: acute chest pain, acute abdominal pain, road traffic injuries, acute respiratory distress, high grade fever, vomiting, loss of consciousness, poisoning and laboratory accidents, and lastly occupational exposure to potential biological hazards.

scholarly journals “DENGUE ENCEPHALITIS – A RARE MANIFESTATION OF DENGUE FEVER.”

2020 ◽  
pp. 1-2
Author(s):  
Showkat Nazir Wani ◽  
Anish Garg Atul Kaushik ◽  
Atul Kaushik ◽  
Naveen Tariq
Keyword(s):  
Cerebrospinal Fluid ◽  
Differential Diagnosis ◽  
Dengue Fever ◽  
High Grade ◽  
High Grade Fever ◽  
Altered Sensorium ◽  
Mri Brain ◽  
Northern India ◽  
Rare Manifestation ◽  
History Of

We report a case of dengue fever with features of encephalitis from Northern India. A 22 years female presented with history of high-grade fever with chills for 2 days followed by altered sensorium and MRI brain, revealed characteristic changes consistent with Encephalitis with hemorrhage mainly involving the bilateral thalami. The diagnosis of dengue was confirmed by the presence of dengue antigen in the serum and the presence of dengue antibodies in the serum as well as cerebrospinal fluid. Dengue is not primarily a neurotropic virus and encephalopathy is an uncommon finding in dengue. This case explains the importance of considering dengue encephalitis as the differential diagnosis of fever with altered sensorium, especially in countries like India where dengue is rampant.

scholarly journals A Survey on Awareness of Dengue Among Public

2019 ◽  
Vol 10 (2) ◽  
pp. 1218-1221
Author(s):  
Sai Sandhya T ◽  
Geetha RV ◽  
Lakshmi Thangavelu
Keyword(s):  
Dengue Fever ◽  
Muscle Pain ◽  
Joint Pain ◽  
Online Survey ◽  
Preventive Measures ◽  
Mosquito Control ◽  
Viral Disease ◽  
Control Measures ◽  
Stagnant Water ◽  
The Common

Dengue fever is endemic in tropical and subtropical areas. It is a non-contagious disease. It is a mosquito-borne viral disease which is spread by the female Ades mosquito. The mosquito breeds in the stagnant water. The symptoms of dengue include a headache, high fever, rashes, severe joint pain and muscle pain. Dengue fever lasts about 3-10days. There is no vaccination for dengue fever. Only preventive measures can be taken to avoid the disease. An online survey was conducted. The participants were asked to take the survey, and the responses were collected. The results are statistically analysed. From the survey, the results are obtained.66% of them said that dengue is transmissible.33% of them are unaware of the common symptoms of dengue. 79% of them say that there are no specific vaccinations for dengue. 71% of the participants say that mosquito breeds in stagnant water. In conclusion, although the awareness regarding dengue and mosquito control measures was quite high, more emphases should be laid on putting this knowledge into practice.

scholarly journals SARS-CoV-2 infection in an infant with non-respiratory manifestations: a case report

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Muhammad Adel ◽  
Ahmed Magdy
Keyword(s):  
Computed Tomography ◽  
Aplastic Anemia ◽  
Rt Pcr ◽  
Positive Real ◽  
Case Presentation ◽  
Chest Computed Tomography ◽  
High Incidence ◽  
Laboratory Investigations ◽  
High Index Of Suspicion ◽  
Specific Symptoms

Abstract Background Coronavirus disease (COVID-19) presents in children usually with less severe manifestations than in adults. Although fever and cough were reported as the most common symptoms, children can have non-specific symptoms. We describe an infant with aplastic anemia as the main manifestation. Case presentation We describe a case of SARS-CoV-2 infection in an infant without any respiratory symptoms or signs while manifesting principally with pallor and purpura. Pancytopenia with reticulocytopenia was the predominant feature in the initial laboratory investigations, pointing to aplastic anemia. Chest computed tomography surprisingly showed typical findings suggestive of SARS-CoV-2 infection. Infection was later confirmed by positive real-time reverse transcription polymerase chain reaction assay (RT-PCR) for SARS-CoV-2. Conclusions Infants with COVID-19 can have non-specific manifestations and a high index of suspicion should be kept in mind especially in regions with a high incidence of the disease. Chest computed tomography (CT) and testing for SARS-CoV-2 infection by RT-PCR may be considered even in the absence of respiratory manifestations.

Fulminant varicella hepatitis: a rare but lethal cause of abdominal pain

2021 ◽  
Vol 14 (9) ◽  
pp. e244081
Author(s):  
Christopher Fang ◽  
Junice Wong ◽  
Wei Wen Ang
Keyword(s):  
Abdominal Pain ◽  
Hepatitis A ◽  
Case Reports ◽  
Antibody Testing ◽  
Salient Points ◽  
Vesicular Rash ◽  
History Of ◽  
Laboratory Investigations ◽  
The Common ◽  
Upper Abdominal

An 81-year-old woman with no history of immunocompromise presented with 2 days of upper abdominal pain associated with nausea. On arrival, her physical examination was unremarkable apart from mild epigastric and right hypochondriac tenderness, and laboratory investigations were unremarkable apart from mild thrombocytopenia and transaminitis. A CT scan performed on the day of admission revealed a tiny 0.3 cm stone in the common bile duct, with no upstream dilatation. On day 2 of admission, she developed a vesicular rash and with acutely worsening transaminitis. She deteriorated rapidly and demised from complications of acute liver failure within the next 24 hours. The diagnosis of varicella was confirmed with antibody testing. Fulminant varicella hepatitis is an extremely rare and lethal condition with only a handful of reported cases in the current literature. We aim to share our clinical experience and summarise the salient points from existing case reports.

Eosinophilic lung disease as a sequela of MSSA pneumonia

2021 ◽  
Vol 14 (3) ◽  
pp. e239304
Author(s):  
Syed Muhammad Zubair ◽  
Muhammad Zaid Hamid Hussain ◽  
Ali Bin Sarwar Zubairi
Keyword(s):  
Emergency Department ◽  
Staphylococcus Aureus ◽  
Bronchoalveolar Lavage ◽  
Complete Resolution ◽  
Lung Diseases ◽  
Disease Process ◽  
High Grade ◽  
Shortness Of Breath ◽  
High Grade Fever ◽  
Rare Group

Eosinophilic lung diseases are a rare group of lung disorders with multiple known and unknown aetiologies and the diagnosis is often challenging. We present a case of a young man who was admitted with pneumonia due to methicillin-sensitive Staphylococcus aureus and was discharged on antibiotics. He presented to the emergency department approximately 2 weeks after discharge with high-grade fever, cough and shortness of breath associated with serum and bronchoalveolar lavage eosinophilia. He was then treated with steroids with complete resolution of disease process.

scholarly journals The Frequent Adiponutrin (PNPLA3) Variant p.Ile148Met Is Associated with Early Liver Injury: Analysis of a German Pediatric Cohort

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Marcin Krawczyk ◽  
Roman Liebe ◽  
Ina B. Maier ◽  
Anna Janina Engstler ◽  
Frank Lammert ◽  
...  
Keyword(s):  
Liver Injury ◽  
Serum Glucose ◽  
Normal Weight ◽  
Study Cohort ◽  
Overweight Children ◽  
Entire Study ◽  
Metabolic Traits ◽  
Glucose Levels ◽  
The Common ◽  
German Children

Introduction.The common adiponutrin (PNPLA3) variant p.Ile148Met is associated with liver injury. Here, we investigate the association of this polymorphism with hepatic and metabolic traits in a pediatric cohort.Patients and Methods.The study cohort comprised 142 German children (age 5–9 years, 98 overweight, 19 children with NAFLD).Results.Overweight children presented with increased serum ALT (P=0.001) and GGT (P<0.001) activities. ALT activities differed significantly (P=0.02) between carriers of differentPNPLA3genotypes in the entire study cohort, in normal weight children (P=0.02) and in children younger than 7 years (P=0.02). Carriers of the prosteatoticPNPLA3genotype p.148Met/Met displayed higher ALT activities as compared to children with the frequent genotype p.148Ile/Ile (P=0.01). The BMI was however a stronger predictor of ALT activities compared to thePNPLA3genotype (P<0.001andP=0.06, resp.). The variant was associated with increased serum glucose levels (P=0.01) and HOMA index (P=0.02) in carriers of the p.148Ile/Met genotype but did not affect other metabolic traits or the presence of NAFLD.Discussion.The frequentPNPLA3variant p.Ile148Met is associated with serum ALT activities already at a young age.

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