scholarly journals Chikungunya Outbreak from 1952-2019: A Prospective to Cope-Up with this Re-emerging Disease

2020 ◽  
Vol 11 (4) ◽  
pp. 11724-11736

Chikungunya is a mosquito-borne disease caused by the alphavirus that belongs to the family Togaviridae. It was first identified in 1952 when the first outbreak of chikungunya occurred in the Tanganyika. From them, several outbreaks had been taken place around the globe, making a severe threat to the human population. High-grade fever, nausea, and body pain mislead the disease with Dengue fever. Disease effects are long-lasting; the disease is characterized by severe joint pains, which leads to arthralgia. To date, no direct treatment is available for the infection, which puts a heavy burden on society. In this review article, the authors focus on the outbreaks of chikungunya since1952 to 2019 worldwide. The mutations occurred in the proteome of chikungunya. The evolution occurred because of those mutations and their effects on human societies. The study results that the two mutations in the proteome made the species more vulnerable to society. The outbreak study suggests that numerous chikungunya cases had been identified worldwide with the common symptoms that turn severe with these mutations. This study result reveals that scientists and researchers must focus on the disease's intensity and work progressively to find the solution for this emerging disease.

Author(s):  
Samia Perwaiz Khan

Background: Dengue fever presentations are from asymptomatic fever to most serious complications. Acute high-grade fever, muscle and joint pain, myalgia, skin rashes, hemorrhage and circulatory shock are the common symptoms. There has been reported increase in number of dengue fever and last few years. Urgent diagnosis is critical to avoid complications like liver injury, cardiomyopathy, pneumonia, orchitis, oophoritis, seizures and encephalopathies. This study aimed to determine the complication caused by dengue fever after the diagnosis by clinical and laboratory investigation by performing ultrasound abdomen and thorax. Methods: In this study one hundred and twenty one (121) patients diagnosed with dengue fever and laboratory investigations done from Jinnah Medical Hospital (JMH) and Pathological & Molecular Laboratories from August to November 2019. Ultrasound of abdomen and thorax was performed for diagnosing complications such as ascites, pleural and pericardial effusion through Xario-100 sonography machine. Results: Out of one hundred and twenty one (121) patients diagnosed with dengue fever forty-three (43) were found to have developed the complications such as ascites, pleural and pericardial effusion by performing ultrasound abdomen and chest. Conclusion: We found 35 % patients with dengue fever complications by ultrasound, which is most convenient diagnostic tool. Therefore, by performing early ultrasound scan of abdomen and thorax in these patients can reduce the risk of morbidity and mortality.


Author(s):  
Mohammad Ashraful Amin ◽  
Md. Taufiqul Islam ◽  
Ishtiakul Islam Khan ◽  
Zahid Hasan Khan ◽  
Firdausi Qadri ◽  
...  

Bangladesh recently faced large outbreaks of both COVID-19 and Dengue fever. A 28-year-old woman suffered from symptoms including hemoptysis as first presentation followed by high-grade fever, sore throat, and fatigue. SARS-CoV-2 was confirmed by RT-PCR and also diagnosed dengue later on.COVID-19 and dengue fever could be a harmful combination.


2012 ◽  
Vol 19 (05) ◽  
pp. 688-694
Author(s):  
SHAHBAZ BAIG ◽  
ABDUL SATTAR ◽  
SHAHBAZ AHMAD

Dengue infection is one of the most common mosquito borne viral diseases of public health significance. It has been identifiedas a clinical entity since 1780. Dengue is caused by viruses that are small enveloped viruses and are members of the family Flaviviridae genusFlavivirus. It is a vector borne disease and is a global health threat. In Pakistan first epidemic was reported in 1994 and since then cases arereported every years. This year dengue infection raised the number of patients and increased the deaths. Objectives: To assess theknowledge, attitude and practices of the people regarding Dengue fever. Study Design: Cross Sectional Study. Setting: Aziz Bhatti Town,Lahore. Duration of Study: One Month. Material and methods: Convenient sampling. The investigator himself collected the information fromthe sample under study. First of all, an informed consent was obtained from the respondent under study and secrecy of the information wasensured. Data was entered and cleaned using Epi Data version 3. Data was analyzed using Epi info version 3.5.1. Results: Out of 41respondent families only 2.4% did not hear about dengue fever while 97.6% respondents were well aware of the dengue fever. 80.5% wereaware of high grade fever in dengue fever, 73.2% were aware of associated body aches. 92.7% were aware that dengue fever is preventable.95.1% were using mats, coils & repellents while 2.4% were using smoke of wet wood.36.6% were covering the water containers. 75.6% werekeeping environment dry and clean.68.3% were having opinion that they will consult GP in case of illness.85.4% told that TV/Radio were thesource of above mentioned knowledge while 9.8% doctor and 4.9% got information through newspapers. only 4.9% respondents were havingopinion that government had sprayed for dengue fever.7.3% families experienced the patient of dengue fever in their family. Conclusions: Inthis study the results are the almost same with little variations as found in other studies. The knowledge, attitude and practice are the almostsame in every studies with little variation. Majority of the families were well aware of dengue fever.


Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Gursharan Kaur ◽  
Amandeep Singh ◽  
Raj Kumar Narang ◽  
Gurmeet Singh

Background: Coronavirus belongs to the phylum- incertae sedis, order- nidovirales, family- coronaviridae, and the subfamily-orthocononaviridae. Coronaviruses spring up from the family of viruses that can cause malady such as the common cold, fever, shortness of breath, aches, chills, loss of smell, etc. Objective: As we all know coronavirus has affected the whole world and many of the affected patients has led to death. As the prevalence of this disease has raised, many myths has also originated like the effect of temperature on the virus; is this virus surely killed by effect of temperature? Is the effect of this virus is more on the old age patients? In the presented compilation, we have tried to exposé the actual reality behind these all myths and also tried to find the morphologic difference of coronavirus from the other viruses. Methods: The recent updates on this virus have been obtained from search engines like Pub med and Google scholar, by using COVID-19, coronavirus, Pandemic corona keywords. Results: After a huge search on the temperature effect on this disease; it was evident that there is no effect of temperature on the coronavirus. Due to the immunity factor, it showed its worst effect on old age people in many countries. Conclusion: The structure, symptoms and incubation period of coronavirus have been given in this review article. We have summarized how the coronavirus is different from others and the effects of temperature and old age have been also discussed.


2021 ◽  
pp. 7-8
Author(s):  
K. Shivaraju ◽  
Manideepa Pogaku ◽  
Mandhala Saikrishna

Dengue fever in its severe form has signicant morbidity and mortality worldwide. Apart from the common complication of dengue fever, infection induced HLH is a rare and life-threatening complication associated with the viral infection. Here we are presenting a case of 28 years old male with no comorbidities and complains of high-grade fever, myalgia, nausea and vomiting, black stools from 5 days. Based on all investigations patient was diagnosed with hemophagocytic lymphohistiocytosis secondary to dengue hemorrhagic fever. Then treated with appropriate medications and supportive therapy, discharged, and advised follow-up on OPD basis.


2020 ◽  
pp. 1-2
Author(s):  
Showkat Nazir Wani ◽  
Anish Garg Atul Kaushik ◽  
Atul Kaushik ◽  
Naveen Tariq

We report a case of dengue fever with features of encephalitis from Northern India. A 22 years female presented with history of high-grade fever with chills for 2 days followed by altered sensorium and MRI brain, revealed characteristic changes consistent with Encephalitis with hemorrhage mainly involving the bilateral thalami. The diagnosis of dengue was confirmed by the presence of dengue antigen in the serum and the presence of dengue antibodies in the serum as well as cerebrospinal fluid. Dengue is not primarily a neurotropic virus and encephalopathy is an uncommon finding in dengue. This case explains the importance of considering dengue encephalitis as the differential diagnosis of fever with altered sensorium, especially in countries like India where dengue is rampant.


1964 ◽  
Vol 4 (2) ◽  
pp. 332-355 ◽  
Author(s):  
Khurshid Haroon ◽  
Yasmin Azra Jan

Very little of the intense interest and activity in the field of family planning in Pakistan has come up in the form of publications. Since the formation of the Family Planning Association of Pakistan in 1953 and the initiative of the government in promoting a national family-planning programme in its Second Five-Year Plan, relatively few reports have been printed. Most of what has been written in Pakistan about family planning has either been reported at conferences abroad or published in foreign journals, or submitted as graduate dissertations at universities within the country and abroad1. While numerous papers presented at conferences in Pakistan have been given limited circulation in mimeographed form2, much of the preliminary data, emanating from most of the action-research projects in progress, are held up till substantive demographic changes are measured and approaches evaluated accordingly.


Author(s):  
Rakshith . ◽  
Shivakumar . ◽  
Sreeharsha . ◽  
Divyasree .

The core principles in Ayurveda give prime importance to Agni, Prakriti, Ahara (food) and Vihara (lifestyle) in maintaining health. Present era people are scheduled to one or the other works due to which they are following unrightful food and habits which lead the manifestation of one of the common disorder which troubles person a lot - Amlapitta. By excess “Hurry, Worry and Curry” GIT disorders are the most common, not only affecting physical health but also psychological and social health. Amlapitta is one of that and it is a burning problem of the whole World. Amalpitta is composed of word Amla and Pitta. Amlapitta is a very common disease caused by Vidagdha Pitta with features like Amlodgara, Tiktodgara, Hrit, Kantha Daha etc. Pathya recommended in Amlapitta are Yava, Godhuma, Purana Shali, Mudga Yusha, Lajasaktu etc. Apathya recommended in Amlapitta are Navanna, Avidugdha, Masha, Kulattha, Dadhi and etc. So this present review article throws light on Pathya (conducive) and Apathya (non conducive) in Amlapitta.


2020 ◽  
Vol 12 (17) ◽  
pp. 17374-17379
Author(s):  
W.G.D. Chathuranga ◽  
K. Kariyawasam ◽  
Anslem De Silva ◽  
W.A.Priyanka P. De Silva

We investigated the impact of dipteran predators on eggs in foam nests of the Common Hour-glass Tree Frog Polypedates cruciger Blyth, 1852 (Anura: Rhacophoridae) in central Sri Lanka.  Foam nests (n=24) of P. cruciger were examined at their natural breeding habitats and infected (n=8) and uninfected spawns (n=16) were identified.  Emerging tadpoles were collected in a water container hung under each spawn and the average number of tadpoles (N) hatched from infected spawns (N=0) was compared with that of uninfected spawns (N=354 ± 67).  Three severely infected spawns were brought to the laboratory and the fly larvae were reared until they metamorphosed to adults.  Morphological and molecular identification of the flies confirmed them as belonging to Caiusa testacea Senior-White, 1923 of the family Calliphoridae.  The infected spawns were completely destroyed and an estimated average of 400 P. cruciger eggs per spawn were lost.  The results revealed a high impact of Caiusa testacea on egg and embryo mortality of P. cruciger.


Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1609
Author(s):  
Lutfun Nahar ◽  
Shaymaa Al-Majmaie ◽  
Afaf Al-Groshi ◽  
Azhar Rasul ◽  
Satyajit D. Sarker

Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L. (Fam: Rutaceae) but also distributed in various species of the genera Boenminghausenia, Clausena and Ruta. The distribution of these compounds appears to be restricted to the plants of the family Rutaceae. To date, there have been a considerable number of bioactivity studies performed on coumarins 1 and 2, which include their anticancer, antidiabetic, antifertility, antimicrobial, antiplatelet aggregation, antiprotozoal, antiviral and calcium antagonistic properties. This review article presents a critical appraisal of publications on bioactivity of these 3-prenylated coumarins in the light of their feasibility as novel therapeutic agents and investigate their natural distribution in the plant kingdom, as well as a plausible biosynthetic route.


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