scholarly journals The Effect of Curcumin On Plasma Histamine Level, PEF Variation and Length of Stay of Patients With Acute Exacerbation Asthma

2018 ◽  
Vol 38 (2) ◽  
pp. 100-108
Author(s):  
Lydia Arista Sutedjo ◽  
Suradi Suradi ◽  
Ana Rima Setijadi
Keyword(s):  
Treatment Group ◽  
Length Of Stay ◽  
Acute Exacerbation ◽  
Inflammatory Marker ◽  
Histamine Level ◽  
Control Group ◽  
Plasma Histamine ◽  
Significant Difference ◽  
Plasma Histamine Level ◽  
And Control

Introduction: Inflammation in asthma occured in airway especially in submucous layer, and involve eosinophil, neutrophil, lymphocytes T, epitheliat cel, basophil, mast cell, and lymphocytes B. Inflammatory cells produce inflammatory mediators (histamine, leucotrienes, and prostanoid), cytokines, and chemokines that can cause bronchocontriction. This study was conducted to determine and prove the effect of curcumin as adjunctive therapy in acute exacerbation asthma. Curcumin is expected to increase the quality therapy of acute exacerbation asthma. The effect of curcumin is known wiith evaluate plasma histamine level, PEF variation, and length of stay of patient with acute exacerbation asthma. Methods: This study is a quasi experimental study with pretest and posttest design. Sampel of study is 30 patients hospitalizes acute exacerbation asthma in Moewardi hospital and Sohadi Prijonegoro Sragen hospital in August 2016 until september 2016. The subject was taken with concecutive random sampling. Independent variable is curcumin 4x550 mg and dependent variables are plasma histamin level, PEF variation, and length of stay. Result: There is no significant difference (P=0.462) of decreasing plasma histamine level between treatment group 3,988±2,739 ng/ml and control group 3,376±1,606 ng/ml. There is no significant difference (P=0.501) of PEF variation between treatment group 28,126±7,886% and control group 30,400±10,217%. There is no significant difference (P=0.936) of length of stay between treatment group perlakuan 6,333±2,193 days and control group 6,400±2,292 days. Conclusion: Giving curcumin in acute exacerbation asthma while hospitalized didn’t reduce inflammatory marker plasma histamin, PEF variation, and length of stay. (J Respir Indo 2018; 38(2): 100-8)

scholarly journals Effects of Mangosteen pericarp Extract to Clinical Improvements, The Plasma Level of IL-6 and Malondialdehyde in Acute Exacerbation of COPD Patients

2018 ◽  
Vol 38 (3) ◽  
pp. 164-172
Author(s):  
Khilyatul Baroroh ◽  
Suradi Suradi ◽  
Ade Rima
Keyword(s):  
Treatment Group ◽  
Plasma Level ◽  
Length Of Stay ◽  
Acute Exacerbation ◽  
Clinical Symptoms ◽  
Control Group ◽  
Chronic Obstructive ◽  
Copd Patients ◽  
Significant Difference ◽  
And Control

Background: Amplification of inflammation in acute exacerbation of chronic obstructive pulmonary disease (COPD) increases inflammatory mediators and oxidative stress in the airways, pulmonary and systemic circulation that are characterized by increased plasma level of IL-6 and MDA, resulting in worsening of clinical symptoms. Xanthones in mangosteen pericarp have anti-inflammatory and antioxidant effects, potentially as an adjuntive therapy in acute exacerbations of COPD. Methods: The aim of this study was to determine the effect of mangosteen pericarp extract to clinical improvements, plasma level of IL-6 and MDA of acute exacerbation COPD patients. A clinical trial of experimental with pretest and posttest was conducted on 34 acute exacerbation of COPD patients in Dr. Moewardi Hospital Surakarta and Dr. Ario Wirawan Lung Hospital Salatiga from April until May 2016. The sample was taken by consecutive sampling. Subjects were divided by randomized double blind technique into the treatment group (n=17) received mangosteen pericarp extract 2x1100mg/day and control group (n = 17) received placebo. Clinical improvements were measured in CAT score and length of stay. CAT score, plasma level of IL-6 and MDA were measured on admission and at discharge. Length of stay based on the number of days of care in hospitals. Results: There was significant difference (p=0,011) towards decreased of IL-6 plasma level between treatment group (-2,17 ± 3,46 pg/ mL) and control group (+1,67 ± 6,81 pg/mL). There were no significant difference towards decreased of length of stay (p=0,34) between treatment group (4,12 ± 1,54 days) and control group (5,24 ± 2,49 days), towards decreased of CAT score (p=0,252) between treatment group (-19,18 ± 3,96) and control group (-18,24 ± 2,75), and towards decreased of MDA plasma level (p=0,986) between treatment group (+0,03 ± 0,36μmol/L) and control group (+0,35 ± 1,58). Conclusions: The addition of mangosteen pericarp extract 2x1100mg/day during hospitalization was significantly lowered plasma levels of IL-6, but were not significant in lowering the CAT score, shortening the length of stay, and reducing the increase in plasma level of MDA.

scholarly journals Pengaruh suplementasi Zn terhadap perubahan indeks TB/U anak stunted usia 24-36 bulan

2017 ◽  
Vol 5 (2) ◽  
pp. 98-104
Author(s):  
Dewi Pertiwi Dyah Kusudaryati ◽  
Siti Fatimah Muis ◽  
Laksmi Widajanti
Keyword(s):  
Treatment Group ◽  
Dietary Intake ◽  
Child Growth ◽  
Control Group ◽  
Control Group Design ◽  
Dietary Allowance ◽  
Significant Difference ◽  
Before And After ◽  
And Control ◽  
Height For Age

Background : Zn supplementation on stunted children in multiple research get the result inconsistent concerning the effect of Zn on children’s growth.Objective : To examine the effect of Zn supplementation to the change in height for index among stunted children age between 24-36 months.Methods: The research design is randomized pretest posttest control group design. The total of thirty six stunted children are divided into two groups. The treatment group is received syrup with 20 mg ZnSO4 twice a week for three months. The control group received placebo without Zn. Height for age z score (HAZ) on WHO Child Growth 2006 is used to measure height for age index while dietary intake and infection diseases are used as confounding variables.Result : There is significant difference in HAZ before and after supplementation at treatment group (p<0.001) and control group (p<0.001). There is a significant difference of the change in HAZ between the treatment group and control group (p=0.006). Percentage Achievement of Energy, Protein, and Zn Dietary Allowance have significant difference between the treatment group and control group (p=0.009; p<0.001; p<0.001, respectively). The change in HAZ, Percentage Achievement of Energy, Protein, and Zn Dietary Allowance are higher in treatment group than control group. Duration of diarrhea (p=0.045) and morbidity (p=0.019) are lower in treatment group than control group. Conclusion : Zn Supplementation among stunted children have significant effect on the change in HAZ, dietary intake, and infection.

scholarly journals Ganji Formulation for Patients with Hepatocellular Carcinoma Who Have Undergone Surgery: A Multicenter, Randomized, Double-Blind, Controlled Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Jing-Hao Zhang ◽  
Chao Zheng ◽  
Xiao-Jun Zhu ◽  
Xin Zhang ◽  
Zhi-Jun Hou ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Treatment Group ◽  
Liver Resection ◽  
Controlled Trial ◽  
Disease Free Survival ◽  
Control Group ◽  
Double Blind ◽  
Local Ablation ◽  
Significant Difference ◽  
And Control

Objective. To ascertain the efficacy and safety of Ganji Formulation (GF) for patients with Hepatocellular carcinoma (HCC) who had undergone surgery. Materials and Methods. A total of 262 HCC patients who had undergone liver resection, local ablation, or transcatheter arterial chemoembolization (TACE) were divided randomly into the treatment group and control group. The former was treated with GF and the later with placebo, both for 6 months. The primary endpoint was overall survival (OS). Second endpoints were disease-free survival (DFS) or time to disease progression (TTP). Results. OS of the treatment group was significantly longer than that of the control group (P < 0.05). Subgroup analysis showed that, for patients who received TACE, the TTP was significantly longer in the treatment group than in the control group (P < 0.05). However, for patients who underwent liver resection or local ablation, there was no significant difference in DFS between the two groups (P > 0.05). Conclusion. GF could improve postoperative cumulative survival and prolong the TTP. This clinical trial number is registered with ChiCTR-IOR-15007349.

scholarly journals Teaching English Vocabulary with Greek or Latin Roots to Iranian EFL Students by PLS Sequential Structures

2020 ◽  
Vol 8 (4) ◽  
pp. p73
Author(s):  
Abolfazl Shirban Sasi
Keyword(s):  
Treatment Group ◽  
Teaching Method ◽  
English Word ◽  
Control Group ◽  
Teaching English ◽  
Control Group Design ◽  
Significant Difference ◽  
Efl Students ◽  
The Mean ◽  
And Control

PLS is a newly developed language teaching method which predominantly applies imaginative and random usage of pictures. The present paper explains and reports the application of a PLS technique in teaching English vocabulary with Greek or Latin roots to Iranian EFL learners. A pretest-posttest control-group design was used to investigate the effects of this sequential structures technique. Participants were intermediate level EFL students in two branches of the same language institute in Tehran (N = 94, p ? 0.05). The subjects were randomly assigned into two groups of treatment and control. The experiment lasted for seven one-hour lessons held in successive sessions in three weeks during which 35 Greek and Latin roots were taught with at least three English word examples. For the research instrument, the students were administered a 35-item multiple-choice vocabulary exam for the pre and post tests prior to and immediately after the teaching phase. Consequently, an independent sample T-test was used to examine the outcome of the experiment. At p = .009, the statistical test revealed a significant difference in the gain scores between the two groups. Also, the mean vocabulary gain score of 7.23 for the treatment group as opposed to the mean of 5.35 for the control group illustrated the relative more L2 vocabulary intake for the treatment group.

scholarly journals PENGARUH PEMBERIAN JUS LIDAH BUAYA TERHADAP KADAR GLUKOSA DARAH PUASA PADA WANITA PREDIABETES

2012 ◽  
Vol 1 (1) ◽  
pp. 107-114 ◽  
Author(s):  
Putri Sukma Pertiwi ◽  
Hesti Murwani Rahayuningsih
Keyword(s):  
Treatment Group ◽  
Fasting Blood Glucose ◽  
Aloe Vera ◽  
Wilcoxon Test ◽  
Control Group ◽  
Food Record ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
And Control

Background: Prediabetes is a condition which pioneers of DM. Diet management is the effective method to decrease fasting blood glucose (FBG) level. One of plant that correlates decreasing FBG level is Aloe vera. The purpose of  the study was to prove the effects of Aloe vera on FBG level in prediabetes women. Method: This study was quasi experiment with pre test-post test design. The subjects were people in Tlogosari Kulon Semarang who taken by consecutive sampling. Total subjects were 26 people which was divided in 2 groups. The treatment group was given juice Aloe vera 150 gram per day during 14 days and control group was not given juice Aloe vera. FBG level was measured before and after intervention using spectrofotometri method. During intervention, both of group recorded food intake using food record and food recall. Data was analyzed by Independent sample t-test, Mann Whitney test, and Wilcoxon test. Result : The decreasing of FBG level in treatment group was 20.38±14.7 (18.92%) mg/dl and control group was 0.38±11.12 mg /dl. Statistic analysis showed that there was significant difference at decreasing of FBG level in treatment group and control group. Conclusion : There was significant decreasing FBG level 20.38 mg/dl after given juice Aloe vera 150 gram per day during 14 days.

scholarly journals Pengaruh Teknik Relaksasi Afirmasi terhadap Stres Mahasiswa yang Menempuh Skripsi di Program Studi Ilmu Keperawatan Universitas Jember

2018 ◽  
Vol 6 (2) ◽  
pp. 319
Author(s):  
Rommiyatun Zainiyah ◽  
Erti Ikhtiarini Dewi ◽  
Wantiyah Wantiyah
Keyword(s):  
Treatment Group ◽  
Sampling Technique ◽  
T Test ◽  
Control Group ◽  
Final Project ◽  
Parasympathetic Nerves ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
And Control

One of stressor in college students is taking a final project as a graduation requirement. The body'sresponse toward stress includes a rise of heart rate, diarrhea and insomnia. One of stressmanagement is affirmation relaxation (AR) technique. This research aimed to analyze the influenceof AR technique towards stress on students who take a final project in Faculty of Nursing, UniversityOf Jember. This research used a quasi experiment with Pretest-Post test approach and controlgroup design. Sampling technique that used is purposive sampling with respondent divided into twogroups, the treatment group and control group with 15 respondents for each group. Data wasanalyzed by using Dependent t test and Independent t test with 95% CI. The result showed thatthere was a significant difference stress before and after given AR technique within average 19,2 to10,87 (p = 0,001). Mean while, there was no significant difference of stress between pretest and posttest in control group within average 18,73 to 18,4 (p = 0,841). Overall, there was a difference ofstress between treatment group and control group (p =0,02, α = 0,05). The AR techniques reducestress because it can influence the sympathetic and parasympathetic nerves to produce endorphinehormone. The conclusion of this research is there was an influence of AR technique towards stresson students who Taking a Final Project in Faculty of Nursing University of Jember.Keywords: affirmation relaxation technique, stress, final project.

scholarly journals Treatment of Non-erosive Effect of Clinical Study of Gastroesophageal Reflux Disease

2018 ◽  
Vol 6 (3) ◽  
Author(s):  
Qian Liu
Keyword(s):  
Treatment Group ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Clinical Symptoms ◽  
Effective Rate ◽  
Control Group ◽  
Significant Difference ◽  
Before And After ◽  
And Control

<p class="18">Abstract: Objective: To observe the clinical effect of “Chaihu Shugan Powder Zuojin Pill” in the treatment of non-erosive gastroesophageal reflux disease. Methods: Sixty patients with non-erosive gastroesophageal reflux disease were randomly divided into treatment group and control group (30 cases in each group). The patients were treated with “Zaohu Shugan Powder” and “Zangjin Pills” and omeprazole respectively. For 8 weeks, the clinical efficacy and changes in clinical symptoms were observed. Results: The total effective rate was 93.3% in the treatment group and 80.0% in the control group. There was significant difference between the two groups before and after treatment (P &lt;0.05). Conclusion: “Chaihu Shugan Powder Zuojin Pill” can effectively improve the clinical symptoms of non-erosive gastroesophageal reflux disease.</p>

scholarly journals Platelet mass index as a novel inflammatory marker for tinnitus

2020 ◽  
Author(s):  
Ahmet Doblan ◽  
togay müderris
Keyword(s):  
Patient Group ◽  
Additional Data ◽  
Inflammatory Marker ◽  
Control Group ◽  
Control Groups ◽  
Study Objective ◽  
Significant Difference ◽  
Hematological Abnormalities ◽  
And Control ◽  
Platelet Mass

Abstract: Although there is plenty of research on the etiology and treatment of tinnitus, a definitive conclusion has not been reached in most studies. Among etiological factors, vascular and hematological abnormalities can be defined as an important cause in the evaluation of tinnitus cases, and these factors may underly many structural and functional problems. In this study, we aimed to investigate whether there was a correlation between platelet mass index (PMI) and tinnitus. To our knowledge, this is the first study exploring the effect of platelet mass on tinnitus. After reviewing the detailed medical records of 1,079 tinnitus patients that presented to our clinic between January 2019 and May 2020, the hemogram values of 177 cases meeting the study criteria were evaluated. There was no statistically significant difference between the patient and control groups in terms of mean age, gender distribution, and RBC (Red Blood Cell) neutrophil, lymphocyte, PLR and NLR levels (p>0.05). Compared to the control group, the hemoglobin and MPV levels of the patient group were statistically significantly higher (p<0.001), and the platelet level was statistically significantly lower (p=0.033). In addition, the PMI level of the patient group was significantly higher than that of the control group (p<0.001). In conclusion, the NLR, PLR and MPV values were found to be higher in the tinnitus group compared to the control group, as expected. Furthermore, the additional data for tinnitus cases showed that PMI was also observed to be significantly higher compared to the control group, indicating that the study objective was reached. PMI seems to be a predictive value for tinnitus, even in patients with MPV values lower than the normal range. Therefore, we consider that PMI is more sensitive than other markers, especially MPV in inflammatory events.

scholarly journals PENGARUH PELATIHAN SIDE JUMP SPRINT DAN SCISSOR JUMP TERHADAP DAYA LEDAK OTOT TUNGKAI PADA SISWA PUTRA PESERTA EKSTRAKURIKULER BOLAVOLI SMP NEGERI 3 ABIANSEMAL TAHUN PELAJARAN 2016/2017

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
I Gede Sunarba . ◽  
Dr. I Ketut Sudiana, S.Pd. M Kes . ◽  
Gede Doddy Tisna, M.S., S.Or., M.Or. .
Keyword(s):  
Treatment Group ◽  
Vertical Jump ◽  
Control Group ◽  
Limb Muscle ◽  
Sprint Training ◽  
Jump Training ◽  
Explosive Power ◽  
Significant Difference ◽  
And Control ◽  
One Way Anova

Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan side jump sprint dan scissor jump terhadap peningkatan daya ledak otot tungkai. Jenis penelitian ini adalah eksperimen semu dengan rancangan the non-randomized control group pretest posttest design. Subjek penelitian adalah siswa putra peserta ektrakurikuler bolavoli SMP Negeri 3 Abiansemal tahun pelajaran 2016/2017 berjumlah 45 orang, kemudian dibagi menjadi 3 kelompok dengan menggunakan teknik ordinal pairing, yaitu 15 orang diberikan pelatihan side jump sprint, 15 orang diberikan pelatihan scissor jump, dan 15 orang kelompok kontrol. Daya ledak otot tungkai diukur dengan test vertical jump. Data yang di dapat dianalisis dengan uji F (one way anova) pada taraf signifikansi (α) = 0,05 dengan bantuan komputer program SPSS 16.0. Hasil analisis data dari kelompok perlakuan side jump sprint terjadi peningkatan daya leda kotot tungkai sebesar 0,097, pada kelompok perlakuaan scissor jump sebesar 0,136 dan pada kelompok control sebesar 0,116. Hasil one awy anova variable daya ledak otot tungkai antara kelompok perlakuan dan kelompok kontrol didapat Fhitung 67,628 dan signifikansi 0,000 yang berarti terdapat perbedaan pengaruh pelatihan side jump sprint dan scissor jump terhadap daya ledak otot tungkai. . Berdasarkan hasil uji least significant difference (LSD), kelompok pelatihan side jump sprint lebih baik pengaruhnya sebesar 44,733 dibandingkan pelatihan sciisor jump terhadap peningkatan daya ledak otot tungkai. Disimpulkan bahwa; (1) pelatihan side jump sprint dan scissor jump berpengaruh pada peningkatan daya ledak otot tungkai. (2) terdapat perbedaan pengaruh pelatihan side jump sprint dan scissor jump terhadap peningkatan daya ledak otot tungkai. (3) pelatihan side jump sprint lebih baik dari pada pelatihan scissor jump terhadap peningkatan daya ledakotot tungkai Kata Kunci : side jump sprint , scissor jump, daya ledak otot tungkai. This research aims to know the influence of side jump sprint and scissor jump towards the improvement the explosive power of limp muscle. This research is a quasi experiment with the non-randomized control group pretest post test design. The subjects were students of extracurricular participants of volley ball at SMP Negeri 3 Abiansemal academic year 2016/2017 amounted to 45 people, then divided into 3 groups using ordinal pairing technique, 15 people were given side jump sprint training, 15 people were given scissor jump training, and 15 People control group. Limb muscle explosive power is measured by a vertical jump test. The data can be analyzed by F (one way anova) test at significance level (α) = 0,05 with computer program of SPSS 16.0. The result of data analysis from side sprint treatment group happened increased limb muscle explosive power of 0.097, in scissor jump treatment group 0.136 and control group 0.116. The result of one way anova variable of explosive muscle limb power between treatment group and control group was obtained Fcount 67,628 and significance 0,000 which mean there is difference of influence of training of side jump sprint and scissor jump on explosive power of limb muscle. . Based on the least significant difference (LSD) test results, the side jump sprint training group had a better effect of 44.733 than the scissor jump training on increasing the muscle limb power. It was concluded that; (1) the training of side jump sprints and scissor jumps has an effect on increasing the muscle tone of the leg muscles. (2) there is a difference in the effect of training of side jump sprint and scissor jump on the increase of explosive power of limb muscle. (3) side jump sprint training is better than scissor jump training on increasing the limbs . keyword : side jump sprint, scissor jump, explosive muscle limb power.

scholarly journals Default sequence of Mozart’s compositions during pregnancy gave higher dendritic density in the cerebrum and cerebellum of Rattus norvegicus offsprings compared with reversed sequence and control

2019 ◽  
Vol 27 (1) ◽  
pp. 5
Author(s):  
Harry Mangasi Binsar Panjaitan ◽  
Hermanto Tri Joewono ◽  
Widjiati Widjiati
Keyword(s):  
Experimental Study ◽  
Treatment Group ◽  
Rattus Norvegicus ◽  
Control Group ◽  
Exposure Group ◽  
Control Group Design ◽  
Group Design ◽  
Significant Difference ◽  
Post Test ◽  
And Control

Objectives: This study aim to determine sequence of Mozart songs in the analyzing differences in dendritic density of cerebellum and cerebellum of new born Rattus novergicusMaterials and Methods: Experimental study randomized post test only control group design using Rattus norvegicus. Animal subjects were divided into three groups which were control group, and the treatment group that were given exposure to default sequence and reversed sequence of Mozart's music from gestation day 10. We used a comparison test in the analysis expression of BDNF.Results: In the cerebrum there was a significant difference in the Mozart group in reverse rather than with Mozart standard sequence and in standard Mozart group with no exposure group, with p=0.003 and p=0.000. In the cerebellum there was a significant difference in the group in reverse rather than with standard Mozart and in the standard Mozart group with the control group, with p=0.000 and p=0.000. However, there was no significant difference between control group and Mozart group upside down in cerebrum and cerebellum with p=0.109 and p=0.077Conclusion: The density of dendrites in the cerebrum and cerebellum of Rattus norvegicus newborn exposed to Mozart's music during pregnancy with standard Mozart sequence was higher than that in those receiving reverse order and without exposure. There were no significant differences between the density of the cerebrum and cerebellum dendrites between groups exposed to reversed sequence of Mozart composition and those without exposure.

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