scholarly journals Ceftriaxone Intercalated Nanostructures Used to Improve Medical Treatment

2018 ◽  
Vol 55 (4) ◽  
pp. 613-615
Author(s):  
Letitia Doina Duceac ◽  
Alina Costina Luca ◽  
Geta Mitrea ◽  
Elena Ariela Banu ◽  
Madalina Irina Ciuhodaru ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Agents ◽  
Interlayer Space ◽  
Drug Carriers ◽  
Morphological Characterization ◽  
The Novel ◽  
Major Purpose ◽  
Layered Nanostructures ◽  
Nanohybrid Materials ◽  
High Incorporation

The development of antibiotic resistance in bacteria possesses a huge threat to public health by nullifying the effect of even the most efficient antibiotics. From years, LDHs type nanomaterials have been used as drug carriers for a wide variety of pharmaceutically active molecules due to their delivery properties, making these inorganic-organic nanohybrids very efficient antimicrobial agents. The major purpose of this work was to synthesize and characterize ceftriaxone intercalated layered nanostructures for further use to treat some infections, mostly of them child infections. The novel nanohybrid materials were prepared by ion exchange route and coprecipitation method. Structural and morphological characterization was performed by FTIR, EDX and SEM techniques. The results revealed a high incorporation of the drug in the interlayer space of promising nanostructures.

Life Lessons of the Pandemic ”Covid - 19”

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 469-471 ◽  
Author(s):  
Bhagyashri Vijay Chaudhari ◽  
Priya P. Chawle
Keyword(s):  
Public Health ◽  
Review Article ◽  
Public Health Emergency ◽  
The Novel ◽  
Global Public Health ◽  
Strange Situation ◽  
Republic Of China ◽  
Lifetime History ◽  
The People ◽  
Life Lessons

“A lesson learned the hard way is a lesson learned for a lifetime.” Every bad situation hurts; however, it sure does teach us something a lesson. In the same manner of a new lesson for Human lifetime, history is observing 'The Novel COVID-19 ’, a very horrible and strange situation created due to fighting with a microscopic enemy. WHO on 11 February 2020 has announced a name for new disease as - 19 and has declared as a global public health emergency and subsequently as pandemic because of its widespread. This began as an outbreak in December 2019, with its in Wuhan, the People Republic of China has emerged as a public health emergency of international concern. is the group of a virus with non-segmented, single-stranded and positive RNA genome. This bad situation of pandemic creates new scenes in the life of people in a different manner, which will be going to be life lessons for them. Such lessons should be kept in mind for the safety of living beings and many more things. In this narrative review article, reference was taken from a different article published in various databases which include the view of different authors and writers on the "Lessons to be from Corona".

scholarly journals Bioactive Compounds from Marine Sponges: Fundamentals and Applications

Marine Drugs ◽  
2021 ◽  
Vol 19 (5) ◽  
pp. 246
Author(s):  
Disha Varijakzhan ◽  
Jiun-Yan Loh ◽  
Wai-Sum Yap ◽  
Khatijah Yusoff ◽  
Rabiha Seboussi ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Antimicrobial Agents ◽  
Marine Sponges ◽  
The Novel ◽  
Human Pathogens ◽  
Fish Pathogens ◽  
Tropical Regions ◽  
Theonella Swinhoei ◽  
Ability To Act ◽  
Sessile Invertebrates

Marine sponges are sessile invertebrates that can be found in temperate, polar and tropical regions. They are known to be major contributors of bioactive compounds, which are discovered in and extracted from the marine environment. The compounds extracted from these sponges are known to exhibit various bioactivities, such as antimicrobial, antitumor and general cytotoxicity. For example, various compounds isolated from Theonella swinhoei have showcased various bioactivities, such as those that are antibacterial, antiviral and antifungal. In this review, we discuss bioactive compounds that have been identified from marine sponges that showcase the ability to act as antibacterial, antiviral, anti-malarial and antifungal agents against human pathogens and fish pathogens in the aquaculture industry. Moreover, the application of such compounds as antimicrobial agents in other veterinary commodities, such as poultry, cattle farming and domesticated cats, is discussed, along with a brief discussion regarding the mode of action of these compounds on the targeted sites in various pathogens. The bioactivity of the compounds discussed in this review is focused mainly on compounds that have been identified between 2000 and 2020 and includes the novel compounds discovered from 2018 to 2021.

scholarly journals A Failure of Political Communication Not a Failure of Bureaucracy: The Danger of Presidential Misinformation During the COVID-19 Pandemic

2020 ◽  
Vol 50 (6-7) ◽  
pp. 614-620 ◽  
Author(s):  
William Hatcher
Keyword(s):  
Public Health ◽  
Political Communication ◽  
Political Polarization ◽  
Medical Procedures ◽  
The Novel ◽  
Health Issues ◽  
Social Distancing ◽  
Health Related ◽  
Novel Coronavirus ◽  
Incorrect Information

President Trump’s communications during the novel coronavirus (COVID-19) pandemic violate principles of public health, such as practicing transparency and deferring to medical experts. Moreover, the president’s communications are dangerous and misleading, and his lack of leadership during the crisis limits the nation’s response to the problem, increases political polarization around public health issues of social distancing, and spreads incorrect information about health-related policies and medical procedures. To correct the dangerous path that the nation is on, the administration needs to adopt a more expert-centered approach to the crisis, and President Trump needs to practice compassion, empathy, and transparency in his communications.

scholarly journals Economic Impacts of Banning Subtherapeutic Use of Antibiotics in Swine Production

2002 ◽  
Vol 34 (3) ◽  
pp. 489-500 ◽  
Author(s):  
B. Wade Brorsen ◽  
Terry Lehenbauer ◽  
Dasheng Ji ◽  
Joe Connor
Keyword(s):  
Public Health ◽  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Economic Effects ◽  
Swine Production ◽  
Livestock Feed ◽  
Long Run ◽  
Short Run ◽  
Public Health Officials ◽  
Growth Promotants

Public health officials and physicians are concerned about possible development of bacterial resistance and potential effects on human health that may be related to the use of antimicrobial agents in livestock feed. The focus of this research is aimed at determining the economic effects that subtherapeutic bans of antimicrobials would have on both swine producers and consumers. The results show that a ban on growth promotants for swine would be costly, totaling $242.5 million annually, with swine producers sharing the larger portion in the short run and consumers sharing the larger portion in the long run.

scholarly journals 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases

2021 ◽  
Author(s):  
Maria-Agustina Rossi ◽  
Veronica Martinez ◽  
Philip Hinchliffe ◽  
Maria-Fernanda Mojica ◽  
Valerie Castillo ◽  
...  
Keyword(s):  
Public Health ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
Health Threat ◽  
Public Health Threat

Infections caused by multidrug resistant (MDR) bacteria are a major public health threat. Carbapenems are among the most potent antimicrobial agents that are commercially available to treat MDR bacteria. Bacterial...

scholarly journals Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Sirijan Santajit ◽  
Nitaya Indrawattana
Keyword(s):  
Public Health ◽  
Antimicrobial Resistance ◽  
Antimicrobial Agents ◽  
Multidrug Resistant ◽  
Resistance Mechanisms ◽  
Global Public Health ◽  
Drug Usage ◽  
Inappropriate Use ◽  
Public Health Challenges ◽  
Eskape Pathogens

The ESKAPE pathogens (Enterococcus faecium,Staphylococcus aureus,Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa, andEnterobacterspecies) are the leading cause of nosocomial infections throughout the world. Most of them are multidrug resistant isolates, which is one of the greatest challenges in clinical practice. Multidrug resistance is amongst the top three threats to global public health and is usually caused by excessive drug usage or prescription, inappropriate use of antimicrobials, and substandard pharmaceuticals. Understanding the resistance mechanisms of these bacteria is crucial for the development of novel antimicrobial agents or other alternative tools to combat these public health challenges. Greater mechanistic understanding would also aid in the prediction of underlying or even unknown mechanisms of resistance, which could be applied to other emerging multidrug resistant pathogens. In this review, we summarize the known antimicrobial resistance mechanisms of ESKAPE pathogens.

scholarly journals A Potential Novel COVID-19 Vaccine With RBD-HR1/HR2 Hexamer Structure

2021 ◽  
Author(s):  
Hongbo Liu ◽  
Xiang Gao ◽  
Guoyong Wang ◽  
Jianjun Zhang ◽  
Jiajie Zhou ◽  
...  
Keyword(s):  
Public Health ◽  
Recombinant Protein ◽  
Global Economy ◽  
Neutralizing Antibody ◽  
Scaling Up ◽  
Heptad Repeat ◽  
The Novel ◽  
Health Consequence ◽  
The World ◽  
Frequent Mutations

The COVID-19 pandemic and the continued spreading of the SARS-CoV-2 variants have brought a grave public health consequence and severely devastated the global economy with recessions. Vaccination is considered as one of the most promising and efficient methods to end the COVID-19 pandemic and mitigate the disease conditions if infected. Although a few vaccines have been developed with an unprecedented speed, scientists around the world are continuing pursuing the best possible vaccines with innovations. Comparing to the expensive mRNA vaccines and attenuated/inactivated SARS-CoV-2 vaccines, recombinant protein vaccines have certain advantages, including their safety (non-virus components), potential stronger immunogenicity, broader protection, ease of scaling-up production, reduced cost, etc. In this study, we reported a novel COVID-19 vaccine generated with RBD-HR1/HR2 hexamer that was creatively fused with the RBD domain and heptad repeat 1 (HR1) or heptad repeat 2 (HR2) to form a dumbbell-shaped hexamer to target the spike S1 subunit. The novel hexamer COVID-19 vaccine induced high titers of neutralizing antibody in mouse studies (>100,000), and further experiments also showed that the vaccine also induced an alternative antibody to the HR1 region, which probably alleviated the drop of immunogenicity from the frequent mutations of SARS-CoV-2.

Fluorinated s-Triazinyl Piperazines as Antimicrobial Agents

2011 ◽  
Vol 66 (7-8) ◽  
pp. 345-352 ◽  
Author(s):  
Rahul V. Patel ◽  
Premlata Kumari ◽  
Kishor H. Chikhalia
Keyword(s):  
Antimicrobial Agents ◽  
Inhibitory Concentration ◽  
Salmonella Typhi ◽  
The Novel ◽  
Proteus Vulgaris ◽  
Aspergillus Clavatus ◽  
H Nmr ◽  
Chemical Structures ◽  
Triazine Derivatives ◽  
C Nmr

A series of 1,3,5-triazine derivatives that contain 4-amino-2-trifl uoromethyl-benzonitrile, 8-hydroxyquinoline, and different piperazines as substituents at the carbon atoms of the triazine ring have been synthesized by a simple and efficient synthetic protocol. The chemical structures of the compounds were elucidated with the aid of IR, 1H NMR and 13C NMR spectroscopy, and elemental analysis. The antimicrobial activity of the compounds was tested against seven bacteria (Staphylococcus aureus MTCC 96, Bacillus cereus MTCC 619, Escherichia coli MTCC 739, Pseudomonas aeruginosa MTCC 741, Klebsiella pneumoniae MTCC 109, Salmonella typhi MTCC 733, Proteus vulgaris MTCC 1771) and four fungi (Aspergillus niger MTCC 282, Aspergillus fumigatus MTCC 343, Aspergillus clavatus MTCC 1323, Candida albicans MTCC 183). The results indicate that some of the novel s-triazines have noteworthy activity in minimum inhibitory concentration as well as agar diffusion tests.

Curating the Evidence About COVID-19 for Frontline Public Health and Clinical Care: The Novel Coronavirus Research Compendium

2021 ◽  
pp. 003335492110587
Author(s):  
Andrew D. Redd ◽  
Lauren S. Peetluk ◽  
Brooke A. Jarrett ◽  
Colleen Hanrahan ◽  
Sheree Schwartz ◽  
...  
Keyword(s):  
Public Health ◽  
Clinical Care ◽  
The United States ◽  
The Novel ◽  
Health Crisis ◽  
The Public ◽  
Successful Model ◽  
Medical Response ◽  
Public Consumption ◽  
Novel Coronavirus

The public health crisis created by the COVID-19 pandemic has spurred a deluge of scientific research aimed at informing the public health and medical response to the pandemic. However, early in the pandemic, those working in frontline public health and clinical care had insufficient time to parse the rapidly evolving evidence and use it for decision-making. Academics in public health and medicine were well-placed to translate the evidence for use by frontline clinicians and public health practitioners. The Novel Coronavirus Research Compendium (NCRC), a group of >60 faculty and trainees across the United States, formed in March 2020 with the goal to quickly triage and review the large volume of preprints and peer-reviewed publications on SARS-CoV-2 and COVID-19 and summarize the most important, novel evidence to inform pandemic response. From April 6 through December 31, 2020, NCRC teams screened 54 192 peer-reviewed articles and preprints, of which 527 were selected for review and uploaded to the NCRC website for public consumption. Most articles were peer-reviewed publications (n = 395, 75.0%), published in 102 journals; 25.1% (n = 132) of articles reviewed were preprints. The NCRC is a successful model of how academics translate scientific knowledge for practitioners and help build capacity for this work among students. This approach could be used for health problems beyond COVID-19, but the effort is resource intensive and may not be sustainable in the long term.

Alternative Therapies

2021 ◽  
pp. 160-182
Author(s):  
Vijay Singh Gondil ◽  
Sanjay Chhibber
Keyword(s):  
Public Health ◽  
Sustainable Development ◽  
Antibiotic Resistance ◽  
Antimicrobial Agents ◽  
Treatment Options ◽  
Alternative Therapies ◽  
Alternative Strategies ◽  
Health Concerns ◽  
Near Future ◽  
Antibiotic Dose

Antibiotic resistance is one of the leading public health concerns across the globe. Antibiotics are losing their effectiveness, leading to uncertainty in available treatment options to clinicians. Resistance to antibiotics is at an all-time high, and there is a pressing demand to look for alternative antimicrobial candidates other than antibiotics. Alternative therapies include use of bacteriophages, lytic proteins, nanoparticles, phytochemicals, quorum quenchers, and other antibacterial or antivirulent agents that can eradicate bacterial infection alone or in conjunction with antibiotics. Alternative therapies can replace or lower the effective antibiotic dose, which can help to tackle antibiotic resistance as well as counter its side effects. For sustainable development of antimicrobials against drug resistant bugs, novel alternative strategies need to be explored in the near future. Alternative therapies can help researchers to construct a toolbox containing a variety of antimicrobial agents, which can be used alone, in combination with other agents, or in rotation.

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