Effect of Oral N-Acetylcysteine Treatment on Plasma Inflammatory and Oxidative Stress Markers in Peritoneal Dialysis Patients: A Placebo-Controlled Study

2010 ◽  
Vol 30 (3) ◽  
pp. 336-342 ◽  
Author(s):  
Marcelo M. Nascimento ◽  
Mohamed E. Suliman ◽  
Margarete Silva ◽  
Tiago Chinaglia ◽  
Josiane Marchioro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Peritoneal Dialysis ◽  
High Sensitivity ◽  
Controlled Study ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Stress Markers ◽  
Before And After ◽  
And Gender ◽  
And Oxidative Stress

♦ BackgroundInflammation and oxidative stress (OS) are cardiovascular risk factors in patients with chronic kidney disease. N-acetylcysteine (NAC) is a thiol-containing antioxidant with anti-inflammatory properties and has been shown to reduce the number of cardiovascular events in hemodialysis patients.♦ MethodsThe current study aimed to determine the effect of oral NAC (2 × 600 mg/daily) on plasma levels of inflammatory and OS markers in peritoneal dialysis (PD) patients. We performed a placebo-controlled study over 8 weeks in 30 patients (40% males, age 52 ± 13 years) on regular PD. Before the study was started, the patients were divided into 2 groups of 15 patients matched for age and gender. 22 patients completed the study (12 on NAC, 10 on placebo). Proinflammatory cytokines [high-sensitivity C-reactive protein, interleukin-6 (IL-6), tumor necrosis factor-alpha, and pentraxin 3] and markers of OS (pentosidine, advanced oxidation protein products, homocysteine, glutathione, asymmetric dimethylarginine, and free sulfhydryls) were measured before and after treatment with NAC.♦ ResultsTreatment with NAC for 8 weeks increased mean baseline plasma NAC levels from 2.6 to 24.8 μmol/L ( p = 0.007). This intervention, which caused no side effects, significantly diminished IL-6 levels, from 9.4 (4.5 – 31) to 7.6 (4.9 – 13.5) pg/mL ( p = 0.006), whereas no such changes were observed in the placebo group. NAC treatment did not significantly affect the other inflammatory and OS markers.♦ ConclusionsShort-term oral NAC treatment resulted in reduction of circulating IL-6, suggesting that such treatment could be a useful strategy in blunting the inflammatory response in PD patients.

Oxydative stress markers and cytokine levels in rosuvastatin-medicated hypercholesterolemia patients

2018 ◽  
Vol 44 (4) ◽  
pp. 530-538
Author(s):  
Aysun Çetin ◽  
İhsan Çetin ◽  
Semih Yılmaz ◽  
Ahmet Şen ◽  
Göktuğ Savaş ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Interleukin 1 ◽  
Paraoxonase 1 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Phenotypic Effect ◽  
Necrosis Factor Alpha ◽  
Stress Markers ◽  
Tnf Α ◽  
Before And After

Abstract Background Limited research is available concerning the relationship between oxidative stress and inflammation parameters, and simultaneously the effects of rosuvastatin on these markers in patients with hypercholesterolemia. We aimed to investigate the connection between cytokines and oxidative stress markers in patients with hypercholesterolemia before and after rosuvastatin treatment. Methods The study consisted of 30 hypercholesterolemic patients diagnosed with routine laboratory tests and 30 healthy participants. The lipid parameters, interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), paraoxonase-1 (PON1) and malondialdehyde (MDA) levels in controls and patients with hypercholesterolemia before and after 12-week treatment with rosuvastatin (10 mg/kg/day), were analyzed by means of enzyme-linked immunosorbent assay. Results It was found that a 12-week cure with rosuvastatin resulted in substantial reductions in IL-1β, IL-6 and TNF-α and MDA levels as in rising activities of PON1 in patients with hypercholesterolemia. Before treatment, the PON1 levels were significantly negatively correlated with TNF-α and IL-6 in control group, while it was positively correlated with TNF-α in patients. Conclusion Our outcomes provide evidence of protected effect of rosuvastatin for inflammation and oxidative damage. It will be of great interest to determine whether the correlation between PON1 and cytokines has any phenotypic effect on PON1.

scholarly journals Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome

2010 ◽  
Vol 2 (3) ◽  
pp. 131
Author(s):  
Waode Nurfina ◽  
Irawan Yusuf ◽  
Mansyur Arif
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Iron Status ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
The Metabolic Syndrome ◽  
Metabolic Conditions ◽  
Inflammatory State ◽  
And Oxidative Stress

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane

scholarly journals Heart Rate Variability in Women with Systemic Lupus Erythematosus: Association with Health-Related Parameters and Effects of Aerobic Exercise

2020 ◽  
Vol 17 (24) ◽  
pp. 9501
Author(s):  
Elena Martínez-Rosales ◽  
Sergio Sola-Rodríguez ◽  
José Antonio Vargas-Hitos ◽  
Blanca Gavilán-Carrera ◽  
Antonio Rosales-Castillo ◽  
...  
Keyword(s):  
Heart Rate ◽  
Aerobic Exercise ◽  
Lupus Erythematosus ◽  
Exercise Intervention ◽  
High Sensitivity ◽  
Sample Entropy ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Stress Markers ◽  
And Oxidative Stress

Abnormal heart rate variability (HRV) has been observed in patients with systemic lupus erythematosus (SLE). In a combined cross-sectional and interventional study approach, we investigated the association of HRV with inflammation and oxidative stress markers, patient-reported outcomes, and the effect of 12 weeks of aerobic exercise in HRV. Fifty-five women with SLE (mean age 43.5 ± 14.0 years) were assigned to either aerobic exercise (n = 26) or usual care (n = 29) in a non-randomized trial. HRV was assessed using a heart rate monitor during 10 min, inflammatory and oxidative stress markers were obtained, psychological stress (Perceived Stress Scale), sleep quality (Pittsburg Sleep Quality Index), fatigue (Multidimensional Fatigue Inventory), depressive symptoms (Beck Depression Inventory), and quality of life (36-item Short-Form Health Survey) were also assessed. Low frequency to high frequency power (LFHF) ratio was associated with physical fatigue (p = 0.019). Sample entropy was inversely associated with high-sensitivity C-reactive protein (p = 0.014) and myeloperoxidase (p = 0.007). There were no significant between-group differences in the changes in HRV derived parameters after the exercise intervention. High-sensitivity C-reactive protein and myeloperoxidase were negatively related to sample entropy and physical fatigue was positively related to LFHF ratio. However, an exercise intervention of 12 weeks of aerobic training did not produce any changes in HRV derived parameters in women with SLE in comparison to a control group.

The association between irisin levels, element distribution and oxidative stress markers in adolescent swimmers

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Muaz Belviranli ◽  
Nilsel Okudan ◽  
Nuran Karakuyu
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Venous Blood ◽  
Element Distribution ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Significant Difference ◽  
And Gender ◽  
Antioxidant Effects ◽  
And Oxidative Stress

Abstract The objective of this investigation was to compare irisin concentration and its relation with oxidative stress markers, antioxidant enzymes and element levels in both male adolescent swimmers and sedentary controls. Twelve male swimmers aged between 11 and 18 years, who performed regular swimming training for at least 2 years and 12 age- and gender-matched sedentary controls participated in this study. After anthropometric measurements were performed, fasting venous blood samples were taken at rest. Irisin, malondialdehyde (MDA) as a marker of oxidative stress, superoxide dismutase (SOD) as a marker of antioxidant enzyme and elements (Zn, Cu, Se, Cr, Ni, Al, Fe) were analyzed in these samples. MDA levels were lower but Zn levels and Zn/Cu ratio were higher in the swimmers than in sedentary controls (p < 0.05). There was no statistically significant difference in the irisin levels and SOD activities between the groups (p > 0.05). The results of the current study suggested that exercise training has antioxidant effects and may reduce oxidative damage. Exercise training has also limited effects on irisin levels in the adolescents.

scholarly journals Assessment of dynamic thiol/disulfide homeostasis in patients with asthma

2018 ◽  
Vol 42 (3) ◽  
pp. 99-104
Author(s):  
Rukiye Nar ◽  
Aliye Gamze Çalış
Keyword(s):  
Oxidative Stress ◽  
Forced Expiratory Volume ◽  
Control Group ◽  
Reactive Protein ◽  
Total Thiol ◽  
Stress Markers ◽  
Group A ◽  
And Gender ◽  
And Control

Abstract Background: Asthma is a chronic inflammatory lung disease and oxidative stress is an important component in airway inflammation. This study aims to investigate dynamic thiol/disulfide homeostasis in patients with asthma. Methods: A total of 103 subjects, including 56 patients with asthma and 47 healthy controls, of similar age and gender were included in the study. The native thiol, total thiol and disulfide levels and the disulfide-native thiol, disulfide-total thiol and native thiol-total thiol ratios were analyzed and compared between the asthma and control groups using a novel automatized spectrophotometric assay. Results: The levels of native thiol (p<0.001), total thiol (p<0.001) and disulfide (p<0.001) were significantly lower and the C-reactive protein (CRP) levels (p<0.001) were significantly higher in patients with asthma when compared with those in the control group. A negative correlation was detected between CRP levels and native thiol, total thiol and disulfide levels (p<0.05). A significant positive correlation was detected between forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) levels and native thiol and total thiol levels (p<0.01). Conclusions: The thiol/disulfide homeostasis parameters may be used as novel oxidative stress markers in asthma but further studies are needed to investigate the role of thiol/disulfide homeostasis in asthma.

scholarly journals Relationship Between C-Reactive Protein and Atherosclerotic Risk Factors and Oxidative Stress Markers Among Young Persons 10–18 Years Old

2007 ◽  
Vol 53 (3) ◽  
pp. 456-464 ◽  
Author(s):  
Roya Kelishadi ◽  
Mohsen Sharifi ◽  
Alireza Khosravi ◽  
Khosrow Adeli
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Young People ◽  
Hdl Cholesterol ◽  
Oxidative Stress Markers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Stress Markers ◽  
And Oxidative Stress

AbstractBackground: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people.Methods: We conducted a population-based study of 512 young people, aged 10–18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG ≤4.52 mmol/LResults: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.Conclusion: We found a significant positive association between CRP and oxidative stress markers in healthy young people, as well as an increase in these markers in the upper quartiles of waist circumference, but not BMI. Oxidative stress and CRP may interact in the early inflammatory processes of atherosclerosis.

Low Intensity Aerobic Exercise and Oxidative Stress Markers in Older Adults

2014 ◽  
Vol 22 (4) ◽  
pp. 536-542 ◽  
Author(s):  
Mohamed A. Bouzid ◽  
Omar Hammouda ◽  
Régis Matran ◽  
Sophie Robin ◽  
Claudine Fabre
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Aerobic Exercise ◽  
Oxidative Stress Markers ◽  
Physically Active ◽  
Low Intensity ◽  
Stress Markers ◽  
Before And After ◽  
And Oxidative Stress ◽  
Sedentary Subjects

This comparative study examined the effects of regular low intensity aerobic exercise on oxidative stress markers in older adults. The study was carried out on 15 sedentary subjects (age: 65.1 ± 3.5 years) versus 18 subjects performing fitness exercises (age: 65.8 ± 3.3 years). Before and after an incremental exercise test, oxidative stress markers were assessed. Superoxide dismutase was higher at rest and at the recovery for the physically active subjects compared with sedentary subjects (p < .05). At recovery, glutathione peroxidase and α -Tocopherol increased significantly above the resting values only in the active group (p < .05). Malondialdehyde had increased in both groups (p < .01), associated with a higher level in the sedentary group (p < .05) at the recovery. These data suggest that low intensity aerobic exercise may be useful to prevent the decline of antioxidants linked with aging.

scholarly journals Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Nicole Noren Hooten ◽  
Ngozi Ejiogu ◽  
Alan B. Zonderman ◽  
Michele K. Evans
Keyword(s):  
Oxidative Stress ◽  
White Women ◽  
High Sensitivity ◽  
Protective Role ◽  
Protective Effects ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Stress Markers ◽  
Important Relationship ◽  
The Relationship

Background. Since high sensitivity C-reactive protein (hsCRP) is predictive of cardiovascular events, it is important to examine the relationship between hsCRP and other inflammatory and oxidative stress markers linked to cardiovascular disease (CVD) etiology. Previously, we reported that hsCRP induces the oxidative stress adduct 8-oxo-7,8-dihydro-2′deoxyguanosine (8-oxodG) and that these markers are significantly associated in women. Recent data indicates that brain-derived neurotrophic factor (BDNF) may have a role in CVD.Methods and Results. We examined BDNF levels in 3 groups of women that were age- and race-matched with low (<3 mg/L), mid (>3–20 mg/L), and high (>20 mg/L) hsCRP (n=39per group) and found a significant association between hsCRP, BDNF, and 8-oxodG. In African American females with high hsCRP, increases in BDNF were associated with decreased serum 8-oxodG. This was not the case in white women where high hsCRP was associated with high levels of BDNF and high levels of 8-oxodG. BDNF treatment of cells reduced CRP levels and inhibited CRP-induced DNA damage.Conclusion. We discovered an important relationship between hsCRP, 8-oxodG, and BDNF in women at hsCRP levels >3 mg/L. These data suggest that BDNF may have a protective role in counteracting the inflammatory effects of hsCRP.

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