scholarly journals Polyphenols Sourced from Terrestrial and Marine Plants as Coronavirus Reproduction Inhibitors

2021 ◽  
Vol 66 (3-4) ◽  
pp. 62-81
Author(s):  
N. N. Besednova ◽  
B. G. Andryukov ◽  
T. S. Zaporozhets ◽  
T. A. Kuznetsova ◽  
S. P. Kryzhanovskiy ◽  
...  
Keyword(s):  
Food Additives ◽  
Polyphenolic Compounds ◽  
The Body ◽  
Biologically Active ◽  
Complex Structures ◽  
Plant Polyphenols ◽  
Modern Problem ◽  
Marine Plants ◽  
Multiple Biological Activity

The review presents the data of recent years concerning the most important modern problem — the search of the new inhibitors of coronaviruses’ reproduction. Polyphenolic compounds (phlorotannins) from terrestrial and marine plants, polyvalent bioregulators with multiple biological activity, are considered as promising compounds of this type. Polyphenols are able to interfere with different stages of coronaviruses’ life cycle. This fact characterizes polyphenols as multipurpose drugs that affect vital proteins of the pathogens. At the same time, the authors of the review draw attention to the fact that many difficulties must be overcome to develop medications based on plant polyphenols, since these compounds are characterized by complex structures, low bioavailability, as well as rapid excretion from the body. In addition, in vivo studies on animals, as well as in clinical trials, are required. Despite all the difficulties, plant polyphenols should eventually the source for creating antiviral medicines, biologically active food additives, and functional food products.

Food supplement “carrageenan” and its effect on the organism

2020 ◽  
Author(s):  
O.E. Luneva ◽  
Keyword(s):  
Gastrointestinal Tract ◽  
Food Additives ◽  
Food Supplement ◽  
The Body ◽  
Laboratory Rats ◽  
Experimental Part ◽  
In Vivo Experiments ◽  
Physiological Processes

Food additives are positioned as harmless, although, their components affectthe physiological processes associated with the permeability of the wall of the gastrointestinal tract (GIT) and intestinal microbiota. This article describes thecarrageenan supplement and its effects on the body in in vitro and in vivo experiments. The experimental part is devoted to analysis of the intestinalmicrobiota of laboratory rats with the consumption of the carrageenan dietary supplement in the amount of about 4,4 % of the standard feed.

The Permeability of Dialytic Membranes to Endotoxins: Clinical and Experimental Findings

1989 ◽  
Vol 12 (8) ◽  
pp. 505-508 ◽  
Author(s):  
G. Passavanti ◽  
E. Buongiorno ◽  
G. De Fino ◽  
D. Fumarola ◽  
P. Coratelli
Keyword(s):  
Active Component ◽  
Lipid A ◽  
In Vitro Study ◽  
The Body ◽  
Biologically Active ◽  
Limulus Amebocyte Lysate ◽  
Membrane Interaction ◽  
Experimental Findings

This study of 20 endotoxemic patients submitted to 70 hemodialyses (HD) found a reduction of the pre-HD limulus amebocyte lysate (LAL) positivity in 50 HD (71%), without appreciable differences in terms of effectiveness between cuprophan and AN 69 membranes. To define the mechanisms responsible for the reduction in LAL positivity during HD, the membranes were used in two in vitro studies, the first of which showed that the LAL positivity of blood containing lipopolysaccharide (LPS), submitted to hemofiltration (HF) for 300 min, remained unchanged and the ultrafiltrate remained constantly LAL negative. These results suggest that the reduction in LAL positivity observed in HD in vivo, an expression of reduced endotoxemia, cannot be attributed either to the filtration of the LPS as such or to its fragmentation following blood-membrane interaction into theoretically less filtrable molecules or to mechanisms of LPS adsorption on the membrane. The in vivo reduction of LAL positivity is more likely due to removal of the filtrable endotoxin fragments already released in the body, like lipid A, the biologically active component of LPS, known to react to LAL. This hypothesis was borne out by the second in vitro study, where the LAL positivity of blood containing lipid A, treated by HF for 80 min, gradually decreased, and dialytic permeability to lipid A was confirmed by the appearance of LAL positivity in the ultrafiltrate.

scholarly journals Recommendations for Nanomedicine Human Subjects Research Oversight: An Evolutionary Approach for an Emerging Field

2012 ◽  
Vol 40 (4) ◽  
pp. 716-750 ◽  
Author(s):  
Leili Fatehi ◽  
Susan M. Wolf ◽  
Jeffrey McCullough ◽  
Ralph Hall ◽  
Frances Lawrenz ◽  
...  
Keyword(s):  
Medical Devices ◽  
Human Subjects ◽  
High Surface ◽  
The Body ◽  
Biologically Active ◽  
Implantable Medical Devices ◽  
Research Oversight ◽  
Insoluble Drugs ◽  
Drug Eluting

Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions (often defined as 1-100 nm, but sometimes defined to include dimensions up to 1000 nm, as discussed further below) where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products (biologics), implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. Nanotherapeutics and in vivo nanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes (including the bloodbrain barrier) and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents.

scholarly journals Optimization of the process of mixing liquid-phase heterogeneous products

2021 ◽  
Vol 83 (1) ◽  
pp. 204-210
Author(s):  
L. E. Glagoleva ◽  
N. P. Zatsepilina ◽  
M. V. Kopylov ◽  
S. O. Rodionov
Keyword(s):  
Software Package ◽  
Raw Materials ◽  
Food Additives ◽  
Whey Proteins ◽  
Experimental Studies ◽  
Good Health ◽  
The Body ◽  
Biologically Active ◽  
Raw Material ◽  
And Performance

The leading direction in the field of nutrition is the creation of a range of products that contribute to improving health when they are used daily in the diet. The urgency of studying bovine colostrum-colostrum, which is an immune-modeling animal raw material, has been substantiated. Colostrum is a natural source of all the ingredients needed to build immunity. Biologically active substances contained in cow colostrum contribute to: restoration of immunity; restoration of the intestines and stomach; strengthening the nervous system; renewal of brain cells; improving emotional tone and mood; increasing vitality and performance; slowing down the aging process; protection against diseases of the intestines and stomach, cardiovascular system, respiratory tract, diabetes, allergies, osteoporosis and a number of other diseases. Colostrum contains a minimum of 37 immune factors and 8 growth factors that help the body fight disease and promote good health and longevity. The classes of immunoglobulins contained in colostrum, which represent the bulk of whey proteins, have been studied. Colostrum is a limited source of raw materials, its production period is short, there are many opportunities for industrial use, but due to the small amount of raw materials, the market remains undeveloped, with the exception of food additives. Taking into account the extensive therapeutic and medicinal properties of colostrum, its unique composition and properties, its composition and physicochemical properties were investigated, the fractionation parameters were determined using various systems. To process the experimental studies, the STATISTICA 12 software package was used. To obtain the regression equation, the matrix data were processed using the Microsoft Excel 2010 software package. The analysis of the data obtained indicates the possibility and prospects of using colostroma in food production technology.

scholarly journals Evaluation of γ-oryzanol Accumulation and Lipid Metabolism in the Body of Mice Following Long-Term Administration of γ-oryzanol

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 104 ◽  
Author(s):  
Eri Kobayashi ◽  
Junya Ito ◽  
Naoki Shimizu ◽  
Takumi Kokumai ◽  
Shunji Kato ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Plasma Lipids ◽  
Rice Bran Oil ◽  
The Body ◽  
Biologically Active ◽  
Lipid Lowering ◽  
Single Oral Administration ◽  
Term Administration

γ-Oryzanol (OZ), abundant in rice bran oil, has gained attention due to its physiological activities (e.g., lipid-lowering effects). However, the absorption and metabolism of orally ingested OZ have not yet been fully elucidated. In this study, diets containing normal or high contents of OZ were fed to obesity model mice for 8 weeks, and OZ concentrations in plasma and organs were analyzed by HPLC-MS/MS. To evaluate the relationship between OZ accumulation and lipid metabolism in vivo, lipid concentrations in the mice plasma and liver were also measured. As a result, the accumulation of intact OZ in plasma and organs was seen in mice fed diets containing OZ, where mice fed diets containing higher OZ contents demonstrated higher levels of OZ accumulation and lower amounts of plasma lipids. These results, in combination with our additional data from a single oral administration test, suggest the possibility that intact OZ, along with its metabolites (e.g., ferulic acid), is biologically-active.

scholarly journals Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues

2021 ◽  
Vol 22 (9) ◽  
pp. 4993
Author(s):  
Christophe Morisseau ◽  
Sean D. Kodani ◽  
Shizuo G. Kamita ◽  
Jun Yang ◽  
Kin Sing Stephen Lee ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Epoxide Hydrolase ◽  
Protein Quantification ◽  
The Body ◽  
Biologically Active ◽  
Relative Importance ◽  
Epoxide Hydrolases ◽  
Epoxy Fatty Acids ◽  
Hydrolysis Of

Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of biological activities, including the regulation of blood pressure, inflammation, angiogenesis, and pain perception. For the past 20 years, soluble epoxide hydrolase (sEH) has been recognized as the primary enzyme for degrading EpFAs in vivo. The sEH converts EpFAs to the generally less biologically active 1,2-diols, which are quickly eliminated from the body. Thus, inhibitors of sEH are being developed as potential drug therapeutics for various diseases including neuropathic pain. Recent findings suggest that other epoxide hydrolases (EHs) such as microsomal epoxide hydrolase (mEH) and epoxide hydrolase-3 (EH3) can contribute significantly to the in vivo metabolism of EpFAs. In this study, we used two complementary approaches to probe the relative importance of sEH, mEH, and EH3 in 15 human tissue extracts: hydrolysis of 14,15-EET and 13,14-EDP using selective inhibitors and protein quantification. The sEH hydrolyzed the majority of EpFAs in all of the tissues investigated, mEH hydrolyzed a significant portion of EpFAs in several tissues, whereas no significant role in EpFAs metabolism was observed for EH3. Our findings indicate that residual mEH activity could limit the therapeutic efficacy of sEH inhibition in certain organs.

Cadmium: exposure markers as predictors of nephrotoxic effects

1994 ◽  
Vol 40 (7) ◽  
pp. 1391-1394 ◽  
Author(s):  
R R Lauwerys ◽  
A M Bernard ◽  
H A Roels ◽  
J P Buchet
Keyword(s):  
Daily Intake ◽  
Epidemiologic Studies ◽  
The Body ◽  
Biologically Active ◽  
Cross Sectional ◽  
Limit Value ◽  
The Us ◽  
Biological Limit Value ◽  
Low Exposure

Abstract Cadmium (Cd) is a cumulative element with a biological half-life of > 10 years in humans. The total amount of Cd accumulated in the liver and in the kidney can be measured in vivo by neutron activation (or x-ray fluorescence), but this technique does not necessarily measure the fraction that is biologically active. At low exposure (i.e., general environmental exposure or moderate occupational exposure), blood Cd is mainly influenced by the last 2 to 3 months of exposure. Under such conditions, the Cd concentration in urine mainly reflects the amount of Cd stored in the body, particularly in the kidney. In Europe and the US, the Cd reference values are usually < 2 nmol/mmol creatinine. Because most of the Cd in urine is probably bound to metallothionein, the changes in the urinary metallothionein concentration parallel those of Cd. The determination of Cd concentration in hair is of limited value because in humans it is difficult to distinguish between externally deposited and endogenous Cd. Fecal Cd is a good indicator of the oral daily intake. The results of several cross-sectional epidemiologic studies of the relation between the prevalence of renal dysfunction and Cd concentration in urine led us to propose a biological limit value for Cd of 5 and 2 nmol/mmol creatine for adult male workers and the general population, respectively.

scholarly journals Features of the diet of athletes playing sports

2019 ◽  
Vol 81 (1) ◽  
pp. 160-167
Author(s):  
V. G. Lobanov ◽  
G. I. Kasyanov ◽  
E. A. Mazurenko
Keyword(s):  
Food Additives ◽  
Team Sports ◽  
The Body ◽  
Biologically Active ◽  
Body Weight Regulation ◽  
Active Components ◽  
Food Ingredients ◽  
Biochemical State ◽  
Definition Of ◽  
Usual Diet

The article is devoted to the peculiarities of the formation of hygienic approaches to nutrition of students involved in game sports. The article analyzes the practical skills and methods of organizing the culture of nutrition of athletes of high-intensity sports. Some approaches to the rationality of the diet, taking into account modern scientific trends in the biochemical state of the organism, have been determined. Features of the diet of participants of game sports are associated with the definition of the needs of the body of athletes in energy, food and biologically active components. The issues of the use of food additives and specialized food ingredients in the practice of sports nutrition are considered. Recommendations on the development of biochemical orientation of dietary regimes were prepared depending on the level of energy expenditure of athletes, indicators of basic metabolism and body weight regulation. Such recommendations will be useful to participants of team sports and to all who are interested in the peculiarities of improving the diets of athletes. Compliance with a specially designed diet for players of game sports is especially important due to the extremely high physical activity during the competition. At the same time, before the game you can not completely abandon the usual diet and dramatically change the range of consumed foods. It is necessary to turn to a benign and simple diet that takes into account the tastes of each athlete, but with the condition that traditional products will be enriched with natural highly concentrated dietary supplements. Team sports players should pay particular attention to adaptogens, substances that are not doping-related, but have a general tonic effect on the athlete's body.

The Role of Polyphenols in the Modulation of Plasma Non-Enzymatic Antioxidant Capacity (NEAC)

2012 ◽  
Vol 82 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Mauro Serafini ◽  
Giuseppa Morabito
Keyword(s):  
Antioxidant Capacity ◽  
Dietary Intervention ◽  
Ex Vivo ◽  
The Body ◽  
Dietary Polyphenols ◽  
Enzymatic Antioxidant ◽  
Endogenous Antioxidant

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.

Neutral Lipids of Oats Fruit (Avena Sativa L.)

2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  
Keyword(s):  
Avena Sativa ◽  
Neutral Lipids ◽  
The Body ◽  
Biologically Active ◽  
Absorption Bands ◽  
Vital Functions ◽  
The Republic ◽  
Living Organisms ◽  
Main Components ◽  
Active Substances

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.

Sign in / Sign up

Export Citation Format

Share Document