Synthesis of Zinc Oxide, Titanium Dioxide and Magnesium Dioxide Nanoparticles and Their Prospective in Pharmaceutical and Biotechnological Applications

The use of nanoparticles for the therapeutic purpose is gaining pronounced importance. In the last two decades, a number of nanomedicines received regulatory approval and several showed promises through clinical trials. In this content, it is important to synthesize nanoparticles from various sources and to check its efficiency, especially its antibacterial activity. In today’s scenario number nanomedicines are proving useful to control multidrug resistance and since the mechanism of action of nanoparticles is totally different from the small molecules like antibiotics it obviates the chances of drug resistance. In this review, we discussed three metal-based nanoparticles prepared from various reducing sources namely Zinc Oxide Nanoparticle (ZnO NPs), Titanium Dioxide Nanoparticle (TiO2 NPs) and Magnesium Dioxide Nanoparticle (MnO2 NPs). The focus also made towards the safety assessment of the several nanoparticles. In addition, the exact interaction of the nanoparticles with the bacterial cell surface and the resultant changes also been highlighted. The review put forward the sources, method, and antibacterial success of these nanoparticles so that future nanomedicines could be put forward.

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Kinetics Analysis and Susceptibility Coefficient of the Pathogenic Bacteria by Titanium Dioxide and Zinc Oxide Nanoparticles

Advanced Pharmaceutical Bulletin ◽

10.15171/apb.2020.007 ◽

2019 ◽

Vol 10 (1) ◽

pp. 56-64 ◽

Cited By ~ 5

Author(s):

Mahmood Alizadeh-Sani ◽

Hamed Hamishehkar ◽

Arezou Khezerlou ◽

Mohammad Maleki ◽

Maryam Azizi-Lalabadi ◽

...

Keyword(s):

Zinc Oxide ◽

Titanium Dioxide ◽

Pathogenic Bacteria ◽

Bacterial Resistance ◽

Treatment Time ◽

Dilution Method ◽

Survival Ratio ◽

Zno Nps ◽

Tio2 Nps ◽

Hospital Infection Control

Purpose: The increase of bacterial resistance to common antibacterial agents is one of the major problems of health care systems and hospital infection control programs. In this study, antimicrobial activity of titanium dioxide (TiO2 ) and zinc oxide (ZnO) nanoparticles (NPs) was investigated against E. coli, Salmonella enteritidis, Listeria monocytogenes, and Staphylococcus aureus pathogenic bacteria by determining sensitivity coefficient and kinetics of bacterial death. Methods: Antimicrobial tests were performed with ~106 CFU/mL of each bacterium at baseline. At first, minimum inhibitory concentration (MIC) was concluded by the dilution method and then, death kinetic and susceptibility coefficient of NPs suspensions was determined at 0 to 360 min. treatment time. Results: The results of this study revealed that, the highest susceptibility was observed for L. monocytogenes (Z=0.025 mL/μg) to TiO2 NPs, whereas the lowest susceptibility was obtained in the reaction of ZnO NPs with S. enteritidis (Z=0.0033 mL/μg). The process of bacterial death in NPs suspension was assumed to follow first-degree kinetic and the survival ratio of bacteria decreased by the increase in treatment time. An increase in the concentration of NPs was seen to enhance the bactericidal action. Conclusion: Results showed that L. monocytogenes had higher sensitivity compared to S. enteritidis. The results of this study also demonstrated that TiO2 NPs have a strong antimicrobial effect in comparison with ZnO NPs and it could be employed to aid the control of pathogenic bacteria.

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Synthesis and Characterization of ZnO Nanoparticles - A Green Chemistry Approach

10.46532/978-81-950008-1-4_079 ◽

2020 ◽

pp. 358-363

Author(s):

Shankar H ◽

Nanthini Sivakumar ◽

Sangavi K ◽

Suhasini Sathiyamoorthy ◽

Pandiyarasan Veluswamy

Keyword(s):

Zinc Oxide ◽

Titanium Dioxide ◽

Zno Nanoparticles ◽

Human Life ◽

Vital Role ◽

Synthesis Methods ◽

Aloe Barbadensis ◽

Titanium Dioxide Nanoparticle ◽

Oxide Nanoparticle

Many green synthesis methods are used for synthesizing the nanoparticles in order not to harm humankind which makes use of it. Sunscreen is one of the vital products that play a vital role in human life nowadays. Sunscreens are generally prepared with titanium dioxide and zinc oxide nanoparticles due to their higher bandgap which helps to protect the skin from UVB and UVA rays respectively. These nanoparticles are chemically prepared as far as now in the case of sunscreen products. Titanium dioxide nanoparticle does not give full protection over the UV-A spectrum when compared to Zinc oxide nanoparticle. So, sunscreen manufacturers opt for ZnO nanoparticles to give better results. Our motivation is to prepare green synthesized ZnO nanoparticles to use in the preparation of transparent sunscreen. Here we use Aloe barbadensis leaf extract for the synthesis of ZnO nanoparticles.

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Insecticidal Effect of Zinc Oxide and Titanium Dioxide Nanoparticles against Bactericera cockerelli Sulc. (Hemiptera: Triozidae) on Tomato Solanum lycopersicum

Agronomy ◽

10.3390/agronomy11081460 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1460

Author(s):

José A. Gutiérrez-Ramírez ◽

Rebeca Betancourt-Galindo ◽

Luis A. Aguirre-Uribe ◽

Ernesto Cerna-Chávez ◽

Alberto Sandoval-Rangel ◽

...

Keyword(s):

Zinc Oxide ◽

Titanium Dioxide ◽

Titanium Dioxide Nanoparticles ◽

Block Design ◽

Field Tests ◽

Laboratory Research ◽

Bactericera Cockerelli ◽

Zno Nps ◽

Tio2 Nps ◽

Insecticidal Effect

The use of nanoparticles (NPs) has generated an alternative pest control. The objective was to evaluate the insecticidal effect of zinc oxide nanoparticles (ZnO NPs), titanium dioxide nanoparticles (TiO2 NPs), and their combination on Bactericera cockerelli (Hemiptera: Triozidae) second-stage nymphs under laboratory and greenhouse conditions in tomato. The laboratory research was carried out with the leaf immersion bioassay method under a complete randomized design, and in the greenhouse by direct plant spraying under a randomized block design; in both designs, a control without NPs was added. Mortality was recorded every 24 h for 4 days. Both NPs in the laboratory and greenhouse showed toxicity to B. cockerelli nymphs. Results in the laboratory showed that NPs significantly caused increased mortality of 88, 99, and 100% 96 h after treatment of ZnO NPs, TiO2 NPs, and their combinations, at 1000, 100, and 250 ppm, respectively. Direct spray of plants in the greenhouse showed low mortality with 27, 32, and 23% after 96 h of ZnO NPs, TiO2 NPs, and their combinations, at 3000, 500, and 250 ppm, respectively. These results on B. cockerelli control seem promising. Nanoparticles as insecticides are a novel strategy, however, further investigation is required in field tests to obtain suitable efficacy for use in a pest management system.

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Mechanisms and effects of zinc oxide nanoparticle transformations on toxicity to zebrafish embryos

Environmental Science Nano ◽

10.1039/d1en00305d ◽

2021 ◽

Author(s):

Gyudong Lee ◽

Byongcheun Lee ◽

Ki-Tae Kim

Keyword(s):

Zinc Oxide ◽

Physicochemical Properties ◽

Zebrafish Embryos ◽

Zinc Ions ◽

Zno Nps ◽

Zinc Oxide Nanoparticle ◽

Toxicity Reduction ◽

Oxide Nanoparticle

Environmental transformations modify the physicochemical properties of ZnO NPs, modulate their ability to reduce zinc ions, and determine the degree of toxicity reduction in zebrafish embryos.

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Impact of titanium dioxide nanoparticles on intestinal community in the 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced acute colitis mice and the intervention effect of vitamin E

Nanoscale ◽

10.1039/d0nr08106j ◽

2020 ◽

Author(s):

Yanjun Gao ◽

Tingyu Li ◽

Shuming Duan ◽

Lizhi Lv ◽

Yuan Li ◽

...

Keyword(s):

Antibacterial Activity ◽

Titanium Dioxide ◽

Vitamin E ◽

Titanium Dioxide Nanoparticles ◽

Trinitrobenzenesulfonic Acid ◽

Acute Colitis ◽

Intervention Effect ◽

Tio2 Nps

Titanium dioxide nanoparticles (TiO2-NPs) is widely applicated as additives in foods for its excellent whitening and brightening capability. Although the toxicity and antibacterial activity of TiO2-NPs has been extensively studied,...

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Erratum: Scherzad, A., et al. Molecular Mechanisms of Zinc Oxide Nanoparticle-Induced Genotoxicity Short Running Title: Genotoxicity of ZnO NPs. Materials 2017, 10, 1427

Materials ◽

10.3390/ma13235462 ◽

2020 ◽

Vol 13 (23) ◽

pp. 5462

Author(s):

Agmal Scherzad ◽

Till Meyer ◽

Norbert Kleinsasser ◽

Stephan Hackenberg

Keyword(s):

Zinc Oxide ◽

Molecular Mechanisms ◽

Zno Nps ◽

Zinc Oxide Nanoparticle ◽

Oxide Nanoparticle

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Graphene oxide decorated with zinc oxide nanoflower, silver and titanium dioxide nanoparticles: fabrication, characterization, DNA interaction, and antibacterial activity

RSC Advances ◽

10.1039/c8ra09788g ◽

2019 ◽

Vol 9 (7) ◽

pp. 3704-3714 ◽

Cited By ~ 22

Author(s):

Nagi El-Shafai ◽

Mohamed E. El-Khouly ◽

Maged El-Kemary ◽

Mohamed Ramadan ◽

Ibrahim Eldesoukey ◽

...

Keyword(s):

Zinc Oxide ◽

Antibacterial Activity ◽

Titanium Dioxide ◽

Graphene Oxide ◽

Titanium Dioxide Nanoparticles ◽

Dna Interaction

The fabrication, characterization, and antibacterial activity of novel nanocomposites based on graphene oxide (GO) nanosheets decorated with silver, titanium dioxide nanoparticles, and zinc oxide nanoflowers were examined.

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Antibacterial Property of Composites of Reduced Graphene Oxide with Nano-Silver and Zinc Oxide Nanoparticles Synthesized Using a Microwave-Assisted Approach

International Journal of Molecular Sciences ◽

10.3390/ijms20215394 ◽

2019 ◽

Vol 20 (21) ◽

pp. 5394 ◽

Cited By ~ 4

Author(s):

Yi-Huang Hsueh ◽

Chien-Te Hsieh ◽

Shu-Ting Chiu ◽

Ping-Han Tsai ◽

Chia-Ying Liu ◽

...

Keyword(s):

Zinc Oxide ◽

Antibacterial Activity ◽

Graphene Oxide ◽

Reductase Activity ◽

Chemical Reduction ◽

Membrane Integrity ◽

Zno Nps ◽

Nano Silver ◽

E Coli ◽

Microwave Assisted

Graphene oxide (GO) composites with various metal nanoparticles (NPs) are attracting increasing interest owing to their broad scope in biomedical applications. Here, microwave-assisted chemical reduction was used to deposit nano-silver and zinc oxide NPs (Ag and ZnO NPs) on the surface of reduced GO (rGO) at the following weight percentages: 5.34% Ag/rGO, 7.49% Ag/rGO, 6.85% ZnO/rGO, 16.45% ZnO/rGO, 3.47/34.91% Ag/ZnO/rGO, and 7.08/15.28% Ag/ZnO/rGO. These materials were tested for antibacterial activity, and 3.47/34.91% Ag/ZnO/rGO and 7.08/15.28% Ag/ZnO/rGO exhibited better antibacterial activity than the other tested materials against the gram-negative bacterium Escherichia coli K12. At 1000 ppm, both these Ag/ZnO/rGO composites had better killing properties against both E. coli K12 and the gram-positive bacterium Staphylococcus aureus SA113 than Ag/rGO and ZnO/rGO did. RedoxSensor flow cytometry showed that 3.47/34.91% Ag/ZnO/rGO and 7.08/15.28% Ag/ZnO/rGO decreased reductase activity and affected membrane integrity in the bacteria. At 100 ppm, these two composites affected membrane integrity more in E. coli, while 7.08/15.28% Ag/ZnO/rGO considerably decreased reductase activity in S. aureus. Thus, the 3.47/34.91% and 7.08%/15.28% Ag/ZnO/rGO nanocomposites can be applied not only as antibacterial agents but also in a variety of biomedical materials such as sensors, photothermal therapy, drug delivery, and catalysis, in the future.

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Toxicity of zinc oxide nanoparticles to the annelid Enchytraeus crypticus in agar-based exposure media

Chemical Papers ◽

10.1515/chempap-2016-0080 ◽

2016 ◽

Vol 70 (11) ◽

Cited By ~ 7

Author(s):

Kateřina Hrdá ◽

Jakub Opršal ◽

Petr Knotek ◽

Miloslav Pouzar ◽

Milan Vlček

Keyword(s):

Zinc Oxide ◽

Zinc Oxide Nanoparticles ◽

Water Soluble ◽

Soluble Salt ◽

Oxide Nanoparticles ◽

Zno Nps ◽

Zinc Oxide Nanoparticle ◽

Enchytraeus Crypticus ◽

Oxide Nanoparticle

AbstractToxicity of zinc oxide nanoparticle (ZnO-NPs) powder and water soluble salt of Zn (ZnCl

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Precursor Concentration Effect on Physicochemical Properties of Zinc Oxide Nanoparticle Synthesized with Banana Peel Extract

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.797.262 ◽

2019 ◽

Vol 797 ◽

pp. 262-270 ◽

Cited By ~ 1

Author(s):

R.A. Abdol Aziz ◽

Siti Fatma Abd Karim ◽

Ummi Kalthum Ibrahim ◽

N Sanuddin

Keyword(s):

Zinc Oxide ◽

Food Packaging ◽

Cost Effective ◽

Xrd Analysis ◽

Band Gap Energy ◽

Banana Peel ◽

Zno Nps ◽

Constant Ph ◽

Oxide Nanoparticle ◽

Musa Species

The present study reports the synthesis of zinc oxide (ZnO) nanoparticles (NPs) using Jackfruit banana peel (Musa Species.) extracts (BPE) as reducing and stabilizing agent. This green synthesis is considered promising an alternative technique that cost effective, nontoxic and environmental friendly. Zinc acetate dehydrate solution ((CH3COO)2.2H2O) was used as the precursor for ZnO synthesis and the concentration was varied in the range of 0.100 M – 0.010 M at constant pH of solutions, 12. The synthesized ZnO NPs were then characterized using fourier transform infrared spectroscopy (FTIR), ultraviolet visible (UV-Vis) absorption spectroscopy, x-ray Diffractometer and Brunauer-Emmett-Teller (BET). The band gap energy was found in the range of 3.44 eV - 3.58 eV while XRD analysis shows a crystalline structure in hexagonal wurtzite shape. These unique characteristics open the possibilities of various potential application in medical and industry as well as for development of antimicrobial agent for food packaging applications.

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