scholarly journals Acute Myocardial Infarction and its association with ABO blood group in Pakistani population

2020 ◽  
Vol 24 (2) ◽  
pp. 103-107
Author(s):  
Imran Iftikhar ◽  
Hamid Sharif Khan ◽  
Adeel Ur Rehman
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Informed Consent ◽  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Pathology Laboratory ◽  
Cross Sectional ◽  
Pakistani Population

OBJECTIVE: To determine the frequency of ABO blood groups among patients with acute myocardial infarction in the Pakistani population STUDY DESIGN: Cross-sectional study PLACE AND DURATION OF STUDY : Department of Interventional Cardiology, Rawalpindi Institute of Cardiology, Rawalpindi, from May 2015 to November 2015. METHODOLOGY: A total of 250 subjects with acute myocardial infarction were included in the study. The study was explained to the patients and informed consent taken. All patients underwent 12 lead electrocardiography using Mortara instrument ELI 250 and were analyzed by a single trained reader unaware of the patients’ blood group. Cardiac troponin levels were assessed at least three hours after the onset of symptoms. The ABO blood group was assessed by using the standard slide agglutination method in the hospital pathology laboratory and verified by the principal investigator. The data was collected on a pre-tested questionnaire by the investigator after taking informed consent from the patient. RESULTS: In our study, the mean age of patients was 57.3 years. 36.4% were between 18-50 years of age while 63.6%were between 51-80 years of age. 79.2% were male and 20.8% were females. Frequency of ABO blood groups among patients with acute myocardial infarction in our study population was recorded as 28.8% with O +ve , 26% with B+ve, 18.4% with A+ve, 13.2% with AB +ve, 5.6% with A-ve, 4.4% with B-ve, 3.2% with O-ve and 0.4% with AB -ve CONCLUSION: We concluded that the frequency of acute myocardial infarction in our population is higher among patients having blood group O+ve followed by B+ve blood group.

scholarly journals Association Between ABO Blood Groups And Myocardial Infarction In Jodhpur City of India

2012 ◽  
Vol 7 (1) ◽  
pp. 13-17
Author(s):  
Priyanka Garg ◽  
Jayant Kumar ◽  
Raghuveer Choudhary ◽  
VK Chawla
Keyword(s):  
Myocardial Infarction ◽  
Blood Group ◽  
Local Population ◽  
Cross Sectional Study ◽  
Blood Groups ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Chi Square ◽  
Cross Sectional ◽  
Group B

Background: Many reports have appeared in recent years showing an association between blood  groups and Myocardial Infarction. Clinical studies have shown a significant association between MI  and blood group B.Objective: To investigate correlation of ABO blood groups with risk of MI.Methods: The present cross sectional study analyzed ABO blood group among total 400 subjects of  any age from the local population of Jodhpur city from July to December 2011.Among them 200  subjects were normal health (135 male and 65 female) students of Dr. S.N. Medical College, Jodhpur  and another 200 (135 male, 65 female) were MI patients admitted in the CCU of Mathura Das  Memorial (MDM) Hospital, Jodhpur. ABO blood group of all subjects were determined by slide  agglutination method. Risk of MI was expressed by risk ratio. Data were analyzed by one sample chi  square test.Results: The results obtained in this study showed that the prevalence of MI in blood  group B is significantly higher than in all other ABO blood groups.Conclusion: The results may  conclude that there is a significant association between MI and blood group B. So this study reveals  MI risk is associated with the blood group B. DOI: http://dx.doi.org/10.3329/jbsp.v7i1.11154 J Bangladesh Soc Physiol. 2012, June; 7(1): 13-17

scholarly journals Blood group A: a risk factor for heart rupture after acute myocardial infarction

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuan Fu ◽  
Mulei Chen ◽  
Hao Sun ◽  
Zongsheng Guo ◽  
Yuanfeng Gao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Risk Factor ◽  
Blood Group ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Blood Group A ◽  
Heart Rupture ◽  
Group A ◽  
The Impact

Abstract Introduction Studies have been performed to identify the association between ABO blood groups and coronary artery disease. However, data is scarce about the impact of ABO blood groups on heart rupture (HR) after acute myocardial infarction (AMI). Methods We conducted a retrospective case–control study that included 61 consecutive patients with HR after AMI during a period from 1 January 2012 to 1 December 2019. The controls included 600 patients who were selected randomly from 8143 AMI patients without HR in a ratio of 1:10. Univariate and multivariate logistic regression analysis were used to identify the association between ABO blood groups and HR. Results Patients with blood group A had a greater risk of HR after AMI than those with non-A blood groups (12.35% vs 7.42%, P < 0.001). After adjusting for age, gender, heart rate at admission, body mass index (BMI), and systolic blood pressure (SBP), blood group A was independently related to the increased risk of HR after AMI (OR = 2.781, 95% CI 1.174–7.198, P = 0.035), and remained as an independent risk factor of HR after AMI in different multivariate regression models. Conclusion Blood group A is significantly associated with increased HR risk after AMI.

scholarly journals Correlation of ABO Blood Groups and Rh Factor with The Severity of Generalized Chronic Periodontitis: Across Sectional Study in Riyadh, Saudi Arabia

2019 ◽  
Vol 7 (4) ◽  
pp. 617-622 ◽  
Author(s):  
Diana Mostafa ◽  
Essam I. Elkhatat ◽  
Pradeep Koppolu ◽  
Muna Mahgoub ◽  
Esam Dhaifullah ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Blood Group ◽  
Chronic Periodontitis ◽  
Periodontal Diseases ◽  
Blood Groups ◽  
Blood Group Antigens ◽  
Abo Blood Groups ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group I

BACKGROUND: The development of periodontal diseases depends on the presence of causative microorganisms, host immunity and risk factors. Although variability present among the types of periodontal diseases, all are represented to a shared interaction between host and bacteria. ABO blood groups are the most investigated erythrocyte antigen system. However, limited investigations have been conducted to explore the alliance between ABO blood groups and periodontal diseases. AIM: Our purpose was to explore any possible association between the severity of chronic periodontitis with ABO blood groups and Rh factor. METHODS: A cross-sectional study was carried out on 205 patients out of 1126 generalised chronic periodontitis patients (GCP) who were referred to Al-Farabi Colleges, Riyadh, Saudi Arabia. They were categorized into; group I (mild), group II (moderate) and group III (sever). RESULTS: The patients with blood group O were at a greater risk to develop GCP irrespective of its severity, followed by those with blood group A, B, and AB. The dispensation of the Rh factor in all groups exhibited a significantly greater distribution of Rh positive. CONCLUSION: Genetic factors such as ABO blood group antigens may act as a risk influencer that affects the progression and severity of the chronic periodontitis.

scholarly journals DISTRIBUTION OF ABO AND RH (D) BLOOD GROUPS AMONG BLOOD DONORS IN DISTRICT MARDAN, PAKISTAN

1969 ◽  
Vol 3 (2) ◽  
pp. 318-322
Author(s):  
MUHAMMAD KHALID ◽  
NAILA ASLAM ◽  
MUHAMMAD SIYAR ◽  
RASHID AHMAD
Keyword(s):  
Blood Group ◽  
Blood Donors ◽  
Local Community ◽  
Healthy Adult ◽  
Blood Groups ◽  
Abo Blood Groups ◽  
Cross Sectional ◽  
Group B ◽  
Abo Blood Grouping ◽  
Blood Grouping

OBJECTIVE: To find out the distribution of ABO and Rh (D) blood groups among blood donors in districtMardan and to help transfusion services in the area.STUDY DESIGN: Cross sectional descriptive study.MATERIALS AND METHODS: The study was conducted in DHQ Hospital Mardan from 1st January2012 to 31st December 2012. A total of 2893 healthy adult, blood donors (both volunteer and directed) fromdistrict Mardan were included. Two ml of blood anti-coagulated with EDTA was taken and both ABO andRh (D) blood groups were determined using commercially available anti-sera of Biolaboratories. Thedistribution ofABO and Rh blood groups in the local community were then calculated.RESULTS: Among ABO blood groups “ B” (27.97%) was the most prevalent, followed by “0” (27.93%),“ A” (24.75%) and “ AB” (19.36%). Group Rh positive (94.30%) was more prevalent than Rh negative(5.70%). Similarly 0+ve (26.65%) was most frequent followed by B+ve (26.17%), A+ve (23.16%), AB+ve(18.32%), B've(1.80%),Ave(l.59%),O ve( 1.28%) and ABve( 1.04%).CONCLUSION: Blood group 'B' was most frequent among the ABO blood groups and Rh (D) positiveamong Rh blood groups while0+vewas the most frequent blood group in the study population.KEYWORDS: ABO Blood grouping, Rh (D) blood grouping, Mardan.

scholarly journals Assessing ABO/Rh Blood Group Frequency and Association with Asymptomatic Malaria among Blood Donors Attending Arba Minch Blood Bank, South Ethiopia

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Getaneh Alemu ◽  
Mohammedaman Mama
Keyword(s):  
Blood Group ◽  
Malaria Infection ◽  
Blood Donors ◽  
Blood Groups ◽  
High Rate ◽  
Abo Blood Group ◽  
Asymptomatic Malaria ◽  
Abo Blood Groups ◽  
Group Frequency ◽  
Rh Blood Group

Background. Determination of the various ABO/Rh blood group distributions and their association with malaria infection has paramount importance in the context of transfusion medicine and malaria control. Methods. Facility based cross-sectional study was conducted from February to June, 2015, to assess ABO/Rh blood groups distribution and their association with asymptomatic malaria. A structured questionnaire was used to collect data. Blood grouping was done using monoclonal antibodies. Thin and thick blood films were examined for Plasmodium parasites. Data were analyzed using SPSS version 20.0. Results. A total of 416 blood donors participated with median age of 22±0.29 (median ± standard error of the mean). Distribution of ABO phenotypes, in decreasing order, was O (175, 42.1%), A (136, 32.7%), B (87, 20.9%), and AB (18, 4.3%). Most of them were Rh+ (386, 92.8%). The overall malaria prevalence was 4.1% (17/416). ABO blood group is significantly associated with malaria infection (P=0.022). High rate of parasitemia was seen in blood group O donors (6.899, P=0.003) compared to those with other ABO blood groups. Conclusion. Blood groups O and AB phenotypes are the most and the least ABO blood groups, respectively. There is significant association between ABO blood group and asymptomatic malaria parasitemia.

scholarly journals Longitudinal SARS-CoV-2 Seroconversion Course and Antibody Levels by Blood Groups in Convalescent Plasma Donors in Turkey

2021 ◽  
Author(s):  
Aziz Karaca ◽  
Mustafa Nuri Günçıkan ◽  
Nazlı Nadire Sözmen ◽  
Gizem Gökçe Karadağ ◽  
Mustafa Yılmaz
Keyword(s):  
Antibody Response ◽  
Blood Group ◽  
Antibody Level ◽  
Time Course ◽  
Blood Groups ◽  
Group Method ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Igg Antibody ◽  
Rh Blood Group

Objective: The present study investigates the seroconversion time course of the IgG antibody against SARS-CoV-2 and ascertains whether its levels change according to the patient’s ABO blood group. Method: A total of 36,003-convalescent plasma (CP) donations of 12,315 Turkish Red Crescent CP donors were analyzed. The ABO blood group of the CP donors was determined by Gel Centrifugation; and IgG was measured using the Euroimmun anti-SARS-CoV-2 ELISA. The differences in the distributions of mean IgG ratios among the different ABO blood groups were analyzed with One-Way ANOVA and Independent Samples T-test. Results: Among the CP donors, 98.4% were male. An antibody response to SARS-CoV-2 was noted-although in a few CP donors- on the 244th day, and a significant association between the ABO blood groups and the mean IgG ratios was noted (p: 0.001). The highest (mean±SD) antibody level was observed in the AB blood group (39.5±15.7), followed by the B (37.9±11.5) and the A blood groups (36.6±10.7), while the lowest value was recorded in the O blood group (34.4±11.5). Significant differences between all paired groups were noted in pairwise comparisons. The Rh (-) blood group (37.4±13.6) had a significantly higher antibody level than the Rh (+) blood group (36.3±11.2) (p: 0.005). Conclusion: An antibody response to SARS-CoV-2 was noted in a CP donor on the 244th day. The average IgG ratios were higher in the CP donors with the AB blood group, but lower in the O blood group. These results may be considered a valuable indication of the effectiveness of CP therapy used for the treatment of COVID-19 patients with clinically relevant blood types.

scholarly journals Relationship between ABO blood group and breast cancer at AL-Nassyria city / Iraq

2008 ◽  
pp. 26-29
Keyword(s):  
Breast Cancer ◽  
Risk Factor ◽  
Cancer Patients ◽  
Blood Group ◽  
High Frequency ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Control Samples

The current study included 200 patients with breast cancer that resemble to patient samples were collected from AL-Nassyria hospital also 279 samples as control which was collected from blood bank at ALNassiryia province . The study attempted to correlate ABO blood group with incidence to breast cancer .The results shown that type A of ABO blood group high frequency then followed by type O with in AL-Nassyria region also the results reported that A, B, O and AB blood groups frequencies of patient samples percentage were 60%, 20%, 10% and 10% respectively as well as the ABO blood groups frequencies of control samples percentage were 26%, 28%,38% and 8% respectively. The results observed there is high significant differences between ABO blood group frequencies of cancer patients and ABO blood group frequencies of control samples .The results indicated that the blood type should be considered one of risk factor as well as regarded as preclinical marker.

scholarly journals Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation

2022 ◽  
Vol 8 ◽  
Author(s):  
Herbert F. Jelinek ◽  
Mira Mousa ◽  
Nawal Alkaabi ◽  
Eman Alefishat ◽  
Gihan Daw Elbait ◽  
...  
Keyword(s):  
Candidate Gene ◽  
Blood Group ◽  
Population Sample ◽  
Blood Groups ◽  
Blood Type ◽  
Candidate Gene Approach ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Allelic Variants ◽  
A Genome

Introduction: Coronavirus disease 2019 (COVID-19) disease severity differs widely due to numerous factors including ABO gene-derived susceptibility or resistance. The objective of this study was to investigate the association of the ABO blood group and genetic variations of the ABO gene with COVID-19 severity in a heterogeneous hospital population sample from the United Arab Emirates, with the use of an epidemiological and candidate gene approach from a genome-wide association study (GWAS).Methods: In this cross-sectional study, a total of 646 participants who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited from multiple hospitals and population-based (quarantine camps) recruitment sites from March 2020 to February 2021. The participants were divided into two groups based on the severity of COVID-19: noncritical (n = 453) and critical [intensive care unit (ICU) patients] (n = 193), as per the COVID-19 Reporting and Data System (CO-RADS) classification. The multivariate logistic regression analysis demonstrated the association of ABO blood type as well as circulating anti-A antibodies and anti-B antibodies as well as A and B antigens, in association with critical COVID-19 hospital presentation. A candidate gene analysis approach was conducted from a GWAS where we examined 240 single nucleotide polymorphisms (SNPs) (position in chr9: 136125788-136150617) in the ABO gene, in association with critical COVID-19 hospital presentation.Results: Patients with blood group O [odds ratio (OR): 0.51 (0.33, 0.79); p = 0.003] were less likely to develop critical COVID-19 symptoms. Eight alleles have been identified to be associated with a protective effect of blood group O in ABO 3'untranslated region (UTR): rs199969472 (p = 0.0052), rs34266669 (p = 0.0052), rs76700116 (p = 0.0052), rs7849280 (p = 0.0052), rs34039247 (p = 0.0104), rs10901251 (p = 0.0165), rs9411475 (p = 0.0377), and rs13291798 (p = 0.0377).Conclusion: Our findings suggest that there are novel allelic variants that link genetic variants of the ABO gene and ABO blood groups contributing to the reduced risk of critical COVID-19 disease. This study is the first study to combine genetic and serological evidence of the involvement of the ABO blood groups and the ABO gene allelic associations with COVID-19 severity within the Middle Eastern population.

ABO blood group and the risk of breast cancer: Multicenter, case-control, observational study.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1572-1572
Author(s):  
Yuksel Urun ◽  
Tulay Koru-Sengul ◽  
Kadri Altundag ◽  
Gungor Utkan ◽  
Handan Onur ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Blood Group ◽  
Blood Groups ◽  
Blood Type ◽  
Abo Blood Group ◽  
Abo Blood Groups ◽  
Blood Types ◽  
Abo Blood Type

1572 Background: The role of genetic factors in the development of cancer is widely accepted. ABO blood type is an inherited characteristic and previous studies have observed an association between ABO blood group and risk of certain malignancies, including pancreatic and gastric cancer. The data on the role of ABO blood group and Rh factor in breast cancer is inconclusive. Methods: All patients who had breast cancer (BC) and treated between 2000-2010 at the Departments of Medical Oncology of both Ankara and Hacettepe Universities (Ankara, Turkey) with defined ABO blood type and Rh factor were included in our retrospective reviews of tumor registry records. A group of volunteer healthy women donors of Turkish Red Crescent between 2004-2011 were identified as a control group, without any matching factors. The relationship of ABO blood types and Rh factor with various prognostic factors such as age at diagnosis, menopausal status, family history of breast cancer, and ER/PR/HER2 status were evaluated from 1740 BC patients. We compared the distributions of ABO blood types, Rh factors among 1740 patients and 204,553 healthy controls. Among BC patients, differences between each of aforementioned ABO blood groups and Rh factors with respect to various prognostic factors were explored, respectively. Results: Overall distributions of ABO blood groups as well as Rh factor were comparable between patients (44% A, 8% AB, 16% B, 32% O, 88% Rh+) and controls (41% A, 8% AB, 16% B, 35% O, 87% Rh+). However, there were statistically significant differences between patients and controls with respect to A vs. nonA (p=0.019) and marginal significance (p=0.051) for O vs. nonO. Among patients, there were statistically significant differences between A and nonA with respect to HER2 (p=0.0421), M stage (p=0.0447), T stage (p=0.0020). Only T stage (p=0.0337) were significantly different between O vs nonO. Grade (p=0.0227) and M stage (p=0.0107) were significantly different between Rh factors. Conclusions: In our study sample, ABO blood type was statistically significantly associated with breast cancer. Additional studies are necessary to determine the mechanisms by which ABO blood type may influence the risk of breast cancer.

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