VACCINE RACE TO BECOME A REALITY AGAINST THE HIGHLY INFECTIOUS CORONAVIRUS (COVID19)

Ensemble ◽  
2021 ◽  
Vol SP-1 (1) ◽  
pp. 146-148
Author(s):  
KOEL MUKHERJEE ◽  
◽  
Apoorva Sahu ◽  
Keyword(s):  
Host Cells ◽  
Cold Chain ◽  
Design And Development ◽  
Chain Management ◽  
Global Pandemic ◽  
Global Threat ◽  
Vaccine Distribution ◽  
Global Population ◽  
Full Proof ◽  
Genomic Material

COVID-19, is a global pandemic started in November 2019, extending beyond its biological scale to infect lives globally by inserting their genomic material inside the host cells. This global threat has till now claimed numerous lives with no possible full proof cure till date. There is no unanimity amongst the countries in the design and development of specific vaccines to cure COVID-19 and its distribution among the global population. India Government acquired “cold chain management” for safe and even distribution of present vaccines (Covaxin, Covisheild). Here, authors intend to put some light on the brief introduction, stages and perspective of cold chain logistics of vaccine distribution in India with 150crores of population.

Sustainable Food Logistics Systems

2020 ◽  
Author(s):  
Zhaohui Wu ◽  
Madeleine Elinor Pullman
Keyword(s):  
Supply Chain ◽  
Food Supply ◽  
Food Systems ◽  
Food System ◽  
New Technology ◽  
Cold Chain ◽  
Community Supported Agriculture ◽  
Food Supply Chain ◽  
Sustainable Food ◽  
Chain Management

Food supply chain management is becoming a critical management and public policy agenda. Climate change, growing demand, and shifting patterns of food production, delivery, and consumption have elicited a series of new challenges, such as food security, safety, and system resiliency. This chapter first introduces the typical players in a food supply chain and examines the global food system characterized by consolidation and industrialization. It then discusses some critical topics of the sustainable food supply chain that aim to address these challenges. These topics include traceability, transparency, certification and standards, and alternatives to industrialized food systems, including cooperatives, community-supported agriculture, and roles of small and medium-sized growers in regenerative agriculture. The chapter ends with a discussion of several important emerging logistics management topics, including last-mile delivery, new technology, and cold chain management.

scholarly journals How Do Consumers’ Food Values across Countries Lead to Changes in the Strategy of Food Supply-Chain Management?

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1523
Author(s):  
Jisung Jo ◽  
Eon-kyung Lee
Keyword(s):  
Supply Chain ◽  
Supply Chain Management ◽  
Random Parameter ◽  
Cold Chain ◽  
Chain Management ◽  
Consumer Values ◽  
Food Market ◽  
Import And Export ◽  
The Relationship ◽  
Food Value

Although one of the main goals of supply-chain management is to maximize consumer values, the research to date has mainly focused on the supply side. In the case of the food industry, understanding consumer needs and maximizing its utility are essential. In this study, we analyze consumers’ 12 meta-values (e.g., safety, taste, health, price, environment, etc.), then suggest the strategy of food cold-chain management satisfying consumers’ perception. We focused on consumers from three countries in Asia: Korea, China, and Japan. The survey was conducted with over 1000 consumers in those three countries, and a random parameter logit model was utilized to determine the importance of each food value that could affect consumers’ food choice. Similarities and differences were both found in share of preference of each food value across countries. While safety is one of the top three values in all three countries, naturalness and nutritional value ranked among the top three only in China. To propose the consumer-centric strategy of food cold-chain management, we investigated the relationship between each food value and each node of supply chain based on the big data analysis. It shows that consumers prefer when the entire supply chain is managed where each node is organically connected with each other instead of individual nodes being managed separately. Further, strategies for food cold-chain management should be developed differently by country, incorporating differences of consumers’ preferences on food value. These results would motivate governments and companies related to food cold chain to reconsider their marketing strategies on the import and export food market.

scholarly journals D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural Effect

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2622
Author(s):  
Romina Oliva ◽  
Abdul Rajjak Shaikh ◽  
Andrea Petta ◽  
Anna Vangone ◽  
Luigi Cavallo
Keyword(s):  
Three Dimensional ◽  
Salt Bridge ◽  
Structural Effect ◽  
Host Cells ◽  
Heptad Repeat ◽  
Genomic Sequences ◽  
Strong Interactions ◽  
Virus Infectivity ◽  
S Protein ◽  
Global Threat

The crown of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is constituted by its spike (S) glycoprotein. S protein mediates the SARS-CoV-2 entry into the host cells. The “fusion core” of the heptad repeat 1 (HR1) on S plays a crucial role in the virus infectivity, as it is part of a key membrane fusion architecture. While SARS-CoV-2 was becoming a global threat, scientists have been accumulating data on the virus at an impressive pace, both in terms of genomic sequences and of three-dimensional structures. On 15 February 2021, from the SARS-CoV-2 genomic sequences in the GISAID resource, we collected 415,673 complete S protein sequences and identified all the mutations occurring in the HR1 fusion core. This is a 21-residue segment, which, in the post-fusion conformation of the protein, gives many strong interactions with the heptad repeat 2, bringing viral and cellular membranes in proximity for fusion. We investigated the frequency and structural effect of novel mutations accumulated over time in such a crucial region for the virus infectivity. Three mutations were quite frequent, occurring in over 0.1% of the total sequences. These were S929T, D936Y, and S949F, all in the N-terminal half of the HR1 fusion core segment and particularly spread in Europe and USA. The most frequent of them, D936Y, was present in 17% of sequences from Finland and 12% of sequences from Sweden. In the post-fusion conformation of the unmutated S protein, D936 is involved in an inter-monomer salt bridge with R1185. We investigated the effect of the D936Y mutation on the pre-fusion and post-fusion state of the protein by using molecular dynamics, showing how it especially affects the latter one.

scholarly journals A cross-sectional survey on cold chain management of vaccines in Cebu, Philippines

2018 ◽  
Vol 16 (2) ◽  
pp. 1167 ◽  
Author(s):  
Patrisha L. Maglasang ◽  
Ma L. Butalid ◽  
Maria F. Pastoril ◽  
Antonius N. Pratama ◽  
Elizabeth Y. Tan
Keyword(s):  
Cold Chain ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Chain Management

scholarly journals The promiscuous and highly mobile resistome of a superbug

2021 ◽  
Author(s):  
Ismael Hernández-González ◽  
Valeria Mateo-Estrada ◽  
Santiago Castillo-Ramírez
Keyword(s):  
Population Dynamics ◽  
Gene Content ◽  
Massive Data ◽  
Nosocomial Pathogen ◽  
Data Set ◽  
Massive Data Set ◽  
The Individual ◽  
Global Threat ◽  
And Control ◽  
Global Population

AbstractAntimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR is critical to restrain and control this issue. However, no study has provided a global picture of the resistome of Acinetobacter baumannii, a very important nosocomial pathogen. Here we analyze 1450+ genomes (covering > 40 countries and > 4 decades) to infer the global population dynamics of the resistome of this species. We show that gene flow and horizontal transfer have driven the dissemination of AR genes in A. baumannii. We found considerable variation in AR gene content across lineages. Although the individual AR gene histories have been affected by recombination, the AR gene content has been shaped by the phylogeny. Furthermore, many AR genes have been transferred to other well-known pathogens, such as Pseudomonas aeruginosa or Klebsiella pneumoniae. Finally, despite using this massive data set, we were not able to sample the whole diversity of AR genes, which suggests that this species has an open resistome. Ours results highlight the high mobilization risk of AR genes between important pathogens. On a broader perspective, this study gives a framework for an emerging perspective (resistome-centric) on the genome epidemiology (and surveillance) of bacterial pathogens.

scholarly journals A Cold Chain-Independent Specimen Collection and Transport Medium Improves Diagnostic Sensitivity and Minimizes Biosafety Challenges of COVID-19 Molecular Diagnosis

2021 ◽  
Author(s):  
Vikram Saini ◽  
Priya Kalra ◽  
Manish Sharma ◽  
Chhavi Rai ◽  
Vikas Saini ◽  
...  
Keyword(s):  
Molecular Diagnosis ◽  
Urban Population ◽  
Viral Transmission ◽  
Diagnostic Sensitivity ◽  
Cold Chain ◽  
Transport Medium ◽  
Contagious Nature ◽  
Specimen Collection ◽  
Rural And Urban ◽  
Global Population

Approximately forty-four percent of the global population lives in villages, including 59% in Africa ( https://unhabitat.org/World%20Cities%20Report%202020 ). The fast-evolving nature of SARS-CoV-2 and its extremely contagious nature warrant early and accurate COVID-19 diagnostics across rural and urban population as a key to prevent viral transmission. Unfortunately, lack of adequate infrastructure, including the availability of biosafety-compliant facilities and an end-to-end cold chain availability for COVID-19 molecular diagnosis, limits the accessibility of testing in these countries.

scholarly journals Factors Related to Practice on DPT Vaccine Distribution and Storage

2014 ◽  
Vol 2 (2) ◽  
pp. 240
Author(s):  
Fitri Rahayu
Keyword(s):  
Simple Random Sampling ◽  
Cold Chain ◽  
Primary Data ◽  
Cross Sectional ◽  
Immunization Service ◽  
Work Duration ◽  
History Of ◽  
Vaccine Distribution ◽  
And Storage ◽  
Dpt Vaccine

ABSTRACTThe diptheria outbreak in Surabaya indicated that immunization program failure. Immunization is primary preventif effort to decrease morbidity of disease. An immunization service is very important to protect vaccine quality through cold chain so that vaccine potency be optimal. The purpose of this study was to analysis of factors which are assosiated with midwive’s practice of DPT vaccine distribution and storage to outreach. This study is applying observational approach using cross sectional method. Populations are all village midwives in public health center East Surabaya. The numbers of sample were 38 midwives taken using simple random sampling. The dependent variable was midwive’s practice of DPT vaccine distribution and storage to outreach and the independent variables of this study were work duration, a history of training of cold chain, sosialization, knowledge, attitude. Primary data were obtained through observation and interview. The results showed that 68.4 % midwive’s practice on DPT vaccine distribution and storage at outreach is good. Independent variable which are significant assosiated with midwive’s practice on DPT vaccine distribution and storage at outreach is sosialization about vaccine distribution and storage (p = 0.026) and value of phi and Cramer’s V = 0.431. Enhancement of socialization again be needed to village midwive as efforts for increase knowledge and attitude.Keywords: midwive, cold chain, vaccine distribution, DPT

scholarly journals Role of Hospital Digital Services in Improvement of Clinical Regime of Patients

2021 ◽  
Author(s):  
Nassim Bout ◽  
Fatima Ouzayd ◽  
Kawtar Retmi
Keyword(s):  
Supply Chain ◽  
Supply Chain Management ◽  
Process Model ◽  
Enterprise Architecture ◽  
Cold Chain ◽  
Chain Management ◽  
Goods And Services ◽  
Digital Services ◽  
Management Approaches

Context: Healthcare supply chain management is the regulation of the flow of medical goods and services from manufacturers to patients. Supply chain management encompasses the planning and managing of all activities involved in sourcing and procurement, conversion, and all logistics management activities. Therefore, it greatly helps material managers to manage through continuous improvement efforts while maintaining the quality of care. Moreover, reinforcing healthcare logistics information technology (IT) architecture immediately leads to more patient satisfaction. Objectives: This study aimed to develop an architecture for designing efficient software aiding with the management of the healthcare supply chain. Methods: This study showed the role of digital services in the improvement of the clinical regime of patients by presenting different approaches with distinguishing the main types of hospital logistics, such as physical flow management, food safety, and cold chain management approaches (e.g., “moving forward”), and modeling these components using the solution architecture principles of ITs, such as Business Process Model and Notation. Results: This study proposed a hospital enterprise architecture by modeling a system to have a base for building a digital catering service that improves the clinical regime of patients.

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