scholarly journals COVID-19 Pandemic in Nigeria: A review

2020 ◽  
Vol 3 (1) ◽  
pp. 11-26
Author(s):  
Charles Elikwu ◽  
Oladapo Walker
Keyword(s):  
International Committee ◽  
Dominant Mode ◽  
Main Body ◽  
African Continent ◽  
Rapid Rise ◽  
Wuhan City ◽  
Infected People ◽  
Health Measures ◽  
The World ◽  
Novel Coronavirus

Background: An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, China. This new virus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses. That disease, caused by the SARS-CoV-2, has been named coronavirus disease 2019 (COVID-19) by the WHO. The outbreak has since spread across the globe, including countries in Africa. Main body: The dominant mode of transmission is from the respiratory tract, via droplets or indirectly via fomites, and to a lesser extent via aerosols.  The rapidity with which the infection spread throughout the world was unexpected. The disease has now affected 212 countries, areas, or territories, with more than 2.1 million total confirmed cases and over 144 thousand fatalities as at the time of writing. It, therefore, behooves countries of the world to take firm public health measures for the pandemic is to be contained. Conclusion: Nigeria, with a population of at least 170 million people, is of global interest because a rapid rise in the number of infected people will have serious implications not only for the country but for the whole African continent.%MCEPASTEBIN%

Treatment Options in COVID-19: The Role of Bioavailable Antiviral Ribonucleoside Analog on NHC in vitro

2020 ◽  
Author(s):  
Lara Bittmann
Keyword(s):  
World Health Organization ◽  
Clinical Picture ◽  
Treatment Options ◽  
World Health ◽  
Wuhan City ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

On December 31, 2019, WHO was informed of cases of pneumonia of unknown cause in Wuhan City, China. A novel coronavirus was identified as the cause by Chinese authorities on January 7, 2020 and was provisionally named "2019-nCoV". This new Coronavirus causes a clinical picture which has received now the name COVID-19. The virus has spread subsequently worldwide and was explained on the 11th of March, 2020 by the World Health Organization to the pandemic.

scholarly journals An outline of SARS-CoV-2 pathogenesis and the complement cascade of immune system

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Padmalochan Hembram
Keyword(s):  
Immune System ◽  
Dark Side ◽  
Main Body ◽  
The Novel ◽  
Transmission Chain ◽  
The World ◽  
Therapeutic Molecules ◽  
Rapid Transmission ◽  
Novel Coronavirus ◽  
Near Future

Abstract Background Coronavirus disease 19 is a viral infection caused by a novel coronavirus, SARS-CoV-2. It was first notified in Wuhan, China, is now spread into numerous part of the world. Thus, the world needs urgent support and encouragement to develop a vaccine or antiviral treatments to combat the atrocious outbreak. Main body of the abstract The origin of this virus is yet unknown; however, rapid transmission from human-to-human “Anthroponosis” has widely confirmed. The world is witnessing a continuous hike in SARS-CoV-2 infection. In light of the outbreak of coronavirus disease 19, we have aimed to highlight the basic and vital information about the novel coronavirus. We provide an overview of SARS-CoV-2 transmission, timeline and its pathophysiological properties which would be an aid for the development of therapeutic molecules and antiviral drugs. Immune system plays a crucial role in virus infection in order to control but may have dark side when becomes uncontrollable. The host and SARS-CoV-2 interaction describe how the virus exploits host machinery and how overactive host immune response can cause disease severity also addressed in this review. Short conclusion Safe and effective vaccines may be the game-changing tools, but in the near future wearing mask, washing hands at regular intervals, avoiding crowed, maintaining physical distancing and hygienic surrounding, must be good practices to reduce and break the transmission chain. Still, research is ongoing not only on how vaccines protect against disease, but also against infection and transmission.

scholarly journals Early epidemiological assessment of the transmission potential and virulence of coronavirus disease 2019 (COVID-19) in Wuhan City: China, January-February, 2020

2020 ◽  
Author(s):  
Kenji Mizumoto ◽  
Katsushi Kagaya ◽  
Gerardo Chowell
Keyword(s):  
Basic Reproduction Number ◽  
Reproduction Number ◽  
Public Health Intervention ◽  
Ecological Modelling ◽  
The Novel ◽  
Wuhan City ◽  
Transmission Potential ◽  
The World ◽  
Novel Coronavirus ◽  
Epidemiological Parameters

AbstractBackgroundSince the first cluster of cases was identified in Wuhan City, China, in December, 2019, coronavirus disease 2019 (COVID-19) rapidly spread around the world. Despite the scarcity of publicly available data, scientists around the world have made strides in estimating the magnitude of the epidemic, the basic reproduction number, and transmission patterns. Accumulating evidence suggests that a substantial fraction of the infected individuals with the novel coronavirus show little if any symptoms, which highlights the need to reassess the transmission potential of this emerging disease. In this study, we derive estimates of the transmissibility and virulence of COVID-19 in Wuhan City, China, by reconstructing the underlying transmission dynamics using multiple data sources.MethodsWe employ statistical methods and publicly available epidemiological datasets to jointly derive estimates of transmissibility and severity associated with the novel coronavirus. For this purpose, the daily series of laboratory–confirmed COVID-19 cases and deaths in Wuhan City together with epidemiological data of Japanese repatriated from Wuhan City on board government–chartered flights were integrated into our analysis.ResultsOur posterior estimates of basic reproduction number (R) in Wuhan City, China in 2019–2020 reached values at 3.49 (95%CrI: 3.39–3.62) with a mean serial interval of 6.0 days, and the enhanced public health intervention after January 23rd in 2020 was associated with a significantly reduced R at 0.84 (95%CrI: 0.81–0.88), with the total number of infections (i.e. cumulative infections) estimated at 1906634 (95%CrI: 1373500–2651124) in Wuhan City, elevating the overall proportion of infected individuals to 19.1% (95%CrI: 13.5–26.6%). We also estimated the most recent crude infection fatality ratio (IFR) and time–delay adjusted IFR at 0.04% (95% CrI: 0.03%–0.06%) and 0.12% (95%CrI: 0.08–0.17%), respectively, estimates that are several orders of magnitude smaller than the crude CFR estimated at 4.06%ConclusionsWe have estimated key epidemiological parameters of the transmissibility and virulence of COVID-19 in Wuhan, China during January-February, 2020 using an ecological modelling approach. The power of this approach lies in the ability to infer epidemiological parameters with quantified uncertainty from partial observations collected by surveillance systems.

scholarly journals Molecular Docking Study of the Potential Relevance of the Natural Compounds Isoflavone and Myricetin to COVID-19

2021 ◽  
Vol 25 (3) ◽  
pp. 271-282
Author(s):  
Didik Priyandoko ◽  
◽  
Wahyu Widowati ◽  
Mawar Subangkit ◽  
Diana Jasaputra ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Severe Acute Respiratory Syndrome ◽  
Active Sites ◽  
Docking Study ◽  
Binding Mode ◽  
Molecular Docking Study ◽  
Wuhan City ◽  
The World ◽  
Novel Coronavirus ◽  
Proteins Interactions

The 2019 novel coronavirus (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly from its origin in Wuhan City, Hubei Province, China, to the rest of the world. The efficacy of herbal treatment in the control of contagious disease was demonstrated during the 2003 outbreak of severe acute respiratory syndrome (SARS). Natural compound used for this study were isoflavone and myricetin. Molecular docking was performed to analyze binding mode of the compounds towards 12 proteins related to COVID-19. The prediction shows that isoflavone and myricetin have moderate probability of antiviral activity. All of the docked compounds occupied the active sites of the proteins related to COVID-19. Based on QSAR and molecular docking, interactions were predicted with 10 out of 12 potential COVID-19 proteins for myricetin and with 9 out of 12 proteins interactions for isoflavone. A potential disease alleviating action is suggested for isoflavone and myricetin in the context of COVID-19 infection.

COVID-19: Pakistan’s Preparedness and response

2021 ◽  
Vol 1 (4) ◽  
pp. e207
Author(s):  
Sahrish Khan ◽  
Atiq ur Rahman ◽  
Muhammad Imran
Keyword(s):  
Preventive Measures ◽  
Awareness Campaign ◽  
Wuhan City ◽  
The World ◽  
Novel Coronavirus

At the end of December 2019 in the Wuhan City of China, a novel coronavirus (Covid-19) outbreak has been proclaimed. Several cases have arisen in other cities of China. It spread simultaneously worldwide in 209 countries of Europe, Australia, America, Asia, and Pakistan. Mortality is high; millions of people have been affected while cases are rapidly increasing in the world. Different controlling strategies have been adopted for COVID-19. Pakistan took rigorous measures like the hospital, specific laboratories for testing, centres for quarantine, awareness campaign, Ehsaas Emergency Cash Programme and lockdown for controlling this virus. There is no antiviral and vaccine based treatment only preventive measures are taken.

scholarly journals The Infection Rate of the Coronavirus Disease 2019 (COVID-19) in Wuhan, China

2020 ◽  
Author(s):  
Hui-Qi Qu ◽  
Zhangkai J. Cheng ◽  
Zhifeng Duan ◽  
Lifeng Tian ◽  
Hakon Hakonarson
Keyword(s):  
Public Health ◽  
Health Policy ◽  
Mortality Rate ◽  
Infection Rate ◽  
Infection Rates ◽  
Policy And Practice ◽  
Wuhan City ◽  
Infected People ◽  
Health Measures ◽  
New Findings

Summary BoxWhat is already known about this subject?The Wuhan city in China had a much higher mortality rate (Feb 10th statistics: 748 death/18,454 diagnosis =4.05%; Apr 24th statistics: 3,869 death/50,333 diagnosis=7.69%) than the rest of China.What are the new findings?Based on our analysis, the number of infected people in Wuhan is estimated to be 143,000 (88,000 to 242,000) in late January and early February, significantly higher than the published number of diagnosed cases.What are the recommendations for policy and practice?Increased awareness of the original infection rates in Wuhan, China is critically important for proper public health measures at all levels, as well as to eliminate panic caused by overestimated mortality rate that may bias health policy actions by the authorities

scholarly journals Analysis and Prediction for the Spreading of Covid-19 Pandemic in India Using Mathematical Modeling

2020 ◽  
Author(s):  
Nanda Poddar ◽  
Subham Dhar ◽  
Kajal Kumar Mondal ◽  
Gourab Saha
Keyword(s):  
Mathematical Modeling ◽  
Applied Mathematics ◽  
Medical Science ◽  
Spreading Rate ◽  
Living Room ◽  
Daily Lives ◽  
Infected People ◽  
Effective Strategies ◽  
The World ◽  
Novel Coronavirus

In the present time, the biggest problem of the world is the outbreak of novel coronavirus. Novel coronavirus (COVID-19), this one name has become a part of our daily lives over the past few months. Beyond the boundaries of medical science, coronavirus is now the main subject of research in all fields like Applied Mathematics, Economy, Philosophy, Sociology, Politics upto living room. The epidemic has brought unimaginable changes in our traditional habits and daily routines. Thousands of people in our country are fighting with the rest of the world to survive in various new situations. There are different kinds of coronavirus appeared in different times. In this time, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is responsible for the coronavirus disease of 2019 (COVID-19). This virus was first identified towards the end of 2019 in the city of Wuhan in the province of Hubei in China. Within very short duration of time and very fast, it has spread throughout a large part of the world. In this study, the main aim is to investigate the spreading rate, death rate, recovery rate due to corona virus infection and to study the future of the coronavirus in India by using mathematical modeling based on the previous data. Mathematical models, in this situation, are the important tools in recruiting effective strategies to fight this epidemic. India is at high risk of spreading the disease and is facing many losses in socio-economic aspects. With current infection rates and existing levels of personal alertness, the number of infected people in India will increase at least in the next three months. Proper social awareness, maintain of social distance, large rate of testing and separation may break the chain of the Coronavirus-2.

scholarly journals Facemask shortage and the coronavirus disease (COVID-19) outbreak: Reflection on public health measures

2020 ◽  
Author(s):  
Huailiang Wu ◽  
Jian Huang ◽  
Casper J. P. Zhang ◽  
Zonglin He ◽  
Wai-Kit Ming
Keyword(s):  
Public Health ◽  
Infectious Disease ◽  
Disease Outbreaks ◽  
Wuhan City ◽  
Medical Resources ◽  
Infectious Disease Outbreaks ◽  
Health Measures ◽  
Global Pandemic ◽  
Novel Coronavirus ◽  
Effective Public Health

AbstractBackgroundA novel coronavirus disease (COVID-19) outbreak due to SARS-CoV-2 infection occurred in China in late-December 2019. Facemask wearing is considered as one of the most cost-effective and important measures to prevent the transmission of SARS-CoV-2, but it became a social concern due to the recent global facemask shortage. China is the major facemask producer in the world, contributing to 50% of global production. However, even full productivity (20 million facemasks per day) does not seem to meet the need of a population of 1.4 billion in China.MethodsPolicy review using government websites and shortage analysis using mathematical modelling based on data obtained from the National Health Commission (NHC), the Ministry of Industry and Information Technology (MIIT), the Center for Disease Control and Prevention (CDC) of the People’s Republic of China, and Wuhan Bureau of Statistics.FindingsSupplies of facemasks in the whole of China would have been sufficient for both healthcare workers and the general population if the COVID-19 outbreak only occurred in Wuhan city or Hubei province. However, if the outbreak occurred in the whole of China, facemask supplies in China could last for 5 days if under the existing public health measures and a shortage of 853 million facemasks is expected by 30 Apr 2020. Assuming a gradually decreased import volume, we estimated that dramatic increase in productivity (42.7 times of the usual level) is needed to mitigate the facemask crisis by the end of April.InterpretationIn light of the COVID-19 outbreak in China, a shortage of facemasks and other medical resources can considerably compromise the efficacy of public health measures. Effective public health measures should also consider the adequacy and affordability of medical resources. Global collaboration should be strengthened to prevent the development of a global pandemic from a regional epidemic via easing the medical resources crisis in the affected countries.Research in contextEvidence before this studyWe searched PubMed and Web of Science for articles in English, between 1 Jan 1980, and 1 Jan 2020, using the search terms 1) (infection OR infectious disease* OR outbreaks) AND (modelling); and 2) (mask* OR facemask* OR medical resource*) AND (infection OR infectious disease* OR outbreaks). Most relevant studies identified were performed to predict diseases spread and to determine the original infection source of previous epidemics like SARS and H7N9. However, few studies focused on the medical resources crisis during the outbreaks.Added value of this studyTo the best of our knowledge, this is the first study to investigate the facemask shortage during the novel coronavirus pneumonia (COVID-19) outbreak in China. We have summarized in detail the management strategies implemented by the Chinese governments during the outbreaks. By considering three scenarios for the outbreak development, we simulated the facemasks availability from late-December 2019 to late-April 2020 and estimated the duration of sufficient facemask supplies. Our findings showed that if the COVID-19 outbreak occurred only in Wuhan city or Hubei province, facemask shortage would not appear with the existing public health measures. However, if the outbreak occurred in the whole of China, a shortage of facemask could be substantial assuming no alternative public health measures.Implications of all the available evidenceOur findings provide insight into the public health measures to confront medical resources crisis during infectious disease outbreaks. Effective public health measures should consider the adequacy and affordability of existing medical resources. Governments across the world should revisit their emergency plans for controlling infectious disease outbreaks by taking into account the supply of and demand for the medical resource. Global collaboration should be strengthened to prevent the development of a global pandemic from a regional epidemic via easing the medical resources crisis in the affected countries.

scholarly journals Another coronavirus, Another challenge

JMS SKIMS ◽  
2020 ◽  
Vol 23 (1) ◽  
pp. 1-2
Author(s):  
Rafi A Jan ◽  
Arif Rehman Sheikh
Keyword(s):  
Animal Species ◽  
Large Family ◽  
Animal Origin ◽  
Chinese Isolate ◽  
Wuhan City ◽  
Animal Reservoir ◽  
The World ◽  
Enteric Infections ◽  
The Many ◽  
Novel Coronavirus

The world is yet again challenged by the outbreak of a new coronavirus, named SARS-CoV-2; disease caused by this virus, now termed as COVID-19,was first reported in Wuhan City, Hubei Province China in the last week of December 2019. As of march 5, WHO reports a total of 80,430 cases of COVID-19 with 3013 deaths from China. The disease has been now reported in all the continents of the world except Antarctica –around 15,053 cases in 85 countries with 273 deaths. Although many cases have been reported in India, whether it going to touch this part of the country too, only time will tell.  It is very likely that by the time this editorial goes in print, the numbers would have changed significantly. It is because of this developing outbreak situation that has engulfed the entire world and has the potential to turn into a pandemic, I decided to focus on this new disease than to comment on one of the many well written papers in this issue of the journal. Understanding of this novel coronavirus, SARS-CoV-2, is evolving. This virus belongs to a large family of viruses known as coronaviridae family which are enveloped positive stranded RNA viruses causing respiratory and enteric infections affecting both animals and humans. The animal species infected by various coronaviruses include camels, cattle, cats and bats. Although very uncommon, coronaviruses of animal origin can infect humans and then spread from person to person, sometimes with devastating morbidity and mortality as is the case with MERS-CoV. The other two animal coronaviruses infecting people are SARS-CoV and SARS-CoV-2. All these three viruses are betacoronaviruses and have their origin in bats1. Sequences from SARS-CoV-2 generated from patients outside China are similar to the original Chinese isolate suggesting a likely single emergence of SARS-CoV-2 from an animal reservoir. In the coming months we expect to learn more about the evolution and other pathogenetic aspects of the disease caused by SARS-CoV-2

SARS-CoV-2: Origin, pathogenesis and Therapeutic Interventions

Coronaviruses ◽  
2020 ◽  
Vol 01 ◽  
Author(s):  
Ipsita G Kundu ◽  
NNV Radharani ◽  
Amit S Yadav ◽  
Srinivas Patnaik ◽  
Gopal C Kundu
Keyword(s):  
Large Population ◽  
Supportive Therapy ◽  
Therapeutic Interventions ◽  
Personal Hygiene ◽  
Therapeutic Approaches ◽  
Wuhan City ◽  
Comprehensive Information ◽  
The World ◽  
Novel Coronavirus ◽  
Different Parts

: In December, 2019 a novel coronavirus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) rapidly infected a large population in Wuhan city, Hubei province, China. Since then it has been spread all over the world causing a pandemic termed as Coronavirus Disease 2019 or COVID-19. It has infected over 32 million people and caused more than nine lakhs casualties worldwide till date. Till now there is no specific drug or vaccine has been developed to prevent the spread of SARS-CoV-2. WHO has announced that personal hygiene and social distancing are the best available options against COVID-19 till now. Various experimental and re-purposed drugs are being used as preventive and supportive therapy in different parts of world. Comprehensive information about SARS-CoV-2 is required to develop therapeutic approaches for prevention of COVID-19. In this article, we have comprehensively reviewed the origin, structure and infection mechanism of SARS-CoV-2. We have also discussed the pathology of COVID-19 and various therapeutic interventions which are being used for drug development against COVID-19.

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