scholarly journals Formulation of Sea Buckthorn Diabo Juice on Treatment of Diabetes

2020 ◽  
Vol 5 (6) ◽  
pp. 253-258
Author(s):  
Akshay S Jadhav ◽  
Pallavi S Kale ◽  
Vaishnavi N Pankade ◽  
Snehal A Kardule ◽  
Shubhangi B Hase ◽  
...  
Keyword(s):  
Blood Flow ◽  
Blood Sugar ◽  
Side Effect ◽  
Blood Sugar Level ◽  
Chemical Substance ◽  
Insulin Production ◽  
Diabetic Medicine ◽  
Pancreatic Cells ◽  
Herbal Formulation ◽  
Treatment Of Diabetes

Now days lot of diabetic medicine are available in market having chemical substance. They have lots of side effect but now days lot of anti diabetic medicines are available but sometimes they does not show effect on same patient. Their bodies does not stimulate B-pancreatic cells in bodies which are insulin production. To overcome this problems by using anti diabetic herbal formulation. It is effective, safe to use It maintain blood sugar level , Regulate the blood flow, It has anti diabetic , antioxidant , anticancer, anti microbial and antiinflammatory properties without any side effect.

Pancreatic beta-cell regeneration

1988 ◽  
Vol 77 (03) ◽  
pp. 147-151 ◽  
Author(s):  
D.P. Rastogi ◽  
A.C. Saxena ◽  
Sunil Kumar
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
Pancreatic Beta Cell ◽  
Diabetic Rats ◽  
Alcoholic Extract ◽  
Β Cells ◽  
Pancreatic Β Cells ◽  
Treatment Of Diabetes ◽  
Wild Variety ◽  
Histopathological Studies

Abstract Cephalendra, indica ∅ (41% v/v alcoholic extract of the wild variety of Cephalendra indica Naud.), on regular administration in doses ranging from 25 μml to 75 μml/100 g of body weight (gbw) by the oral or intraperitoneal (ip) route produced a significant fall in blood sugar level in alloxan-induced diabetic rats. Biochemical studies showed stabilization of blood sugar level in 70% of cases of fourteen to twenty days after withdrawal of the drug. Histopathological studies revealed regeneration of pancreatic β cells. The hypothesis is that the drug acts through the hypothalamo-hypophysial-pancreatic axis, producing selective regeneration of β cells. The drug may indirectly release inhibitory factors from hypothalamic neurons, inhibiting the secretion of growth hormone and triggering insulin secretion from β cells. The therapeutic action of the drug on pancreatic β cells and lack of acute and subacute toxicity may open up new prospects in the treatment of diabetes mellitus.

scholarly journals REVIEW OF POTENTIAL PLANTS IN INDONESIA AS AN ANTIDIABETIC WITH HYPOGLYCEMIC ACTIVITIES

2021 ◽  
Vol 3 (2) ◽  
pp. 57
Author(s):  
Mutiarani Dasha Hanggaresty ◽  
Ni Kadek Warditiani
Keyword(s):  
Diabetes Mellitus ◽  
Pancreatic Tissue ◽  
Review Article ◽  
Keywords Diabetes Mellitus ◽  
Hypoglycemic Activity ◽  
Asiatic Acid ◽  
Insulin Production ◽  
Keywords Diabetes ◽  
Pancreatic Cells ◽  
Treatment Of Diabetes

Background: Diabetes mellitus which is characterized by hyperglycemia is a metabolic disease due to insulin action, defects in insulin secretion, or both. Various studies have shown that herbs that have a hypoglycemic effect can be used in the treatment of diabetes mellitus. Generally, herbs can slow down the complications of diabetes mellitus and improve metabolism. The ability of plants to restore the function of pancreatic tissue to increase insulin production or make it easier for insulin to process glucose is related to the effects of hypoglycemia. Objective: Comparing plants that have a hypoglycemic activity that can be used in the treatment of diabetes mellitus in Indonesia. Methods: studying literature from various databases, websites, national journals, and relevant international journals to identify plants that have hypoglycemic activity. Results: The mechanism A. sativum as a hypoglycemic involves different fiber viscosities; A. vera involved as a hypoglycemic by protecting pancreatic? cells; Asiatic acid in C. asiatica increasing glycolysis by restoring the activity of key enzymes; G. max inhibiting ?-amylase and the stigmasterol increasing the absorption of blood glucose and reducing insulin resistance; P. macrocarpa exert their antidiabetic action via ?-glucosidase modulation, an extra distinctive pancreatic mechanism; S. arvensis has the potential to inhibit ?-amylase enzymes. Conclusions: This review article has presented 6 detailed comparisons of plants that have a hypoglycemic activity that can be used in the treatment of diabetes mellitus in Indonesia and we believe can be useful for students, researchers, or practitioners. Keywords: Diabetes mellitus, hypoglycemia, Indonesian plants

scholarly journals Fluid Nanocarrier for Insulin for Noninvasive Treatment of Diabetes Mellitus

2020 ◽  
Author(s):  
Jamal Alyoussef Alkrad
Keyword(s):  
Blood Sugar ◽  
Blood Sugar Level ◽  
The Body ◽  
Noninvasive Treatment ◽  
Oral Application ◽  
Poor Patient Compliance ◽  
Transdermal Application ◽  
High Illumination ◽  
Treatment Of Diabetes ◽  
Term Monitoring

Abstract Background A real solution for diabetics to end their suffering with injection and the consequences of poor patient compliance based on the understanding how the body releases insulin as well as the nature of insulin is an argent demand. In this study a novel management strategy was developed using fluid nanocarrier as well as a solution of insulin to treat this problem. The developed nanocarrier is a microemulsion (ME) containing insulin. The transdermal flux of insulin was estimated through rat’s skin using a Franz diffusion cell. Moreover, the efficacy of the treatments was assessed orally and transdermally in rats. Results Based on the rheological properties and droplets size results the formulated fluids were microemulsions. Also, a flux of insulin as high as 1.77±0.22 iu.cm-2.h-1 through rat’s epidermis could be achieved. The short term monitoring of blood sugar level after transdermal application exhibited a slight decrease. On the other hand, the frequent application could achieve a satisfied decline. However, the rapid and significant reduction of the blood sugar level after oral application was surprised. The X-raying of the GI after oral application of the preparation showed high illumination in the lower part of the esophagus and upper part of the stomach. Conclusion This study reveals high potential esophageal absorption using fluid dosage forms. It must be taken in consideration as sublingual and intranasal application. The developed nanofluid can control the blood sugar level orally or in combination with transdermal application and help the diabetics to adhere their therapeutic course.

scholarly journals Pharmacopeial Testing of Poly-Herbal Formulation for the Management of Diabetes Mellitus

2021 ◽  
pp. 31-40
Author(s):  
Farah-Saeed . ◽  
S. M. Alam ◽  
A. S. Memon
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Research Work ◽  
Morbidity And Mortality ◽  
Herbal Preparation ◽  
Efficacy And Safety ◽  
Natural Origin ◽  
Herbal Formulation ◽  
Pharmacological Studies

Diabetes mellitus is a global cause of morbidity and mortality. There is a continuous rise in the patients of diabetes in Pakistan. Many conventional and natural origin medicines are available for maintaining optimum blood sugar level. There is a need to carry out standardization of the natural origin medicine to authenticate their efficacy and safety. The objective of this research work was to carry out preliminary pharmacognostic, phytochemical, biological, pharmacological studies on poly-herbal formulation. The poly-herbal preparation was prepared and evaluated for the standard pharmacopeial tests. The results of the tests performed were found to be adequate to evaluate the poly-herbal formulation and may be used as reference standards in future for further studies.

PENGARUH SENAM KAKI TERHADAP KADAR GULA DARAH PADA PASIEN DENGAN DIABETES MELITUS

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Niken Sukesi
Keyword(s):  
Diabetes Mellitus ◽  
Kidney Disease ◽  
Blood Sugar ◽  
Research Design ◽  
Blood Circulation ◽  
Blood Sugar Level ◽  
Consecutive Sampling ◽  
Post Test ◽  
The One ◽  
Diabetes Melitus

Penyakit Diabetes Melitus dapat menyebabkan komplikasi yang sangat berat. Komplikasi dari Diabetes Melitus ini meliputi jantung iskemik, serebrovaskuler, gagal ginjal, ulkus pada kaki, gangguan penglihatan. Komplikasi yang paling sering terjadi adanya perubahan patologis pada anggota gerak bawah yang disebut kaki diabetik. Salah satu jenis olahraga yang dianjurkan dengan diabetes mellitus adalah senam kaki. Senam kaki merupakan latihan yang dilakukan bagi penderita DM atau bukan penderita untuk mencegah terjadinya luka dan membantu melancarkan peredaran darah bagian kaki. Penelitian ini bertujuan untuk menganalisis pengaruh senam kaki terhadap kadar gula darah pasien diabetes mellitus. Desain dalam penelitian ini adalah Quasy Eksperiment dengan rancangan Pre and Post Test Without Control. Teknik pengambilan sampel menggunakan Consecutive sampling. Alat pengumpul data yang digunakan instrument observasi senam kaki untuk menilai senam kaki, dan alat menilai kadar gula darah yaitu glucometer, kapas dan jarum. Rata-rata kadar gula darah sebelum dan setelah dilakukan senam kaki mengalami penurunan dan ada pengaruh kadar gula darah sebelum dengan sesudah dilakukan senam kaki pada pasien diabetes melitusKata Kunci: Senam Kaki, Kadar Gula Darah THE EFFECT OF GYMNASTIC FEET TOWARD THE BLOOD SUGAR LEVEL FOR THE DIABETICSDiabetes Mellitus causes the complication case. It concludes the heart iskemik, serebrovaskuler, cronic kidney disease, ulcus on the feet, and the impairment of sight. The complication often causes the changing of pathological in certain place such as feet. The one of recommended sport for diabetics is gymnastic feet. Gymnastic feet is an experience for diabetics or not in order to prevent the wound and launch the blood circulation. The research objective is to analyze the effect of gymnastic feet to blood sugar level for diabetics. The research design is using experiment quasy with pre and post test without control. It is using consecutive sampling as the sample of collecting technique, and using observation of gymnastic feet as the collecting data technique to assess the blood sugar level, those are glucometer, cotton, and needle. The average of blood sugar level is decrease after doing the gymnastic feet. Moreover, there is differences between after and before doing the gymnastic feet for diabetics.Key Words : Gymnastic Feet, Blood sugar level

scholarly journals THE HYPOPHYSIS AND SECRETION OF INSULIN

1942 ◽  
Vol 75 (5) ◽  
pp. 547-566 ◽  
Author(s):  
B. A. Houssay ◽  
V. G. Foglia ◽  
F. S. Smyth ◽  
C. T. Rietti ◽  
A. B. Houssay
Keyword(s):  
Insulin Secretion ◽  
B Cells ◽  
Blood Sugar ◽  
Anterior Pituitary ◽  
Blood Sugar Level ◽  
Pituitary Hormone ◽  
Pituitary Extract ◽  
Histological Changes ◽  
High Blood Sugar ◽  
Anterior Pituitary Hormone

The ability of the pancreas, from various types of dogs, to correct diabetic hyperglycemia has been studied (Table XI). The pancreas from one animal was united by a vascular union with the neck blood vessels of another dog which had been pancreatectomized for 20 hours. The time necessary to reduce the blood sugar level to 120 mg. per cent was determined. 1. Pancreas from 6 hypophysectomized dogs produced a normal insulin secretion, showing that an anterior pituitary hormone is not necessary for its production or maintenance. 2. In 14 of 17 normal dogs given anterior pituitary extract for 3 or more consecutive days and presenting diabetes (fasting blood sugar 150 mg. per cent or more) the pancreas showed diminished insulin production. 3. In animals which remained diabetic after discontinuing the injections of hypophyseal extract, the pancreas islands were markedly pathologic and the insulin secretion was practically nil. 4. When hyperglycemia existed on the 2nd to 5th day but fell later, the insulin secretion of 5 dogs was normal in 2, supernormal in 1, and less than normal in 2. Histologic examination showed a restoration of beta cells. 5. In 14 dogs resistant to the diabetogenic action of anterior pituitary extract, as shown by little or no change in blood sugar, the pancreatic secretion of insulin was normal in 6 cases, supernormal in 3, and subnormal in 5 cases. Clear signs of hyperfunction of B cells were observed. In 6 resistant animals a high blood sugar (150 mg. per cent) appeared shortly before transplanting, but insulin secretion was normal in 4, supernormal in 1, and subnormal in 1 case. 6. With one injection of extract and 1 day of hyperglycemia the capacity of the pancreas to secrete insulin was not altered. 7. A high blood sugar level lasting 4 days does not alter the islets. The hypophyseal extract acts, therefore, by some other mechanism. In normal dogs, the continuous intravenous infusion of glucose for 4 days maintained the blood sugar at levels as high as those after pituitary extract. In these animals the B cells were hyperplastic and insulin secretion normal. 8. Anterior hypophyseal hyperglycemia is due at first to extrapancreatic factors which are the most important, and last only during the injections of extracts. Pancreatic factors appear afterwards and are responsible for permanent diabetes. Hypophyseal extract produces histological changes in many tissues and damages the Langerhans islands. The coexistent high blood sugar probably exhausts the B cells and exaggerates their injury. 9. In all cases there is a relation between the cytology of the islet B cells and the insulin secreting capacity.

PLASMA FREE FATTY ACID AND BLOOD SUGAR LEVELS IN NEWBORN INFANTS AND THEIR MOTHERS

PEDIATRICS ◽  
1966 ◽  
Vol 37 (4) ◽  
pp. 597-604
Author(s):  
Doman K. Keele ◽  
Jacob L. Kay
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Blood Sugar ◽  
Blood Sugar Level ◽  
Newborn Infants ◽  
Plasma Free Fatty Acid ◽  
Significant Negative Correlation ◽  
The Mean ◽  
Sugar Levels ◽  
Diabetic Mothers

Simultaneous plasma free fatty acid (FFA) and blood sugar levels were determined for fasting newborn infants during the first 24 hours of life, for their cord bloods, and for their mothers at delivery. The following observations were made. In control infants the mean FFA level rose about three times the cord level after birth and was accompanied by a 25% drop in the mean blood sugar level. Thereafter, the mean blood sugar level remained relatively constant, but the mean FFA level varied from 2½ to 3 times the cord level. There was no significant correlation between the length of maternal fasting prior to delivery and the infant FFA level; there was, however a significant negative correlation between the length of maternal fasting prior to delivery and the infant blood sugar level at 24 hours of age. High FFA levels occurred in the infants of obese mothers and low levels were observed in infants with delayed respirations, in infants of preeclamptic mothers, and in infants of diabetic mothers.

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