scholarly journals Effect of Combined Application of Growth Factors and Diode Laser Bio-Stimulation on the Osseo Integration of Dental Implants

2019 ◽  
Vol 7 (15) ◽  
pp. 2520-2527
Author(s):  
Mohamed Ali Ali Arakeeb ◽  
Ahmed Abbas Zaky ◽  
Tarek Abdel-Hamid Harhash ◽  
Walid S. Salem ◽  
Mohamed El-Mofty

BACKGROUND: The success of implants is associated first with their osseointegration, and later on with their survival rate. In recent years, many efforts have been exerted to develop implant design, geometry, materials and techniques to enhance the osseointegration process and also to increase the success rate of implant procedures. New techniques, like leukocyte and platelet-rich fibrin (L-PRF) and low-level laser treatment (LLLT), have been developed to enhance the osseointegration around dental implants. AIM: This study aims at accelerating bone osseointegration process around dental implant using new techniques to increase the success rate, to allow immediate or early loading of a dental implant, and to make a comparison between the various new techniques in dental implant procedures to figure out which technique will achieve the best results. METHODS: The study was conducted on a random sample of 40 male patients. Dental implants were placed in the posterior areas of the lower jaw. Patients were divided randomly into 4 groups; control group, LLLT group, L-PRF group and L-PRF plus LLLT group. They were assessed using cone-beam computed tomography (CBCT). RESULTS: The results showed significant differences between all groups over different measured times. All the groups showed improvement in comparison with Normal group, where L-PRF group showed the best result followed by (L-PRF+LLLT) group, while the LLLT group showed the least improvement in comparison with bothL-PRF group and (L-PRF+LLLT) group. CONCLUSION: The study demonstrates that L-PRF gives a better performance in the osseointegration around dental implants than LLLT.

2015 ◽  
Vol 27 (04) ◽  
pp. 1550037 ◽  
Author(s):  
G. Uzcátegui ◽  
E. Dávila ◽  
M. Cerrolaza

Objective: To propose a methodology based on virtual simulation to assist in the design proposals of dental implants. Methods: The finite element method (FEM) was used to analyze the biomechanical dental implant system behavior, determining von Mises stress distribution induced by functional loads, varying parameter as load direction and geometric characteristic of the implant (taper, length, abutment angulation, thread pitch and width pitch). A final design was obtained by considering the parameters that showed improved performance. The estimated lifetime of the final design was calculated by reproducing in a virtual way the experimental fatigue test required by the ISO:14801 standards. Results: For all the studied cases, the maximum stresses were obtained in the connecting screw under oblique loads (OLs). The estimated lifetime for this critical part is at least 5 × 106 cycles, which meets the requirement of the ISO:14801. In bone tissue, the largest stresses were concentrated in cortical bone, in the zone surrounding the implant, in good agreement with previous reports. Conclusions: A dental implant design was obtained and validated through a simple and efficient methodology based on the application of numerical methods and computer simulations.


2020 ◽  
Vol 6 (1) ◽  
pp. 55
Author(s):  
Evan Chandra ◽  
Suparyono Saleh ◽  
Murti Indrastuti

The osseointegration process of dental implants begins with osteoblast differentiation and proliferation, which is an important aspect of the bone regeneration process. Platelet-rich fibrin (PRF) is a platelet that contains a large amount of fibrin and growth factor, which is widely used to accelerate bone regeneration. This study aims to determine the effect of PRF on the acceleration of osteoblast proliferation after endosseous dental implant insertion. Twelve male Wistar rats weighing 250 to 300 gr of 8 to 15 weeks as an animal model were divided into two groups, the control group and treatment group, based on days and PRF treatment. Three ml of Wistar rat blood was obtained and centrifuged for 12 minutes at a speed of 2700 rpm to make PRF. Afterward, platelet-rich fibrin was applied to implant bed, and the dental implant was inserted at the lateral epicondyle of the right femur in 3 mm depth and 1.8 mm diameter dimension. Incontrol groups, dental implants were immediately inserted after implant bed preparation without PRF administration. Observation of the Wistar rats was carried out on days 14 and 28 for each group. The rats were terminated accordingto the timeline of group design. The epicondylus lateralis femoris dextra bone of the rats was taken and fixed with 10% buffered formalin solution. Then, histological samples were made with hematoxylin-eosin staining. Sample observation was done under a light microscope to calculate the number of osteoblasts. The data were analyzed using the two-way ANOVA test, followed by LSD post hoc test. Based on the two-way ANOVA test, there was a significant difference between control groups and treatment groups (p<0.05), and there were significant differences between the observation result of days 14 and 28 (p<0.05). The application of PRF increased osteoblast proliferation for the first 14 days, but the rate decreased after that. Based on the LSD post hoc test, there were differences in osteoblast proliferation between the treatment and control group (p<0.05). Thus, it is concluded that platelet-rich fibrin increased the acceleration ofosteoblast proliferation after endosseous dental implant insertion.


Author(s):  
Mohammed Ghazi Sghaireen ◽  
Abdulrahman A. Alduraywish ◽  
Kumar Chandan Srivastava ◽  
Deepti Shrivastava ◽  
Santosh R Patil ◽  
...  

Diabetes mellitus is known to compromise the various aspects of homeostasis, including the immune response and the composition of oral microflora. One of the oral manifestations of diabetes mellitus is tooth loss and the survival rate of dental implants chosen as a treatment modality for its rehabilitation is controversial. The current study aims to evaluate and compare the failure rate of dental implants between well-controlled diabetic and healthy patients. A retrospective study of case-control design was conceptualized with 121 well-controlled diabetic and 136 healthy individuals. Records of subjects who had undergone oral rehabilitation with dental implants between the periods of January 2013 to January 2016 were retrieved. Post-operative evaluation was carried out for all patients for about three years to assess the immediate and long-term success of the procedure. From a total of 742 dental implants, 377 were placed in well-controlled diabetic patients (case group) and 365 in healthy subjects (control group). A comparable (9.81%), but non-significant (p = 0.422) failure rate was found in the case group in comparison to the control group (9.04%). A non-significant (p = 0.392) raised number (4.98%) of failure cases were reported among females in comparison to males (4.44%). In respect to arch, the mandibular posterior region was reported as the highest failure cases (3.09%; p = 0.411), with 2.29% of cases reported in the mandibular anterior (p = 0.430) and maxillary posterior (p = 0.983) each. The maxillary anterior region was found to have the least number (1.75%; p = 0.999) of failure cases. More (4.98%; p = 0.361) cases were reported to fail during the functional loading stage in contrast to osseointegration (4.44%; p = 0.365). A well-controlled diabetic status does not impose any additional risk for individuals undergoing dental implant therapy.


2020 ◽  
Vol 10 (6) ◽  
pp. 743-748
Author(s):  
Wan-Ting Huang ◽  
Han-Yi Cheng

The objective of this research was to investigate dental bridges with and without implants. Threedimensional (3D) mandible models were reconstructed by computer tomography (CT) to simulate biting behaviors. The dental implant is an important factor in dental bridge applications. Several studies have investigated finite element models for dental implants; however, few have examined a model for dental bridge with implant. The results revealed that stress was significantly increased when dental bridge was used with implant. Moreover, the dental bridge with implant group demonstrated a relatively big stress in mandible, which was 4.01% lower compared with that of the control group. Dental bridge would be an effective means of recovering dental performance. However, the present research stated that the implant of dental bridge has a potential to increase abnormal stress, and uniformly distributing stress in the dental bridges.


Author(s):  
Nigman Lukmanovich Khabilov ◽  
Tatyana Olegovna Mun ◽  
Farkhodjon Komiljonovich Usmonov ◽  
Iskander Mukhamedovich Baybekov

The widespread introduction of dental implant in the dental practice will determine progress and the future of prosthetic dentistry. At the same time, like any new direction dental implantation has generated a lot of questions and unsolved problems. On many of these issues and problems can be answered only by using morphological methods. Therefore, after the development of a new construction of the dental implant one of the main issues was the question of its interaction with the jawbone and soft tissues of the oral cavity.We performed the experiment on 24 long snout dogs of both sexes, weighing 30-35 kg, with normal bite, at the age of 20-24 months. Animals were divided into 2 groups, according to samples of screw dental implants used in the experiment: basic group - 12 dogs in which were used samples of the new construction of dental implant “Implant.uz” (Uzbekistan); control group – 12 dogs in which were applied screw dental implant system “Dentium” (South Korea). Terms of derivation of animals from experiments were 1, 3, and 6 months.By using morphological techniques were studied implants “Implant.uz” from medical titanium BT-1.00 brand, their interaction with bone of alveolar ridge. “Implant.uz” did not cause pathological changes in the bone tissue of alveolar ridges of jaws and could be an alternative to known dental implants.


2007 ◽  
Vol 8 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Catherine M. Flaitz ◽  
C. Mark Nichols ◽  
Gene C. Stevenson ◽  
Patricia C. Riano ◽  
Antonio J. Moretti ◽  
...  

Abstract Purpose Except for the occasional case report, there are no studies evaluating the success rate of osseointegrated dental implants in individuals infected with the human immunodeficiency virus (HIV). This study investigated the short-term clinical outcome of implant placement in a group of HIV-positive and HIV-negative individuals who required complete dentures. Methods and Materials Edentulous subjects were recruited from an HIV-dedicated clinic and a dental school clinic. Two BioHorizons® dental implants were placed in the anterior mandible to support an overdenture opposing a maxillary denture. Outcome measurements obtained six months after activation of implants were presence of pain, mobility, soft tissue status, and radiographic bone level. Descriptive statistics were used. Results Twenty-nine edentulous adults, including 20 HIV-positive subjects (test) and nine HIV-negative subjects (control), participated. The test group had six females, 14 males; 13 Whites, four African-Americans, and three Hispanics with a mean age of 48.9 years (range: 35-59). The mean CD4 count was 467 cells/mm3 (range: 132-948). The control group had six females, three males; seven Whites, and two Hispanics with a mean age of 65.3 years (range: 50-82). Short-term success rate was 100% for both groups. No difference in clinical outcome was found between the groups. Conclusion This study demonstrated dental implants are well tolerated and have predictable outcomes for HIV-infected individuals for the duration of the study and probably over an even longer term. Citation Stevenson GC, Riano PC, Moretti AJ, Nichols CM, Engelmeier RL, Flaitz CM. Short-term Success of Osseointegrated Dental Implants in HIV-positive Individuals: A Prospective Study. J Contemp Dent Pract 2007 January;(8)1:001-010.


Author(s):  
Florin Ciprian Badea ◽  
Elvis Sachir Erdogan ◽  
Gheorghe Raftu ◽  
Victoria Badea ◽  
Mircea Grigorian

Partial and total edentation has been a real problem worldwide and at all times. The realization of an individualized treatment plan for each form of edentation takes into account the particularities of the edentulous prosthetic field and the materials used as well as the conventional or modern techniques applied. The study group consisted of 220 patients in whom dental implants were inserted; the control group was randomized from 10 patients with a favorable evolution out of the 210 (94.55%). At 7 and 60 days after the insertion of the dental implants and 6 months after their prosthetic loading, crevicular fluid and peri-implant fluid was harvested, for the quantitative determination of Osteoprotegerin (OPG) and Interleukin 1β (IL1-β). Of the 220 patients studied, 10 developed peri implantitis (5.45%) as follows: 4 patients with mucositis and 6 patients with severe form. The results obtained show that there are differences with statistical significance between the OPG values obtained in crevicular fluid in healthy compared to patients with mucositis after 7 days (p <0.001). Regarding IL1-β, there are differences with high statistical significance between the levels in healthy patients and those with peri-implantitis after 7 days (p <0.001). Our results show the existence of a high correlation between the clinical status and these two parameters, especially after the determinations performed at 7 and 60 days. In conclusions, the present study shows that the OPG and IL1-β can be considered useful markers in the evaluation of the patient after the insertion of the dental implant and after its prosthetic loading.


Author(s):  
VP Tlustenko ◽  
IM Bayrikov ◽  
DA Trunin ◽  
SS Komlev ◽  
AV Zhestkov ◽  
...  

The problem of complications arising after dental implantation is still relevant. The aim of the work was to investigate the effect of various types of removable appliances and dental implants on the oral microbiocenosis during orthopedic treatment of 64 people: 12 patients of the first index group, 40 patients of the second index group and 12 people of the control group. 6 months after the implants were installed, as a result of a microbiological study of the oral cavity, the differences were found in the qualitative composition of the microflora of the mucous membrane around the neck of the dental implant. In the first index group representatives of normal microflora prevailed. In 100% of cases Streptococcus vestibularis was isolated, from more than half patients S. oralis, S. mitis, Rothia mucilaginosa were isolated, S. gordonii was isolated from one patient. In the second index group, a significant diversity of microbial species was observed, including enterobacteria, which were isolated from 22.5% of the examined patients. In the control group, in addition to representatives of the normal microflora of the oral mucosa S. vestibularis (75.5%), S. oralis (50.0%), Neisseria subflava (66.7%) and Haemophylus parainfluenzae (50.0%) were found. From all patients of the control groups S. gordonii was isolated, as well as the other potentially pathogenic streptococci species, S. anginosus and S. constellatus by 66.7%. The type of removable appliances and dental implants used affects the microflora composition of the oral cavity, and, consequently, the further prognosis and the risk of complications. Collapsible dental implant supported removable prosthetic appliances with a metal frame and fixing elements, telescopic crowns and clasps less than other types of prosthetic appliances change the qualitative composition of the microflora of the oral mucosa around the neck of the dental implant.


Author(s):  
VP Tlustenko ◽  
IM Bayrikov ◽  
DA Trunin ◽  
OA Gusyakova ◽  
SS Komlev

An objective assessment of the morphofunctional characteristics of the state of soft tissues and bone structures adjacent to the dental implant allows to control the dynamics of the processes of osseointegration in the jaw-dental implant system. The aim of the work was to investigate the level of the β-CrossLaps, С-reactive protein (CRP), osteocalcin markers after orthopedic treatment of patients using dental implant supported advanced dental restoration technologies, to perform a biochemical analysis of the oral fluid of patients after restoration using dental implants and new two-part dental implants. In patients of the index group (52 people), the removable prostheses with metal frame and fixing elements or the commercially available dental implant supported removable prostheses were installed. For the patients of the control group (12 people), the commercially available dental implant supported removable prostheses of acrylic plastics were constructed. For all the patients after 6 months the level of β-CrossLaps, CRP, osteocalcin markers in the oral fluid was analysed. In patients of the index group, the average content of β-CrossLaps was 0.0126 ± 0.002 ng/ml, in the control group it was 0.0147 ± 0.002 ng/ml. The average content of the CRP in patients of the index group was 0.358 ± 0.019 mg/l, in patients of the control group it was 0.78 ± 0.01 mg/l. In patients of the index group, the average content of osteocalcin was 1.46 ± 0.25 ng/ml, in the control group it was 1.98 ± 0.31 ng/ml. It has been shown that biochemical markers of the oral fluid can be used to predict complications after the dental implants installation. Restoration with two-part dental implants of modern design is associated with fewer complications.


2021 ◽  
Vol 10 (4) ◽  
pp. 3101-3105
Author(s):  
Ajit Singh

Dental implants are a proven therapeutic option for replacing missing teeth, with positive long-term health outcomes. Dental implant performance is largely determined by the implant’s primary durability, which is affected by surgical procedure, bone quality and quantity, implant surface characteristics, implant geometry, and implant surface characteristics. The implant’s geometry and surface can be modified. The implant geometry and surface can be changed if needed to achieve good primary stability and long-term implant therapy effectiveness. Implant architecture refers to the implant’s three-dimensional structure, as well as all of the components and elements that make it up. Different surface topographies can affect a sequence of coordinated actions such cell proliferation, osteoblast transformation, and the production of bone tissue. At the macro, micro, and increasingly nano sizes, surface topography of implants may be detected. The surgical location of end osseous oral implants is influenced by the prosthetic architecture, as well as the shape and quality of the alveolar bone. There are several alternatives for replacing missing teeth, but within the past few decades, dental implants have been one of the most common biomaterials for replacing one (or more) missing teeth. In a substantial number of patients, titanium dental implants have been shown to be secure and reliable. This study examines the most important historical information of dental implants, as well as the various vital factors that will ensure successful Osseo-integration and a safe prosthesis anchorage. Not only


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