STUDY ON THE EVALUATION OF ORAL REHABILITATION USING DENTAL IMPLANT BY QANTIFYING OSTEOPROTEGERIN AND INTERLEUKIN

2020 ◽  
Author(s):  
Florin Ciprian Badea ◽  
Elvis Sachir Erdogan ◽  
Gheorghe Raftu ◽  
Victoria Badea ◽  
Mircea Grigorian
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Treatment Plan ◽  
Statistical Significance ◽  
Clinical Status ◽  
Severe Form ◽  
Control Group ◽  
Real Problem ◽  
Oral Rehabilitation ◽  
Crevicular Fluid

Partial and total edentation has been a real problem worldwide and at all times. The realization of an individualized treatment plan for each form of edentation takes into account the particularities of the edentulous prosthetic field and the materials used as well as the conventional or modern techniques applied. The study group consisted of 220 patients in whom dental implants were inserted; the control group was randomized from 10 patients with a favorable evolution out of the 210 (94.55%). At 7 and 60 days after the insertion of the dental implants and 6 months after their prosthetic loading, crevicular fluid and peri-implant fluid was harvested, for the quantitative determination of Osteoprotegerin (OPG) and Interleukin 1β (IL1-β). Of the 220 patients studied, 10 developed peri implantitis (5.45%) as follows: 4 patients with mucositis and 6 patients with severe form. The results obtained show that there are differences with statistical significance between the OPG values obtained in crevicular fluid in healthy compared to patients with mucositis after 7 days (p <0.001). Regarding IL1-β, there are differences with high statistical significance between the levels in healthy patients and those with peri-implantitis after 7 days (p <0.001). Our results show the existence of a high correlation between the clinical status and these two parameters, especially after the determinations performed at 7 and 60 days. In conclusions, the present study shows that the OPG and IL1-β can be considered useful markers in the evaluation of the patient after the insertion of the dental implant and after its prosthetic loading.

scholarly journals Comparative Evaluation of Dental Implant Failure among Healthy and Well-Controlled Diabetic Patients—A 3-Year Retrospective Study

2020 ◽  
Vol 17 (14) ◽  
pp. 5253 ◽  
Author(s):  
Mohammed Ghazi Sghaireen ◽  
Abdulrahman A. Alduraywish ◽  
Kumar Chandan Srivastava ◽  
Deepti Shrivastava ◽  
Santosh R Patil ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Retrospective Study ◽  
Dental Implants ◽  
Dental Implant ◽  
Failure Rate ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Oral Rehabilitation ◽  
Operative Evaluation

Diabetes mellitus is known to compromise the various aspects of homeostasis, including the immune response and the composition of oral microflora. One of the oral manifestations of diabetes mellitus is tooth loss and the survival rate of dental implants chosen as a treatment modality for its rehabilitation is controversial. The current study aims to evaluate and compare the failure rate of dental implants between well-controlled diabetic and healthy patients. A retrospective study of case-control design was conceptualized with 121 well-controlled diabetic and 136 healthy individuals. Records of subjects who had undergone oral rehabilitation with dental implants between the periods of January 2013 to January 2016 were retrieved. Post-operative evaluation was carried out for all patients for about three years to assess the immediate and long-term success of the procedure. From a total of 742 dental implants, 377 were placed in well-controlled diabetic patients (case group) and 365 in healthy subjects (control group). A comparable (9.81%), but non-significant (p = 0.422) failure rate was found in the case group in comparison to the control group (9.04%). A non-significant (p = 0.392) raised number (4.98%) of failure cases were reported among females in comparison to males (4.44%). In respect to arch, the mandibular posterior region was reported as the highest failure cases (3.09%; p = 0.411), with 2.29% of cases reported in the mandibular anterior (p = 0.430) and maxillary posterior (p = 0.983) each. The maxillary anterior region was found to have the least number (1.75%; p = 0.999) of failure cases. More (4.98%; p = 0.361) cases were reported to fail during the functional loading stage in contrast to osseointegration (4.44%; p = 0.365). A well-controlled diabetic status does not impose any additional risk for individuals undergoing dental implant therapy.

scholarly journals Oral Rehabilitation on Implants and Introduction of Pathogenic Mechanisms in Relation to Oral Implants - Sugar Diabetes

2019 ◽  
Vol 70 (10) ◽  
pp. 3750-3752
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Failure Rate ◽  
Primary Stability ◽  
Advanced Technology ◽  
Diabetic Patients ◽  
Oral Rehabilitation ◽  
Complete Replacement ◽  
Oral Implants ◽  
Dental Aesthetics

Dental implants are made of medical titanium and perfectly fit into human bone tissue; the dental implant can last a lifetime. Not beeing living organic structures, there are no nerve endings, neither at the implant level nor at the artificial crown level. The use of quality implants by an experienced implantologist, assisted by advanced technology, transforms the treatment with dental implants into the medical-surgical act with the highest success rate among dental and even medical treatments.Through the complete replacement of the tooth, including the root, can artificially reproduce the function of the natural tooth, with a strong and stable base. The implant crown, made of aesthetic materials (porcelain, zirconium) and anchored to it by means of the prosthetic abutment, will be surrounded by a healthy and aesthetic gum. Especially if the prosthetic abutment (the connecting element between the implant itself and the artificial crown) will be made of zirconium - natural light will cross ceramic layers, similar to enamel and dentine, offering a white of envy and glitter to the smile. Around the porcelain crowns (whole ceramics or zirconia ceramics) the gingiva will conform healthily, without the slightest sign of inflammation. These elements, the white of the teeth and the pink of the gums define the concept of dental aesthetics. The main problems that diabetic patients may encounter, are gingival inflammation and periodontal disease, dental mobility and tooth loss. When a dental implant is influenced by the type of diabetes, its failure rate is higher in patients with type 1 diabetes than in patients with type 2 diabetes. The study included a number of 56 patients, who presented themselves for performing an implant. Of these, 7 patients did not perform an implant. Diabetes mellitus defines a chronic metabolic disorder, which may have multiple etiopathogenesis, characterized by changes in carbohydrate, lipid and protein metabolism. Stability of the implant in the bone, immediately after implantation is crucial for the success of the treatment; this immediate stability is called primary stability and is purely mechanical in nature. Keywords: Dental implants, dental treatments, diabetes, failure rate

scholarly journals The effect of platelet-rich fibrin on the acceleration of osteoblast proliferation after endosseous dental implant insertion

2020 ◽  
Vol 6 (1) ◽  
pp. 55
Author(s):  
Evan Chandra ◽  
Suparyono Saleh ◽  
Murti Indrastuti
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Dental Implant ◽  
Wistar Rats ◽  
Control Group ◽  
Osteoblast Proliferation ◽  
Platelet Rich Fibrin ◽  
Anova Test ◽  
Implant Bed ◽  
Post Hoc

The osseointegration process of dental implants begins with osteoblast differentiation and proliferation, which is an important aspect of the bone regeneration process. Platelet-rich fibrin (PRF) is a platelet that contains a large amount of fibrin and growth factor, which is widely used to accelerate bone regeneration. This study aims to determine the effect of PRF on the acceleration of osteoblast proliferation after endosseous dental implant insertion. Twelve male Wistar rats weighing 250 to 300 gr of 8 to 15 weeks as an animal model were divided into two groups, the control group and treatment group, based on days and PRF treatment. Three ml of Wistar rat blood was obtained and centrifuged for 12 minutes at a speed of 2700 rpm to make PRF. Afterward, platelet-rich fibrin was applied to implant bed, and the dental implant was inserted at the lateral epicondyle of the right femur in 3 mm depth and 1.8 mm diameter dimension. Incontrol groups, dental implants were immediately inserted after implant bed preparation without PRF administration. Observation of the Wistar rats was carried out on days 14 and 28 for each group. The rats were terminated accordingto the timeline of group design. The epicondylus lateralis femoris dextra bone of the rats was taken and fixed with 10% buffered formalin solution. Then, histological samples were made with hematoxylin-eosin staining. Sample observation was done under a light microscope to calculate the number of osteoblasts. The data were analyzed using the two-way ANOVA test, followed by LSD post hoc test. Based on the two-way ANOVA test, there was a significant difference between control groups and treatment groups (p<0.05), and there were significant differences between the observation result of days 14 and 28 (p<0.05). The application of PRF increased osteoblast proliferation for the first 14 days, but the rate decreased after that. Based on the LSD post hoc test, there were differences in osteoblast proliferation between the treatment and control group (p<0.05). Thus, it is concluded that platelet-rich fibrin increased the acceleration ofosteoblast proliferation after endosseous dental implant insertion.

scholarly journals Awareness among Patients regarding Dental Implants as a Treatment Option for replacing Missing Teeth in Melmaruvathur Population

2016 ◽  
Vol 6 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Venkatesan Narayanan ◽  
Prabhu Karuppiah ◽  
Arunkumar Rajasekar ◽  
Lakshmi D Mayavan
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Treatment Option ◽  
Tamil Nadu ◽  
Dental Education ◽  
Education Programs ◽  
Missing Teeth ◽  
Oral Rehabilitation ◽  
Implant Therapy ◽  
Knowledge And Attitude

ABSTRACT Background Treatment with dental implants has become increasingly important in the range of prosthodontic treatment. Significant improvements in oral rehabilitation particularly in edentulous individuals have been seen. In Adhiparasakthi Dental College, Melmaruvathur, a survey was made to evaluate awareness among patients for dental implants, their level of knowledge, and attitude toward replacement of missing teeth by dental implants. Materials and methods A survey of 480 people was conducted through a printed questionnaire and completed by willing respondents. The questionnaires were prepared in English and Tamil language to enable better understanding and completion. Results Of the 510 people surveyed, 480 responses were retrieved, of which 331 were aware of dental implant treatment in Melmaruvathur, Tamil Nadu. Among them, 304 respondents were aware that implants could be used for replacement of missing teeth. Most of the respondents stated that dental implants were placed in the jawbone, followed by gums. Only 41% respondents assumed that implants last for a lifetime and only 35% of respondents believe that poor oral hygiene was the most common cause of implant failure. Conclusion More dental education programs are needed to improve understanding of the importance of restoration of missing teeth. General implant awareness levels are satisfactory. However, increased awareness of patients for restoration of missing tooth with dental implants is necessary. Dental education programs with special emphasis on advantages, treatment, maintenance, and postoperative care of dental implant therapy are needed. More than two-thirds of the surveyed population is interested in knowing about and being treated with dental implants. How to cite this article Narayanan V, Karuppiah P, Rajasekar A, Mayavan LD. Awareness among Patients regarding Dental Implants as a Treatment Option for replacing Missing Teeth in Melmaruvathur Population. Int J Prosthodont Restor Dent 2016;6(1):6-9.

scholarly journals Graphene–Chitosan Hybrid Dental Implants with Enhanced Antibacterial and Cell-Proliferation Properties

2020 ◽  
Vol 10 (14) ◽  
pp. 4888 ◽  
Author(s):  
Sunho Park ◽  
Hyeran Kim ◽  
Kyoung Soon Choi ◽  
Min-Kyung Ji ◽  
Sujin Kim ◽  
...  
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Cell Activity ◽  
Functional Abilities ◽  
Tooth Replacement ◽  
Oral Rehabilitation ◽  
Natural Teeth ◽  
New Type ◽  
Implant Treatment ◽  
Effective Design

Dental implants are widely used tooth replacement tools owing to their good oral rehabilitation and reconstruction capacities. Since dental implants are designed as a replacement for natural teeth, multi-functional abilities are desired to achieve successful implant treatment with improved osseointegration through promotion of mammalian cell activity and prevention of bacterial cell activity. In this study, we developed a graphene–chitosan hybrid dental implant (GC hybrid implant) using various concentrations of graphene, which demonstrated the different surface properties including increased wettability and roughness. Importantly, the GC hybrid implant under the optimal condition (i.e., 1% GC hybrid implant) could significantly promote osteoblast proliferation while reducing biofilm formation and bacterial activity. Our study demonstrates the potential of using this GC hybrid implant as a new type of dental implant, which can offer an effective design for the fabrication of advanced dental implants.

Finite Element Analysis of Stress in Dental Bridge with Implant

2020 ◽  
Vol 10 (6) ◽  
pp. 743-748
Author(s):  
Wan-Ting Huang ◽  
Han-Yi Cheng
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Dental Implants ◽  
Dental Implant ◽  
Computer Tomography ◽  
Effective Means ◽  
Control Group ◽  
Finite Element Models ◽  
Element Analysis

The objective of this research was to investigate dental bridges with and without implants. Threedimensional (3D) mandible models were reconstructed by computer tomography (CT) to simulate biting behaviors. The dental implant is an important factor in dental bridge applications. Several studies have investigated finite element models for dental implants; however, few have examined a model for dental bridge with implant. The results revealed that stress was significantly increased when dental bridge was used with implant. Moreover, the dental bridge with implant group demonstrated a relatively big stress in mandible, which was 4.01% lower compared with that of the control group. Dental bridge would be an effective means of recovering dental performance. However, the present research stated that the implant of dental bridge has a potential to increase abnormal stress, and uniformly distributing stress in the dental bridges.

scholarly journals Failure of dental implants in cemento-osseous dysplasia: a critical analysis of a case

2014 ◽  
Vol 43 (3) ◽  
pp. 223-227 ◽  
Author(s):  
Maiolino Thomaz Fonseca OLIVEIRA ◽  
Sérgio Vitorino CARDOSO ◽  
Cláudia Jordão SILVA ◽  
Darceny ZANETTA-BARBOSA ◽  
Adriano Mota LOYOLA
Keyword(s):  
Case Report ◽  
Dental Implants ◽  
Dental Implant ◽  
Critical Analysis ◽  
Bone Diseases ◽  
Limiting Factor ◽  
Oral Rehabilitation ◽  
Present Case Report ◽  
Osseous Dysplasia ◽  
And Behavior

Introduction: Osseointegrated dental implants have been routinely used in oral rehabilitation. Patients with dysplastic bone diseases represent a particular challenge for oral rehabilitation with dental implants. Nevertheless, the installation of implants in patients with cemento-osseous dysplasia (COD) has been reported with apparent success. Objective: In this paper, we present a case of a patient with COD in which a dental implant had been installed and lost six months later. In this regard, we analyzed pertinent aspects of the indications for dental implants in patients with COD considering the pathogenesis, dysplastic nature, and behavior of the disease. Conclusion: The present case report illustrates that COD can be considered a limiting factor in the recommendation for a dental implant. Because of this, it is imperative to inform the patient about the risks of surgically manipulating the diseased bone.

scholarly journals Subgingival Microbiome Colonization and Cytokine Production during Early Dental Implant Healing

mSphere ◽  
2017 ◽  
Vol 2 (6) ◽  
Author(s):  
Jeffrey B. Payne ◽  
Paul G. Johnson ◽  
Car Reen Kok ◽  
João C. Gomes-Neto ◽  
Amanda E. Ramer-Tait ◽  
...  
Keyword(s):  
Dental Implants ◽  
Dental Implant ◽  
Cytokine Production ◽  
Gingival Crevicular Fluid ◽  
Oral Microbiome ◽  
Anatomical Location ◽  
Implant Placement ◽  
Natural Teeth ◽  
Crevicular Fluid ◽  
Early Healing

ABSTRACT Little is known about longitudinal development of the peri-implant subgingival microbiome and cytokine production as a new sulcus forms after dental implant placement. Therefore, the purpose of this observational study was to evaluate simultaneous longitudinal changes in the oral microbiome and cytokine production in the developing peri-implant sulcus compared to control natural teeth. Four and 12 weeks after implant placement and abutment connection, a dental implant and a natural tooth were sampled in 25 patients for subgingival plaque and gingival crevicular fluid (GCF [around teeth] and peri-implant crevicular fluid [PICF] around implants). DNA from plaque samples was extracted and sequenced using Illumina-based 16S rRNA sequencing. GCF and PICF samples were analyzed using a customized Milliplex human cytokine and chemokine magnetic bead panel. Beta diversity analysis revealed that natural teeth and implants had similar subgingival microbiomes, while teeth had greater alpha diversity than implants. At the genus level, however, few differences were noted between teeth and dental implants over 12 weeks. Specifically, Actinomyces and Selenomonas were significantly elevated around teeth versus dental implants at both 4 weeks and 12 weeks, while Corynebacterium and Campylobacter were significantly elevated only at 4 weeks around teeth. The only difference between PICF and GCF biomarkers was significantly elevated granulocyte-macrophage colony-stimulating factor levels around teeth versus dental implants at the 4-week visit. The subgingival microbiome and cytokine production were similar between teeth and implants during early healing, suggesting that these profiles are driven by the patient following dental implant placement and are not determined by anatomical niche. IMPORTANCE Dental implants are a common treatment option offered to patients for tooth replacement. However, little is known regarding initial colonization of the subgingival microbiome and simultaneous longitudinal cytokine production in humans during the early healing phase following implant placement. We report findings from an in vivo study that assessed initial colonization of the subgingival microbiome and concomitant early cytokine production in a newly formed anatomical space, namely, an implant sulcus. This approach may be useful in future interventional studies to influence dental implant success. Our data showed that the subgingival microbiome and cytokine profile were similar for control natural teeth and dental implants at both 4 and 12 weeks after implant placement. These data suggest that these profiles are driven by the patient and not by anatomical location (i.e., tooth versus dental implant).

scholarly journals Comparison of Proinflammatory Cytokine Levels in Gingival Crevicular Fluid around Dental Implants with Ceramic and Titanium Abutments

2017 ◽  
Vol 18 (9) ◽  
pp. 831-836
Author(s):  
Ramin Negahdari ◽  
Mahdi Rahbar ◽  
Vahid Fakhrzadeh ◽  
Hosein Eslami ◽  
Taleb Akbari ◽  
...  
Keyword(s):  
Dental Implants ◽  
Proinflammatory Cytokine ◽  
Gingival Crevicular Fluid ◽  
Statistical Significance ◽  
Titanium Implants ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cytokine Levels ◽  
Biologic Response ◽  
Ceramic Implants ◽  
Crevicular Fluid

ABSTRACT Background Considering the high success rate of osseointegration, there is ever-increasing use of dental implants. The mechanisms and biologic response of peri-implant tissues are different depending on the biocompatibility of the implant material. The aim of this study was to compare the proinflammatory cytokine levels in the gingival crevicular fluid (GCF) around dental implants with ceramic and titanium abutments. Materials and methods All the patients with dental implants referring to two private offices of two prosthodontists from June to August 2016 were examined in relation to implant health, and eligible subjects, based on inclusion criteria, were included in this study with a slit-mouth design. In this context, on one side titanium implants and, on the other side, ceramic implants were used. Samples were collected from the peri-implant sulcus in each patient and sent to the immunology laboratory for determination of interleukin (IL)-6 and IL-1β proinflammatory cytokine levels using an enzyme-linked immunosorbent assay kit. Data were analyzed with Statistical Package for the Social Sciences version 16. Statistical significance was set at p < 0.05. Results The results showed lower levels of IL-1β and IL-6 in the GCF around ceramic abutments compared with titanium implants. In addition, statistical comparison between IL-6 and IL-1β levels showed higher levels of IL-6 around titanium and ceramic abutments compared with IL-1β levels. Conclusion Based on the results of this study, the human body immune response to ceramic abutments is much better than that to titanium implants. Clinical significance Considering that proinflammatory cytokine levels in GCF around ceramic abutments are lower than titanium ones, ceramic abutments are preferred for clinical usage. How to cite this article Negahdari R, Rahbar M, Fakhrzadeh V, Eslami H, Akbari T, Bohluli S. Comparison of Proinflammatory Cytokine Levels in Gingival Crevicular Fluid around Dental Implants with Ceramic and Titanium Abutments. J Contemp Dent Pract 2017;18(9):831-836.

scholarly journals The effect of X-ray irradiation to the formation of polychromatic erythrocyte cell micronucleus in Wistar rats (Rattus norvegicus)

2021 ◽  
Vol 54 (3) ◽  
pp. 128
Author(s):  
Eha Renwi Astuti ◽  
Hutojo Djajakusuma ◽  
Indeswati Diyatri ◽  
Nastiti Faradilla Ramadhani
Keyword(s):  
Treatment Group ◽  
Wistar Rats ◽  
Treatment Plan ◽  
Statistical Significance ◽  
Clinical Parameter ◽  
Control Group ◽  
X Ray ◽  
Polychromatic Erythrocytes ◽  
Male Wistar Rats ◽  
Group 2

Background: Panoramic and cephalometric radiography is very important for diagnosis, treatment plan, and evaluation of orthodontic treatment results. Panoramic and cephalometric radiography are frequently performed at the same time, causing DNA damage and chromosome aberration. Purpose: This study aims to analyse the effect of X-ray exposure in panoramic and cephalometric radiography on micronuclei cell numbers. Methods: Laboratory-based analytical study with 60 healthy-male Wistar rats weighing 200–300 grams divided into 6 treatment groups (n=10). The control group: without radiographic exposure, the treatment group 2: using panoramic radiographic exposure followed by cephalometric, and the treatment group 3: using panoramic radiographic exposure and 24 hours later performed cephalometric radiographic. The unit of analysis was the polychromatic erythrocytes of mice cell, were examined 24 hours and 48 hours after irradiation had been finished. The polychromatic erythrocytes were examined using May-Gruenwald-Giemsa staining and 100x magnification under a microscope with 2000 cells per view. Data obtained were analysed using the SPSS 20 version software. The mean and standard deviations were calculated for each clinical parameter, and a one‐way ANOVA statistical test of significance was used. Statistical significance was set at p<0.05. Results: The analysis showed a significant increase (p<0.05) in the number of micronucleus in groups that used panoramic radiographic exposure followed by cephalometric. Conclusion: X-ray radiation can increase the number of micronucleus in polychromatic erythrocyte cells in rats.

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