scholarly journals Pulmonary Involvement in the Antisynthetase Syndrome: A Comparative Cross-sectional Study

2016 ◽  
Vol 43 (6) ◽  
pp. 1107-1113 ◽  
Author(s):  
Helena Andersson ◽  
Trond Mogens Aaløkken ◽  
Anne Günther ◽  
Georg Karl Mynarek ◽  
Torhild Garen ◽  
...  
Keyword(s):  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Pulmonary Involvement ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Walking Distance ◽  
Antisynthetase Syndrome ◽  
High Resolution Computed Tomography ◽  
Cross Sectional ◽  
Significant Difference

Objective.Interstitial lung disease (ILD) is a major component of the antisynthetase syndrome, but quantitative data on longterm pulmonary outcome in antisynthetase syndrome are limited. In this study, the main aims were to compare pulmonary function tests (PFT) and the 6-min walking distance (6MWD) between patients with antisynthetase syndrome and healthy sex- and age-matched controls, to evaluate the extent of ILD by lung high-resolution computed tomography (HRCT), and to assess correlations between PFT measures and ILD extent.Methods.Concurrent PFT and 6MWD were performed in 68 patients with antisynthetase syndrome and their individually matched controls. Additionally, in the patients, the extent of ILD was determined in 10 HRCT sections, expressed as percentage of total lung volumes.Results.Median disease duration in the antisynthetase syndrome cohort was 71 months. Compared with the matched controls, the patients with antisynthetase syndrome had mean 28%, 27%, and 53% lower absolute values of forced vital capacity (FVC), forced expiratory volume in 1 s, and DLCO (p < 0.001). Mean difference in 6MWD between patients and controls was 116 m (p < 0.001). Median extent of ILD by HRCT was 20% (range 0–73) and correlated with FVC and DLCO. Pulmonary outcome did not differ between Jo1 and non-Jo1 subsets.Conclusion.To our knowledge, this study is the first to demonstrate a highly significant difference in PFT between patients with antisynthetase syndrome with 6 years of followup and healthy controls. DLCO displayed the highest difference with mean 53% lower value in the patients. FVC and DLCO correlated significantly with ILD extent, indicating these variables as appropriate outcome measures in antisynthetase syndrome–associated ILD.

scholarly journals Effect of obesity on lung function test among adults

2020 ◽  
Vol 7 (12) ◽  
pp. 1795
Author(s):  
Dhairya Salvi ◽  
Dhanvi Moradia
Keyword(s):  
Vital Capacity ◽  
Lung Function Test ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Sectional Study ◽  
Cross Sectional ◽  
Group Iii ◽  
Group I ◽  
Significant Difference ◽  
Function Test

Background: Obesity is a chronic disease characterized by excessive body fat that causes damage to the individual’s health and is associated with comorbidities such as diabetes and hypertension and vascular dysfunction. This cross-sectional study was carried out with the objective of evaluating the effect of obesity on lung function test in obese but otherwise healthy adults.Methods: It was a cross-sectional study carried out at tertiary care institute of Gujarat, India. It was conducted over a period of 5 months. A total of 240 adult healthy subjects of both sexes were selected randomly belonging to varying socio-economic status. The study subjects were divided into 3 categories (normal body mass index i.e. BMI, overweight, obese). BMI were calculated for the randomly selected subjects from each list till the desired number in each BMI group were attained. Four respiratory parameters viz. forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory volume in 3 seconds (FEV3), and maximum voluntary ventilation (MVV) were used to assess their lung functions.Results: Two hundred and forty subjects (each group having n=80). The mean age of group I, group II and group III were 27.45±6.37, 28.18±6.42 and 28.98±6.74 respectively. Lung volumes showed significant difference in relation to the BMI. FVC and FEV1 show significant decrease. Group III verses group I (p˂0.001 and p˂0.017 respectively) FEV3 showed significant difference between group I and group III and between group II and group III (p˂0.001). MVV was significantly lower in group III when compared to group I.Conclusions: There is decline in pulmonary function in obese as compared to normal weight adults. These findings suggest deleterious effects on ventilatory mechanics caused by obesity, due to probable lung compression (reduction in the expiratory reserve volume i.e. ERV), leading to a compensatory increase in the inspiratory reserve volume (IRV) in an attempt to maintain a constant vital capacity (VC).

scholarly journals Novel associations between cytokines and pulmonary involvement in juvenile dermatomyositis – a cross-sectional study of long-term disease

Rheumatology ◽  
2019 ◽  
Vol 59 (8) ◽  
pp. 1862-1870
Author(s):  
Henriette Marstein ◽  
Thomas Schwartz ◽  
Trond Mogens Aaløkken ◽  
May Britt Lund ◽  
Berit Flatø ◽  
...  
Keyword(s):  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Pulmonary Involvement ◽  
Cross Sectional Study ◽  
High Resolution Computed Tomography ◽  
Cross Sectional ◽  
Pulmonary Damage ◽  
Active Patients ◽  
Tgf Β1

Abstract Objectives To examine associations between cytokines and pulmonary involvement in patients with medium- to long-term JDM. Methods In a cross-sectional study, 58 patients examined median (range) 16.8 (6.6–27.0) years after symptom onset were stratified in inactive (JDM-inactive) and active (JDM-active) disease (updated PRINTO criteria); 56 age/sex matched controls were included. Twenty-nine cytokines (in serum) were analysed (Luminex technology/ELISA). Pulmonary function test included forced vital capacity, total lung capacity (TLC) and diffusing capacity for carbon monoxide reported as % of predicted and low forced vital capacity/TLC/diffusing capacity for carbon monoxide. In patients, the presence of clinical pulmonary damage was assessed and high resolution computed tomography scans were scored for interstitial lung disease, chest wall calcinosis and airways disease. Results Median age of patients was 21 (7–55) years, 59% were female and 36% inactive. In JDM-active and all patients, higher MCP-1, IP-10 and eotaxin correlated with high-resolution computed tomography findings (rs 0.34–0.61; P &lt; 0.05). MCP-1 and eotaxin correlated with pulmonary damage in JDM-active and all patients (rs 0.41–0.49; P &lt; 0.01). Higher TGF-β1 and PDGF (growth factors) were associated with lower lung volumes (forced vital capacity/TLC measures) in all patients; PDGF in JDM-active and TGF-β1 in JDM-inactive patients. IP-10 correlated with TLC% in JDM-active patients. No associations between cytokines and pulmonary function test were found in controls. Conclusions In JDM, we found a novel association (not previously described in myositis) between eotaxin and pulmonary involvement; we have previously shown an association between eotaxin and cardiac dysfunction. The associations between IP-10/growth factors/MCP-1 and pulmonary involvement are novel in JDM and were mostly seen in JDM-active patients.

scholarly journals The Role of Pressure and Duration of Dive on Lung Physiology in Professional and Non-Professional Divers

2020 ◽  
Vol 40 (2) ◽  
pp. 103-112
Author(s):  
Jerry Indra Setiawan ◽  
Suradi Suradi ◽  
Yusup Subagio Sutanto
Keyword(s):  
Vital Capacity ◽  
Cross Sectional Study ◽  
Professional Group ◽  
Sectional Study ◽  
Test Statistic ◽  
Cross Sectional ◽  
Lung Physiology ◽  
Significant Difference ◽  
Normally Distributed

Backgrounds: Professional divers have a greater lung volume than non-professional divers in higher force vital capacity (FVC) and force expiratory flow in 1 second (FEV1) values. The purpose of this study is to analyse the effect of pressure and duration of diving on changes in lung physiology in professional divers and non-professional divers. Methods: This is a cross sectional study on the personnel of the Indonesian Navy Dislambair Koarmada II Surabaya and RSAL personnel of dr. Ramelan Navy Hospital in Lakesla Surabaya in March-April 2019. Samples was collected with purposive sampling. This study used unpaired subjects with the independent t-test statistic analysis if the data is normally distributed and the Mann-Whitney U test if the data is not normally distributed Results: There was a significant difference in the professional divers group compared to non-professional divers group in the values of FVC (P=0.042) and FEV1 (P=0.040) at 1.3 ATA for 10 minutes and the FEV1 (P=0.049) for 20 minutes. No significant differences in FVC (P=0.092) at 1.3 ATA pressure for 20 minutes. There were no significant differences in FVC (P=0.865), FEV1 (P=0.659) at 1.5 ATA pressure for 10 minutes and FVC (P=0.858) and FEV1 (P=0.857) for 20 minutes. Conclusions: The different pressure in non-professional group could reduce the FEV1 value. There was a difference in the FVC value of the professional diver group and non-professional divers at a pressure of 1.5 ATA for 10 minutes. (J Respir Indo. 2020; 40(2): 103-12)

scholarly journals The association between chronic airflow obstruction and poverty in 12 sites of the multinational BOLD study

2017 ◽  
Vol 49 (6) ◽  
pp. 1601880 ◽  
Author(s):  
John Townend ◽  
Cosetta Minelli ◽  
Kevin Mortimer ◽  
Daniel O. Obaseki ◽  
Mohammed Al Ghobain ◽  
...  
Keyword(s):  
Vital Capacity ◽  
Meta Analysis ◽  
Airflow Obstruction ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Sectional Study ◽  
Cross Sectional ◽  
Unit Increase ◽  
Household Assets ◽  
Lower Limit Of Normal

Poverty is strongly associated with mortality from COPD, but little is known of its relation to airflow obstruction.In a cross-sectional study of adults aged ≥40 years from 12 sites (N=9255), participating in the Burden of Obstructive Lung Disease (BOLD) study, poverty was evaluated using a wealth score (0–10) based on household assets. Obstruction, measured as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) (%) after administration of 200 μg salbutamol, and prevalence of FEV1/FVC<lower limit of normal were tested for association with poverty for each site, and the results were combined by meta-analysis.Mean wealth scores ranged from 4 in Blantyre (Malawi) and Kashmir (India) to 10 in Riyadh (Saudi Arabia), and the prevalence of obstruction, from 16% in Kashmir to 3% in Riyadh and Penang (Malaysia). Following adjustments for age and sex, FEV1/FVC increased by 0.36% (absolute change) (95%CI: 0.22, 0.49; p<0.001) per unit increase in wealth score. Adjustments for other confounders reduced this effect to 0.23% (0.11, 0.34), but even this value remained highly significant (p<0.001). Results were consistent across sites (I2=1%; phet=0.44). Mean wealth scores explained 38% of the variation in mean FEV1/FVC between sites (r2=0.385, p=0.031).Airflow obstruction is consistently associated with poverty at individual and community levels across several countries.

scholarly journals Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Kei Nakajima ◽  
Yulan Li ◽  
Hiroshi Fuchigami ◽  
Hiromi Munakata
Keyword(s):  
Metabolic Syndrome ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Heart Diseases ◽  
Past History ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Common Finding ◽  
Cross Sectional

Studies have shown that low forced vital capacity (LFVC) is associated with atherosclerosis. However, it is unclear whether LFVC is associated with resting electrocardiographic ST-T abnormalities, a common finding that is prognostic for cardiovascular events. Therefore, pulmonary functions, ST-T abnormalities defined with Minnesota Code, and cardiometabolic risk factors were examined in a cross-sectional study of 1,653 asymptomatic adults without past history of coronary heart diseases. The prevalence of diabetes, metabolic syndrome, and ST-T abnormalities significantly increased with decreasing percent of predicted forced vital capacity (%PFVC). ST-T abnormalities were observed in 73 subjects (4.4% in total). Multiple logistic regression analysis showed that, compared with the highest quartile of %PFVC (≥99.7%), the lowest quartile of %PFVC (≤84.2%) was persistently associated with ST-T abnormalities even after further adjustment for diabetes or metabolic syndrome (odds ratio (95%CI): 2.44 (1.16–5.14) and 2.42 (1.15–5.10), resp.). Similar trends were observed when subjects were divided into quartiles according to percent of predicted forced expiratory volume in 1 second (FEV1), but not the ratio of FEV1/FVC. In conclusion, LFVC may be associated with ST-T abnormalities independent of metabolic abnormalities in asymptomatic adults, suggesting a plausible link between impaired pulmonary defects and cardiovascular diseases.

scholarly journals Which is better among FEV1/FVC and FEV1/SVC in obstructive airway disease?

2018 ◽  
Vol 5 (6) ◽  
pp. 1328
Author(s):  
Saravanan M. ◽  
P. M. Ramesh ◽  
K. Rajarajeswari
Keyword(s):  
Airway Obstruction ◽  
Vital Capacity ◽  
Airway Disease ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Obstructive Airway Disease ◽  
Cross Sectional ◽  
Medical College ◽  
The Difference ◽  
Mixed Groups

Background: Forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio (FVC) is being used to diagnose the obstructive lung diseases. Forced manoeuvre (FVC) or relaxed/slow manoeuvre (SVC) can be used to determine vital capacity (VC). In healthy individuals the difference between SVC and FVC (SVC-FVC) is minimal whereas in the presence of airway obstruction this difference will become significant. The present study was done with the objective to detect and compare the airway obstruction by determining the FEV1/FVC and FEV1/ SVC ratios.Methods: This was a prospective cross-sectional study done at OPD, Government Thiruvoteeswarar hospital of thoracic medicine/Kilpauk medical college during the period from September 2016 to February 2017among the patients presenting with symptoms of obstructive airway disease. The sample comprised of 353 patients who underwent spirometry according to standard of ATS/ERS guidelines. As per the criteria, the patients are classified into four groups, by spirometry.Results: The analysis of FEV1/FVC revealed the presence of airway obstruction in 131 (37%) individuals compared to 165 (46%) individuals by the analysis of Fev1/SVC ratio. In the obstruction and mixed groups, the difference in vital capacity SVC – FVC is statistically superior (p<0.05) when compared to normal and restriction groups.Conclusions: The FEV1/SVC ratio detected the presence of airway obstruction in more individuals than did FEV1/FVC ratio and hence FEV1/SVC considered as more reliable factor in the detection of obstructive airway diseases.

scholarly journals Chronic Respiratory Symptoms and Lung Function of Farmer and Breeder in UTU Village, Tabanan, Bali

2020 ◽  
Vol 8 (B) ◽  
pp. 709-715
Author(s):  
Ni Luh Putu Eka Arisanti ◽  
Ni Putu Ayu Widiasari ◽  
Ida Bagus Ngurah Rai
Keyword(s):  
Lung Function ◽  
Respiratory Symptoms ◽  
Vital Capacity ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Smoking History ◽  
Sectional Study ◽  
Lung Function Decline ◽  
Cross Sectional ◽  
Passive Smoker

AIM: The objective of the study was to determine chronic respiratory symptoms and lung function of farmers. METHODS: The study was conducted in Utu Village, Tabanan, Bali with 84 subjects. This research was observational analytic cross sectional study. RESULTS: Three dominant chronic respiratory symptoms in farmers were coughing (15.1%), dyspnea (13.1%), and phlegm (13.1%). Average values of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and FEV1/FVC were 83.75 ± 34.42, respectively, 81.62 ± 34.30 and 104.90 ± 13.90, respectively. Cough was dominant experiencing by smokers (p = 0.008). Mean of FEV1% prediction and FVC% prediction value was lower in passive smoker group than no smoker group (p = 0.005 and p = 0.03). CONCLUSION: Occupational exposure while farming and raising livestock can cause chronic respiratory symptom and lung function decline in farmers and can be influenced by smoking history and secondhand smoke exposure.

The Relationship between the Results of Coagulation Profile and Severity of Pulmonary Involvement in COVID-19 Patients

2021 ◽  
Author(s):  
Mohsen Ebrahimi ◽  
Samaneh Abiri ◽  
Esmaeal Rayat Dost ◽  
Fatemeh Rahmanian ◽  
Mahdi Foroughian ◽  
...  
Keyword(s):  
Platelet Count ◽  
Pulmonary Involvement ◽  
Cross Sectional Study ◽  
High Resolution Computed Tomography ◽  
Cross Sectional ◽  
Coagulation Profile ◽  
Discriminating Power ◽  
Global Pandemic ◽  
Coagulation Tests ◽  
Severe Group

ntroduction: COVID-19 is currently a global pandemic, and coagulation-related mortality has been widely reported in patients suffering from it. Objective: this article aimed to investigate the coagulation profile of COVID-19 patients. Methods: This was a cross-sectional study conducted using a retrospective research design. We recruited patients with COVID-19 admitted to a hospital from June 15th to July 7th, 2020. Upon patients’ entering a blood sample was drawn from each patient for assessing patient’s coagulation profile (PT, PTT, INR, Platelet count); and a chest high-resolution computed tomography (HRCT) scan was performed for each patient. The study patients were divided in to sever group (CO-RADS score 5) and non-sever group (CO-RADS score <5). Results: Thirty-six patients (20 males and 16 females) with a mean age of 54.7±17.5 years were studied. Of them, 11 cases (30.56%) had severe pulmonary involvement. Also, the coagulation profiles were longer in the severe group than non-sever group. As well, the means of platelet count that were 232.440 per microliter in the non-severe group and 289.180 per microliter in the severe and non-sever groups, respectively; but still not statistically significant (p>0.05). The Area under the ROC Curve (AUC) for PT and INR was 0.615 and 0.611, respectively. The AUC for platelet count was 0.680 (95% CI: 0.501 to 0.859) and had an acceptable discriminating power. Conclusions: In this study, we did not find any statistically significant relationship between the results of coagulation tests and the severity of pulmonary involvement according to HRCT scan findings in COVID-19 patients. But further analyses suggest that, except PTT, the other coagulation tests (PT, INR, and platelet count) may discriminate severe COVID-19 patients.

scholarly journals Gender Differences: Does it affect clinical, radiological and microbiological features in adult non-cystic fibrosis bronchiectasis?

Acta Medica ◽  
2019 ◽  
Vol 50 (2) ◽  
pp. 25-31
Author(s):  
Elif Yelda Niksarlıoğlu
Keyword(s):  
Gender Differences ◽  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Severity Index ◽  
Cross Sectional Study ◽  
Smoking History ◽  
High Resolution Computed Tomography ◽  
Cross Sectional ◽  
Group I

Objective: This study aimed to investigate the gender effect on the clinic, radiological, and microbiological features in adult non-cystic fibrosis (CF) bronchiectasis (BR). Material and Methods:This was a cross-sectional study of 217 patients with adult non-CF BR. Patients with a confirmed diagnosis of bronchiectasis with high resolution computed tomography were investigated. Patients were clinically stable in the previous four weeks enrolled in the study. Symptoms, pulmonary function tests, radiological findings, microbiological results, and bronchiectasis severity index (BSI) were recorded. Results: The mean age of patients was 49.7 (15.3) years (range 18-82). Fouty-one percent patients had smoking history. BR patients had a history of pneumonia sequel (47.9%), post-tuberculosis (33.6%) and idiopathic (15.7%). Patients divided in to 2 groups as group I (female, n=122 (56.2%)) and group II (male, n=95 (43.8%)). There were a differences in cough (84.4% vs 71.6%, p=0.029), smoking history (19.7% vs 75.9 %,p=0.001), COPD (4.1% vs 37.9%, p=0.001), diabetes mellitus (21.3% vs 9.5%, p=0.025), depression history(36.1% vs 10.6%, p=0.001), panic disorders (10.7% vs 3.2%, p=0.039), long term oxygen usage (6.6% vs 17.9%,p=0.017). Forty-two percent of male BR patients had post-tuberculosis history, fifty-six female had post-pneumonia history, also. FEV1 and FVC value were higher in man (1.5±0.7 vs 1.9±0.9,p= 0.001; 1.9±0.7 vs 2.7±1.0, p=0.0001 respectively). And also, FEV1/FVC ratio was lower in male (73.8±12.3 vs 67.8±15.3, p=0.01). But, There was no difference between gender and age, dyspnea, heamoptysis, BSI category, radiologic severity using Reiff’s score, microbiological features and BPAP usage. Conclusion: We concluded that gender differences in non-CF BR might be clinically important in our study population. It is important to consider the gender differences might be effect symptoms, comorbidity, and pulmonary function test results to non-CF BR patients.

scholarly journals Incremental shuttle walk test performed in a hallway and on a treadmill: are they interchangeable?

2018 ◽  
Vol 25 (4) ◽  
pp. 395-403
Author(s):  
Cristiane Santos de Oliveira ◽  
Anderson José ◽  
Crislaine Oliveira Santos ◽  
Cristiane Helga Yamane de Oliveira ◽  
Thiago Cristiano Oliveira Carvalho ◽  
...  
Keyword(s):  
Aerobic Training ◽  
Physiological Responses ◽  
Cross Sectional Study ◽  
Walking Distance ◽  
Walk Test ◽  
Healthy Individuals ◽  
Sectional Study ◽  
Cross Sectional ◽  
Walking Test ◽  
Significant Difference

ABSTRACT The performances of healthy individuals in an incremental shuttle walking test performed in a hallway (ISWT-H) and on a treadmill (ISWT-T) were compared to assess their physiological responses during aerobic training sessions with the speeds estimated from both tests. This was a cross-sectional study with 55 healthy subjects, who were randomized to perform the ISWT tests with 24 hours between them. Training sessions were held using a treadmill at 75% of the speeds obtained from the ISWT-H and ISWT-T. Measurements included walking distance, oxygen uptake (VO2), carbon dioxide (VCO2) production, heart rate (HR), and ventilation (VE). There was a significant difference between walking distances (ISWT-T: 823.9±165.2 m and ISWT-H:685.4±141.4 m), but similar physiological responses for VO2 (28.6±6.6 vs. 29.0±7.3 ml-1.kg-1.min-1), VCO2 (1.9±0.7 vs. 1.9±0.5 1), HR (158.3±17.8 vs. 158.6±17.7 bpm), and VE (41.5±10.4 vs. 43.7±12.9 1). The estimated speeds were different for the training sessions (5.5±0.5 km/h and 4.9±0.3 km/h), as well as the VO2, VCO2, VE, and HR. It was concluded that in healthy young adults, ISWTs carried out in a hallway and on a treadmill are not interchangeable. Since the ISWT-H was determined to have lower speed, the training intensity based on this test may underestimate a patient’s responses to aerobic training.

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