Which is better among FEV1/FVC and FEV1/SVC in obstructive airway disease?

Background: Forced expiratory volume in 1 second (FEV1) to forced vital capacity ratio (FVC) is being used to diagnose the obstructive lung diseases. Forced manoeuvre (FVC) or relaxed/slow manoeuvre (SVC) can be used to determine vital capacity (VC). In healthy individuals the difference between SVC and FVC (SVC-FVC) is minimal whereas in the presence of airway obstruction this difference will become significant. The present study was done with the objective to detect and compare the airway obstruction by determining the FEV1/FVC and FEV1/ SVC ratios.Methods: This was a prospective cross-sectional study done at OPD, Government Thiruvoteeswarar hospital of thoracic medicine/Kilpauk medical college during the period from September 2016 to February 2017among the patients presenting with symptoms of obstructive airway disease. The sample comprised of 353 patients who underwent spirometry according to standard of ATS/ERS guidelines. As per the criteria, the patients are classified into four groups, by spirometry.Results: The analysis of FEV1/FVC revealed the presence of airway obstruction in 131 (37%) individuals compared to 165 (46%) individuals by the analysis of Fev1/SVC ratio. In the obstruction and mixed groups, the difference in vital capacity SVC – FVC is statistically superior (p<0.05) when compared to normal and restriction groups.Conclusions: The FEV1/SVC ratio detected the presence of airway obstruction in more individuals than did FEV1/FVC ratio and hence FEV1/SVC considered as more reliable factor in the detection of obstructive airway diseases.

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GENDER DIFFERENCES IN CHILDHOOD POISONING

Journal of Health and Allied Sciences NU ◽

10.1055/s-0040-1703657 ◽

2013 ◽

Vol 03 (02) ◽

pp. 069-072

Author(s):

Pratik Vijay Tarvadi ◽

Shankar M. Bakkannavar ◽

Vikram Palimar ◽

G. Pradeep Kumar ◽

Mahabalesh Shetty ◽

...

Keyword(s):

Cross Sectional Study ◽

Morbidity And Mortality ◽

Medical Emergency ◽

High Morbidity ◽

Sectional Study ◽

Cross Sectional ◽

Medical College ◽

Childhood Poisoning ◽

Males And Females ◽

The Difference

Abstract Background: Accidental paediatric poisoning is a common medical emergency and also associated with a high morbidity and mortality in children. In developing countries like India, the poisoning emergencies are becoming a major cause of mortality in infants and toddlers. Among the various studies done on poisoning cases in our country, the study on poisoning is more or less only on adults and hence this study is taken up to understand the number of childhood poisoning cases (based on gender). Method: A ten year record based cross sectional study from January 1999 to December 2008 was conducted at the Department of Forensic Medicine & Toxicology, Kasturba Medical College, Manipal, to understand the magnitude of childhood poisoning cases among males and females at Kasturba Hospital, Manipal. Results: Male children were predominantly affected (male: female::1.32: 1). Most of the poisoning cases occurred at home in both the genders with boy to girl ratio based on percentage in indoor poisoning being 0.92:1 and boy to girl ratio based on percentage in outcome being 1.06:1. Conclusion: Our study examines the difference in place and outcome of poisoning among boys and girls to identify population at risk and give suggestions so as to reduce the morbidity and mortality.

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The association between chronic airflow obstruction and poverty in 12 sites of the multinational BOLD study

European Respiratory Journal ◽

10.1183/13993003.01880-2016 ◽

2017 ◽

Vol 49 (6) ◽

pp. 1601880 ◽

Cited By ~ 15

Author(s):

John Townend ◽

Cosetta Minelli ◽

Kevin Mortimer ◽

Daniel O. Obaseki ◽

Mohammed Al Ghobain ◽

...

Keyword(s):

Vital Capacity ◽

Meta Analysis ◽

Airflow Obstruction ◽

Cross Sectional Study ◽

Forced Expiratory Volume ◽

Sectional Study ◽

Cross Sectional ◽

Unit Increase ◽

Household Assets ◽

Lower Limit Of Normal

Poverty is strongly associated with mortality from COPD, but little is known of its relation to airflow obstruction.In a cross-sectional study of adults aged ≥40 years from 12 sites (N=9255), participating in the Burden of Obstructive Lung Disease (BOLD) study, poverty was evaluated using a wealth score (0–10) based on household assets. Obstruction, measured as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) (%) after administration of 200 μg salbutamol, and prevalence of FEV1/FVC<lower limit of normal were tested for association with poverty for each site, and the results were combined by meta-analysis.Mean wealth scores ranged from 4 in Blantyre (Malawi) and Kashmir (India) to 10 in Riyadh (Saudi Arabia), and the prevalence of obstruction, from 16% in Kashmir to 3% in Riyadh and Penang (Malaysia). Following adjustments for age and sex, FEV1/FVC increased by 0.36% (absolute change) (95%CI: 0.22, 0.49; p<0.001) per unit increase in wealth score. Adjustments for other confounders reduced this effect to 0.23% (0.11, 0.34), but even this value remained highly significant (p<0.001). Results were consistent across sites (I2=1%; phet=0.44). Mean wealth scores explained 38% of the variation in mean FEV1/FVC between sites (r2=0.385, p=0.031).Airflow obstruction is consistently associated with poverty at individual and community levels across several countries.

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Low Vital Capacity and Electrocardiographic ST-T Abnormalities in Asymptomatic Adults

Pulmonary Medicine ◽

10.1155/2012/460398 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Kei Nakajima ◽

Yulan Li ◽

Hiroshi Fuchigami ◽

Hiromi Munakata

Keyword(s):

Metabolic Syndrome ◽

Forced Vital Capacity ◽

Vital Capacity ◽

Heart Diseases ◽

Past History ◽

Multiple Logistic Regression Analysis ◽

Cross Sectional Study ◽

Forced Expiratory Volume ◽

Common Finding ◽

Cross Sectional

Studies have shown that low forced vital capacity (LFVC) is associated with atherosclerosis. However, it is unclear whether LFVC is associated with resting electrocardiographic ST-T abnormalities, a common finding that is prognostic for cardiovascular events. Therefore, pulmonary functions, ST-T abnormalities defined with Minnesota Code, and cardiometabolic risk factors were examined in a cross-sectional study of 1,653 asymptomatic adults without past history of coronary heart diseases. The prevalence of diabetes, metabolic syndrome, and ST-T abnormalities significantly increased with decreasing percent of predicted forced vital capacity (%PFVC). ST-T abnormalities were observed in 73 subjects (4.4% in total). Multiple logistic regression analysis showed that, compared with the highest quartile of %PFVC (≥99.7%), the lowest quartile of %PFVC (≤84.2%) was persistently associated with ST-T abnormalities even after further adjustment for diabetes or metabolic syndrome (odds ratio (95%CI): 2.44 (1.16–5.14) and 2.42 (1.15–5.10), resp.). Similar trends were observed when subjects were divided into quartiles according to percent of predicted forced expiratory volume in 1 second (FEV1), but not the ratio of FEV1/FVC. In conclusion, LFVC may be associated with ST-T abnormalities independent of metabolic abnormalities in asymptomatic adults, suggesting a plausible link between impaired pulmonary defects and cardiovascular diseases.

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Effect of obesity on lung function test among adults

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20204965 ◽

2020 ◽

Vol 7 (12) ◽

pp. 1795

Author(s):

Dhairya Salvi ◽

Dhanvi Moradia

Keyword(s):

Vital Capacity ◽

Lung Function Test ◽

Cross Sectional Study ◽

Forced Expiratory Volume ◽

Sectional Study ◽

Cross Sectional ◽

Group Iii ◽

Group I ◽

Significant Difference ◽

Function Test

Background: Obesity is a chronic disease characterized by excessive body fat that causes damage to the individual’s health and is associated with comorbidities such as diabetes and hypertension and vascular dysfunction. This cross-sectional study was carried out with the objective of evaluating the effect of obesity on lung function test in obese but otherwise healthy adults.Methods: It was a cross-sectional study carried out at tertiary care institute of Gujarat, India. It was conducted over a period of 5 months. A total of 240 adult healthy subjects of both sexes were selected randomly belonging to varying socio-economic status. The study subjects were divided into 3 categories (normal body mass index i.e. BMI, overweight, obese). BMI were calculated for the randomly selected subjects from each list till the desired number in each BMI group were attained. Four respiratory parameters viz. forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), forced expiratory volume in 3 seconds (FEV3), and maximum voluntary ventilation (MVV) were used to assess their lung functions.Results: Two hundred and forty subjects (each group having n=80). The mean age of group I, group II and group III were 27.45±6.37, 28.18±6.42 and 28.98±6.74 respectively. Lung volumes showed significant difference in relation to the BMI. FVC and FEV1 show significant decrease. Group III verses group I (p˂0.001 and p˂0.017 respectively) FEV3 showed significant difference between group I and group III and between group II and group III (p˂0.001). MVV was significantly lower in group III when compared to group I.Conclusions: There is decline in pulmonary function in obese as compared to normal weight adults. These findings suggest deleterious effects on ventilatory mechanics caused by obesity, due to probable lung compression (reduction in the expiratory reserve volume i.e. ERV), leading to a compensatory increase in the inspiratory reserve volume (IRV) in an attempt to maintain a constant vital capacity (VC).

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Study of Thyroid Function Status in Type 2 Diabetic Patients

KYAMC Journal ◽

10.3329/kyamcj.v10i2.42787 ◽

2019 ◽

Vol 10 (2) ◽

pp. 95-98

Author(s):

Kamrunnahar Alo ◽

Shyamal Chandra Banik ◽

Safayet Ahammed ◽

Ayesha Yasmin ◽

Tania Rahman

Keyword(s):

Thyroid Function ◽

Thyroid Dysfunction ◽

Cross Sectional Study ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Medical College ◽

The Difference ◽

Type 2 Diabetic

Background: Thyroid dysfunction specially hypothyroidism may occur in type 2 diabetic patients. Objective: To observe thyroid function status in type 2 diabetic patients Materials and Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2016 to June 2017. Total 60 subjects including male and female, age ranged from 40 to 60 years were included in this study, among them 30 were non-diabetic subjects and 30 were type 2 diabetic patients. Results: In this study, mean serum TSH level was significantly (p<0.001) higher and serum FT4 level was significantly (p<0.01) lower in diabetic patients than that of apparently healthy non-diabetic subjects. Serum FT3 level was lower in type 2 diabetic patients in comparison to that of non-diabetic subjects but the difference was not statistically significant. However, among the diabetic patients 10% were subclinical hypothyroid and 6.67% were hypothyroid Conclusion: The present study reveals that hypothyroidism occurs in type 2 diabetic patients. So type 2 diabetic patients should measure thyroid hormone levels routinely to detect thyroid dysfunction. KYAMC Journal Vol. 10, No.-2, July 2019, Page 95-98

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Chronic Respiratory Symptoms and Lung Function of Farmer and Breeder in UTU Village, Tabanan, Bali

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2020.4538 ◽

2020 ◽

Vol 8 (B) ◽

pp. 709-715

Author(s):

Ni Luh Putu Eka Arisanti ◽

Ni Putu Ayu Widiasari ◽

Ida Bagus Ngurah Rai

Keyword(s):

Lung Function ◽

Respiratory Symptoms ◽

Vital Capacity ◽

Cross Sectional Study ◽

Forced Expiratory Volume ◽

Smoking History ◽

Sectional Study ◽

Lung Function Decline ◽

Cross Sectional ◽

Passive Smoker

AIM: The objective of the study was to determine chronic respiratory symptoms and lung function of farmers. METHODS: The study was conducted in Utu Village, Tabanan, Bali with 84 subjects. This research was observational analytic cross sectional study. RESULTS: Three dominant chronic respiratory symptoms in farmers were coughing (15.1%), dyspnea (13.1%), and phlegm (13.1%). Average values of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and FEV1/FVC were 83.75 ± 34.42, respectively, 81.62 ± 34.30 and 104.90 ± 13.90, respectively. Cough was dominant experiencing by smokers (p = 0.008). Mean of FEV1% prediction and FVC% prediction value was lower in passive smoker group than no smoker group (p = 0.005 and p = 0.03). CONCLUSION: Occupational exposure while farming and raising livestock can cause chronic respiratory symptom and lung function decline in farmers and can be influenced by smoking history and secondhand smoke exposure.

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Pulmonary Involvement in the Antisynthetase Syndrome: A Comparative Cross-sectional Study

The Journal of Rheumatology ◽

10.3899/jrheum.151067 ◽

2016 ◽

Vol 43 (6) ◽

pp. 1107-1113 ◽

Cited By ~ 10

Author(s):

Helena Andersson ◽

Trond Mogens Aaløkken ◽

Anne Günther ◽

Georg Karl Mynarek ◽

Torhild Garen ◽

...

Keyword(s):

Vital Capacity ◽

Pulmonary Function Tests ◽

Pulmonary Involvement ◽

Cross Sectional Study ◽

Forced Expiratory Volume ◽

Walking Distance ◽

Antisynthetase Syndrome ◽

High Resolution Computed Tomography ◽

Cross Sectional ◽

Significant Difference

Objective.Interstitial lung disease (ILD) is a major component of the antisynthetase syndrome, but quantitative data on longterm pulmonary outcome in antisynthetase syndrome are limited. In this study, the main aims were to compare pulmonary function tests (PFT) and the 6-min walking distance (6MWD) between patients with antisynthetase syndrome and healthy sex- and age-matched controls, to evaluate the extent of ILD by lung high-resolution computed tomography (HRCT), and to assess correlations between PFT measures and ILD extent.Methods.Concurrent PFT and 6MWD were performed in 68 patients with antisynthetase syndrome and their individually matched controls. Additionally, in the patients, the extent of ILD was determined in 10 HRCT sections, expressed as percentage of total lung volumes.Results.Median disease duration in the antisynthetase syndrome cohort was 71 months. Compared with the matched controls, the patients with antisynthetase syndrome had mean 28%, 27%, and 53% lower absolute values of forced vital capacity (FVC), forced expiratory volume in 1 s, and DLCO (p < 0.001). Mean difference in 6MWD between patients and controls was 116 m (p < 0.001). Median extent of ILD by HRCT was 20% (range 0–73) and correlated with FVC and DLCO. Pulmonary outcome did not differ between Jo1 and non-Jo1 subsets.Conclusion.To our knowledge, this study is the first to demonstrate a highly significant difference in PFT between patients with antisynthetase syndrome with 6 years of followup and healthy controls. DLCO displayed the highest difference with mean 53% lower value in the patients. FVC and DLCO correlated significantly with ILD extent, indicating these variables as appropriate outcome measures in antisynthetase syndrome–associated ILD.

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PREVALENCE OF PSYCHIATRIC MORBIDITIES AMONG COVID -19 PATIENTS IN A TERTIARY CARE HOSPITAL, CHENNAI, TAMIL NADU.

10.36106/ijsr/4322050 ◽

2021 ◽

pp. 63-64

Author(s):

Anupama Roshan S ◽

Priyasubhashini. M ◽

M Mathivanan

Keyword(s):

Tamil Nadu ◽

Acute Stress ◽

Tertiary Care Hospital ◽

Treatment Options ◽

Tertiary Care ◽

Cross Sectional Study ◽

Care Hospital ◽

Cross Sectional ◽

Medical College ◽

The Difference

Background: Due the lack of treatment options, isolation guidelines and fear about the disease, the cases with COVID 19 may experience high psychiatric related disorders. Hence this study was conducted to assess the prevalence of psychiatric morbidities among the cases with COVID 19 in a tertiary care hospital. Methods: Cross sectional study in the Department of Psychiatry at Government Medical College , Omandurar Government Estate, Chennai, a tertiary care teaching hospital during the period of April 2020 to September 2020. A total of 11,704 cases with COVID-19 were included in the study. Demographic details and psychiatry related clinical prole were assessed and entered in a proforma. Data was entered and analyzed using Statistical Package for Social Sciences (SPSS) version 20. Results: Overall prevalence of psychiatric morbidities among the COVID 19 cases was reported as 24.4% with signicant difference in prevalence among males and females. Most common psychiatric illness reported was COVID related anxiety (16.5%) followed by COVID related depression (6.6%), insomnia (0.87%), alcohol dependence syndrome (0.3%), acute stress reaction (0.03%), intellectual disability (0.03%), psychosis (0.02%) and hemophobia (0.008%). The difference in proportion of cases with various psychiatric morbidities like insomnia, COVID related anxiety, COVID related depression, and alcohol dependance syndrome among the male and female genders was found to be statistically signicant. Conclusion: Almost one fourth of the COVID cases are suffering from psychiatric morbidities. It can be recommended that all the cases with COVID can undergo screening and counseling for the psychiatric disorders.

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The Relative Importance of Clinical, Radiological and Pulmonary Function Variables in Evaluating Asbestosis and Chronic Obstructive Airway Disease in Asbestos Workers

Clinical Science ◽

10.1042/cs0410569 ◽

1971 ◽

Vol 41 (6) ◽

pp. 569-582 ◽

Cited By ~ 24

Author(s):

Gillian M. Regan ◽

Beryl Tagg ◽

Joan Walford ◽

M. L. Thomson

Keyword(s):

Pulmonary Function ◽

Vital Capacity ◽

Disease Process ◽

Principal Component ◽

Airway Disease ◽

Forced Expiratory Volume ◽

Obstructive Airway Disease ◽

Chronic Obstructive ◽

Pleural Thickening ◽

Present Context

1. The relative power of sixteen clinical, radiological and pulmonary function variables for evaluating asbestosis and chronic osbtructive airway disease has been assessed by principal component analysis of the data from a survey of 201 asbestos workers. 2. A decrease in the transfer factor (diffusing capacity) for carbon monoxide followed by a decrease in the vital capacity had the greatest power to measure the severity of both types of disease but had little ability to distinguish between the two. 3. In decreasing order of potency, the best indicators for distinguishing between asbestosis and obstructive airway disease were forced expiratory volume as a proportion of vital capacity, phlegm, radiological pleural thickening, cough and finger clubbing. Low values in FEV/VC and high values in phlegm and cough indicated obstructive airway disease: high values of pleural thickening and finger clubbing indicated asbestosis in the present context. 4. The analysis also provided numerical scores for each individual that could be plotted on a two-dimensional diagram. Orientation along one axis showed the degree of involvement of individuals by lung disease, whereas separation along the other axis depended on the nature of the disease process, asbestosis and obstructive airway disease in this instance.

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Hypersegmented airway neutrophils and its association with reduced lung function in adults with obstructive airway disease: an exploratory study

BMJ Open ◽

10.1136/bmjopen-2018-024330 ◽

2019 ◽

Vol 9 (1) ◽

pp. e024330 ◽

Cited By ~ 4

Author(s):

Ravi Lokwani ◽

Peter A B Wark ◽

Katherine J Baines ◽

Daniel Barker ◽

Jodie L Simpson

Keyword(s):

Exploratory Study ◽

Airflow Obstruction ◽

Airway Disease ◽

Systemic Circulation ◽

Forced Expiratory Volume ◽

Obstructive Airway Disease ◽

Chronic Obstructive ◽

Nuclear Morphology ◽

Healthy Controls ◽

Cross Sectional

ObjectivesThe significance of neutrophilic inflammation in obstructive airway disease remains controversial. Recent studies have demonstrated presence of an active neutrophil population in systemic circulation, featuring hypersegmented morphology, with high oxidative burst and functional plasticity in inflammatory conditions. The aim of this study was to characterise neutrophil subsets in bronchial lavage (BL) of obstructive airway disease participants (asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis) and healthy controls on the basis of nuclear morphology and to assess the association between neutrophil subsets and the clinical parameters of the obstructive airway disease participants.DesignA cross-sectional exploratory study.SettingJohn Hunter Hospital and Hunter Medical Research Institute, Australia.ParticipantsSeventy-eight adults with obstructive airway disease comprised those with stable asthma (n=39), COPD (n=20) and bronchiectasis (n=19) and 20 healthy controls.Materials and methodsCytospins were prepared and neutrophil subsets were classified based on nuclear morphology into hypersegmented (>4 lobes), normal (2–4 lobes) and banded (1 lobe) neutrophils and enumerated.ResultsNeutrophils from each subset were identified in all participants. Numbers of hypersegmented neutrophils were elevated in participants with airway disease compared with healthy controls (p<0.001). Both the number and the proportion of hypersegmented neutrophils were highest in COPD participants (median (Q1–Q3) of 1073.6 (258.8–2742) × 102/mL and 24.5 (14.0–46.5)%, respectively). An increased proportion of hypersegmented neutrophils in airway disease participants was significantly associated with lower forced expiratory volume in 1 s/forced vital capacity per cent (Spearman’s r=−0.322, p=0.004).ConclusionNeutrophil heterogeneity is common in BL and is associated with more severe airflow obstruction in adults with airway disease. Further work is required to elucidate the functional consequences of hypersegmented neutrophils in the pathogenesis of disease.

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