Histopathological effects of Aloe vera on wound healing process in penile fracture model: an experimental study

The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

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Variations of Magnesium, Iron, Copper and Zinc during the Colonic Wound Healing Process: Experimental Study on Rabbits

European Surgical Research ◽

10.1159/000129217 ◽

1992 ◽

Vol 24 (5) ◽

pp. 283-290 ◽

Cited By ~ 6

Author(s):

F. Vaxman ◽

S. Olender ◽

H. Maldonado ◽

S. Randriamananjo ◽

G. Chalkiadakis ◽

...

Keyword(s):

Experimental Study ◽

Wound Healing ◽

Healing Process ◽

Wound Healing Process ◽

Iron Copper ◽

Copper And Zinc ◽

Colonic Wound

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Influence of suturing material on wound healing: Experimental study in dogs

Vojnosanitetski pregled ◽

10.2298/vsp140122054g ◽

2015 ◽

Vol 72 (5) ◽

pp. 397-404 ◽

Cited By ~ 2

Author(s):

Dragan Gazivoda ◽

Dejan Pelemis ◽

Goran Vujaskovic ◽

Slavisa Djurdjevic

Keyword(s):

Experimental Study ◽

Wound Healing ◽

Absorption Rate ◽

Experimental Testing ◽

Healing Process ◽

Human Organism ◽

Wound Healing Process ◽

Suture Materials ◽

German Shepherd ◽

Tissue Reactions

Background/Aim. The most common materials implanted in the human organism are suture materials that are classified on the basis of several criteria, usually the origin, structure, and properties. The properties of suture materials are related to its absorbability and non-absorbability. When using resorbable materials it is of great importance to determine whether its absorbability and tensile strength help wound healing in function of time. Sutures themselves can become a source of inflammation, that may reduce or compromise the potential of reparation and regeneration. The aim of this experimental study on dogs was to ascertain whether the absorption rate and the degree of local tissue reactions differ from information provided by the manufacturers, whether there are differences between the applied suture materials and which of the used suture materials have better effect on wound healing. Methods. Experimental testing of the selected suture materials basic characteristics was performed on 6 German Shepherd dogs, which, after induction of general anesthesia, were made 3 identical incisions each in all 4 quadrants (left and right side of the upper and lower jaws), so that 12 horizontal incisions were formed, 10 mm long, 20-25 mm distant from one another, on each animal. Randomly, incisions were stitched up in the following order, starting from back to front: catgut, Dexon?, Vicryl-Rapid?. The experiment was terminated by histopathological examination of tissue samples, taken on postoperative day 3, 7, 14 and 21 in order to identify the effect of healing and the degree of local reaction. Results. The obtained results suggest that catgut has the highest absorption rate, while Dexon? the lowest. Vicryl-Rapid? causes the lowest level of local reactions, while Dexon? the highest. Conclusion. There is no ideal suture material because various patient factors also influence the wound healing process.

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THE EFFECT OF ALOE VERA TOWARD THE NUMBER OF FIBROBLASTS ON THE WOUND INCISION OF WISTAR RAT’S (RATUS NORVEGICUS)

Journal of Vocational Nursing ◽

10.20473/jovin.v1i1.19905 ◽

2020 ◽

Vol 1 (1) ◽

pp. 30

Author(s):

Chusnul Nur Fatmawati ◽

Ekowati Retnanin ◽

Tavip Dwi Wahyuni

Keyword(s):

Wound Healing ◽

Transforming Growth Factor ◽

Healing Process ◽

Aloe Vera ◽

T Test ◽

Field Of View ◽

Wound Healing Process ◽

Wistar Strain ◽

Alternative Choice ◽

Group 1

Introduction: Incision is a wound caused by a sharp object, for example in surgery. The characteristics of the wound are pain, open wounds, and the length of the wound is greater than in it. Handling the wound there are various ways, one of which is using Aloe Vera. The aim of this study was to determine the effect of topical Aloe vera gel concentration of 10%, 20%, and 40% to determine the amount of fibroblast tissue in wistar strain rats (Rattus orvegicus) in incisions. Methods: This study uses an experimental design with a sample of 75 rats divided into 5 groups; 0.9% NaCl group, 1% tulle-framycetin sulfate group, 10% Aloe vera group, 20% Aloe vera group and 40% Aloe vera group. Samples of incisional wound skin were performed on days 3.7, and 12. All data were processed and analyzed statistically using SPSS 20. Based on microscopic observations at 10 times per field of view, the highest number of fibroblasts given at NaCl was given on the day 12th is 28.98 per field of view, treatment using tulle-framycetin sulfate 1% is 34.5 per field of view, treatment using Aloe vera 10% is 17.32 per field of view, treatment using Aloe vera 20% is 33, 9 per field of view while the treatment using Aloe vera was 40% ie 18.7 per view. Results : The results of the study with the Independent T-test and Paired T-test showed that the results of fibroblast tissue between 0.9% NaCl group, 1% tulle-framycetin sulfate, 10% Aloe vera, 40% Aloe vera with 20% Aloe vera there were differences which were significant (p <0.05) where 20% Aloe vera gave effective results in the wound healing process. Conclusion : This study concluded that 20% of Aloe vera can be used as an alternative choice of wound healing. In the next study it is expected to examine the variable TGF (Transforming Growth Factor) that affects cell growth in wound healing.

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Uji efek ekstrak daun dewa (Gyanurasegetum [Lour]. Merr) terhadap masa penyembuhan luka insisi kulit kelinci (Oryctolaguscuniculus)

Jurnal e-Biomedik ◽

10.35790/ebm.4.1.2016.11614 ◽

2016 ◽

Vol 4 (1) ◽

Author(s):

. Aaron ◽

Henoch Awaloei ◽

Jane Wuisan

Keyword(s):

Experimental Study ◽

Wound Healing ◽

Healing Process ◽

Wound Healing Process ◽

Rabbit Skin ◽

The Public ◽

Accelerate Wound Healing ◽

Left And Right ◽

The Right ◽

Incision Wound

Abstract: Marsh fleabane (Gynurasegetum [Lour].Merr.) is one of the medicinal plants used by the public as an anti-septic to accelerate wound healing. The contents of Marsh fleabane that could accelerate wound healing are flavonoids, saponins, and atsiri oil. This study aimed to determine the effect of Marsh fleabane extract on wound healing incision of rabbit skin. This was an experimental study. This study was conducted in the Laboratory of Pharmacology and Therapeutics Faculty of Medicine, University of Sam Ratulangi. Samples were 3 rabbits. Incised wounds of 4 cm length and 2 mm depth were made on the rabbits’ left and right backs. The wounds on the left backs were given Marsh fleabane extract, meanwhile the wounds on the right backs were not treated. The results showed that the wound healing process of the incised wounds treated with Marsh fleabane extract was faster compared to the incised wounds without treatment. Conclusion: Marsh fleabane extract could accelerate the wound healing process of rabbit incised wound. Keywords: marsh fleabane, incision wound healing Abstrak: Daun dewa (Gyanurasegetum [Lour].Merr.) merupakan salah satu tanaman berkhasiat yang biasa digunakan oleh masyarakat sebagai obat anti septik dan mempercepat penyembuhan luka. Kandungan yang terkandung dalam daun dewa yang dipercaya dapat mempercepat penyembuhan luka yaitu flavonoid, saponin, dan minyak atsiri. Penelitian ini bertujuan untuk mengetahui uji efek ekstrak daun dewa terhadap penyembuhan luka insisi pada kulit kelinci. Metode penelitian yang digunakan ialah rancangan eksperimental. Penelitian ini dilaksanakan di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Sam Ratulangi. Sampel yang digunakan berjumlah 3 ekor kelinci yang masing-masing punggung kiri dan kanannya diberi luka insisi sepanjang 4 cm dan kedalaman 2 mm. Luka pada punggung sebelah kiri diberikan ekstrak daun dewa sedangkan luka pada punggung bagian kanan tidak diberikan ekstrak daun dewa. Hasil penelitian memperlihatkan bahwa masa penyembuhan luka insisi kulit kelinci yang diberikan ekstrak daun dewa lebih singkat dibandingkan dengan luka insisi kulit kelinci yang tidak diberikan ekstrak daun dewa. Simpulan: Ekstrak daun dewa berefek terhadap penyembuhan luka insisi kulit kelinci.Kata kunci: daun dewa, penyembuhan luka insisi

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Influence of Aloe Vera Gel on Dermal Wound Healing Process in Rat

Toxicology Mechanisms and Methods ◽

10.1080/15376510802442444 ◽

2008 ◽

Vol 19 (1) ◽

pp. 73-77 ◽

Cited By ~ 31

Author(s):

Nasrin Takzare ◽

Mir-jamal Hosseini ◽

Gholamreza Hasanzadeh ◽

Hamideh Mortazavi ◽

Alireza Takzare ◽

...

Keyword(s):

Wound Healing ◽

Healing Process ◽

Aloe Vera ◽

Wound Healing Process ◽

Dermal Wound Healing ◽

Aloe Vera Gel ◽

Dermal Wound

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The effectiveness of platelet-rich plasma on the skin wound healing process: A comparative experimental study in sheep

Veterinary World ◽

10.14202/vetworld.2018.800-808 ◽

2018 ◽

Vol 11 (6) ◽

pp. 800-808 ◽

Cited By ~ 6

Author(s):

Daikh Badis ◽

Bennoune Omar

Keyword(s):

Experimental Study ◽

Wound Healing ◽

Platelet Rich Plasma ◽

Healing Process ◽

Skin Wound ◽

Wound Healing Process ◽

Skin Wound Healing

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Aloe Vera as an Antidiabetic and Wound Healing Agent for Diabetic Patients

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i57a33994 ◽

2021 ◽

pp. 256-263

Author(s):

. Harshali ◽

Pitambri Thakur ◽

Gunjan Mukherjee

Keyword(s):

Wound Healing ◽

Side Effects ◽

Healing Process ◽

Aloe Vera ◽

Therapeutic Drug ◽

Wound Healing Process ◽

Diabetic Patients ◽

Active Components ◽

Liver And Kidney ◽

Herbal Plant

Diabetes is a metabolic disorder that has been prevalent among the population and has been reported to rise worldwide at an alarming rate. Diabetes puts a person through a lot of risk to his or her life because of the late complications developed with time if this is not cured. It affects some metabolic processes related to lipid and glucose such that they further can lead to liver and kidney disorders. An evergreen, herbal, plant which is called aloe vera is a health remedy and in large demand these days because of its ability to cure many diseases. The present study is designed for the purpose to examine and check the efficacy of aloe vera to cure diabetes, reducing the risk of complications and also reducing the chance of liver and kidney dysfunction. The glucose level in the patient and lipid profile status is also an important part of studying effectiveness. It is also known that a therapeutic drug already is responsible to cure the disease but as it is a chemical compound, so it is important to note the side effects of the same on the patient’s health, no matter how effective the drug is. To reduce this risk, the therapeutic drug in low quantity is combined with aloe vera extract to enhance effectiveness and lower down the side effects in patients. The aloe vera extract has also shown benefit in increasing the rate of the wound healing process in diabetic patients because of the problem of lack in their cell’s ability to recover and heal the wound. Clinical trials have also become the evidence of proving the fact about the anti-diabetic nature of aloe vera so that in the future all the chemical drugs may get replaced by herbal plant active components to reduce health problems in most people.

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Expression of fibroblast growth factor-2 after application of the Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extract gel in the wound healing process of hyperglycemic

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol33no1.21276 ◽

2021 ◽

Vol 33 (1) ◽

pp. 48

Author(s):

Fachrul Razi ◽

Andri Hardianto ◽

Lucky Riawan ◽

Bambang Pontjo Priosoeryanto

Keyword(s):

Wound Healing ◽

Healing Process ◽

Aloe Vera ◽

Simple Random Sampling ◽

Fibroblast Growth Factor 2 ◽

Control Group ◽

Wound Healing Process ◽

Sprague Dawley ◽

Lagerstroemia Speciosa ◽

Significant Difference

Introduction: Fibroblast Growth Factor-2 (FGF-2) have a role in stimulating the proliferation and migration of various types of cells in the wound healing process. Hyperglycemic conditions can disrupt the wound healing process. Lagerstroemia speciosa are known to have antyphyerglycemic and antioxidant effects. Aloe vera is a plant that has been used for long time in topical treatment of wounds.This study was aimed to analyse the FGF-2 expressions on the wound healing process of subjects with hyperglycemia after application of Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extracts gel. Methods: A pure experimental study was conducted with simple random sampling. The sample was 27 experimental animals (CI 95%; power test 80%) of Sprague Dawley rat induced to have a hyperglycemic state using alloxan and had their palate injured. The immunohistochemical examination was performed to assess FGF-2 expression level. Samples were divided into three groups with a simple random sampling technique: nine of the rats received the Lagerstroemia speciosa extract gel application; nine rats received the aloe vera extract gel application on the injured palate; another nine rats in the control group. Examination of the FGF-2 expression level was performed on the third, seventh, and fourteenth observation days. Results: Overall, the control group had a significant difference with the Lagerstroemia speciosa and aloe vera extract gel group (p-value<0.05), however, the Lagerstroemia speciosa group did not have any significant difference with the aloe vera group (0.123>0.05). Conclusion: There was no difference in the amount of FGF-2 expressions on the wound healing process of the injured palatal tissue of Sprague-Dawley rats with hyperglycemic after application of the Lagerstroemia speciosa and aloe vera extract gel.

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