scholarly journals Aloe Vera as an Antidiabetic and Wound Healing Agent for Diabetic Patients

2021 ◽  
pp. 256-263
Author(s):  
. Harshali ◽  
Pitambri Thakur ◽  
Gunjan Mukherjee
Keyword(s):  
Wound Healing ◽  
Side Effects ◽  
Healing Process ◽  
Aloe Vera ◽  
Therapeutic Drug ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Active Components ◽  
Liver And Kidney ◽  
Herbal Plant

Diabetes is a metabolic disorder that has been prevalent among the population and has been reported to rise worldwide at an alarming rate. Diabetes puts a person through a lot of risk to his or her life because of the late complications developed with time if this is not cured. It affects some metabolic processes related to lipid and glucose such that they further can lead to liver and kidney disorders. An evergreen, herbal, plant which is called aloe vera is a health remedy and in large demand these days because of its ability to cure many diseases. The present study is designed for the purpose to examine and check the efficacy of aloe vera to cure diabetes, reducing the risk of complications and also reducing the chance of liver and kidney dysfunction. The glucose level in the patient and lipid profile status is also an important part of studying effectiveness. It is also known that a therapeutic drug already is responsible to cure the disease but as it is a chemical compound, so it is important to note the side effects of the same on the patient’s health, no matter how effective the drug is. To reduce this risk, the therapeutic drug in low quantity is combined with aloe vera extract to enhance effectiveness and lower down the side effects in patients. The aloe vera extract has also shown benefit in increasing the rate of the wound healing process in diabetic patients because of the problem of lack in their cell’s ability to recover and heal the wound. Clinical trials have also become the evidence of proving the fact about the anti-diabetic nature of aloe vera so that in the future all the chemical drugs may get replaced by herbal plant active components to reduce health problems in most people.

scholarly journals Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 961
Author(s):  
Sibusiso Alven ◽  
Vuyolwethu Khwaza ◽  
Opeoluwa O. Oyedeji ◽  
Blessing A. Aderibigbe
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Mechanical Performance ◽  
Healing Process ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Wound Management ◽  
Wound Healing Process ◽  
Treatment Of Wounds

The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

scholarly journals THE EFFECT OF ALOE VERA TOWARD THE NUMBER OF FIBROBLASTS ON THE WOUND INCISION OF WISTAR RAT’S (RATUS NORVEGICUS)

2020 ◽  
Vol 1 (1) ◽  
pp. 30
Author(s):  
Chusnul Nur Fatmawati ◽  
Ekowati Retnanin ◽  
Tavip Dwi Wahyuni
Keyword(s):  
Wound Healing ◽  
Transforming Growth Factor ◽  
Healing Process ◽  
Aloe Vera ◽  
T Test ◽  
Field Of View ◽  
Wound Healing Process ◽  
Wistar Strain ◽  
Alternative Choice ◽  
Group 1

Introduction: Incision is a wound caused by a sharp object, for example in surgery. The characteristics of the wound are pain, open wounds, and the length of the wound is greater than in it. Handling the wound there are various ways, one of which is using Aloe Vera. The aim of this study was to determine the effect of topical Aloe vera gel concentration of 10%, 20%, and 40% to determine the amount of fibroblast tissue in wistar strain rats (Rattus orvegicus) in incisions. Methods: This study uses an experimental design with a sample of 75 rats divided into 5 groups; 0.9% NaCl group, 1% tulle-framycetin sulfate group, 10% Aloe vera group, 20% Aloe vera group and 40% Aloe vera group. Samples of incisional wound skin were performed on days 3.7, and 12. All data were processed and analyzed statistically using SPSS 20. Based on microscopic observations at 10 times per field of view, the highest number of fibroblasts given at NaCl was given on the day 12th is 28.98 per field of view, treatment using tulle-framycetin sulfate 1% is 34.5 per field of view, treatment using Aloe vera 10% is 17.32 per field of view, treatment using Aloe vera 20% is 33, 9 per field of view while the treatment using Aloe vera was 40% ie 18.7 per view. Results : The results of the study with the Independent T-test and Paired T-test showed that the results of fibroblast tissue between 0.9% NaCl group, 1% tulle-framycetin sulfate, 10% Aloe vera, 40% Aloe vera with 20% Aloe vera there were differences which were significant (p <0.05) where 20% Aloe vera gave effective results in the wound healing process. Conclusion : This study concluded that 20% of Aloe vera can be used as an alternative choice of wound healing. In the next study it is expected to examine the variable TGF (Transforming Growth Factor) that affects cell growth in wound healing.

Angiogenic Nanoscaffold Accelerates Diabetic Wound Healing and Improves Wound Tissue Strength in db/db Mice

2009 ◽  
Author(s):  
Swathi Balaji ◽  
Abdul Q. Sheikh ◽  
Lee Morris ◽  
Foong Y. Lim ◽  
Timothy M. Crombleholme ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Normal Wound Healing ◽  
Inflammatory Phase ◽  
Diabetic Wound Healing ◽  
Ecm Degradation ◽  
Chronic Ulcers

Chronic ulcers are a leading cause of morbidity in diabetic patients. Diabetes is associated with major changes in the wound microenvironment and disruption of normal wound healing process, characterized by a prolonged inflammatory phase with elevated levels of wound proteases and increased degradation of extracellular matrix (ECM) components [1]. This impedes wound healing due to a lack of provisional matrix, impaired recruitment and survival of endothelial (EC) and endothelial precursor (EPC) cells, and insufficient neovascularization, resulting in delayed healing. Therefore, strategies focused on restoring the diabetic wound microenvironment by decreasing ECM degradation and promoting neovascularization are promising for development of new therapies to treat chronic diabetic ulcers.

scholarly journals Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends

Materials ◽  
2019 ◽  
Vol 12 (16) ◽  
pp. 2540 ◽  
Author(s):  
Federica Paladini ◽  
Mauro Pollini
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Antimicrobial Agents ◽  
Healing Process ◽  
Wound Management ◽  
Resistant Bacteria ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Special Focus ◽  
European Economic Area

Recent data have reported that the burden of infections related to antibiotic-resistant bacteria in the European Union and European Economic Area (EEA) can be estimated as the cumulative burden of tuberculosis, influenza, and human immunodeficiency virus (HIV). In wound management, the control of infections represents a crucial issue and a multi-billion dollar industry worldwide. For diabetic wounds ulcers, in particular, infections are related to the majority of amputations in diabetic patients, which today represent an increasing number of the elderly. The greatest barrier to healing is represented by the biofilm, an organized consortium of bacteria encapsulated in a self-produced extracellular polymeric substance with high resistance to conventional antimicrobial therapies. There is an urgent need for novel anti-biofilm strategies and novel antimicrobial agents and, in this scenario, silver nanotechnology has received tremendous attention in recent years in therapeutically enhanced healthcare. Due to its intrinsic therapeutic properties and the broad-spectrum antimicrobial efficacy, silver nanoparticles have opened new horizons towards novel approaches in the control of infections in wound healing. This review aims at providing the reader with an overview of the most recent progress in silver nanotechnology, with a special focus on the role of silver in the wound healing process.

Characteristics of microbial drug resistance and its correlates in chronic diabetic foot ulcer infections

2014 ◽  
Vol 63 (10) ◽  
pp. 1377-1385 ◽  
Author(s):  
Thokur S. Murali ◽  
Shettigar Kavitha ◽  
Jain Spoorthi ◽  
Deepika V. Bhat ◽  
Alevoor S. Bharath Prasad ◽  
...  
Keyword(s):  
Immune Response ◽  
Wound Healing ◽  
Diabetic Foot ◽  
Healing Process ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Bacterial Strains ◽  
Microbial Drug Resistance

While virulence factors and the biofilm-forming capabilities of microbes are the key regulators of the wound healing process, the host immune response may also contribute in the events following wound closure or exacerbation of non-closure. We examined samples from diabetic and non-diabetic foot ulcers/wounds for microbial association and tested the microbes for their antibiotic susceptibility and ability to produce biofilms. A total of 1074 bacterial strains were obtained with staphylococci, Pseudomonas, Citrobacter and enterococci as major colonizers in diabetic samples. Though non-diabetic samples had a similar assemblage, the frequency of occurrence of different groups of bacteria was different. Gram-negative bacteria were found to be more prevalent in the diabetic wound environment while Gram-positive bacteria were predominant in non-diabetic ulcers. A higher frequency of monomicrobial infection was observed in samples from non-diabetic individuals when compared to samples from diabetic patients. The prevalence of different groups of bacteria varied when the samples were stratified according to age and sex of the individuals. Several multidrug-resistant strains were observed among the samples tested and most of these strains produced moderate to high levels of biofilms. The weakened immune response in diabetic individuals and synergism among pathogenic micro-organisms may be the critical factors that determine the delicate balance of the wound healing process.

Influence of Aloe Vera Gel on Dermal Wound Healing Process in Rat

2008 ◽  
Vol 19 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Nasrin Takzare ◽  
Mir-jamal Hosseini ◽  
Gholamreza Hasanzadeh ◽  
Hamideh Mortazavi ◽  
Alireza Takzare ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Aloe Vera ◽  
Wound Healing Process ◽  
Dermal Wound Healing ◽  
Aloe Vera Gel ◽  
Dermal Wound

DECISION TREES FOR SEGMENTATION AND ASSESSMENT OF WOUND HEALING PROCESS OF DIABETIC PATIENTS

2019 ◽  
Vol 31 (04) ◽  
pp. 1950029
Author(s):  
K. S. Babu ◽  
Sukanta Sabut ◽  
Y. B. Ravi Kumar
Keyword(s):  
Wound Healing ◽  
Decision Trees ◽  
Healing Process ◽  
Ground Truth ◽  
The Body ◽  
Automated System ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Segmentation Accuracy ◽  
Diabetic Wound Healing

Wound healing is a slow process in diabetic patients due to levels of insulin variations in the body. Thus, we present an automated system to analyze and assess different stages of wound healing process of diabetic patients. The diabetic wound healing stages have been defined into three types, such as the level of tissues present in the wound: The percentage of granulations tissues, Necrotic tissues and Slough tissues present in the diabetic patients. The performance of the proposed method shall be assessed based on the clear accuracy of segmentation of wound region present in the patient body. The Decision Tree-based Segmentation method has yielded a good segmentation accuracy of 98.32% in comparison with the ground truth results of clinical data. Further, the assessment of wound healing stages of proposed method has given a good accuracy of measuring the stages of diabetic patients by measuring the percentage of different types of tissues present in the wound region. Based on the results of classification accuracy of the proposed method, we assess whether the wound is going to heal quickly or not. Thus, we presented an algorithm of Decision Trees for the purpose of segmentation and assessment of wound healing process of diabetic patients.

scholarly journals EFFECT MOIST WOUND HEALING TECHNIQUE TOWARD DIABETES MELLITUS PATIENTS WITH ULKUS DIABETIKUM IN DHOHO ROOM RSUD PROF Dr. SOEKANDAR MOJOSARI

2017 ◽  
Vol 6 (1) ◽  
pp. 63-69
Author(s):  
Lutfi Wahyuni
Keyword(s):  
Diabetes Mellitus ◽  
Wound Healing ◽  
Research Design ◽  
Cell Damage ◽  
Healing Process ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Treatment Technique ◽  
Wound Treatment ◽  
Granulation Process

Wound healing of ulkus diabetikum depends on wound treatment given; an appropriate wound treatment technique is able to help the healing process quickly and prevent amputation effectively. It needs wound treatment that is able to prevent advanced complication and increase wound healing process such as moist wound healing. This study aimed to aplicated technique with moist wound healing toward diabetes mellitus patients with ulcer diabetic in dhoho room RSUD Prof Dr. Soekandar Mojosari. Deskriptive explorative research design was used in this study. The number of sample were 20 respondents who were the whole ulcer diabetic patients on January – March 2016. The date were collected from the 1st and 7th wound treatment days of embroider medic and used observation sheets. The findings revealed that 20 respondents were on wound healing degree with regeneration wound; it means that the whole respondents cared by moist wound healing within 7 days got regeneration wound or net amelioration. Moist wound healing technique is able to keep moist of wound itself, so that it can facilitate cell and wound movement as well as expedite the granulation process about 50%. Therefore, after doing wound healing during 7 days, the significant change was on wound granulation development. Besides, it can minimize cell damage while the alteration bandage in order to prevent the new trauma and wound spread.

A Novel Functionalization of Bioactive Antimicrobial Peptide onto the Nano-CeO2/Reduced Graphene Oxide Cluster Type Biocomposite Wound Dressings for Diabetic Wound Care Management: In Vitro and In Vivo Evaluations

2020 ◽  
Vol 10 (1) ◽  
pp. 37-45 ◽  
Author(s):  
Ran Wei ◽  
Shijun Nie ◽  
Jing Ma ◽  
Changmei Feng ◽  
Hongyu Kuang
Keyword(s):  
Wound Healing ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Healing Process ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Diabetic Wound ◽  
Reduced Graphene ◽  
Diabetic Wound Healing

Diabetic wound ulcers and unhealed ulcerations have caused in severe difficulties of diabetic patients all around the world. The anti-microbial peptides (AMP) and nanomaterials have been demonstrated beneficial in diabetic wound healing studies. Diabetic wound healing process can be delayed significantly due to the infection issues. Hence in this report, biologically synthesized cerium oxide (CeO2) nanoparticles incorporated with reduced graphene oxide (RGO) and AMP for effective and rapid diabetic wound healing have been reported. At first, reduced graphene oxide was prepared from graphene oxide to prepare CeO2/RGO nanocomposites. Biocompatible AMP (IP-1) functionalized CeO2/RGO nanocomposites were accordingly prepared to study the diabetic wound healing process. Rats, the wound healing models with the wound size of about 1.5 cm2 were tested with the as-prepared samples. Further, the prepared samples were tested in a wound healing model of rate with the wound of size 1.5 cm2. Almost complete recovery of wounds i.e., 100% closure of wound area was observed after 2 weeks of treatment by the prepared samples. Biocompatible AMP (IP-1) functionalized CeO2/RGO nanocomposites enhances rapid keratinocytes proliferation by short time thereby it proves the enhanced ability of the prepared samples to act as a wound healing in-vivo drugs. HE and MTC staining protocols to illustrate histological observations elucidates the keratinocytes creation by biocompatible AMP (IP-1) functionalized CeO2/RGO nanocomposites.

scholarly journals Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Bei Qian ◽  
Jialun Li ◽  
Ke Guo ◽  
Nengqiang Guo ◽  
Aimei Zhong ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Responses ◽  
Healing Process ◽  
Diabetic Rats ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Skin Defect ◽  
Diabetic Wound ◽  
Sod Activity ◽  
Post Surgery

Abstract Associated with persistent oxidative stress, altered inflammatory responses, poor angiogenesis and epithelization, wound healing in diabetic patients is impaired. N-acetylcysteine (NAC) is reported to resist excess reactive oxygen species (ROS) production, prompt angiogenesis and maturation of the epidermis. Studies have revealed that graphene oxide (GO) can regulate cellular behavior and form cross-links with naturally biodegradable polymers such as collagen (COL) to construct composite scaffolds. Here, we reported a COL-based implantable scaffold containing a mixture of GO capable of the sustained delivery of NAC to evaluate the wound healing in diabetic rats. The morphological, physical characteristics, biocompatibility and NAC release profile of the GO-COL-NAC (GCN) scaffold were evaluated in vitro. Wound healing studies were performed on a 20 mm dorsal full-skin defect of streptozotocin (STZ)-induced diabetic rats. The injured skin tissue was removed at the 18th day post-surgery for histological analysis and determination of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) activity. In diabetic rats, we confirmed that the GCN scaffold presented a beneficial effect in enhancing the wound healing process. Additionally, due to the sustained release of NAC, the scaffold may potentially induce the antioxidant defense system, upregulating the expression levels of the antioxidant enzymes in the wound tissue. The findings revealed that the antioxidant biocompatible composite collagen dressing could not only deliver NAC in situ for ROS inhibition but also promote the wound healing process. This scaffold with valuable therapy potential might enrich the approaches for surgeon in diabetic wound treatment in the future.

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