Influence of Aloe Vera Gel on Dermal Wound Healing Process in Rat

2008 ◽  
Vol 19 (1) ◽  
pp. 73-77 ◽  
Author(s):  
Nasrin Takzare ◽  
Mir-jamal Hosseini ◽  
Gholamreza Hasanzadeh ◽  
Hamideh Mortazavi ◽  
Alireza Takzare ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Aloe Vera ◽  
Wound Healing Process ◽  
Dermal Wound Healing ◽  
Aloe Vera Gel ◽  
Dermal Wound

scholarly journals The possibility of polymorphonuclear leukocyte activation in dental socket healing by freeze-dried Aloe vera induction

2021 ◽  
Vol 54 (3) ◽  
pp. 124
Author(s):  
Pratiwi Soesilawati ◽  
Ester Arijani Rachmat ◽  
Ira Arundina ◽  
Nita Naomi
Keyword(s):  
Wound Healing ◽  
Tooth Extraction ◽  
Healing Process ◽  
Aloe Vera ◽  
Inflammatory Cells ◽  
Control Group ◽  
Wound Healing Process ◽  
Control Group Design ◽  
Aloe Vera Gel ◽  
Freeze Dried

Background: Research has proved that Aloe vera has anti-inflammatory, anti-bacterial, and immunomodulator properties that can accelerate the healing process. These properties could be beneficial in the tooth extraction wound-healing process. Neutrophils are the first inflammatory cells to invade and are the predominant cell markers in the wound for 24 hours after injury. Polymorphonuclear leukocytes (PMN) provide initial protection against micro-organisms, as they engulf and digest foreign bodies. Purpose: The aim of this study was to prove the effect of Aloe vera 90% gel application on the PMN count in the healing process of Cavia cobaya following tooth extraction. Methods: This laboratory experimental research was done using Post-Test Only Control Group Design. The lower incisive of twelve male Cavia cobayas were extracted then divided into four groups. Group P1 and P3 had 90% Aloe vera gel applied into the socket and sutured; group K1 and K3, received no 90% Aloe vera gel application and acted as controls. Samples from group P1 and K1 were terminated and had their mandibula taken one day after tooth extraction, and those from group P3 and K3 were terminated after three days. Tissues were then processed into histology slides, and PMN cells were counted. Results: There were significant differences in the PMN count between groups K1, P1, and K3 compared with P3 (p < 0.05). Higher PMN count was shown on the group containing Aloe vera 90% gel compared with control group, both on day one and three after tooth extraction. Conclusion: Aloe vera 90% gel can increase the PMN count in the inflammation phase of the tooth extraction wound-healing process.

scholarly journals Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 961
Author(s):  
Sibusiso Alven ◽  
Vuyolwethu Khwaza ◽  
Opeoluwa O. Oyedeji ◽  
Blessing A. Aderibigbe
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Mechanical Performance ◽  
Healing Process ◽  
Aloe Vera ◽  
Antimicrobial Properties ◽  
Biological Properties ◽  
Wound Management ◽  
Wound Healing Process ◽  
Treatment Of Wounds

The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

scholarly journals THE EFFECT OF ALOE VERA TOWARD THE NUMBER OF FIBROBLASTS ON THE WOUND INCISION OF WISTAR RAT’S (RATUS NORVEGICUS)

2020 ◽  
Vol 1 (1) ◽  
pp. 30
Author(s):  
Chusnul Nur Fatmawati ◽  
Ekowati Retnanin ◽  
Tavip Dwi Wahyuni
Keyword(s):  
Wound Healing ◽  
Transforming Growth Factor ◽  
Healing Process ◽  
Aloe Vera ◽  
T Test ◽  
Field Of View ◽  
Wound Healing Process ◽  
Wistar Strain ◽  
Alternative Choice ◽  
Group 1

Introduction: Incision is a wound caused by a sharp object, for example in surgery. The characteristics of the wound are pain, open wounds, and the length of the wound is greater than in it. Handling the wound there are various ways, one of which is using Aloe Vera. The aim of this study was to determine the effect of topical Aloe vera gel concentration of 10%, 20%, and 40% to determine the amount of fibroblast tissue in wistar strain rats (Rattus orvegicus) in incisions. Methods: This study uses an experimental design with a sample of 75 rats divided into 5 groups; 0.9% NaCl group, 1% tulle-framycetin sulfate group, 10% Aloe vera group, 20% Aloe vera group and 40% Aloe vera group. Samples of incisional wound skin were performed on days 3.7, and 12. All data were processed and analyzed statistically using SPSS 20. Based on microscopic observations at 10 times per field of view, the highest number of fibroblasts given at NaCl was given on the day 12th is 28.98 per field of view, treatment using tulle-framycetin sulfate 1% is 34.5 per field of view, treatment using Aloe vera 10% is 17.32 per field of view, treatment using Aloe vera 20% is 33, 9 per field of view while the treatment using Aloe vera was 40% ie 18.7 per view. Results : The results of the study with the Independent T-test and Paired T-test showed that the results of fibroblast tissue between 0.9% NaCl group, 1% tulle-framycetin sulfate, 10% Aloe vera, 40% Aloe vera with 20% Aloe vera there were differences which were significant (p <0.05) where 20% Aloe vera gave effective results in the wound healing process. Conclusion : This study concluded that 20% of Aloe vera can be used as an alternative choice of wound healing. In the next study it is expected to examine the variable TGF (Transforming Growth Factor) that affects cell growth in wound healing.

scholarly journals Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

2021 ◽  
Vol 22 (9) ◽  
pp. 4748
Author(s):  
Kaushita Banerjee ◽  
Radha Madhyastha ◽  
Yuichi Nakajima ◽  
Masugi Maruyama ◽  
Harishkumar Madhyastha
Keyword(s):  
Wound Healing ◽  
Perioperative Management ◽  
New Products ◽  
Healing Process ◽  
Nutritional Supplements ◽  
Review Article ◽  
Cellular Interaction ◽  
Wound Healing Process ◽  
Pathological Conditions ◽  
Dermal Wound

Dermal wound healing describes the progressive repair and recalcitrant mechanism of 12 damaged skin, and eventually, reformatting and reshaping the skin. Many probiotics, nutritional supplements, metal nanoparticles, composites, skin constructs, polymers, and so forth have been associated with the improved healing process of wounds. The exact mechanism of material-cellular interaction is a point of immense importance, particularly in pathological conditions such as diabetes. Bioengineered alternative agents will likely continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new products continue to cut costs and improve the wound healing process. This review article provides an update on the various remedies with confirmed wound healing activities of metal-based nanoceutical adjuvanted agents and also other nano-based counterparts from previous experiments conducted by various researchers.

scholarly journals Aloe Vera as an Antidiabetic and Wound Healing Agent for Diabetic Patients

2021 ◽  
pp. 256-263
Author(s):  
. Harshali ◽  
Pitambri Thakur ◽  
Gunjan Mukherjee
Keyword(s):  
Wound Healing ◽  
Side Effects ◽  
Healing Process ◽  
Aloe Vera ◽  
Therapeutic Drug ◽  
Wound Healing Process ◽  
Diabetic Patients ◽  
Active Components ◽  
Liver And Kidney ◽  
Herbal Plant

Diabetes is a metabolic disorder that has been prevalent among the population and has been reported to rise worldwide at an alarming rate. Diabetes puts a person through a lot of risk to his or her life because of the late complications developed with time if this is not cured. It affects some metabolic processes related to lipid and glucose such that they further can lead to liver and kidney disorders. An evergreen, herbal, plant which is called aloe vera is a health remedy and in large demand these days because of its ability to cure many diseases. The present study is designed for the purpose to examine and check the efficacy of aloe vera to cure diabetes, reducing the risk of complications and also reducing the chance of liver and kidney dysfunction. The glucose level in the patient and lipid profile status is also an important part of studying effectiveness. It is also known that a therapeutic drug already is responsible to cure the disease but as it is a chemical compound, so it is important to note the side effects of the same on the patient’s health, no matter how effective the drug is. To reduce this risk, the therapeutic drug in low quantity is combined with aloe vera extract to enhance effectiveness and lower down the side effects in patients. The aloe vera extract has also shown benefit in increasing the rate of the wound healing process in diabetic patients because of the problem of lack in their cell’s ability to recover and heal the wound. Clinical trials have also become the evidence of proving the fact about the anti-diabetic nature of aloe vera so that in the future all the chemical drugs may get replaced by herbal plant active components to reduce health problems in most people.

scholarly journals Nanoceutical Adjuncts as Wound Healing Material: Precepts and Prospects

2021 ◽  
Author(s):  
Harishkumar Madhyastha ◽  
Kaushita Banerjee ◽  
Radha Madhyastha ◽  
Yuichi Nakajima
Keyword(s):  
Wound Healing ◽  
Perioperative Management ◽  
Pathological Condition ◽  
Healing Process ◽  
Review Article ◽  
Cellular Interaction ◽  
Wound Healing Process ◽  
Diverse Group ◽  
Dermal Wound ◽  
Improve Wound Healing

Dermal wound healing describes the progressive repair and recalcitrant mechanism of damaged skin and eventually reformatting and reshaping the skin. Many probiotics, nutraceuticals, metal nanoparticles have been associated with improved healing process of intra and inter tissue wounds. Despite the vast nature on material based wound healing mediators, the exact mechanism on material-cellular interaction is still point of repent issue particularly in diabetics and pathological condition. The use of bioengineered alternative agents will likely only continue to dominate the outpatient and perioperative management of chronic, recalcitrant wounds as new additional products continue to cut costs and improve wound healing process. This review article provides an update of the various remedies with confirmed wound healing activities by a diverse group of agents from previous experiments conducted by various researchers

scholarly journals Expression of fibroblast growth factor-2 after application of the Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extract gel in the wound healing process of hyperglycemic

2021 ◽  
Vol 33 (1) ◽  
pp. 48
Author(s):  
Fachrul Razi ◽  
Andri Hardianto ◽  
Lucky Riawan ◽  
Bambang Pontjo Priosoeryanto
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Aloe Vera ◽  
Simple Random Sampling ◽  
Fibroblast Growth Factor 2 ◽  
Control Group ◽  
Wound Healing Process ◽  
Sprague Dawley ◽  
Lagerstroemia Speciosa ◽  
Significant Difference

Introduction: Fibroblast Growth Factor-2 (FGF-2) have a role in stimulating the proliferation and migration of various types of cells in the wound healing process. Hyperglycemic conditions can disrupt the wound healing process. Lagerstroemia speciosa are known to have antyphyerglycemic and antioxidant effects. Aloe vera is a plant that has been used for long time in topical treatment of wounds.This study was aimed to analyse the FGF-2 expressions on the wound healing process of subjects with hyperglycemia after application of Queen's crepe-myrtle leaf (Lagerstroemia speciosa) and aloe vera extracts gel. Methods: A pure experimental study was conducted with simple random sampling. The sample was 27 experimental animals (CI 95%; power test 80%) of Sprague Dawley rat induced to have a hyperglycemic state using alloxan and had their palate injured. The immunohistochemical examination was performed to assess FGF-2 expression level. Samples were divided into three groups with a simple random sampling technique: nine of the rats received the Lagerstroemia speciosa extract gel application; nine rats received the aloe vera extract gel application on the injured palate; another nine rats in the control group. Examination of the FGF-2 expression level was performed on the third, seventh, and fourteenth observation days. Results: Overall, the control group had a significant difference with the Lagerstroemia speciosa and aloe vera extract gel group (p-value<0.05), however, the Lagerstroemia speciosa group did not have any significant difference with the aloe vera group (0.123>0.05). Conclusion: There was no difference in the amount of FGF-2 expressions on the wound healing process of the injured palatal tissue of Sprague-Dawley rats with hyperglycemic after application of the Lagerstroemia speciosa and aloe vera extract gel.

Transforming growth factor-β (TGF-β) activation in cutaneous wounds after topical application of aloe vera gel

2016 ◽  
Vol 94 (12) ◽  
pp. 1285-1290 ◽  
Author(s):  
Nasrin Takzaree ◽  
Abbas Hadjiakhondi ◽  
Gholamreza Hassanzadeh ◽  
Mohammad Reza Rouini ◽  
Azadeh Manayi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Wound Healing ◽  
Transforming Growth Factor ◽  
Skin Diseases ◽  
Healing Process ◽  
Aloe Vera ◽  
Cell Counting ◽  
Control Group ◽  
Aloe Vera Gel ◽  
Experimental Group

Aloe vera is a medicinal plant used to treat various skin diseases. The effects of using aloe vera gel on the healing process were investigated by microscopic methods, cell counting, and TGF-β gene expression in the wound bed. Sixty Wistar rats weighing 200–250 g were placed under anesthesia in sterile conditions. A square 1.5 cm × 1.5 cm wound was made on the back of the neck. The rats were divided into control and 2 experimental groups. Additionally, the control and experimental groups were separated into 3 subgroups corresponding to 4, 7, and 14 days of study. In the first experimental group, aloe vera was used twice on the wound. The second experimental group received aloe vera overtreatment once on the wound. The positive control group received daily application of 1% phenytoein cream following surgical wound creation. The control group did not receive any treatment. This tissue was examined using histological staining (H&E) and Masson’s Trichrome. Wound surface and wound healing were evaluated separately. TGF-β gene expression was analyzed by RT–PCR. Results showed that fibroblasts in both experimental groups were significantly increased, thereby acceleration wound healing. Application of aloe vera gel will increase TGF-β gene expression, ultimately accelerating the wound healing process.

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