Machine Learning Through Data Mining

2012 ◽  
pp. 23-31
Author(s):  
Diego Liberati

In dealing with information it often turns out that one has to face a huge amount of data, often not completely homogeneous and often without an immediate grasp of an underlying simple structure. Many records, each one instantiating many variables, are usually collected with the help of various technologies. Given the opportunity to have so many data not easy to correlate by the human reader, but probably hiding interesting properties, one of the typical goals one has in mind is to classify subjects on the basis of a hopefully reduced meaningful subset of the measured variables. The complexity of the problem makes it worthwhile to resort to automatic classification procedures. Then, the question arises of reconstructing a synthetic mathematical model, capturing the most important relations between variables, in order to both discriminate classes of subjects and possibly also infer rules of behaviours that could help identify their habits. Such interrelated aspects will be the focus of the present contribution. The data mining procedures that will be introduced in order to infer properties hidden in the data are in fact so powerful that care should be put in their capability to unveil regularities that the owner of the data would not want to let the processing tool discover, like for instance, in some cases the customer habits investigated via the usual smart card used in commerce with the apparent reward of discounting. Four main general purpose approaches will be briefly discussed in the present article, underlying the cost effectiveness of each one. In order to reduce the dimensionality of the problem, simplifying both the computation and the subsequent understanding of the solution, the critical issues of selecting the most salient variables must be addressed. This step may already be sensitive, pointing to the very core of the information to look at. A very simple approach is to resort to cascading a divisive partitioning of data orthogonal to the principal directions (PDDP) (Boley, 1998) already proven to be successful in the context of analyzing micro-arrays data (Garatti, Bittanti, Liberati, & Maffezzoli, 2007). A more sophisticated possible approach is to resort to a rule induction method, like the one described in Muselli and Liberati (2000). Such a strategy also offers the advantage to extract underlying rules, implying conjunctions or disjunctions between the identified salient variables. Thus, a first idea of their even nonlinear relations is provided as a first step to design a representative model, whose variables will be the selected ones. Such an approach has been shown (Muselli & Liberati, 2002) to be not less powerful over several benchmarks than the popular decision tree developed by Quinlan (1994). An alternative in this sense can be represented by Adaptive Bayesian networks (Yarmus, 2003) whose advantage is also to be available on a commercial wide spread data base tool like Oracle. Dynamics may matter. A possible approach to blindly build a simple linear approximating model is thus to resort to piece-wise affine (PWA) identification (Ferrari-Trecate, Muselli, Liberati, & Morari, 2003). The joint use of (some of) such four approaches briefly described in this article, starting from data without known priors about their relationships, will allow to reduce dimensionality without significant loss in information, then to infer logical relationships, and, finally, to identify a simple input-output model of the involved process that also could be used for controlling purposes, even those potentially sensitive to ethical and security issues.

Author(s):  
Diego Liberati

In dealing with information it often turns out that one has to face a huge amount of data, often not completely homogeneous and often without an immediate grasp of an underlying simple structure. Many records, each one instantiating many variables, are usually collected with the help of various technologies. Given the opportunity to have so many data not easy to correlate by the human reader, but probably hiding interesting properties, one of the typical goals one has in mind is to classify subjects on the basis of a hopefully reduced meaningful subset of the measured variables. The complexity of the problem makes it worthwhile to resort to automatic classification procedures. Then, the question arises of reconstructing a synthetic mathematical model, capturing the most important relations between variables, in order to both discriminate classes of subjects and possibly also infer rules of behaviours that could help identify their habits. Such interrelated aspects will be the focus of the present contribution. The data mining procedures that will be introduced in order to infer properties hidden in the data are in fact so powerful that care should be put in their capability to unveil regularities that the owner of the data would not want to let the processing tool discover, like for instance, in some cases the customer habits investigated via the usual smart card used in commerce with the apparent reward of discounting. Four main general purpose approaches will be briefly discussed in the present article, underlying the cost effectiveness of each one. In order to reduce the dimensionality of the problem, simplifying both the computation and the subsequent understanding of the solution, the critical issues of selecting the most salient variables must be addressed. This step may already be sensitive, pointing to the very core of the information to look at. A very simple approach is to resort to cascading a divisive partitioning of data orthogonal to the principal directions (PDDP) (Boley, 1998) already proven to be successful in the context of analyzing micro-arrays data (Garatti, Bittanti, Liberati, & Maffezzoli, 2007). A more sophisticated possible approach is to resort to a rule induction method, like the one described in Muselli and Liberati (2000). Such a strategy also offers the advantage to extract underlying rules, implying conjunctions or disjunctions between the identified salient variables. Thus, a first idea of their even nonlinear relations is provided as a first step to design a representative model, whose variables will be the selected ones. Such an approach has been shown (Muselli & Liberati, 2002) to be not less powerful over several benchmarks than the popular decision tree developed by Quinlan (1994). An alternative in this sense can be represented by Adaptive Bayesian networks (Yarmus, 2003) whose advantage is also to be available on a commercial wide spread data base tool like Oracle. Dynamics may matter. A possible approach to blindly build a simple linear approximating model is thus to resort to piece-wise affine (PWA) identification (Ferrari-Trecate, Muselli, Liberati, & Morari, 2003). The joint use of (some of) such four approaches briefly described in this article, starting from data without known priors about their relationships, will allow to reduce dimensionality without significant loss in information, then to infer logical relationships, and, finally, to identify a simple input-output model of the involved process that also could be used for controlling purposes, even those potentially sensitive to ethical and security issues.


The range of properties obtainable in titanium alloys derives from the use which is made of the j5~oc phase transformation, and alloying elements are classified according to their effect on the transformation temperature. The relation between composition and heat treatment on the one hand and the resultant microstructure and mechanical properties on the other hand are considered. In addition to the commonly used ‘general purpose’ alloy Ti-6A1-4V, more advanced alloys have been developed for three main applications, namely high strength forging alloys, creep resistant alloys and sheet alloys. For each type of alloy a different balance of material properties is required and the process of optimizing the alloy composition and heat treatment to give the best balance in each case is discussed. Factors affecting the cost of titanium alloys are outlined and consideration is given to the likely trends of titanium alloy development in the future.


2021 ◽  
Author(s):  
Cameron Mura ◽  
Saskia Preissner ◽  
Susanne Nahles ◽  
Max Heiland ◽  
Philip Bourne ◽  
...  

Abstract COVID-19 has spurred much interest in the therapeutic potential of repurposed drugs, such as acid-reducing drugs that act as histamine H2 receptor antagonists (H2RA). These compounds, exemplified by famotidine (e.g., Pepcid) and ranitidine (e.g., Zantac), bind the H2R and block the histamine-triggered stimulation of signal transduction cascades. Histamine and H2RAs, on the one hand, and downstream physiological pathways, on the other hand, form a dense web of disparate pathways and signaling networks; these networks are ultimately tied to the dysregulated inflammatory cascades (cytokine storm) that underlies the pathophysiology of COVID-19. Is famotidine beneficial in treating COVID-19? This question remains unresolved, despite much recent effort: over 10 studies have examined the potential value of famotidine in COVID-19, but have found largely contradictory results. Given the conflicting reports, we have undertaken a new analysis reported herein, drawing upon a cohort of 22,560 COVID-19 patients. Using electronic health records, we statistically analyzed outcomes for treatment with the H1RAs loratadine (e.g., Claritin) and cetirizine (e.g., Zyrtec), the H2RA famotidine, the general-purpose anti-inflammatory aspirin, and a famotidine & aspirin combination. For severe cases (requiring respiratory support), we found a significantly reduced fatality risk for famotidine treatment. Notably, famotidine combined with aspirin exhibited a significant synergistic survival benefit (odds ratio of 0.55). The relative risk for death decreased by 32.5%—an immense benefit, given the more than 2.6 million COVID-19-related deaths thus far. The large, multi-center retrospective study reported here, sampling over 250,000 COVID-19 cases internationally, hopefully helps clarify the possible value of clinically-approved histamine antagonists such as famotidine. Given these findings, alongside the cost-effectiveness and mild side-effects of common over-the-counter drugs like famotidine and aspirin, we suggest that further prospective clinical trials, perhaps utilizing the aspirin combination reported here, are advisable.


Author(s):  
Andri Setyorini ◽  
Niken Setyaningrum

Background: Elderly is the final stage of the human life cycle, that is part of the inevitable life process and will be experienced by every individual. At this stage the individual undergoes many changes both physically and mentally, especially setbacks in various functions and abilities he once had. Preliminary study in Social House Tresna Wreda Yogyakarta Budhi Luhur Units there are 16 elderly who experience physical immobilization. In the social house has done various activities for the elderly are still active, but the elderly who experienced muscle weakness is not able to follow the exercise, so it needs to do ROM (Range Of Motion) exercise.   Objective: The general purpose of this research is to know the effect of Range Of Motion (ROM) Active Assitif training to increase the range of motion of joints in elderly who experience physical immobility at Social House of Tresna Werdha Yogyakarta unit Budhi Luhur.   Methode: This study was included in the type of pre-experiment, using the One Group Pretest Posttest design in which the range of motion of the joints before (pretest) and posttest (ROM) was performed  ROM. Subjects in this study were all elderly with impaired physical mobility in Social House Tresna Wreda Yogyakarta Unit Budhi Luhur a number of 14 elderly people. Data analysis in this research use paired sample t-test statistic  Result: The result of this research shows that there is influence of ROM (Range of Motion) Active training to increase of range of motion of joints in elderly who experience physical immobility at Social House Tresna Wredha Yogyakarta Unit Budhi Luhur.  Conclusion: There is influence of ROM (Range of Motion) Active training to increase of range of motion of joints in elderly who experience physical immobility at Social House Tresna Wredha Yogyakarta Unit Budhi Luhur.


2020 ◽  
Vol 9 (3) ◽  
pp. 111-119
Author(s):  
Yu.Yu. IERUSALIMSKY ◽  
◽  
A.B. RUDAKOV ◽  

The article is devoted to the study of such an important aspect of the activities of the World Russian People's Council (until 1995 it was called the World Russian Council) in the 90-s of the 20-th century as a discussion of national security issues and nuclear disarmament. At that time, a number of political and public figures actively called for the nuclear disarmament of Russia. Founded in 1993, the World Russian Council called for the Russian Federation to maintain a reasonable balance between reducing the arms race and fighting for the resumption of detente in international relations, on the one hand, and maintaining a powerful nuclear component of the armed forces of the country, on the other. The resolutions of the World Russian Council and the World Russian People's Council on the problems of the new concepts formation of foreign policy and national security of Russia in the context of NATO's eastward movement are analyzed in the article. It also shows the relationship between the provisions of the WRNS on security and nuclear weapons issues with Chapter VIII of the «Fundamentals of the Social Concept of the Russian Orthodox Church».


Elenchos ◽  
2020 ◽  
Vol 41 (1) ◽  
pp. 181-194
Author(s):  
Angela Longo

AbstractThe following work features elements to ponder and an in-depth explanation taken on the Anca Vasiliu’s study about the possibilities and ways of thinking of God by a rational entity, such as the human being. This is an ever relevant topic that, however, takes place in relation to Platonic authors and texts, especially in Late Antiquity. The common thread is that the human being is a God’s creature who resembles him and who is image of. Nevertheless, this also applies within the Christian Trinity according to which, not without problems, the Son is the image of the Father. Lastly, also the relationship of the Spirit with the Father and the Son, always within the Trinity, can be considered as a relationship of similarity, but again not without critical issues between the similarity of attributes, on the one hand, and the identity of nature, on the other.


SynOpen ◽  
2021 ◽  
Author(s):  
Mina Ghassemi ◽  
Ali Maleki

Copper ferrite (CuFe2O4) magnetic nanoparticles (MNPs) were synthesized via thermal decomposition method and applied as a reusable and green catalyst in the synthesis of functionalized 4H-pyran derivatives using malononitrile, an aromatic aldehyde and a β-ketoester in ethanol at room temperature. Then it was characterized by Fourier transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX) analysis, scanning electron microscopy (SEM) images, thermo gravimetric and differential thermo gravimetric (TGA/DTG) analysis. The catalyst was recovered from the reaction mixture by applying an external magnet and decanting the mixture. Recycled catalyst was reused for several times without significant loss in its activity. Running the one-pot three-component reaction at room temperature, no use of eternal energy source and using a green solvent provide benign, mild, and environmentally friendly reaction conditions; as well, ease of catalyst recovering, catalyst recyclability, no use of column chromatography and good to excellent yields are extra advantages of this work.


Energies ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3611
Author(s):  
Sandra Gonzalez-Piedra ◽  
Héctor Hernández-García ◽  
Juan M. Perez-Morales ◽  
Laura Acosta-Domínguez ◽  
Juan-Rodrigo Bastidas-Oyanedel ◽  
...  

In this paper, a study on the feasibility of the treatment of raw cheese whey by anaerobic co-digestion using coffee pulp residues as a co-substrate is presented. It considers raw whey generated in artisanal cheese markers, which is generally not treated, thus causing environmental pollution problems. An experimental design was carried out evaluating the effect of pH and the substrate ratio on methane production at 35 °C (i.e., mesophilic conditions). The interaction of the parameters on the co-substrate degradation and the methane production was analyzed using a response surface analysis. Furthermore, two kinetic models were proposed (first order and modified Gompertz models) to determine the dynamic profiles of methane yield. The results show that co-digestion of the raw whey is favored at pH = 6, reaching a maximum yield of 71.54 mLCH4 gVSrem−1 (31.5% VS removed) for raw cheese whey and coffee pulp ratio of 1 gVSwhey gVSCoffe−1. The proposed kinetic models successfully fit the experimental methane production data, the Gompertz model being the one that showed the best fit. Then, the results show that anaerobic co-digestion can be used to reduce the environmental impact of raw whey. Likewise, the methane obtained can be integrated into the cheese production process, which could contribute to reducing the cost per energy consumption.


Author(s):  
Frederico Finan ◽  
Maurizio Mazzocco

Abstract Politicians allocate public resources in ways that maximize political gains, and potentially at the cost of lower welfare. In this paper, we quantify these welfare costs in the context of Brazil’s federal legislature, which grants its members a budget to fund public projects within their states. Using data from the state of Roraima, we estimate a model of politicians’ allocation decisions and find that 26.8% of the public funds allocated by legislators are distorted relative to a social planner’s allocation. We then use the model to simulate three potential policy reforms to the electoral system: the adoption of approval voting, imposing a one-term limit, and redistricting. We find that a one-term limit and redistricting are both effective at reducing distortions. The one-term limit policy, however, increases corruption, which makes it a welfare-reducing policy.


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