Testing and Validating Youth Leaders' Competencies in the UAE Governmental Organizations

2021 ◽  
Vol 12 (4) ◽  
pp. 97-111
Author(s):  
Shamsa Almarri
Keyword(s):  
Federal Government ◽  
Industrial Revolution ◽  
Validity And Reliability ◽  
Economic Success ◽  
Leadership Positions ◽  
Stage Design ◽  
Youth Leaders ◽  
Governmental Organizations ◽  
Government Leadership ◽  
Stage 1

To date, youth leaders' competencies (YLC) have not been systematically investigated. This study aims to identify the required YLC to determine their readiness and openness amongst other qualities to be able to identify those youths who are able to take on federal government leadership positions in the upcoming 4th Industrial Revolution, which is important for the future economic success of the country. In order to contribute to fill this gap, this study adopted a two-stage design seeking to develop and test a scale of youth leaders' competencies in the UAE governmental organizations. In Stage 1, the author generated and refined the scale items, recognizing unique characteristics of the UAE governmental organizations. In Stage 2, the scale has been assessed in terms of dimensionality, validity, and reliability. Using a sample of 242 youth leaders, the YLC's are then tested and validated.

Recounting the Empowerment of Women in Rural Areas of KwaZulu-Natal from Information and Knowledge in the Fourth Industrial Revolution Era

Libri ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Glenrose Jiyane
Keyword(s):  
South Africa ◽  
Rural Areas ◽  
Industrial Revolution ◽  
The Body ◽  
Non Profit ◽  
Fourth Industrial Revolution ◽  
Governmental Organizations ◽  
Body Of Knowledge ◽  
Non Governmental Organizations ◽  
Critical Resource

Abstract The fourth industrial revolution (4IR) marks the new, advanced era of development in humankind, and globally countries are in the process of ensuring their citizenry’s readiness. In South Africa, various governmental departments, organizations, non-governmental organizations (NGOs) and non-profit organisations (NPOs) are making efforts, through their plans, talks and actions, to attain this status for all her people, particularly women in rural areas. However, the development of women in the rural areas for empowerment remains a concern in developing countries. Consequently, there is a dire need to ensure the developmental status for women in rural areas in the advent of the 4IR, and this paper seeks to demonstrate that information and knowledge may be instrumental in empowering women in rural areas to strive in the 4IR. Accordingly, information and knowledge are a critical resource contributing to the empowerment of women in rural areas for their development. An exploratory question is raised to determine whether South Africa is ready for Fourth Industrial Revolution. The outcome of this paper will contribute to the body of knowledge advocating the importance of information and knowledge in the empowerment of women in rural areas. Significantly, it will generate insights for policymakers on the important role of information and knowledge for women’s development.

Palbociclib (P) in patients (pts) with soft tissue sarcoma (STS) with CDK4 amplification: Results from the Targeted Agent and Profiling Utilization Registry (TAPUR) study.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 11565-11565
Author(s):  
Scott Schuetze ◽  
Michael Rothe ◽  
Pam K. Mangat ◽  
Liz Garrett-Mayer ◽  
Funda Meric-Bernstam ◽  
...  
Keyword(s):  
Treatment Options ◽  
Objective Response ◽  
Progression Free Survival ◽  
Complete Response ◽  
Stage Design ◽  
Secondary Endpoints ◽  
Grade 3 ◽  
Ecog Ps ◽  
Stage 1 ◽  
Anti Tumor Activity

11565 Background: TAPUR is a phase II basket study evaluating anti-tumor activity of commercially available targeted agents in pts with advanced cancers with genomic alterations. Results in a cohort of STS pts with CDK4 amplification treated with P are reported. Methods: Eligible pts had advanced STS, no standard treatment options, measurable disease, ECOG PS 0-2, and adequate organ function. Genomic testing was performed in CLIA-certified, CAP-accredited site selected labs. Pts received P at 125 mg orally once daily for 21 days, followed by 7 days off until disease progression. Pts matched to P had CDK4 amplification and no RB mutations. Simon 2-stage design tested the null disease control (DC) - defined as partial (PR), complete response (CR) or stable disease at 16+ weeks (SD 16+) - rate of 15% vs. 35% (power = 0.85; α = 0.10). If ≥2 of 10 pts in stage 1 have DC, 18 more pts are enrolled. If ≥7 of 28 pts have DC, the null DC rate is rejected. Secondary endpoints are progression-free survival (PFS), overall survival (OS) and safety. Results: 29 pts (66% male) with STS with CDK4 amplification were enrolled from July 2016 to Nov 2019. 1 pt was not evaluable and excluded from efficacy analyses. Demographics and outcomes are summarized in Table. One pt with partial response (PR) and 12 pts with SD16+ were observed for DC and objective response (OR) rates of 48% (95% CI: 31%, 62%) and 3.7% (95% CI: 0.1%, 19%), respectively, and the null DC rate of 15% was rejected (p<0.001). 9/13 pts with DC continued on treatment for >32 weeks. 14 pts had at least one grade 3-4 AE at least possibly related to P with the most common being low WBC/platelets. Other grade 3 AEs included increased alanine aminotransferase, anemia, and fatigue. Conclusions: Monotherapy P demonstrated anti-tumor activity in heavily pre-treated pts with STS with CDK4 amplification. Additional study is warranted to confirm the efficacy of P in pts with STS with CDK4 amplification. Clinical trial information: NCT02693535. [Table: see text]

scholarly journals Student Perspective on Technology Enabled/Enhanced Active Learning in Educational: Rasch Measurement Model

2020 ◽  
Vol 16 (06) ◽  
pp. 34
Author(s):  
Nur Farha Hassan ◽  
Saifullizam Puteh ◽  
Amanina Muhamad Sanusi ◽  
Nor Hartini Che Mohamad Zahid
Keyword(s):  
Pilot Study ◽  
Active Learning ◽  
Engineering Students ◽  
Industrial Revolution ◽  
Measurement Model ◽  
Rasch Measurement ◽  
Technology In Education ◽  
Validity And Reliability ◽  
Survey Question ◽  
Rasch Measurement Model

Nowadays, the industrial revolution 4.0 had given a great impact on education. An active environment which applied technology in education can developed multiple skills in students. Technology Enabled/Enhanced Active Learning (TEAL) is one of the active environments that used technology in education. TEAL is the combination of several active learning domains which enhances students' understanding of learning and built job-related skills. However, students have lack of knowledge in their field which led to increase in unemployment of students. Hence, TEAL can help students in perform their practical works to develop knowledge and skills in students. This pilot study was distributed survey question about create an active and effective environment using TEAL application among the engineering students. The survey is consisted of 141 items and was distributed to 40 respondents. This pilot study used Rasch Measurement Model for measuring the validity and reliability of survey questions. Winsteps software is used to check the functionality of the item in terms of (i) Reliability and separation of respondents - items; (ii) detect the polarity items of PTMEA CORR Value; (iii) the item fit based on MNSQ Value; and (iv) Determine the dependent items based on the standardized residual value measurement correlation. The final result 109 items is suitable to use for measurement of the real study in future work.

scholarly journals Flexible Supply of Apprenticeship in the British Industrial Revolution

2017 ◽  
Vol 77 (1) ◽  
pp. 208-250 ◽  
Author(s):  
Nadav Ben Zeev ◽  
Joel Mokyr ◽  
Karine van der Beek
Keyword(s):  
Instrumental Variable ◽  
Industrial Revolution ◽  
Vector Autoregression ◽  
Variable Method ◽  
Response Functions ◽  
Economic Success ◽  
Demand Shocks ◽  
Long Run ◽  
Instrumental Variable Method

We use annual information on apprenticeships in England between 1710–1805 to estimate the dynamic supply-responsiveness in this market in the presence of the increasingly powerful technological shocks as the Industrial Revolution proceeded apace. Using both an Instrumental Variable method and a dynamic Vector Autoregression framework (VAR) system to identify the long-run response functions, we find evidence of an elastic supply, sufficiently high as to allow quantities to rise considerably in response to demand shocks. This finding lends support to the view that Britain's apprenticeship institution was the source of its advantage in skilled mechanical labor, so critical to its economic success.

A phase II study of cisplatin (CDDP) and oral vinorelbine (NVBO) concomitantly with radiotherapy (RT) in locally advanced (LA) non-small cell lung cancer (NSCLC) treatment: Interim analysis.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e17545-e17545
Author(s):  
Oscar Juan Vidal ◽  
Sergio Vazquez-Estevez ◽  
Vicente Giner ◽  
Joaquin Casal Rubio ◽  
Jose-luis Firvida ◽  
...  
Keyword(s):  
Interim Analysis ◽  
Phase Ii Study ◽  
Locally Advanced ◽  
Stage Iiia ◽  
Oral Vinorelbine ◽  
Stage Design ◽  
Type 1 Error ◽  
Stage 1

e17545 Background: CDDP+NVBO as induction and concomitant regimen with RT has shown good efficacy outcomes and safety profile (Krzakowski, J Thor Oncol. 2008). The objective of this study was to evaluate the effectiveness and toxicities of the combination of CDDP and NVBO given at full doses concomitantly with RT in LA-NSCLC. Methods: Between February 2010 and May 2011, 26 chemo-naive patients (p) with histologically confirmed stage IIIA/IIIB unresectable LA NSCLC were treated. Treatment consisted of 4 cycles (cy) of NVBO 60 mg/m2 on days 1 and 8 and CDDP 80 mg/m2 every 3 weeks plus RT 66 Gy starting on day 1, cy 2. A standard Fleming two stage design is being used. The sample size is calculated with a power of 90% and a two-sided type 1 error allowance of 5%. Stage 1 included 25 pts, with subsequent expansion to a total of 45. Results: Patient’s characteristics were: Median age, 59 years (range 48-71); males, 92%; smokers, 60%; adenocarcinoma, 28% / squamous, 64%; stage IIIA, 54% / IIIB, 46%. 21 p completed the 4 cy treatment as per protocol. We analyzed 92 cy. Hematological toxicities (% cy): grade (g) 3/4 neutropenia, 42.3%; g3 anemia, 3.3%; g3 thrombocytopenia, 2.2%; febrile neutropenia, 1 p. Non-hematological toxicities (% cy): g3 oesophagitis, 6.5%; g4 diarrhea, 1.1%. 21 p were evaluable for response. 1 CR (4.8%), 17 PR (81%) and 1 SD (4.5%) were reported. ORR 85.8%. Survival analysis has not been performed due to short follow-up. Conclusions: The findings of this interim analysis confirm the previously reported outcomes of efficacy and safety with NVBO plus CDDP when administered concurrently with RT in stage IIIA/IIIB p. The trial has met the criteria for continuation into stage 2.

Phase Ib/IIa study of GC1118 in combination with irinotecan or FOLFIRI in patients with metastatic solid tumors.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 3592-3592
Author(s):  
Keun Wook Lee ◽  
Sae-Won Han ◽  
Ji-Won Kim ◽  
Dae-Won Lee ◽  
Yong Sang Hong ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Solid Tumors ◽  
Skin Rash ◽  
Single Agent ◽  
Objective Response ◽  
Maximum Tolerated Dose ◽  
Stage Design ◽  
Phase 1B ◽  
Grade 3 ◽  
Stage 1

3592 Background: GC1118 is a novel anti-EGFR monoclonal antibody which has a unique binding epitope and superior ligand inhibition potential. It showed promising antitumor activity as a single agent in the phase I study. This study aimed to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of GC1118 in combination with irinotecan or FOLFIRI in metastatic solid tumors and evaluate the efficacy of GC1118 plus FOLFIRI as a second line therapy for RAS and BRAF wild-type metastatic colorectal cancer. Methods: Phase 1b part was designed to evaluate weekly GC1118 (starting from 3 mg/kg) in combination with biweekly irinotecan (180mg/m2) or FOLFIRI (irinotecan 180mg/m2, leucovorin 400mg/m2, 5-FU 400 mg/m2 bolus, and 5-FU 2400mg/m2 over 46hrs) in a 3+3 design. In the phase 2a part, the RP2D of GC1118 is administered in combination with FOLFIRI in a Simon’s two stage design with objective response rate (ORR) as the primary endpoint. Results: 13 pts were enrolled in phase 1b and received 3mg/kg of GC1118 with irinotecan (N = 6) or FOLFIRI (N = 7). DLT occurred in 2 pts (G4 neutropenia, G2 rash) in irinotecan arm and 1pt (G3 neutropenia) in FOLFIRI arm with 3mg/kg of GC1118 and it was determined as MTD and RP2D. Adverse events (AE) of grade ≥ 3 included neutropenia (61.5 %), skin rash (15.4 %) and diarrhea (15.4%). Dose reductions due to GC1118-related AE were required in 6 (46.2%) patients. Among 10 response-evaluable pts in phase 1b, best overall response was PR in 3 and SD in 6, and median PFS was 12 months. In stage 1 of phase 2a (N = 9), 4 PR and 5 SD were observed (ORR 44.4%, 95% CI 13.7 – 78.8). We moved to stage 2, and are currently enrolling additional 20 pts. AE of grade ≥ 3 included neutropenia (66.7%), skin rash (22.2%) and diarrhea (11.1%). Updated data of the phase 2a part will be presented at the meeting. Conclusions: The MTD and RP2D of weekly GC1118 in combination with irinotecan or FOLFIRI was 3mg/kg. Preliminary results of GC1118 and FOLFIRI as a 2nd line treatment in mCRC suggests promising antitumor activity and acceptable safety profile. Clinical trial information: NCT03454620 .

Phase II study of lamivudine in p53 mutant metastatic colorectal cancer (mCRC).

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 149-149
Author(s):  
Aparna Raj Parikh ◽  
Mihir Rajurkar ◽  
Emily E. Van Seventer ◽  
Angelo J. Gemma ◽  
Jill N. Allen ◽  
...  
Keyword(s):  
Cell Cancer ◽  
Single Agent ◽  
High Dose ◽  
Stage Design ◽  
Drug Intolerance ◽  
Fresh Frozen ◽  
Initial Drop ◽  
Pre Treatment ◽  
Grade 3 ◽  
Stage 1

149 Background: Non-coding repeat RNAs in cancers are pervasive and “mimic” viruses with activation of pattern recognition receptors and the innate immune response. Many repeat RNAs replicate in cancer genomes through a reverse transcriptional intermediate analogous to retroviruses. Nucleoside reverse transcriptase inhibitors (NRTIs) block this retroviral life cycle to increases repeat RNAs in p53 mutant colon cancer cell cancer lines. We initiated a Phase 2 study of lamivudine (3TC) in TP53 mutant mCRC. Methods: Two-stage design with target accrual of 20 patients (pts) in stage 1 and total of 32. Eligibility: pts with p53 mutant refractory mCRC with progression on or intolerance to 5FU, oxaliplatin and irinotecan and anti-EGFR if RAS WT. RNA sequencing was performed on pre-treatment (tx) and on tx biopsy to evaluate for repeat RNA expression and expression of other genes linked to 3TC response/resistance. Radiation was allowed. 9 pts were treated with 3TC 150 mg po bid for 28-day cycles, the maximum FDA approved dose of 3TC in HIV. Subsequent pts were treated at 600 mg po bid, previously tested in P1 trials. Tumor assessments were performed every 8 weeks until documented disease progression by RECIST 1.1 criteria or drug intolerance. Results: 29/32 pts have been treated. Median age: 60 yrs. (27-82) 18 males, 11 females. 2/ 9 (22%) pts on standard 3TC dosing had stable disease (SD) on single agent 3TC with a duration of tx of 169 and 167 days, respectively. Both pts had an initial drop in CEA upon initiation of 3TC. Of the next 20 pts on high dose 3TC, 19 were evaluable. 4 had SD, for 110, 159, 130 and 228+ days. 14 pts had tx-related adverse events (TRAE). 1 pt with a definite Grade 1 TRAE (fatigue). No pts with Grade ≥3 TRAEs. We obtained pre-tx fresh frozen biopsies on 24/29 pts. Of those with SD, 4 had biopsies and differential expression identified significantly higher HSATII repeat RNA in pts with SD compared to PD. There was an association of decreased epigenetic gene expression in HSATII repeat RNA high tumors. Conclusions: This proof-of-concept study demonstrates the safety and activity of single-agent 3TC. Repeat RNA levels appear to correlate with clinical benefit and can be measured in biopsies. Further combination studies and correlatives are planned. Clinical trial information: NCT03144804.

scholarly journals PENGEMBANGAN INSTRUMEN LITERASI DIGITAL SEKOLAH, SISWA DAN GURU

2020 ◽  
Vol 5 (1) ◽  
pp. 1
Author(s):  
Asyti Febliza ◽  
Oktariani Okatariani
Keyword(s):  
Data Collection ◽  
Digital Literacy ◽  
Industrial Revolution ◽  
High Reliability ◽  
Validity And Reliability ◽  
Digital Era ◽  
Question Item ◽  
Teachers And Students ◽  
Very High ◽  
Made In

This study aims to develop digital literacy instruments for schools, teachers and students whose function is to measure the extent of the digital literacy levels of schools, teachers, and students. It is not possible for a school to follow the development of science and technology if the school's potential is inadequate and its human resources are not ready. Therefore, the development of digital literacy instruments needs to be made in order to identify the level of readiness of schools, teachers and students in facing the digital era in the industrial revolution 4.0. Subjects of the study were 90 respondents consisting of 30 teachers and 60 students in SMA Negeri 14 Pekanbaru. The questionnaire that was made was first validated by 2 expert validators, after being declared valid by the expert validator, then the questionnaire was conducted a limited test to calculate the level of validity and reliability of each question item. The questionnaire uses a Likert scale with 3 categories of answer choices (often, rarely, never or there is, is being planned, no, etc.). Based on the results and conclusions, conclusions can be drawn, namely: the items that can be used as data collection tools on the school digital literacy questionnaire instrument are 23 questions, while the items that can be used as data collection tools on the teacher's digital literacy questionnaire are 52 items and instrument digital student literacy questionnaire as many as 31 questions. Based on the reliability criteria, the three digital literacy questionnaires show high and very high reliability criteria with a reliability level greater than 0.684.

scholarly journals Phone Snubbing Scale (Phub-S) : A Phubbing Measurement For Young Moslem In Industry 4.0

2021 ◽  
Vol 6 (2) ◽  
pp. 179-195
Author(s):  
Iredho Fani Reza
Keyword(s):  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Industrial Revolution ◽  
Three Dimensions ◽  
Measurement Scale ◽  
Validity And Reliability ◽  
Cronbach’S Alpha ◽  
Cronbach's Alpha ◽  
Total Correlation ◽  
Confirmatory Factor

The purpose of this study is to develop a measurement scale for phone snubbing among Moslem youth in the era of the industrial revolution 4.0. This research is used a quantitative survey research with the number of respondents N = 503 who were Moslem youths at a university in the Republic of Indonesia which was determined by multistage sampling technique. The instrument used is the Phone Snubbing Scale (Phub-S) which consists of three dimensions - ignore others, dependency on gadgets and social disconnectedness. In analyzing the data through the process of building validity consisting of confirmatory factor analysis and total correlation of corrected items, analyzing internal consistency reliability using Cronbach's alpha technique. The results showed that the Phone Snubbing Scale (Phub-S) has a good item validity and reliability test as a measurement scale for phone insulting behavior young Moslems in the era of the industrial revolution 4.0. The recommended Phub-S items totaling 45 items that have been fulfilled are valid based on testing confirmatory factor analysis (CFA) technique (standardized solution (SS) > 0.4 and T-Values > 1.96), Corrected Item-Total Correlation ≥ 0.30 and with a scale reliability value. 0.932 (Cronbach's Alpha value> 0.8).

scholarly journals Tinjauan Yuridis Interaksi Manusia Terhadap Digital Dalam Penegakan Hukum Di Era Revolusi Industri 4.0

2019 ◽  
Vol 1 ◽  
pp. 1041
Author(s):  
Ari Dermawan ◽  
Sumantri Sumantri ◽  
Sudarmin Sudarmin ◽  
Indra Ramadona Harahap
Keyword(s):  
Law Enforcement ◽  
Industrial Revolution ◽  
Criminal Code ◽  
Human Interaction ◽  
Human Needs ◽  
Governmental Organizations ◽  
Non Governmental Organizations ◽  
Library Research ◽  
Electronic Transactions ◽  
Computer Interaction

Human and computer interaction or human computer interaction or abbreviated as HCI is a discipline that studies the relationship between humans and computers. Human to digital interactions are increasing according to human needs that are increasingly complex. At present the world community has entered the stage of industrial revolution 4.0, and law enforcement is needed so that in the Era of the industrial revolution 4.0. get legal certainty in using digital technology or computer technology. As for the formulation of the problem is the Juridical Review of Human Interaction on Digital in Law Enforcement in the Age of Industrial Revolution 4.0, How the causes of misuse of Human Interaction Against Digital in the Age of Industrial Revolution 4.0, and How to prevent abuse of Human Interaction against Digital in the Era of Industrial Revolution . The research methodology uses normative research and library research data collection tools. Human Interaction Against Digital in Law Enforcement In the Age of Industrial Revolution 4.0 the legal foundation is needed, namely the Criminal Code and Law Number 11 of 2008 concerning Information and Electronic Transactions. Causes of Abuse of Human Interaction Against Digital in the Era of Industrial Revolution 4.0. among others are unlimited internet access. Efforts to Prevent Abuse of Human Interaction Against Digital in the Era of Industrial Revolution 4.0 can be done with the support of special institutions, both state-owned and NGOs (Non Governmental organizations).

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