Ethanol Extract Combinations Effect of Celery Herb (Apium graveolens L.) and Bay Leaf (Syzygium polyanthum W.) Toward Hypertensive Mice Induced by Sodium Chloride and High Fat Feed

2021 ◽  
Vol 1162 ◽  
pp. 151-158
Author(s):  
Moch. Saiful Bachri ◽  
Widyasari Putranti ◽  
Lina Widiyastuti ◽  
Resalianti Sintiana Devie
Keyword(s):  
Blood Pressure ◽  
Sodium Chloride ◽  
Research Result ◽  
Ethanol Extract ◽  
Apium Graveolens ◽  
Control Group ◽  
High Fat ◽  
Control Group Design ◽  
Group Design ◽  
Hypertension Therapy

The combination of herb medicine is alternative option in hypertension because it has more potential for treatment with complications like hyperlipida. Plant which can be used for anti-hypertension therapy is combination of celery herb (Apium graveolens) and bay leaf ethanol extract (Syzygium polyanthum). This research aims to determine the activity of a combination of celery herb ethanol extract (CHEE) and bay leaf ethanol extract (BLEE) and find out how much the decrease of blood pressure on the combination of both toward hypertension with high fat Wistar mice. The design of this research used an experimental design with pre-post control group design. Hypertensive mice are induced with high fat feed and orally with sodium chloride 8%, then the mice are supplied with combinations extract with the dose of 1.125 ; 6.25 ; 2.25 ; 12.5 and 4.5 ; 25 mg/kg, hydrochlorotiazide 2.25 mg/kg, Simvastatin 0.9 mg/kg, CHEE 4.5 mg/kg, BLEE 25 mg/kg and CMC-Na 0.5%. Research result shows that the combination can decrease systole blood pressure in the 22nd day. The extract combination has anti-hypertension effect (it is able to decrease systole blood pressure ≥ 20 mmHg) and it is not significantly different with normal group (p<0.05). Based on the research, it can be concluded that ethanol extract combination can decrease systole blood pressure with high fat complications after using it for 22 days.

Test Activity Combinations of Celery Herb (Apium graveolens L.) and Bay Leaf (Syzygium polyanthum W.) Ethanol Extract Toward DecreasedLipid Profile Levels in Hypertensive Mice

2021 ◽  
Vol 1162 ◽  
pp. 166-172
Author(s):  
Widyasari Putranti ◽  
Lina Widiyastuti ◽  
Moch. Saiful Bachri ◽  
Defianti
Keyword(s):  
Total Cholesterol ◽  
Total Cholesterol Level ◽  
Ethanol Extract ◽  
Fluid Secretion ◽  
Apium Graveolens ◽  
Control Group ◽  
High Fat ◽  
Control Group Design ◽  
Group Control Group ◽  
Coa Reductase

Celery herb contains flavonoid which can hamper cholesterol synthesis through inhibitor HMG-CoA reductase. Bay leaf has a working mechanism that stimulates bile fluid secretion and stimulates blood circulation. This research aims to know the activity combinations of bay leaf ethanol extract (BLEE) and celery herb ethanol extract (CHEE) and to know which dose mostly can decrease lipid profile levels. The design of this research uses experimental with pre-post control group design. The mice are rendered with NaCl 8% solution and High Fat Feed. The mice are divided into 9 groups, in each group there are 5 mice which are normal group, control group, HCT group, Simvastatin group, and CHEE 4.50 mg/kgBW, BLEE 25.00 mg/kgBW, combination 1, combination 2, and combination 3. Data analysis is conducted with Normality test, One Way ANOVA test, Kruskal-Wallis, Mann-Whitney. Based on the research after they are induced with NaCl 8% solvent and given high-fat feed, the extract can increase total cholesterol levels, triglycerides, LDL, and also significantly decrease HDL (p <0.05). After giving a test extract solution, it can reduce total cholesterol, triglycerides, LDL, and also significantly increase HDL levels (p <0.05). The conclusion, the three variations combinations dose can decrease total cholesterol, Triglycerides, LDL, and also increase HDL levels, and combination dose 3 has the greatest decrease in total cholesterol, triglyceride, LDL, and the highest increase in HDL levels. So the lower the total cholesterol level, the lower the possibility of hypertension.

Pengaruh Model PjBL Terhadap Hasil Belajar Murid pada Mata Pelajaran Akidah Akhlak di Madrasah Ibtidaiyah

2020 ◽  
Vol 8 (01) ◽  
pp. 110-126
Author(s):  
Nashran Azizan ◽  
Rahmadani Tanjung
Keyword(s):  
Research Result ◽  
Control Group ◽  
Research Model ◽  
Control Group Design ◽  
Islamic School ◽  
Group Design ◽  
Quasi Experimental ◽  
Moral Lesson ◽  
Learning Test ◽  
Academic Year

This aimed to know the influence of PjBL model toward learning results of moral lessons in knowing the prophet and apostle in IV grade of Islamic School Padangsidimpuan Angkola Julu in academic year 2019/2020 by using PjBL and Direct Instruction model. The research model used Quasi-Experimental Design with None Quivalent Control-Group Design. The used instrument is the learning result test. Data analysis used t-Test. Research result showed (1) there is the influence of PjBL model toward student's learning test on moral lesson of knowing prophet and apostle material.

scholarly journals Metaphor Counseling and Students Responsibility on Elementary School

2017 ◽  
Vol 7 (2) ◽  
pp. 140
Author(s):  
Riana Mashar ◽  
Juntika Nurihsan
Keyword(s):  
Elementary School ◽  
Research Result ◽  
First Grade ◽  
Control Group ◽  
Untreated Control Group ◽  
Sample Design ◽  
Control Group Design ◽  
Group Design ◽  
Analysis Technique ◽  
Experimental Group

The research aimed to figure out the effect of metaphor counseling in STAR KIDS (Story Teach Responsibility for Kids) module toward the responsibility of 6-7-year-old students of the first grade of elementary school. The research used untreated control group design by providing pretest and posttest sample design. The research subject consisted of 21 students in the experimental group and 26 students as the control group. The responsibility data collection performed by using observation guideline checklist, which quantified in the interval scale. SPM Raven scale measured the children's bits of intelligence. The STAR KIDS treatment is given in 15 meetings. The results of the pretest and posttest were analyzed by using Anacova analysis technique through SPSS 17 for Windows. The research result showed that (1) students of experiment group who received STAR KIDS metaphor counseling showed higher responsibility increase rather than students of a control group who did not receive the treatment, (2) The intelligence of the students did not show the effect on the effectiveness of counseling metaphor.

scholarly journals EFEK PEMBERIAN SEDUHAN SELEDRI (APIUM GRAVEOLENS L.)TERHADAP KADAR ASAM URAT PADA TIKUS PUTIH JANTAN STRAIN WISTAR (RATTUS NORVEGICUS) HIPERURISEMIA

2017 ◽  
Vol 9 (2) ◽  
pp. 75
Author(s):  
Reni Deviandra ◽  
Fathiyah Safitri ◽  
Djaka Handaja
Keyword(s):  
Rattus Norvegicus ◽  
Apium Graveolens ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Test Control

Efek Pemberian Seduhan Seledri (Apium graveolens L.)Terhadap Kadar Asam Urat Pada Tikus Putih Jantan Strain Wistar (Rattus norvegicus) Hiperurisemia. Latar Belakang: Salah satu jenis tanaman yang diduga dapat menurunkan kadar asam urat adalah seledri. Seledri mengandung flavonoid dan 3-n butylphtalide (3nB) dapat menurunkan kadar asam urat dengan menghambat kerja enzim xantin oksidase. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh seduhan seledri (Apium graveolens L.) terhadap penurunan kadar asam urat pada tikus putih jantan hiperurisemia. Metode Penelitian: Menggunakan eksperimental murni, dengan rancangan Randomized Post Test Control Group Design. Sampel penelitian dibagi menjadi 5 kelompok. Kelompok I: Kontrol positif (Saripati hati ayam mentah 3 ml/150grBB selama 21 hari + pakan normal selama 7 hari), II, III dan IV: diberikan Saripati hati ayam mentah 3 ml/150grBB selama 21 hari + seduhan seledri dengan dosis 50, 100, 150mg/ekor/hari selama 7 hari, V: Kontrol negatif (Pakan normal selama 28 hari). Pengukuran kadar asam urat dengan menggunakan metode kolometrik enzimatik. Hasil: Hasil pengukuran asam urat kelompok dengan pemberian seduhan seledri dosis 150 mg/ekor/hari menunjukkan kadar asam urat paling rendah (4,679±0,687) dibanding dengan kelompok kontrol positif menunjukkan kadar asam urat paling tinggi (11,563±1,541). Kesimpulan: Ada hubungan antara dosis seduhan seledri (Apium graveolens L.) terhadap kadar asam urat pada tikus putih jantan (Rattus Norvegicus) hiperurisemia.Kata Kunci: Seledri, Hiperurisemia, Kadar Asam Urat, Saripati Hati Ayam,

scholarly journals PENGARUH PEMBERIAN JUS CAMPURAN BELIMBING (Averhoa carambola linn) DAN MENTIMUN (Cucumis sativus linn) TERHADAP TEKANAN DARAH PASIEN HIPERTENSI RAWAT JALAN DI RUMAH SAKIT UMUM DAERAH KOTA MATARAM

2019 ◽  
Vol 4 (1) ◽  
pp. 40
Author(s):  
Devi Rahma ◽  
Suhaema Suhaema ◽  
Fifi Luthfiyah ◽  
Made Darawati
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Antihypertensive Drugs ◽  
Vegetable Consumption ◽  
Research Result ◽  
T Test ◽  
Control Group ◽  
High Potassium ◽  
Control Group Design ◽  
Average Blood Pressure

Background. Hypertension can be a risk factor for stroke, coronary heart disease, heart failure and kidney failure and is known as the thesilent killer. The prevalence of hypertension in West Nusa Tenggara Province is 24.3% (Riskesdas, 2013). Medical Record Data of Mataram City Public Hospital, hypertension became the first of the top 10 outpatient diseases in 2015. The only treatment for non-pharmacological hypertension was by increasing fruit and vegetable consumption due to high potassium content. Research Methods. The type of this research is experimentation with Randomized Control Trial (RCT) design with Pretest-Posttest with Control Group design. The number of subjects is 20 people obtained from the formula Lemeshow (1997). Both groups continued to take antihypertensive drugs, but the treatment group was given 250 ml of starfruit juice and cucumber juice for 7 days. The statistical analysis used was the paired t-test and independent t-test. Research Result. The average blood pressure before the study in the treatment group was 150/91 mmHg, in the control group it was 142/83 mmHg. The average blood pressure after the study for the treatment group was 132/81 mmHg, while the control group was 144/81 mmHg. There was a decrease in blood pressure in the treatment group after the intervention was 18 mmHg for systolic (p = 0.000) and 10 mmHg for diastolic (p = 0.004), but there was no decrease in blood pressure both systolic and diastolic in the control group. Conclusion. Giving a mixture of star fruit and cucumber juice affects the decrease in systolic and diastolic blood pressure.

scholarly journals Efektifitas Teh Buah Mengkudu Dalam Menurunkan Tekanan Darah Lansia Dengan Hipertensi (Studi di UPTD. Griya Werdha Kota Surabaya Tahun 2018)

2018 ◽  
Vol 2 (2) ◽  
pp. 163
Author(s):  
Arum Reyan Safitri ◽  
Rita Ismawati
Keyword(s):  
Blood Pressure ◽  
Treatment Group ◽  
Nutrition Education ◽  
The Elderly ◽  
Study Data ◽  
Wilcoxon Test ◽  
Control Group ◽  
Control Group Design ◽  
Group Design

Background: Hypertension is the silent disease which a person will not know if he has increased blood pressure. The incidence rate of hypertension is very high especially in the elderly population over 60 years. Hypertension management can be done in pharmacological ways such as medicines and can use natural ingredients in lowering blood pressure that is by utilizing the noni fruit.Objectives: This study aimed to analyze the effectiveness of Noni fruit tea in lowering elderly blood pressure with hypertensionMethod: This research was quasy experimental throug with Pretest-Postest Control Group Design design. Determination of research sample by using inclusion and exclusion criteria. The sample of the study was 34 respondents divided into two groups. Intervention of Noni fruit tea given as much as 5 gram for 30 days with frequency of giving 2 times a day in the morning and afternoon. Blood pressuremeasurement was performed at the beginning of the study and at the end of the study. Data were analysed using wilcoxon test and Mann Whitney test.Result: Mann Whitney test results showed that there was significant effect after the intervention of noni fruit tea in treatment group compared with control group with systolic blood pressure value (p =0.000171) and diastolic blood pressure (p = 0.000480) with α = 0.05Conclusions: Blood pressure in the treatment group after the intervention of noni fruit tea decreased blood pressure compared with the control group. It is Suggested of research, need to do periodic nutrition education and giving noni fruit tea as alternative medicine that effectively decrease hypertension, scheduled.ABSTRAKLatar Belakang : Hipertensi merupakan the silent disease dimana seseorang tidak akan mengetahui jika dirinya mengalami peningkatan tekanan darah. Angka insiden hipertensi sangat tinggi terutama pada populasi lanjut usia diatas 60 tahun. Penatalaksaan hipertensi dapat dilakukan dengan cara farmakologis seperti obat-obatan serta dapat menggunakan bahan alami dalam menurunkan tekanan darah yaitu dengan memanfaatkan buah mengkudu.Tujuan : Penelitian ini bertujuan menganalisis efektifitas teh buah mengkudu dalam menurunkan tekanan darah lansia dengan hipertensiMetode : Penelitian ini bersifat quasy eksperimental dengan desain Pretest-Postest Control Group Design. Penentuan sampel penelitian dengan menggunakan kriteria inklusi dan eksklusi. Sampel penelitian sebanyak 34 responden yang dibagi menjadi dua kelompok. Intervensi teh buah mengkudu diberikan sebanyak 5 gram selama 30 hari dengan frekuensi pemberian 2 kali sehari pada pagi dan sore hari. Pengukuran tekanan darah darah dilakukan pada awal penelitian dan di akhir penelitian. Analisis data penelitian menggunakan uji wilcoxon dan uji Mann Whitney.Hasil : Hasil uji Mann Whitney menunjukkan bahwa terdapat pengaruh yang signifikan sesudah intervensi teh buah mengkudu pada kelompok perlakuan dibandingkan kelompok kontrol dengan nilai tekanan darah sistolik (p=0.000171) dan tekanan darah diastolik (p=0,000480) dengan α=0.05Kesimpulan : Tekanan darah pada kelompok perlakuan susudah intervensi teh buah mengkudu mengalami penurunan tekanan darah dibandingkan dengan kelompok kontrol. Saran penelitian, perlu dilakukan pendidikan gizi secara berkala dan pemberian teh buah mengkudu sebagai obat alternatif yang efektif menurunkan hipertensi, secara terjadwal.

scholarly journals PENGARUH PEMBERIAN REBUSAN DAUN SELEDRI (Apium Graveolens L) TERHADAP TEKANAN DARAH PADA WANITA MENOPAUSE DENGAN HIPERTENSI

2020 ◽  
Vol 3 (1) ◽  
pp. 67-74
Author(s):  
Diah Evawanna Anuhgera ◽  
Rizky Yolanda ◽  
Riris Sitorus ◽  
Nikmah Jalilah Ritonga ◽  
Damayanti .
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Level ◽  
T Test ◽  
Apium Graveolens ◽  
Control Group ◽  
P Value ◽  
Menopausal Woman ◽  
Control Group Design ◽  
Group Data ◽  
Before And After

Woman menopause in hypertension is often associated with increase vascularity and physiological changes during menopause. This study aims to examine the effect of celery leaf stew on blood pressure levels in menopausal woman in hypertension. This study was a quasy experiment with pretest-posttest control group design, conducted in the Sidodadi Village District Beringin, Deli Serdang on Januari to March 2020. There were 28 participants selected using purposive sampling, with 14 assigned in the experimental and control group. Data were analyzed using paired t-test and unpaired t-test. There were statistically significance difference of blood pressure levels before and after intervention in the experiment group with p value sitolic level  0.000 dan diastolic level 0.001 (<0.05). Celery leaf stew has a significant effect in reducing  blood pressure level in menopausal woman in hypertension. This intervention could be applied as an alternative theraphy in treating menopausal woman in hypertension.

scholarly journals KOMBINASI PROJECT BASED LEARNING DAN METODE EKSPERIMEN UNTUK MELATIHKAN KEMAMPUAN 5M

Vidya Karya ◽  
2018 ◽  
Vol 32 (2) ◽  
pp. 110
Author(s):  
Sarah Miriam ◽  
Zainuddin Zainuddin
Keyword(s):  
Physics Education ◽  
Research Result ◽  
Learning Model ◽  
Project Based Learning ◽  
Control Group ◽  
Research Subjects ◽  
Design Data ◽  
Control Group Design ◽  
Group Design ◽  
Experiment Method

Abstract. The education curriculum addressed the science learning which involves learner in the scientific process in order to find a product by promoting the scientific attitude. This idea has encouraged the researcher team to design an instructional which combines the project based learning model and the experiment method to train the 5M skills for students. The research subjects are the 6th semester students of physics education study program of the teacher training and educational sciences faculty of Lambung Mangkurat University (FKIP ULM) in the academic year of 2016/2017. The research used posttest only control group design. Learning effectiveness was gained from students’ project evaluation and posttest. The research result showed that students’ project was in good category with the mean score of 4.09. The students’ achievement has reached the individual mastery as big as 100%. It can be concluded that the combination of project based learning model and experiment method is effective to train the students’ 5M skills for the physics experiment course. Keywords: Project based learning, experiment method, 5M skills. Abstrak. Kurikulum pendidikan menghendaki pembelajaran sains yang melibatkan peserta didik dalam proses ilmiah untuk menemukan sebuah produk dengan mengedepankan sikap ilmiah. Hal ini mendorong tim peneliti untuk merancang pembelajaran yang mengkombinasikan project based learning dan metode eksperimen yang diharapkan mampu melatihkan  kemampuan 5M bagi mahasiswa. Subjek penelitian ini adalah mahasiswa semester 6 Pendidikan Fisika FKIP ULM pada tahun akademik 2016/2017. Desain penelitian menggunakan postest only control group design. Data efektivitas pembelajaran didapatkan dari evaluasi proyek mahasiswa dan postest. Hasil penelitian menunjukkan bahwa  proyek mahasiswa berkategori baik dengan skor rata-rata perolehan sebesar 4,09. Selanjutnya hasil belajar mahasiswa berhasil mencapai ketuntasan individu sebesar 100%. Dengan demikian dapat disimpulkan bahwa pembelajaran yang mengkombinasikan project based learning dan metode eksperimen efektif untuk melatihkan kemampuan 5M mahasiswa pada perkuliahan Eksperimen Fisika. Kata Kunci: Project based learning, metode eksperimen, kemampuan 5M.

scholarly journals Hemostatic Effect of Ethanol Extract of Piper betle, Linn Leaves to Male Mice

Molekul ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. 23
Author(s):  
Sadakata Sinulingga ◽  
Subandrate Subandrate ◽  
Bebbi Arisya Kesumaputri ◽  
Galuh Anggraini
Keyword(s):  
Bleeding Time ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Piper Betle ◽  
Control Group Design ◽  
Minimum Concentration ◽  
Group Design ◽  
Hemostatic Effect

Hemorrhage occurs in most of the dental care. Untreated hemorrhage could cause excessive blood loss, hypotension, and cyanosis. A Natural resource that reported has an hemostatic effect is ethanol extract of betel leaves (Piper betel, Linn).The aim of this study is to find the minimum concentration of ethanol extract of betel leaves which capable of shortening the bleeding time in mice. The experimental study used pretest-posttest with control group design was conducted on 35 mice that divided into 7 group which are negative control, positive control (feracrylum 1%), the ethanol extract of betel leaves 1%, 5%, 10%, 15%, and 20%. All mice were injected heparin intravenously. Mice’s tail was cut at diameter 3 mm and pretest bleeding time was counted. Mice’s tail was recut at diameter 4 mm, given treatment for 5 seconds and posttest bleeding time was counted. Results of paired t-test showed that reduction of bleeding time between pretest and posttest was significant (p<0,050). The enhancement of ethanol extract of betel leaves concentration leads to better hemostatic effect. Results of ANOVA test showed that comparison of posttest bleeding time among groups was significant (p<0,050). The minimum concentration of ethanol extract of betel leaves which capable of shortening the bleeding time in mice is 5%.

scholarly journals PENGARUH HYPERTENTION SELF MANAGEMENT EDUCATION ( HSME) TERHADAP TEKANAN DARAH DI PUSKESMAS KABANJAHE

2019 ◽  
Vol 2 (1) ◽  
pp. 121-127
Author(s):  
Lam Murni Sagala
Keyword(s):  
Blood Pressure ◽  
Management Education ◽  
T Test ◽  
Self Management ◽  
Health Promotion Program ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Quasi Experimental ◽  
Paired T Test

Hypertension is a persistent blood pressure with systolic blood pressure above 140 mmHg and diastolic blood pressure above 90 mmHg. The treatment of hypertension is highly depend on the information given by nurse to patients’ skills on self care management to modify and maintain effective behavior. These activities include self management in prescribed medication, health monitoring, adequate rest, stress management and prescribed diet and exercises. The purpose of this study was to determine the effect of Hypertension Self Management Education (HSME) on controlling blood pressure in hypertensive patients in the Kabanjahe health center.This research used the quasi experimental research, using pretest and posttest with control group design. The samples of  research consisted of 40 respondents, and they were divided into two groups, namely: control group and intervention group. The data of research were analyzed by using the Paired T-test. The result of research shows that the p-values of Paired T-test of the experiment and control groups were 0.782 and 0.577 respectively whereas the p- value of Independent T-test was 0.001 (p <α; α = 0.05). Thus, there was an effect of Hypertention Self Management Education (HSME) on the control of  blood pleasure of the patient hypertention, Community Health Center, Kabanjahe. The nurses, therefore, are suggested to extend the HSME to control the blood pleasure hypertention client and and utilize the HSME as a health promotion program.   Hipertensi adalah tekanan darah persisten dengan tekanan darah sistolik di atas 140 mmHg dan tekanan darah diastolik di atas 90 mmHg. Perawatan hipertensi sangat tergantung pada informasi yang diberikan oleh perawat kepada keterampilan pasien tentang manajemen perawatan diri untuk memodifikasi dan mempertahankan perilaku yang efektif. Kegiatan-kegiatan ini termasuk manajemen diri dalam pengobatan yang diresepkan, pemantauan kesehatan, istirahat yang cukup, manajemen stres dan diet dan olahraga yang ditentukan. Tujuan  penelitian ini untuk mengetahui pengaruh Hypertention Self Management Education (HSME) terhadap pengontrolan tekanan darah pasien hipertensi di puskesmas kabanjahe. Metode penelitian adalah quasi experimental dengan menggunakan metode pre-test and post-test with control group design. Sampel penelitian terdiri dari 40 responden, dan mereka dibagi menjadi dua kelompok, yaitu: kelompok kontrol dan kelompok intervensi. Data penelitian dianalisis dengan menggunakan Paired T-test. Hasil penelitian menunjukkan bahwa nilai-p dari uji-T Berpasangan dari eksperimen dan kelompok kontrol masing-masing adalah 0,782 dan 0,577 sedangkan p-nilai dari Independent T-test adalah 0,001 (p <α; α = 0,05). Dengan demikian, ada efek dari Edukasi Manajemen Diri Hipertensi (HSME) pada kontrol tekanan darah dari pasien hipertensi, Puskesmas, Kabanjahe. Oleh karena itu, perawat disarankan untuk memberikan penkes HSME untuk mengendalikan tekanan darah pasien hipertensi dan memanfaatkan HSME sebagai program promosi kesehatan.

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