Core Cross-Linked Polyethylene Glycol Oleate Micelles as Novel Drug Carriers

2011 ◽  
Vol 236-238 ◽  
pp. 1770-1774
Author(s):  
Yan Ling Guo ◽  
Bao Qi Wang ◽  
Jun Zhao ◽  
Zhao Shan Cui
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Release Rate ◽  
Drug Carriers ◽  
Double Bonds ◽  
The Core ◽  
Drug Efficiency ◽  
Novel Drug

Polyethylene Glycol Oleate was synthesized by esterification of polyethylene glycol and Oil acid using DMAP as a catalyst. The double bonds of the product in the core of micelles were cross-linked by the initiation of (NH4)2S2O8 during the micelles formed. Applications of the noncross-linked and cross-linked polyethylene glycol oleate in drug delivery were studied, which indicates that drug efficiency decreased after micelles were core cross-linked, but release rate of MTX from core cross-linked micelles seems slower than that from noncross-linked micelles.

scholarly journals Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid

Biomolecules ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 73 ◽  
Author(s):  
Feuangthit Niyamissara Sorasitthiyanukarn ◽  
Chawanphat Muangnoi ◽  
Wuttinont Thaweesest ◽  
Pahweenvaj Ratnatilaka Na Bhuket ◽  
Pongsakorn Jantaratana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Iron Oxide ◽  
Zeta Potential ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Chitosan Oligosaccharide ◽  
Glycol Chitosan ◽  
Novel Drug Delivery System ◽  
Novel Drug

Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using a Box–Behnken statistical design in order to achieve the minimum size, optimal zeta potential (≥ ±20 mV), and maximum loading efficiency and capacity. The results demonstrated that CG-PEG-CSO-SPIONs prepared under the optimal condition were almost spherical in shape with a smooth surface, a diameter of 130 nm, zeta potential of 30.6 mV, loading efficiency of 83.3%, and loading capacity of 8.3%. The vibrating sample magnetometer results of the optimized CG-PEG-CSO-SPIONs showed a superparamagnetic behavior. Fourier transform infrared spectroscopy and X-ray diffraction analyses indicated that the CG physically interacted with PEG-CSO-SPIONs. In addition, the CG-PEG-CSO-SPIONs could be stored dry for up to 12 weeks or in aqueous solution for up to 4 days at either 4 °C or 25 °C with no loss of stability. The CG-PEG-CSO-SPIONs exhibited a sustained release profile up to 72 h under simulated physiological (pH 7.4) and tumor extracellular (pH 5.5) environments. Furthermore, the CG-PEG-CSO-SPIONs showed little non-specific protein binding in the simulated physiological environment. The CG-PEG-CSO-SPIONs enhanced the cellular uptake and cytotoxicity of CG against human colorectal adenocarcinoma HT-29 cells compared to free CG, and more CG was delivered to the cells after applying an external magnetic field. The overall results suggest that PEG-CSO-SPIONs have potential to be used as a novel drug delivery system for CG.

scholarly journals Study of the Dynamic Uptake of Free Drug and Nanostructures for Drug Delivery Based on Bioluminescence Measurements

2017 ◽  
Vol 2017 ◽  
pp. 1-12
Author(s):  
Zhongjian Fang ◽  
Houchao Xu ◽  
Xiangjun Ji ◽  
Congbiao Liu ◽  
Kai Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Multicellular Tumor Spheroid ◽  
The Past ◽  
Loading Methods ◽  
Model Drug ◽  
Novel Drug ◽  
Liposomal Drugs ◽  
Great Growth

The past two decades have witnessed the great growth of the development of novel drug carriers. However, the releasing dynamics of drug from drug carriers in vivo and the interactions between cells and drug carriers remain unclear. In this paper, liposomes were prepared to encapsulate D-luciferin, which was the substrate of luciferase and served as a model drug. Based on the theoretical calculation of active loading, methods of preparation for liposomes were optimized. Only when D-luciferin was released from liposomes or taken in by the cells could bioluminescence be produced under the catalysis of luciferase. Models of multicellular tumor spheroid (MCTS) were built with 4T1-luc cells that expressed luciferase stably. The kinetic processes of uptake and distribution of free drugs and liposomal drugs were determined with models of cell suspension, monolayer cells, MCTS, and tumor-bearing nude mice. The technology platform has been demonstrated to be effective for the study of the distribution and kinetic profiles of various liposomes as drug delivery systems.

An Overview of the Recent Developments and Patents in The Field of Pharmaceutical Nanotechnology

2020 ◽  
Vol 14 ◽  
Author(s):  
Deepika Purohit ◽  
Deeksha Manchanda ◽  
Manish ◽  
Jyoti Rathi ◽  
Ravinder Verma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Carbon Nanomaterials ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Correlation Spectroscopy ◽  
Colloidal System ◽  
The Novel ◽  
Pharmaceutical Nanotechnology ◽  
Novel Drug

Background: Compared to traditional dosage methods, the novel drug delivery systems (NDDS) provide various advantages. In the last few years, tremendous focus has been given to work focused on the novel drug delivery methods for small and large molecular drug carriers utilizing particulate drug delivery systems as well. It is evident from last decade as seen in number of patents cited in this field that the technology has evolved tremendously. Objective: Drug carriers utilized by this novel technology includes liposomes, dendrimers, polymeric nanoparticles, magnetic nanoparticles, solid lipid nanoparticles, carbon nanomaterials. Various forms of polymers have been used in the production of nanocarriers. Methods: Nanocarriers are colloidal system varying in size from 10 to 1000 nm. This technology now used to identify, manage and monitor numerous diseases and physical methods to alter and enhance the pharmacokinetic and pharmacodynamic properties of specific types of drug molecules. Results: Nanoparticles can be formulated by a number of techniques including ionic gelation, cross-linking, coacervation/precipitation, nanoprecipitation, spray drying, emulsion- droplet coalescence, nano sonication techniques etc. Several methods are used with which these nanoparticles can be characterized. These methods include nuclear magnetic resonance, optical microscopy, atomic force microscopy, photon correlation spectroscopy and electron microscopy, surface charge, in-vitro drug release, etc. Conclusion: In the present review, authors have tried to summarize the recent advances in the field of pharmaceutical nanotechnology and also focuses on the application and new patents in the area related to NDDS.

Formulation, Characterization and In vitro Drug Delivery of Vitexin Loaded Liposomes

2021 ◽  
Vol 14 (2) ◽  
pp. 5364-5371
Author(s):  
Dr.S.Bhagavathy Sivathanu ◽  
Shivapriya G ◽  
Shivapriya G
Keyword(s):  
Drug Delivery ◽  
Drug Carrier ◽  
Egg Yolk ◽  
Drug Carriers ◽  
Good Choice ◽  
Target Site ◽  
Carrier System ◽  
Liposome Preparation ◽  
Drug Carrier System ◽  
Novel Drug

Liposome is a spherical vesicle which contains atleast one lipid bilayer. Liposomes are used as a novel drug carriers because of its hydrophobic and hydrophilic nature, it has many advantages in the field of medical sciences. There are some other drug carriers like dendrimers, micelles, niosomes. Out of all, liposomes are considered to be the most promising agent for drug delivery. The uniqueness of liposome is when it is used as a pharmaceutical drug, it acts as a natural receptor. Thus it acts as an antigen and binds with the antibody (cancer cell) without causing any damage to the adjacent cells. For the synthesis of liposomes, a phospholipid is required. The liposomes can be synthesized using egg yolk and chloroform. So the basic phospholipid is obtained from egg yolk. For more stability, the liposomes are prepared using popc. The present work  discuss about the effective preparation of drug loaded liposomes using popc (1- palmitoyl-2-oleoyl-sn-glycero-3- phosphocholine). POPC is an important phospholipid for biophysical experiments. Additionally chloroform is used as the solvent for the liposome preparation. The drug chosen for liposome loading is vitexin (vxn), which is an effective therapeutic agent against inflammation and cancer. The vesicular size, shape, drug entrapment efficacy, stability, electrochemical property and drug releasing property of the formulated liposomes were characterized. The results showed that the formulated liposomes are considered as the better drug carrier system and good choice for biotransformation within the cell to reach the target site such as cancer cells. Even though available treatments like chemotherapy and radiation therapy, causes damage to the surrounding cells, the alternative drug transferring system such as liposomal mediated drug transfer within the cell is considered as good choice of treatment to avoid such complications. The aim of liposome mediated  drug carrier system is to develop a method to reach the drug to the target site. After drug delivery at the target site, the liposomes are fused within the surface of the body. This is because of the pH of liposomes, which is at 7.4 and temperature is maintained at 37 oC. So, the vxn loaded liposomes are considered as the novel drug carriers for the successful targetted drug delivery.

Nanosponge Approach -A Plethora Of Opportunities As A Promising Nanocarrier For Novel Drug Delivery

2021 ◽  
Vol 15 ◽  
Author(s):  
Shah Esha Bhavin ◽  
Gajjar Anuradha
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Genetic Material ◽  
Analytical Techniques ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Synthetic Methods ◽  
Ongoing Research ◽  
Factors Affecting ◽  
Novel Drug

Background: Nanotechnology is the need of the hour! The design of nanotechnology aided carriers as a tool for the delivery of low solubility molecules offers a potential platform to overcome the issues of current clinical treatment and achieve good targeted release and bioaccessibility. Objective: Nanosponges (NS) are encapsulating type of nanocarriers capable of carrying both lipophilic and hydrophilic substances. They are synthesized by mixing a solution of polyester which is biodegradable with cross linkers. These tiny porous structures are round shaped having multiple cavities wherein drugs can be housed to offer programmable release. Method: The detailed literature review and patent search summarize the ongoing research on NS. Substances such as poorly soluble drugs, nutraceuticals, gases, proteins and peptides, volatile oils, genetic material, etc. can be loaded on these novel carriers, which are characterized using various analytical techniques. Target-specific drug delivery and controlled drug release are the advantages offered by NS along with a myriad of other promising applications. Results: This review stresses on the development of cyclodextrin based NS, the synthetic methods and characterization of NS along with factors affecting NS formation, their applications and information on the patented work in this area. NS are solid in character and can be formulated in various dosage forms such as parenteral, topical, oral or inhalation. Conclusion: Therefore, owing to their promising benefits over other nanocarriers in terms of drug loading, adaptability, sustainability, solubility and tailored release profile, NS are immediate technological revolution for drug entrapment and as novel drug carriers. The authors expect that these fundamental applications of NS could help the researchers to develop and gain insight about NS in novel drug delivery applications.

Drug Delivery to the Brain – Realization by Novel Drug Carriers

2004 ◽  
Vol 4 (5) ◽  
pp. 471-483 ◽  
Author(s):  
Rainer H. Müller ◽  
Cornelia M. Keck
Keyword(s):  
Drug Delivery ◽  
Drug Carriers ◽  
Novel Drug ◽  
The Brain

scholarly journals Toward Understanding Curcumin Delivery by Trimethyl Chitosan -polyethylene Glycol: Optimization Ofpolymer Concentration and Chain Length by Molecular Dynamics

2020 ◽  
Author(s):  
Somayeh Sohrabi ◽  
Mohammad Khedri ◽  
Reza Maleki ◽  
Mostafa Moraveji ◽  
Ebrahim Ghasemy
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Delivery System ◽  
Chain Length ◽  
Delivery System ◽  
Drug Carriers ◽  
Molecular Study ◽  
Cancer Drug ◽  
Optimal Value ◽  
Peg Chain Length

Abstract The second main cause of death in the world and one of the major public health problems is cancer. Curcumin is anatural bioactive substance with good anti-cancerous effect.However, due to thelow cellular uptake of curcumin anti-cancer drug, it is vital to exploit a noble formulation, which can contribute to a decrease in its hydrophobicity and enables theefficient therapeutic effect of curcumin. Biocompatibility and hydrophilicity of the polyethylene glycol cause itto be one of the most attractive drug carriers. Chitosan is also of great importance, consideringits biocompatibility,and is used along with thedrug-carrying polymers. In this study, for the first time, a combination oftrimethyl chitosan and polyethylene glycol was employedto deliver curcumin.Herein, hydrophilicity, stability, and energy analysis of the systems have been investigated, from which it was found thatthe 60/40 is the optimum ratio concentration ofchitosan to polyethylene glycol for Curcumin delivery. Another characteristic property of the hybrid drug delivery system was the PEG chain length, with its least magnitude being the optimal value. Results of the present molecular study give a practicalinsight into the curcumin drug delivery system and propose a novel hybrid carrier for efficient curcumin delivery, which can be further exploited to develop novel nanomedicine systems.

scholarly journals A Novel Drug Delivery System: Review on Microspheres

2021 ◽  
Vol 11 (2-S) ◽  
pp. 156-161
Author(s):  
Hans Raj ◽  
Shagun Sharma ◽  
Ankita Sharma ◽  
Kapil Kumar Verma ◽  
Amit Chaudhary
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Drug Carriers ◽  
Magnetic Microspheres ◽  
Oral Drug ◽  
Optimum Level ◽  
Target Tissue ◽  
Fixed Rate ◽  
Target Drug ◽  
Novel Drug

Microspheres are multiparticulate drug delivery systems that are designed to deliver drugs to a particular location at a fixed rate. Microspheres are free-flowing powders made up of biodegradable proteins or synthetic polymers with particle sizes ranging from 1 to 1000µm. Benefits of the use of microspheres in fields such as drug delivery, bone tissue manufacturing, and the absorption and desorption of contaminants by regeneration. The study shows the method of planning and measurement of microsphere parameters. Microspheres are complex, such as bioadhesive microspheres, polymeric microspheres, magnetic microspheres, floating microspheres, radioactive microspheres. Microspheres may be used in various fields such as cosmetics, oral drug delivery, target drug delivery, ophthalmic drug delivery, gene delivery, and others listed in the study. In order to achieve optimal therapeutic effectiveness, it is important to deliver the agent to the target tissue at an optimum level within the right timeframe, resulting in little toxicity and minimal side effects. There are different approaches to supplying the medicinal drug to the target site in a continuous managed manner. One such strategy is the use of microspheres as drug carriers. In this article, the value of the microsphere is seen as a novel drug delivery carrier to achieve site-specific drug delivery was discussed. Keywords: microspheres, method of preparations, polymer, bioadhesion, types of microspheres

scholarly journals Microencapsulation: A potential and promising approach in drug delivery system

2016 ◽  
Vol 1 (1) ◽  
pp. 30-39
Author(s):  
Madiha Jabeen ◽  
Shireen Begum ◽  
Aroosa Siddique ◽  
Syeda Saniya Fatima
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Core Material ◽  
Wall Material ◽  
The Core ◽  
Novel Drug Delivery System ◽  
Reduced Toxicity ◽  
Novel Drug

Novel drug delivery system is a method by which drug delivered can have significant effect on its efficacy. There are several advantages of novel drug delivery system over conventional multi dose therapy, which include improved efficacy, reduced toxicity, improved patient compliance and convenience. Many efforts have been made in developing novel drug delivery system, which emphasizes on controlled and sustained release dosage forms to obtain optimum benefits. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. One such approach is using microspheres or microcapsules. Microencapsulation is a process by which solids, liquids or gases can be enclosed in microscopic particles by forming a thin coating of wall material around substances, which protects it from external environment and control the drug release yielding capsules ranging for one micron to several hundred microns in size (1µ- 800µ). There are different microencapsulation techniques, which are used to obtain microcapsules for controlled release of drug. The morphology of microcapsules depends on the core material and deposition of coating material. Substances may be microencapsulated for the purpose of confining core material within capsule wall for specific period of time. Core materials are also encapsulated so that the core material can be gradually released (controlled release or diffusion) or when external conditions trigger the capsule walls to rupture, melt, or dissolve. Microencapsulation has found many applications in science and technology.

Sign in / Sign up

Export Citation Format

Share Document