The Effect of Beef Flavor on the Fat Metabolism in Mice

2013 ◽  
Vol 781-784 ◽  
pp. 1574-1581
Author(s):  
Jing Jing Ouyang ◽  
Yu Qiang Wang ◽  
Wen Tang ◽  
Xiao Li Zhou ◽  
Yi Ming Zhou ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Low Density Lipoprotein ◽  
Fat Metabolism ◽  
Density Lipoprotein ◽  
Whole Body ◽  
Control Group ◽  
Lung Weight ◽  
Blood Biochemical ◽  
Beef Flavor

The beef flavor was selected to carry out toxicological analysis regarding food intake, body weight, organs weight and blood biochemical indexes in mice. The results show that beef flavor could suppress food intake but promote mice weight compared with the control group. Flavor intake has significant effect on the ratio of liver and lung weight to the whole body weight, but it has no difference in the ratio of heart, spleen and kidney weight. Some biochemical indexes about fat metabolism in blood such as the total protein, total bile acid and alkaline phosphatase are respectively 4 g/L, 0.7μmol/L and 23 IU/L more than the control group. These factors and cholesterol, triglyceride, low density lipoprotein, high-density lipoprotein cholesterol in the mice blood all have extremely significant differences (P<0.01) in different conditions. The results suggest that the beef flavor has significant impact on fat metabolism in mice.

scholarly journals Effects of Apple Polyphenol on Fat Metabolism in Mice

2021 ◽  
Vol 267 ◽  
pp. 02025
Author(s):  
Ruimin Fu ◽  
Wei Tang ◽  
Hong Zhang ◽  
Huiping Chang ◽  
Wuling Chen
Keyword(s):  
Body Weight ◽  
Low Density Lipoprotein ◽  
Fat Metabolism ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
The Body ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Obese Mice ◽  
Total Triglyceride

To study the regulation effect of apple polyphenol on fat metabolism in mice. The mice were randomly divided into 5 groups, except the basic control group, the other 4 groups were given high fat diet, body weight was measured once a week, and the obesity model was established. The basal control group and the obesity model group were intragastrically given normal saline (4.2mg/(kgbw.d), The three dose groups were gavaged separately with apple polyphenol 4.2, 8.4, 12.6 mg/(kg bw. d). After 4 consecutive weeks, the body weight of mice, the contents of total cholesterol (TC), total triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) in serum and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), liver lipase (HL) and lipoprotein lipase (LPL) in serum. should be measured respectively. Apple polyphenol can significantly reduce the body weight, TG, LDL-C, TC and MDA contents, coupled with the atherosclerosis index (AI) of obese mice. It can increase the serum HDL-C content of obese mice, and effectively increase the activities of SOD, GSH-Px, HL and LPL in mice. Apple Polyphenol can reduce blood lipid and prevent atherosclerosis via regulating fat metabolism in mice.

scholarly journals EVALUATION OF ANTI-OBESITY EFFECT OF AQUEOUS EXTRACT OF MUCUNA PRURIENS SEEDS ON RATS

2017 ◽  
Vol 9 (3) ◽  
pp. 111
Author(s):  
Javid Mansuri ◽  
Archana Paranjape
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Aqueous Extract ◽  
Density Lipoprotein ◽  
Mucuna Pruriens ◽  
Control Group ◽  
Dopamine Level ◽  
Sprague Dawley ◽  
Brain Dopamine ◽  
Standard Drug

Objective: Evaluation of the anti-obesity effect of aqueous extract of Mucuna pruriens seeds on rats.Methods: Male Sprague-Dawley (SD) rats were subjected to high-fat diet (HFD) for 12 wk. L-DOPA (12.5 mg/kg, p. o.) as standard drug and aqueous extract of Mucuna pruriens (AEMP) seeds (200 mg/kg, p. o. and 400 mg/kg, p. o.) as test drugs were administered in last 4 wk along with HFD. Body weight, food intake, body mass index (BMI), serum total cholesterol (TC), triglyceride (TG) and high-density lipoprotein (HDL) levels were measured at the end of fourth, eighth and twelfth wk, while white adipose tissue (WAT) mass and brain dopamine levels were measured at the end of the twelfth wk.Results: AEMP (200 mg/kg, p. o.) and (400 mg/kg, p. o.) treated groups showed a significant decrease in food intake and weight gain without altering BMI. Moreover, TG levels were lower in treated groups as compared to the HFD group, but no significant changes were observed in TC and HDL levels. L-DOPA-treated group showed a significant decrease in body weight, food intake, BMI and WAT. Both AEMP and L-DOPA-treated groups showed an increase in brain dopamine levels as compared to disease control group (p<0.05).Conclusion: L-DOPA and AEMP showed anti-obesity activity by reducing body weight gains, food intake and WAT weights; modulating TG with increased brain dopamine level which correlates to the inhibitory action of dopamine on reward mechanism. 

scholarly journals Ketone Body Rescued Seizure Behavior Of LRP1 Deficiency By Modulating Glutamate Transport

2022 ◽  
Author(s):  
Jin-Ming Zhang ◽  
Ming-Jie Chen ◽  
Jiong-Hui He ◽  
Ya-Ping Li ◽  
Zhi-Cai Li ◽  
...  
Keyword(s):  
Ketogenic Diet ◽  
Ketone Body ◽  
Low Density Lipoprotein ◽  
Glutamate Transporter ◽  
Density Lipoprotein ◽  
Whole Body ◽  
Control Group ◽  
Seizure Rate ◽  
High Sucrose ◽  
Behavior Test

Abstract LRP1, the low-density lipoprotein receptor 1, would be a novel candidate epilepsy gene according to our bioinformatic results and the animal study. In this study, we explored the role of LRP1 in Epilepsy and whether Beta-hydroxybutyrate, the principal ketone body of the ketogenic diet can treat epilepsy caused by LRP1 deficiency. UAS/GAL4 system was used to establish different genotype models. Flies were given Standard, High-sucrose, and ketone body food randomly. The bang-sensitive test was performed on flies and seizure-like behavior was assessed. Morphologic alteration of LRP1 defect in the brain was detected under GPF expression flies. We established global, astrocytic, and neuronal LRP1 knockdown flies. Whole body and glia LRP1 defect flies had a higher seizure rate compared to the control group in the behavior test. Ketone body decreased the seizure rate in behavior test in all LRP1 defect flies, compared to Standard and High sucrose diet. In morphologic experiments, we found that LRP1 deficiency caused partial loss of the ellipsoidal body and partial destruction of the fan-shaped body. Overexpression of glutamate transporter gene Eaat1 could mimic the ketone body effect on LRP1 deficiency flies. This study demonstrated that LRP1 defect globally or in astrocytes or neurons could induce epilepsy. The ketone body efficaciously rescued epilepsy caused by LRP1 knockdown. The results support screening for LRP1 mutations as discriminating conduct for individuals who require clinical attention and further clarify the mechanism of the ketogenic diet in Epilepsy, which could help Epilepsy patients making a precise treatment case by case.

scholarly journals The Hypolipidemic Effect of Aqueous Extract of Hibiscus sabdariffa on Paracetamol-induced Hepatotoxicity in Albino Wistar Rats

2020 ◽  
pp. 54-60
Author(s):  
E. B. Umoren ◽  
J. F. Ekpenyong ◽  
O. E. Oyama ◽  
A. O. Obembe
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Treated Group ◽  
The Body ◽  
Control Group ◽  
Hypolipidemic Effect ◽  
Low Density ◽  
Hibiscus Sabdariffa

Aim of the Study: This study was undertaken to ascertain if Hibiscus sabdariffa extract can affect the lipid profile (Total cholesterol (TC), triglycerides (TG), high density lipoprotein (HDL), very low density lipoprotein (VLDL), and low density lipoprotein (LDL)) levels in a paracetamol- induced hepatotoxicity using albino Wistar rat as a model. Materials and Methods: Thirty (30) rats used for this study were divided into three groups. Group A (n=10) served as control. Group B (n=10) was administered paracetamol only at a dose of 750 mg/kg body weight. Group C (n=10) was administered paracetamol (dose 750 mg/kg body weight) and aqueous extract of H. sabdariffa (dose 10 ml/kg body weight) of the animal for 3 weeks. All animals were allowed free access to clean drinking water and normal rat chow. Results: Results of the study revealed that TC was significantly lower (p<0.05) in the paracetamol + H. sabdariffa-treated group as compared to paracetamol-treated group and control respectively. Similar trend was observed with TG, VLDL-c, LDL-c and HDL-c. However, the decrease in HDL-c was not statistically significant when compared to control. Conclusion: The presence of bioactive constituents vis; anthocyanins, flavonoids, polyvenols and free radical scavenging properties in H. sabdariffa enabled a hypolipidemic effect on the animals by lowering the levels of serum TG, VLDL-c, LDL-c despite challenge on the liver. However, it was unable to produce significant effect on HDL concentration -very important cholesterol required in high level to maintain homeostasis inside the body. This may be due to the challenge on the liver as a result of the paracetamol abuse.

scholarly journals Effects of Nigerian Piliostigma thonningii Species Leaf Extract on Lipid Profile in Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
O. M. Ighodaro ◽  
J. O. Omole
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Leaf Extract ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cardiovascular Complications ◽  
Control Group ◽  
Piliostigma Thonningii ◽  
Aqueous Leaf Extract

Cardiovascular complications and associated conditions remain a major cause of death, globally. Piliostigma thonningii has been used for different and several medicinal purposes. On this background, the effect of aqueous leaf extract of the plant on the lipid profile of physiologically normal rats was examined. Graded doses of the extract, 0.0, 0.2, and 0.4 g/kg of body weight (bwt) were orally administered to rats for a period of 14 days. The effect of the extract was assessed on the basis of comparative determinations of the evaluated indices in treated rats vis-à-vis the nontreated group as well as in respect to the differences between the basal and final concentrations of the indices in each group. The extract, especially at 0.2 g per kg body weight caused a significant decrease in the total cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol in the treated rats when compared to the control group and basal concentrations. Though, the level of high-density lipoprotein (HDL) cholesterol increased in the treated rats, the increase was not significant when compared to the basal concentration. The LDL/HDL ratio in all the experimental groups was less than 0.9. The results obtained in this study suggest that P. thonningii aqueous leaf extract likely contains antilipidaemic and anticholesterolaemic substance(s), which may be useful in the prophylactic and curative management of lipid peroxidation, high blood pressure, and cardiovascular disorders.

scholarly journals Thymoquinone Protects Neurons in the Cerebellum of Rats through Mitigating Oxidative Stress and Inflammation Following High-Fat Diet Supplementation

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 165
Author(s):  
Aziza Alrafiah
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
High Fat Diet ◽  
Neuronal Damage ◽  
Morphological Changes ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
The Body ◽  
Control Group ◽  
High Fat

High-fat diet (HFD) is a major problem causing neuronal damage. Thymoquinone (TQ) could regulate oxidative stress and the inflammatory process. Hence, the present study elucidated the significant role of TQ on oxidative stress, inflammation, as well as morphological changes in the cerebellum of rats with HFD. Rats were divided into three groups as (1) control, (2) saturated HFD for eight weeks and (3) HFD supplementation (four weeks) followed by TQ 300 mg/kg/day treated (four weeks). After treatment, blood samples were collected to measure oxidative stress markers glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), and inflammatory cytokines. Furthermore, neuronal morphological changes were also observed in the cerebellum of the rats. HFD rats show higher body weight (286.5 ± 7.4 g) as compared with the control group (224.67 ± 1.78 g). TQ treatment significantly (p < 0.05) lowered the body weight (225.83 ± 13.15 g). TQ produced a significant (p < 0.05) reduction in cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). The antioxidative enzymes significantly reduced in HFD rats (GSH, 1.46 ± 0.36 mol/L and SOD, 99.13 ± 5.41 µmol/mL) as compared with the control group (GSH, 6.25 ± 0.36 mol/L and SOD, 159.67 ± 10.67 µmol/mL). MDA was increased significantly in HFD rats (2.05 ± 0.25 nmol/L) compared to the control group (0.695 ± 0.11 nmol/L). Surprisingly, treatment with TQ could improve the level of GSH, MDA, and SOD. TQ treatment significantly (p < 0.05) reduced the inflammatory markers as compared with HFD alone. TQ treatment minimizes neuronal damage as well as reduces inflammation and improves antioxidant enzymes. TQ can be considered as a promising agent in preventing the neuronal morphological changes in the cerebellum of obese populations.

scholarly journals Antioxidant Capacity and Hepatoprotective Effect of Silymarin Against Salinomycin – Induced Toxicity in Adult Rabbits

2021 ◽  
Author(s):  
Ahmed Hamdy ghonaim ◽  
Mai G Hopo ◽  
tarek AboElnaga ◽  
Rania Abdelrahman Elgawish ◽  
RH Abdou ◽  
...  
Keyword(s):  
Body Weight ◽  
Low Density Lipoprotein ◽  
Relative Weight ◽  
Density Lipoprotein ◽  
Control Group ◽  
Weight Group ◽  
Group 4 ◽  
Body Weights ◽  
Group 5 ◽  
Weight Groups

Abstract Salinomycin was evaluated for its toxicity and silymarin for prophylactic management in male rabbits. Male rabbits were randomly divided into 7 groups with 7 rabbits / each. Groups 1, 2, 3 were kept as control group, salinomycin (20 mg / kg ration) and salinomycin (40 mg / kg ration), respectively. Group 4 was fed on feed containing salinomycin (20 mg / kg ration) and silymarin (6.5 mg / kg body weight). Group 5 received feed containing salinomycin (40 mg / kg ration) and silymarin (13 mg / kg body weight). Groups 6 and 7 were nourished feed containing silymarin (6.5 and 13 mg / kg body weight), respectively. Duration of the experiment was 28 days. Weekly body weights showed a significant reduction in the 3rd group when compared with control group. The activity of Malondialdhyde and the values of aspartate aminotransferase, alanine aminotransferase, total protein, albumin, total cholesterol, triglycerides, low density lipoprotein, urea and creatinine were significantly elevated in 2nd and 3rd group while glutathione, catalase, superoxide dismutase and high density lipoprotein were significantly lowered when compared with control group. Thus, it is clarified that salinomycin toxicity is owed to oxidative damage and the usage of silymarin in feed tends to treat and prevent any accidental toxicity. Relative weight of the liver increased significantly in 3rd group. There were mild pathologic changes in liver of 2nd group while there were sever pathologic changes at 3rd group when compared with control group.

scholarly journals Evaluation of the Effects of Aqueous Fruit Extract of Tamarindus indica on Body Weight, Lipid Profile, Some Electrolytes and Urea of Wistar Rats

2021 ◽  
pp. 444-451
Author(s):  
I. P. Ekpe ◽  
Dennis Amaechi ◽  
B. N. Yisa ◽  
O. G. Osarhiemen
Keyword(s):  
Body Weight ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Healthy Weight ◽  
Group I ◽  
Significant Difference

Objectives: The objectives of this research is to evaluate the effects of aqueous extract of T. indica on  weight, lipid parameters, some electrolytes and urea of Wistar rats Design & Methods: Twenty-five Male  Adult  rats were grouped into four  consisting of six rats each. Group I served as control group, group II was administered 100mg/kg of the Aqueous extract, group III was administered 150mg/kg of the Aqueous extract, and Group IV was administered 200mg/kg of the Aqueous extract. The administration took place for seven days, and on the eight day, The Animals were sacrificed. The blood samples was collected via cardiac puncture and used for analysis using a visible spectrophotometer. Results: From the result, there was no significant difference (p<0.05) in body weight of Wistar rats. In the Test Groups; Serum cholesterol, low density lipoprotein (LDL), High density lipoprotein (HDL), Very Low-density Lipoprotein and Triglycerides revealed a significant increase (p<0.05) compared to Group 1 which is the control Group but had a significant decrease (p<0.05) compared within test groups. For electrolytes concentrations, potassium, Sodium, Chloride and Urea concentrations was significant at p<0.05. Conclusion: the results above ,T. indica extract may help to maintain healthy weight, may have hypolipidemic properties, may help in body homeostatic and fluid balance and may also prevent renal damages. 

scholarly journals Antidiabetic effect of bitter melon/Kerala (Momordica charantia) in alloxan induced diabetic rat

2018 ◽  
Vol 5 (3) ◽  
pp. 373-379
Author(s):  
Rupaly Akhter ◽  
Imrul Hasan Rasel ◽  
Mohammad Saiful Islam
Keyword(s):  
Body Weight ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Control ◽  
Momordica Charantia ◽  
Lipoprotein Cholesterol ◽  
Diabetic Rat ◽  
Control Group ◽  
Bitter Melon ◽  
Group B

This study aims at investigating the effect of Momordica charantia extract on glucose tolerance and some biochemical parameters in alloxan induced diabetes rat. A total of 150 rats (50 normal rats and 100 alloxan induced diabetic rats) were used for five trials. The rats were divided into three groups for each trial, each containing 10 individuals as follows: Group A: is the control group, Group B as diabetic control group and group C were diabetic rat received bitter melon (Momordica charantia). Then alloxan injection was injected at a dose rate of 150 mg/kg body weight through intra-peritoneal route to each rat to induce diabetes in groups B and C. Aqueous extract of bitter melon (Momordica charantia) were fed by gavage at a dose of 300 mg/kg body weight daily for 21 days in group C. On 15th day blood glucose level and the body weights, biochemical parameters were measured for the first time to ensure diabetic induction. Then all the rats of this group were kept for more 21 days for the treatment of diabetic condition. Alloxan produced a significant increase in serum glucose, triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), Alanine aminotransaminase (ALT) and Aspartate aminotransaminase (AST) and significant decrease in body weight and high density lipoprotein cholesterol (HDLC). Bitter melon treatment reduced non-fasting and fasting glucose level (p<0.05). In addition, administration of bitter melon juice was associated with a reduction in the serum levels of Alanine aminotransaminase (ALT) and Aspartate aminotransaminase (AST), Triglyceride (TG), Total Cholesterol (TC) and Low Density Lipoprotein Cholesterol (LDL-C) when compared with positive diabetic control (p<0.05). High density lipoprotein cholesterol (HDLC) and body weight level significantly increased in bitter melon treated group C compare to Group B (p<0.05). Res. Agric., Livest. Fish.5(3): 373-379, December 2018

Methanolic extract of Moringa oleifera leaves improves glucose tolerance, glycogen synthesis and lipid metabolism in alloxan-induced diabetic rats

2015 ◽  
Vol 26 (6) ◽  
Author(s):  
Luqman A. Olayaki ◽  
Justice E. Irekpita ◽  
Musa T. Yakubu ◽  
Opeolu O. Ojo
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Glucose Tolerance ◽  
Glucose Uptake ◽  
Glycogen Synthase ◽  
Serum Insulin ◽  
Low Density Lipoprotein ◽  
Glycogen Synthesis ◽  
Density Lipoprotein ◽  
Diabetic Control

AbstractGlucose-lowering effects ofMOLE was screened for key phytochemicals and its total flavonoids and phenolic contents were quantified. Diabetes was induced by intraperitoneal injection of 120 mg/kg BW alloxan. Normal and diabetic control rats received saline, while rats in other groups received 300 or 600 mg/kg body weight of MOLE or metformin (100 mg/kg body weight of metformin) for 6 weeks. Food intake and body weight were monitored throughout the experiment. Intraperitoneal glucose tolerance was assessed and serum glucose, insulin, and lipids were measured at the end of the experiment. Liver and muscle glycogen synthase activities, glycogen content, and glucose uptake were determined.Administration of MOLE did not affect food intake but inhibited weight loss, significantly (p<0.01) improved glucose tolerance, and increased serum insulin levels by 1.3–1.7-fold (p<0.01). MOLE treatment significantly (p<0.001) reduced serum concentrations of triglyceride, total cholesterol, and low-density lipoprotein (LDL)-cholesterol and enhanced serum level of high-density lipoprotein (HDL) by 2.4- to 3.2-fold (p<0.001). Glycogen synthase activities and glycogen contents were higher in MOLE-treated rats compared with rats receiving metformin or saline and the extract improved glucose uptake by 49%–59% (p<0.01).These results showed that hypoglycemic effects of MOLE might be mediated through the stimulation of insulin release leading to enhanced glucose uptake and glycogen synthesis.

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