scholarly journals The Effect of Snakehead Fish (Channa striata) Extract on Blood Leukocyte Number and Cesarean Sectio Wound Healing

2020 ◽  
Author(s):  
Yuli Suryanti ◽  
Suharyo Hadisaputro ◽  
Sri Nugraheni
Keyword(s):  
Wound Healing ◽  
Leukocyte Number ◽  
Channa Striata ◽  
Blood Leukocyte

scholarly journals The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar Strain Male Rats

2017 ◽  
Vol 22 (2) ◽  
pp. 97 ◽  
Author(s):  
Fransisca Daisa ◽  
Mohamad Andrie ◽  
Wintari Taurina
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Negative Control ◽  
Stage Ii ◽  
Male Rats ◽  
Wound Healing Process ◽  
Omega 3 ◽  
Significant Difference ◽  
Healing Power ◽  
Channa Striata

The snakehead (Channa striata) contained fatty acids omega-3 and omega-6 are useful as nutrients in accelerating the wound healing process. This study aims to determine the effectiveness of the oil phase extract ointment snakehead in the healing of acute wounds open stage II. Testing the effectiveness of wound healing using 6 groups: normal, gel bioplacenton (positive control), ointment base (negative control), ointments snakehead extract oil phase concentration of 10; 20 and 40% of the 4 rats with acute wounds open stage II and observation until day 16 injury. The area of the wound was measured with the image J program Macbiophotonic, calculated% healing power, and AUC values. A statistical test to the total AUC values per rat with SPSS for Windows 22.0 program using One Way ANOVA and Post-hoc LSD test. The results showed a significant difference in the negative group with ointment concentration of 20% (p <0.05). The treatment group phase ointment fish oil extract is effective for wound healing is best to have a concentration of 20% for percentage of wound healing power of 97.157% and the average AUC value of 865.683% of the day.

scholarly journals Esktrak ikan haruan (Channa striata) menurunkan jumlah makrofag pada fase inflamasi proses penyembuhan luka (Extract of haruan (Channa striata) decreases macrophages count in inflammation phase of wound healing process )

2015 ◽  
Vol 14 (1) ◽  
pp. 6
Author(s):  
Putri Sri Hartini ◽  
Nurdiana Dewi ◽  
Lisda Hayatie
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Wistar Rats ◽  
Healing Process ◽  
Positive Control ◽  
Wound Healing Process ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Post Test ◽  
Channa Striata

Haruan is a kind of freshwater fishes commonly found in South Kalimantan. Haruan extract contains nutritional substancessuch as albumin, Zn, Fe, Cu, and unsaturated fatty acid which can help accelerate wound healing. The aim of this studywas to histopathologically assess the effect of 100%, 50%, and 25%haruan extract compared to aquadest and ibuprofenon macrophages count in inflammation phase of wistar rats’ buccal mucosa wound healing. This research was a trueexperimental with post test-only with control design. Samples used were 30 wistar rats divided into 5 groups, 100%, 50%,25% haruan extract treatment groups, ibuprofen treatment group as positive control, and aquadest treatment group asnegative control. Mean macrophages counted on day 3 of 100%, 50%, 25% haruan extract treatment groups aquadest,and ibuprofenl were 2.05, 4.4, 3.9, 3.3, 2.4 respectively. In conclusion, haruan extract had a significant effect in decreasingmacrophages count in inflammation phase of wound healing.

scholarly journals EFEKTIVITAS PEMBERIAN EKSTRAK IKAN HARUAN (Channa striata) TERHADAP JUMLAH NEUTROFIL PADA PROSES PENYEMBUHAN ULKUS TRAUMATIKUS

DENTA ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 8
Author(s):  
Isidora Karsini ◽  
Farhana Nur Fadhila ◽  
Nafiah Nafiah
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Healing Process ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Unsaturated Fat ◽  
Post Test ◽  
Channa Striata ◽  
The Mean

<p><strong><em>Background:</em></strong><em> </em><em>Channa striata contains important compounds in the process of tissue synthesis and important role in wound healing, such as albumin, zinc (Zn), copper (Cu), iron (Fe) and unsaturated fat acids. <strong>Purpose :</strong> To determine the effect of Channa striata extract to the amount of neutrophil in healing process of traumatic ulcer. <strong>Material and Method :</strong> The design of this study used randomized post test only control group design. 18 wistar rats were divided into 6 groups, i.e: K-1 (no treatment for 1 day), K-3 (no treatment for 3 days), K+1 (giving hyaluronic acid 0.2% for 1 day), K+3 (giving hyaluronic acis 0.2% for 3 days), P1 (giving Channa striata extract 100% for 1 day), P3 (giving Channa striata extract 100% for 3 days). <strong>Results :</strong> There was a decrease in the number of neutrophil in the treatment group. The mean and standart deviation of the number of neutrophil in the K-1 group (75,96±3,65), K-3 (50,76±2,04), K+1(72,96±2,97),K+3(45,06±2,83),P1(54,20±1,31),P3(32,50±,85). <strong>Conclusion :</strong> The using of Channa striata extract 100% for 3 days are the most effective in decreasing the amount of neutrophil in healing process of traumatic ulcer of Rattus Novergicus Strain Wistar.</em></p>

scholarly journals Ekstrak ikan haruan (Channa striata) meningkatkan jumlah neokapiler pada penyembuhan luka (Extract of haruan (Channa striata) increases neocapillaries count in wound healing process )

2015 ◽  
Vol 14 (1) ◽  
pp. 1
Author(s):  
Muhammad Reza Setiawan ◽  
Nurdiana Dewi ◽  
Ika Kustiyah Oktaviyanti
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Negative Control ◽  
Control Group ◽  
Wound Healing Process ◽  
Control Group Design ◽  
Treatment Groups ◽  
Accelerate Wound Healing ◽  
Channa Striata ◽  
Post Hoc

Haruan is Kalimantan’s indigenous fish which has the potency to accelerate wound healing. Haruan extract hassubstantial properties such as albumin, Zn,Cu, and Feto accelerate wound healing. The purpose of this study is to assessthe effect of haruan extract on wistar rats buccal mucosa wound healing on day 1, 3, 5, and 7 histopathologically. Thisstudy was purely experimental with pretest-posttest with control group design. Samples were divided into 4 treatmentgroups, haruan extract 25%, 50%, 100% treatment groups and aquadest treatment group as negative control, eachtreatment wasperformed for 7 days. Neocapillariescount reached its peak on day 5. Mean neocapillaries scoring of eachgroup was 12, 16.5, 18.5, 6 respectively. Two way Anova and post hoc LSD tests presented a significant differencebetween negative control and haruan extract groups. In conclusion, haruan extract treatment significantly increasedneocapillaries count in wound healing process.

scholarly journals Effectiveness of Snakehead Fish (Channa striata) and Turmeric (Curcuma domestica) Extract towards Wound Healing in Rats (Rattus norvegicus)

2020 ◽  
Vol 2 (2) ◽  
pp. 39-43
Author(s):  
Ratna Widyawati ◽  
◽  
H. Bagus Uda Palgunadi ◽  
Reissa Yunia ◽  
◽  
...  
Keyword(s):  
Wound Healing ◽  
Rattus Norvegicus ◽  
Povidone Iodine ◽  
Positive Control ◽  
Male Rats ◽  
Wound Fluid ◽  
Turmeric Extract ◽  
Significant Difference ◽  
Channa Striata ◽  
The One

This study aimed to determine the effect of snakehead fish extracts (Channa striata) and turmeric extract (Curcuma domestica) towards incision wound healing in rats (Rattus norvegicus). Twenty-four male rats, aged 8-week-old, 200-300 grams of body weight divided into 4 groups: control (P0), treatment with povidone iodine as positive control (P1), treatment with snakehead fish extract (P2) and treatment with turmeric extract (P3). The rats were given premedication consisting of acepromazine 0.5 mg kg / BW and atropine 10 mg / kg BW. The rats were then anesthetized using ketamine 0.1 mg / kg BW. An incision was made on each rats’ back area along 2 cm with 0.05 mm depth and observed for 14 days. Observations were carried out every day with data collection at <7 days, 7-14 days, and 14 days. The One-Way ANOVA statistical analysis resulted that the wound fluid parameters and the duration of wound healing showed no significant difference between P0, P1, P2 and P3. This study concluded that the administration of povidone iodine, snakehead fish extract, and turmeric extract influenced the healing of incision wounds in rats.

scholarly journals Bioactive Proteins in Channa striata Promote Wound Healing through Angiogenesis and Cell Proliferation

2019 ◽  
Vol 27 (1) ◽  
pp. 48-59
Author(s):  
Soon Hong Kwan ◽  
Nur Hidayah Kaz Abdul Aziz ◽  
Mohd Nazri Ismail
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Ex Vivo ◽  
Healing Process ◽  
Signalling Pathway ◽  
Wound Healing Process ◽  
Water Extracts ◽  
Bioactive Proteins ◽  
Freeze Dried ◽  
Channa Striata

Background: Channa striata are speculated to contain bioactive proteins with the ability to enhancing wound healing. It is commonly consumed after surgery for a faster recovery of the wound. Objective: To identify the bioactive proteins and evaluate their ability in cell proliferation and angiogenesis promotion. Material and Methods: Freeze-Dried Water Extracts (FDWE) and Spray-Dried Water Extracts (SDWE) of C. striata were tested with MTT assay using EA.hy926 endothelial cell line and ex-vivo aortic ring assay. Later the proteins were fractionated and analysed using an LC-QTOF mass spectrometer. The data generated were matched with human gene database for protein similarity and pathway identification. Results: Both samples have shown positive cell proliferation and pro-angiogenic activity. Four essential proteins/genes were identified, which are collagen type XI, actin 1, myosin light chain and myosin heavy chain. The pathways discovered that related to these proteins are integrin pathway, Slit-Robo signalling pathway and immune response C-C Chemokine Receptor-3 signalling pathway in eosinophils, which contribute towards wound healing mechanism. Conclusions: The results presented have demonstrated that C. striata FDWE and SDWE protein fractions contain bioactive proteins that are highly similar to human proteins and thus could be involved in the wound healing process via specific biological pathways.

scholarly journals In Vitro and In Vivo Effects of Holotoxin A1 From the Sea Cucumber Apostichopus japonicus During Ionizing Radiation

2020 ◽  
Vol 15 (6) ◽  
pp. 1934578X2093203 ◽  
Author(s):  
Olesya S. Malyarenko ◽  
Lyudmila A. Ivanushko ◽  
Elena L. Chaikina ◽  
Mikhail I. Kusaykin ◽  
Alexandra S. Silchenko ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocyte ◽  
Lymphoid Organs ◽  
X Ray ◽  
Solid Carcinoma ◽  
Leukocyte Number ◽  
Blood Leukocyte

Radiation therapy is one of the most important approaches to cancer therapy, but radiotoxicity to normal tissue is a serious limitation of this treatment. Compounds which are able to either sensitize cancer cells or protect normal cells to radiation are of great interest. The cytotoxicity of holotoxin A1 and the effects of radiation against DLD-1 and HT-29 cells were measured by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay. The effect of the combination of holotoxin A1 with X-ray on colony formation of cancer cells was determined by the soft agar assay. The effect of holotoxin A1 on the recovery of peripheral blood leukocyte number, mass, and cellularity of the lymphoid organs of irradiated mice, as well as on growth of murine Ehrlich solid carcinoma was studied. Holotoxin A1 enhanced the sensitivity of colorectal carcinoma cells to radiation in vitro. Injection of holotoxin A1 to mice led to an increase in the spleen endogenous colony number and peripheral blood leukocyte number, as well as the weight and cellularity of the lymphoid organs of the irradiated mice. Holotoxin A1 in combination with X-ray radiation effectively inhibited the growth of Ehrlich solid carcinoma in vivo. Holotoxin A1 is suggested to be a promising agent for improving the efficiency of radiotherapy.

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