scholarly journals Diabetes and COVID-19 in Congolese patients

2021 ◽  
Vol 21 (3) ◽  
pp. 1100-1106
Author(s):  
Henriette Poaty ◽  
Guy Emergence Poaty ◽  
Gilbert NDziessi ◽  
Emile Godefroy Ngakeni ◽  
Tatiana Doukaga Makouka ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Clinical Characteristics ◽  
Diabetic Patients ◽  
Older Individuals ◽  
Rt Pcr ◽  
Glucose Assay ◽  
Global Pandemic ◽  
Pcr Method ◽  
Male Sex ◽  
Morbid Conditions

Background: The global pandemic Coronavirus Disease 2019 (COVID-19) due to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is reported to be potentially severe in patients with morbid conditions. One common reported comorbidities is diabetes. We aimed in this study to precise the clinical characteristics and outcomes in a series of congolese diabetic patients affected by COVID-19 infection. Patients and methods: We retrospectely studied from 256 COVID-19 patients, a cohort of 30 persons with previously known diabetes. The glycaemia controls have been obtained by plasma glucose assay. All patients have been tested positive to SARS-CoV-2 by RT-PCR method. Results: The COVID-19 diabetic patients represented 11,7% of all COVID-19 patients with confidence interval of 95% [7,77-15,65]. Older individuals and male sex were predominent. Dyspnea and sauration of oxygen < 90 were significatives and added risk factors were noted in 63.3% of patients, particulary hyperglycaemia with hypertension or obesity. The mortality rate at the percentage of 36.7% was more prevalent in patients with added comorbidities (30%) versus without comorbidities (6.7%). Conclusion: Congolese COVID-19 diabetic patients of male sex and older age exhibiting arterial hypertension and obesity are the most exposed to severe COVID-19 and increasead mortality rate. Keywords: COVID-19, SARS-CoV-2, diabetes, Congolese patients.

The role of enterovirus infections in type 1 diabetes in Tunisia

2017 ◽  
Vol 30 (12) ◽  
Author(s):  
Imen Boussaid ◽  
Asma Boumiza ◽  
Ramzi Zemni ◽  
Elyes Chabchoub ◽  
Latifa Gueddah ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Tunisian Population ◽  
Acid Decarboxylase ◽  
Diabetic Patients ◽  
Rt Pcr ◽  
Highly Sensitive ◽  
Significant Difference ◽  
Healthy Control ◽  
Pcr Method

AbstractBackground:Enteroviral infections have long been suspected in having a role in β cell destruction and therefore leading to the onset of clinical type 1 diabetes (T1D). The frequency of enterovirus (EV)-related T1D in North Africa is still unknown. The aim of the present study was to investigate the relationship between infection with EV and T1D in Tunisia.Methods:A total of 95 T1D patients (41 children and 54 adults) and 141 healthy control subjects (57 children and 84 adults) were tested for the presence of EV-RNA by a highly sensitive nested reverse transcription-polymerase chain reaction (RT-PCR) method.Results:EV-RNA was detected more frequently in plasma from diabetic patients than in plasma of controls (31.6% vs. 7.8%, p<0.0001; OR=5.45; 95% CI 2.44–12.43). RT-PCR revealed positive in 53.7% of T1D children and 14.8% of T1D adults. There was a statistically significant difference between children and adults with T1D (p<0.0001). Positivity of EV-RNA according to the time after the occurrence of the disease did not show any significant difference (p=0.34). Anti-glutamic acid decarboxylase (GAD) antibodies were not associated with EV-RNA (p=0.65).Conclusions:EV-RNA is associated with T1D mellitus in the Tunisian population especially in children. These results support the hypothesis that EV act as environmental risk factors for T1D.

scholarly journals STUDY OF DEMOGRAPHIC ANALYSIS, CLINICAL CHARACTERISTICS, DIAGNOSIS, MANAGEMENT AND COMPLICATIONS IN COVID-19 PATIENTS

2021 ◽  
pp. 64-68
Author(s):  
PAVAN KUMAR M ◽  
REVATHI G ◽  
SUPRAJA K, SECHANA K
Keyword(s):  
Clinical Characteristics ◽  
Standard Treatment ◽  
Signs And Symptoms ◽  
Age Group ◽  
Demographic Analysis ◽  
Morbid Condition ◽  
Rt Pcr ◽  
Mineral Supplements ◽  
Loss Of Appetite ◽  
Morbid Conditions

Objective: To study the demographic analysis, clinical characteristics, diagnosis, and management in covid-19 patients. To assess the complications in covid-19 patients. Methods: A retrospective observational single centered study is carried out to study the demographic analysis, clinical characteristics, diagnosis, management, and complications in covid-19 patients. Results: Among 100 covid-19 patients 58% were male and 42% were female. Percentages of age group between 60-70 years (27%), 50-60 (20%), 40-50 (16%), 70-80 (16%), 30-40 (8%), 20-30 (5%), 80-90 (4%), and 10-20 (4%). Co-morbidities were diabetes (44%), hypertension (28%), CAD (21%), thyroid (19%), COPD (12%), anemia (8%), and renal impairment (4%). Signs and symptoms were fever (88%), cough (80%), SOB (72%), fatigue (68%), myalgia (60%), loss of appetite (52%), cold (24%), loss of smell and taste (20%), diarrhea and vomiting (12%). (97%) of the patients had two or more symptoms. Diagnostic test include RT-PCR (100%), HRCT (100%), O2 saturation (99%), D-dimer (65%), c-reactive (60%), Procalcitonin (60%), and also LDH, IL-6,PT, INR, ferritin, CBP, WBC. Treatment includes antiviral (100%), antibiotics (100%), corticosteroids (73%), immunosuppressant (54%), and antihypertensive, antidiabetic, Antiplatelets, bronchodilators, vitamins, and mineral supplements. Conclusion: Covid-19 infects the males more and average ages of 65 years are at risk. Hypertension and diabetes were most common co-morbid condition. Fever and cough are major followed by weakness sob and cold. RT- PCR and HRCT are accurate tool to detect covid-19. Although standard treatment is not yet available antibiotics and antiviral are used followed by corticosteroids. Majority of the patients have mild and moderate injection and with the lowest death rate. Older age and co-morbid conditions are major risk factors.

scholarly journals Diabetic Emergencies presenting during the COVID-19 Pandemic: A Retrospective Case Analysis

2021 ◽  
Author(s):  
Tobin Joseph ◽  
Eleanor Crawley ◽  
Sulmaaz Qamar ◽  
Maya Zosmer ◽  
Girish Rayanagoudar ◽  
...  
Keyword(s):  
Case Analysis ◽  
Diabetic Patients ◽  
Rt Pcr ◽  
Metabolic Disturbances ◽  
Retrospective Case ◽  
Biochemical Processes ◽  
Global Pandemic ◽  
Admission Data ◽  
Patients With Diabetes ◽  
Underlying Mechanisms

Abstract IntroductionCOVID-19 has triggered a global pandemic and is an emerging situation. Diabetes has been associated with significant mortality in SARS and MERS- COV infections. Patients with diabetes are at risk of COVID-19 triggering diabetic emergencies due to known and unknown mechanisms. There is little evidence overviewing the clinical course of COVID19 patients who either present or have diabetic emergencies during their disease course. MethodsWe conducted a retrospective case analysis of all patients admitted to our hospital during the COVID-19 pandemic. The inclusion criteria were all patients receiving treatment for COVID-19 and either presenting with a diabetic emergency on admission or developing an emergency during their admission. Data collected for the study were all routinely collected data as part of the admission. We compared this data to 9 patients with no COVID-19. Results30 patients received treatment for a diabetic emergency, of which 21 also received treatment for COVID-19. Significant differences were found between pH and bicarbonate on admission between RT-PCR positive and both RT-PCR negative and non-COVID-19 patients. Other results approaching significance include ALP and eGFR. DiscussionLittle is known about the metabolic disturbances COVID-19 has on diabetic patients. Further, prospective detailed investigation into biochemical processes is needed to elucidate underlying mechanisms that affect these patients’ outcomes.

Dietary and living regimen of covid-19 with special reference to Ayurveda Varsha and Sharad Ritucharya

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 758-762
Author(s):  
Amit Biswas ◽  
KunalChandankhede
Keyword(s):  
Environmental Changes ◽  
World Health ◽  
Human Beings ◽  
Dietary Regimen ◽  
Global Pandemic ◽  
The World ◽  
Health Organization ◽  
Disease Free ◽  
Individual Disease ◽  
Morbid Conditions

Wuhan originated Covid-19 disease is caused by SARC-COV 2 virus. It is a contagious disease it spread all over the world. World health organization declared a global pandemic disease. In Covid-19 immunity plays an important role. In old age people or having other co-morbid conditions the mortality rate is more. Ayurveda has a big role in improved immunity or to intact immunity. The principle of Ayurveda is to keep individual swastha (diseases free). To maintain individual disease-free Ritucharya is one of the important subjects of Ayurveda. Aimed of study is to find out Ritucharya literature from the Ayurveda and modern research specifically Varsha and Sharad ritu. Ritucharya contains dietary regimen, living modification, common medicine, and contraindicated things those changing according to environmental change. Upcoming season in India is Varsha and Sharad ritu. Environmental changes are huge in this season and it directly affected human beings. So this study reveals property of ritu, dietary regimen, living modification, common medicine and contraindicated things in upcoming varsha and sharad ritu.

Territorial Distribution of Alcohol and Drug Addictions Mortality Concerning Regional Disparities in the Slovak Republic from Year 1996 to Year 2015

2020 ◽  
Keyword(s):  
Mortality Rate ◽  
Slovak Republic ◽  
Regional Disparities ◽  
Point Of View ◽  
Extreme Position ◽  
Data Set ◽  
Female Sex ◽  
Male Sex ◽  
The Individual ◽  
High Level

BACKGROUND: This paper deals with territorial distribution of the alcohol and drug addictions mortality at a level of the districts of the Slovak Republic. AIM: The aim of the paper is to explore the relations within the administrative territorial division of the Slovak Republic, that is, between the individual districts and hence, to reveal possibly hidden relation in alcohol and drug mortality. METHODS: The analysis is divided and executed into the two fragments – one belongs to the female sex, the other one belongs to the male sex. The standardised mortality rate is computed according to a sequence of the mathematical relations. The Euclidean distance is employed to compute the similarity within each pair of a whole data set. The cluster analysis examines is performed. The clusters are created by means of the mutual distances of the districts. The data is collected from the database of the Statistical Office of the Slovak Republic for all the districts of the Slovak Republic. The covered time span begins in the year 1996 and ends in the year 2015. RESULTS: The most substantial point is that the Slovak Republic possesses the regional disparities in a field of mortality expressed by the standardised mortality rate computed particularly for the diagnoses assigned to the alcohol and drug addictions at a considerably high level. However, the female sex and the male sex have the different outcome. The Bratislava III District keeps absolutely the most extreme position. It forms an own cluster for the both sexes too. The Topoľčany District bears a similar extreme position from a point of view of the male sex. All the Bratislava districts keep their mutual notable dissimilarity. Contrariwise, evaluation of a development of the regional disparities among the districts looks like notably heterogeneously. CONCLUSIONS: There are considerable regional discrepancies throughout the districts of the Slovak Republic. Hence, it is necessary to create a common platform how to proceed with the solution of this issue.

scholarly journals 365. Characteristics and outcomes of COVID-19 patients admitted to a regional health system in the southeast

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S251-S253
Author(s):  
Charles Teixeira ◽  
Henry Shiflett ◽  
Deeksha Jandhyala ◽  
Jessica Lewis ◽  
Scott R Curry ◽  
...  
Keyword(s):  
Renal Failure ◽  
Health System ◽  
Patient Characteristics ◽  
Supplemental Oxygen ◽  
Regional Health ◽  
Cancer Symptoms ◽  
Presenting Symptoms ◽  
Global Pandemic ◽  
Male Sex ◽  
Previous Admission

Abstract Background COVID-19, first described in Wuhan, China, is now a global pandemic. We describe a cohort of patients (pts) admitted to our academic health system (HS) in the southeast, where demographics and comorbidities differ significantly from other regions in the U.S. Methods This was a retrospective review of 161 consecutive pts admitted with COVID-19 from 3/12/20 to 6/1/20. We assessed demographics, comorbidities, presenting symptoms, treatments and outcomes and compared pts who died during hospitalization to those who survived to discharge (EpiInfo 7.2, Atlanta, GA). Results Mean age was 60.5 years, 51.6% were female, 72% African American (AA) and 69.6% admitted from home. 54.5% had a BMI &gt;30, 72% had HTN, 47.2% diabetes, and 33.6% COPD or asthma. The majority (68.8%) presented with fever (&gt;38.0) and required supplemental oxygen within 8 hours of admission (63.4%). Cough (65.6%), dyspnea (57.5%), myalgias (30.6%) and diarrhea (23.8%) were also common. 40.4% received hydroxychloroquine, 23.6% steroids and 19.9% convalescent plasma. 42.9% required ICU care, 27.3% were intubated, and 19.3% died. Characteristics associated with death included older age, male sex, HTN, ESRD on HD, and cancer. Symptoms associated with death included absence of cough, absence of myalgias, previous admission for COVID-19, tachypnea, need for supplemental oxygen, elevated BUN and creatinine, and elevated ferritin. Interventions associated with death included use of steroids, receipt of ICU care, intubation, delay to intubation, and use of vasopressors or inotropes. Complications associated with death included development of a new arrhythmia, bacteremia, pneumonia, ARDS, thrombosis, and new renal failure requiring HD (Table). Table 1. Patient Characteristics by Death Table 2. Patient Characteristics by Death Table 3. Patient Characteristics by Death Conclusion COVID-19 pts admitted to our southeast U.S. HS had significant comorbidities, most commonly obesity, HTN, and diabetes. Additionally, AA comprised a disproportionate share (72%) of our cohort compared to the general population of our state (30%), those tested in our region (32.9%), and those found to be positive for COVID-19 (35.8%). In-hospital mortality was 19.3% and intubation, particularly if delayed, was associated with death as were several complications, most notably arrhythmia, ARDS, and renal failure with HD. Disclosures All Authors: No reported disclosures

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