The efficacy of a single oral dose of albendazole against soil-transmitted helminthiasis in Ogun State, Nigeria

2021 ◽  
Vol 42 (2) ◽  
pp. 360-365
Author(s):  
S.O. Sam-Wobo ◽  
Amadou D. Garba ◽  
J. Vlaminck ◽  
B. Levecke ◽  
O.N. Adekunle ◽  
...  
Keyword(s):  
Drug Administration ◽  
Neglected Tropical Diseases ◽  
Infected Individual ◽  
Primary School Children ◽  
Global Public Health ◽  
Public Health Importance ◽  
Ogun State ◽  
Fecal Egg Count ◽  
Stool Samples ◽  
Study Participants

Soil Transmitted Helminths (STHs) are Neglected Tropical Diseases of global public health importance. This study evaluated the efficacy of albendazole (ALB) amongst primary school children aged 6 – 16 years in STH-endemic communities in Ogun State, Nigeria. Demographic characteristics were obtained and stool samples were collected and analysed by Kato-Katz at baseline and 15 and 21 days post-treatment. All study participants were treated with a single ALB 400 mg tablet. A total of 282 participants were screened at baseline, of which 151 were found to be excreting STH (51.4%) of which A. lumbricoides was the most prevalent STH (n = 137, 48.6%), followed by hookworm (n = 60 children, 21.3%) and T. trichiura (n = 3; 1.1%). The prevalence across the four schools varied from 31.3% to 73.9% for A. lumbricoides, from 6.8% to 56.3% for hookworm, and from 0.0% and 2.2% for T. trichiura  infections. Of the 151 children excreting any STH infection at baseline, 131 (86.8%) provided a stool sample 15 and 21 days after treatment. The mean fecal egg counts across these complete cases at baseline was 5,096 (± 13,735) eggs per gram (EPG) for A. lumbricoides, 2,202 (±7,849) for hookworms and 288 (±375) for T. trichiura. Fifteen days after drug administration the therapeutic efficacy, measured as the reduction in mean fecal egg count (FEC) following drug administration (ERR), was 99.7% (95CI: 99.4-99.9) for A. lumbricoides and 69.2% (95CI: 28.7-92.8) for hookworms. The hookworm ERR at day 14 was reduced due to the continued high egg output of one highly infected individual. One week later, 21 days following drug administration, ERR for hookworm also reached satisfactory levels (99.4% (95CI: 98.7-99.8)). This study highlights that ALB still shows satisfactory efficacy to Ascaris and hookworm infections in Ogun State, Nigeria.

Expansion of the Priority Review Voucher Program Under the 21st Century Cures Act: Implications for Innovation and Public Health

2018 ◽  
Vol 44 (2-3) ◽  
pp. 329-341
Author(s):  
Michael S. Sinha ◽  
Nina Jain ◽  
Thomas Hwang ◽  
Aaron S. Kesselheim
Keyword(s):  
Public Health ◽  
Research And Development ◽  
Neglected Tropical Diseases ◽  
Financial Incentive ◽  
Priority Review ◽  
Neglected Diseases ◽  
Pharmaceutical Manufacturer ◽  
Global Public Health ◽  
Public Health Importance ◽  
Voucher Program

The U.S. federal government awards a priority review voucher (“PRV”) to a pharmaceutical manufacturer after the Food and Drug Administration (“FDA”) approves a product for one of a list of voucher-eligible indications. The voucher, which can be transferred or sold, allows the company to accelerate the review timeline of another product for any indication. The PRV program was proposed in 2006 as an incentive for research and development for neglected diseases, such as dengue and leishmaniasis.Neglected tropical diseases (“NTDs”) predominantly affect the world’s poorest populations and are associated with significant morbidity and mortality. Despite their global public health importance, neglected diseases were estimated to account for less than 1% of pharmaceutical research and development expenditures. The voucher program was intended to address this gap between investment and disease burden: “[t]he major obstacle to stimulating the R&D of new medicines for neglected diseases is lowincome nations' inability to pay for such medicines.” The voucher would provide an additional financial incentive to fund clinical development of these products without requiring additional appropriations from Congress.

scholarly journals The EnergyKids Pilot Study: Comparing Energy Balance of Primary School Children during School and Summer Camp

Nutrients ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 92
Author(s):  
Cinzia Franchini ◽  
Alice Rosi ◽  
Cristian Ricci ◽  
Francesca Scazzina
Keyword(s):  
Physical Activity ◽  
Energy Balance ◽  
Weight Status ◽  
Summer Camp ◽  
Negative Energy ◽  
Primary School Children ◽  
Food Diary ◽  
Activity Tracker ◽  
School Time ◽  
Study Participants

Children’s energy requirements may vary during school and summer camp days. To evaluate energy balance during these two periods, seventy-eight children (45% females, 8–10 years) living in Parma, Italy, were enrolled in this observational study. Participants completed a 3-day food diary and wore an activity tracker for three consecutive days during a school- and a summer camp-week to estimate energy intake (EI) and energy expenditure (TEE). Height and body weight were measured at the beginning of each period to define children’s weight status. BMI and EI (school: 1692 ± 265 kcal/day; summer camp: 1738 ± 262 kcal/day) were similar during both periods. Both physical activity and TEE (summer camp: 1948 ± 312; school: 1704 ± 263 kcal/day) were higher during summer camp compared to school time. Therefore, energy balance was more negative during summer camp (−209 ± 366 kcal/day) compared to school time (−12 ± 331 kcal/day). Similar results were observed when males and females were analyzed separately but, comparing the sexes, males had a higher TEE and a more negative energy balance than females, during both periods. The results strongly suggest that an accurate evaluation of children’s energy balance, that considers both diet and physical activity, is needed when planning adequate diets for different situations.

scholarly journals Prevalence and Correlates of Intestinal Parasites among Patients Admitted to Mirembe National Mental Health Hospital, Dodoma, Tanzania

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Azan A. Nyundo ◽  
David Z. Munisi ◽  
Ainory P. Gesase
Keyword(s):  
Neglected Tropical Diseases ◽  
Intestinal Parasites ◽  
Psychiatric Patients ◽  
Parasitic Infection ◽  
Parasitic Infections ◽  
Intestinal Parasitic Infection ◽  
Psychiatric Facility ◽  
Concentration Data ◽  
Cross Sectional ◽  
Stool Samples

Background. Neglected tropical diseases continue to be one of the leading causes of morbidity and mortality in the developing world. Psychiatric patients are among groups at risk for parasitic infection although control and monitoring programs largely overlook this population. This study aimed at determining prevalence and factors associated with intestinal parasitic infection among patients admitted to a psychiatric facility.Method. The study followed cross-sectional design; all the residing patients that met the inclusion criteria were included in the survey. Stool samples were collected and examined by direct wet preparation and formol-ether concentration. Data were analyzed with STATA version 12.1; Chi-square test was computed to determine the level of significance atpvalue < 0.05.Results.Of all 233 patients who returned the stool samples, 29 (12.45%) screened were positive for an intestinal parasite. There was no significant association between parasite carriage and age, sex, or duration of hospital stay.Conclusion. The study shows that intestinal parasitic infection is common among patients in a psychiatric facility and highlights that parasitic infections that enter through skin penetration may be a more common mode of transmission than the oral route. Furthermore, the study underscores the need for surveillance and intervention programs to control and manage these infections.

scholarly journals Costs of Integrated Mass Drug Administration for Neglected Tropical Diseases in Haiti

2011 ◽  
Vol 85 (5) ◽  
pp. 826-833 ◽  
Author(s):  
Ann S. Goldman ◽  
Molly A. Brady ◽  
Luccene Desir ◽  
Abdel Direny ◽  
Roland Oscard ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Neglected Tropical Diseases ◽  
Tropical Diseases

The U.S. Food and Drug Administration’s Complex Innovative Trial Design Pilot Meeting Program: Progress to date

2021 ◽  
pp. 174077452110505
Author(s):  
Dionne Price ◽  
John Scott
Keyword(s):  
Public Health ◽  
Drug Administration ◽  
Trial Design ◽  
Drug Evaluation ◽  
Food And Drug Administration ◽  
Medical Product ◽  
Global Public Health ◽  
Multiple Sources ◽  
Meeting Program ◽  
The U.S

Background The Center for Drug Evaluation and Research and the Center for Biologics Evaluation and Research of the U.S. Food and Drug Administration have been leaders in advancing science to protect and promote public health by ensuring that safe and effective drugs and biological products are available to those who need them. Recently, new therapeutic discoveries, increased understanding of disease mechanisms, the need for innovation to optimally use resources, and global public health crises have led to an evolving drug development landscape. As a result, the U.S. Food and Drug Administration and medical product developers are faced with unique challenges and opportunities. The U.S. Food and Drug Administration is proactively meeting the challenges of this evolving landscape through various efforts, including the Complex Innovative Trial Design Pilot Meeting Program. Our focus, here, will be on the pilot meeting program. Methods The U.S. Food and Drug Administration has defined a process to facilitate the implementation of the Complex Innovative Trial Design Pilot Meeting Program. The process is transparent and outlines the steps and timeline for submission, review, and meetings. Results Five submitted meeting requests have been selected for participation in the Complex Innovative Trial Design Pilot Meeting Program. Conclusion The pilot meeting program has been successful in further educating stakeholders on the potential uses of complex innovative designs in trials intended to provide substantial evidence of effectiveness. The selected submissions, thus far, have all utilized a Bayesian framework. The reasons for the use of Bayesian approaches may be due to the flexibility provided, the ability to incorporate multiple sources of evidence, and a desire to better understand the U.S. Food and Drug Administration perspective on such approaches. We are confident the pilot meeting program will have continued success and impact the collective goal of bringing safe and effective medical products to patients.

scholarly journals Eliminating Neglected Tropical Diseases in Urban Areas: A Review of Challenges, Strategies and Research Directions for Successful Mass Drug Administration

2018 ◽  
Vol 3 (4) ◽  
pp. 122 ◽  
Author(s):  
Alayne Adams ◽  
Myriam Vuckovic ◽  
Eleanor Birch ◽  
Tara Brant ◽  
Stephanie Bialek ◽  
...  
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Rural Areas ◽  
Urban Areas ◽  
Neglected Tropical Diseases ◽  
Monitoring And Evaluation ◽  
Population Heterogeneity ◽  
Tropical Diseases ◽  
Urban Settings ◽  
Context Specific

Since 1950, the global urban population grew from 746 million to almost 4 billion and is expected to reach 6.4 billion by mid-century. Almost 90% of this increase will take place in Asia and Africa and disproportionately in urban slums. In this context, concerns about the amplification of several neglected tropical diseases (NTDs) are warranted and efforts towards achieving effective mass drug administration (MDA) coverage become even more important. This narrative review considers the published literature on MDA implementation for specific NTDs and in-country experiences under the ENVISION and END in Africa projects to surface features of urban settings that challenge delivery strategies known to work in rural areas. Discussed under the thematics of governance, population heterogeneity, mobility and community trust in MDA, these features include weak public health infrastructure and programs, challenges related to engaging diverse and dynamic populations and the limited accessibility of certain urban settings such as slums. Although the core components of MDA programs for NTDs in urban settings are similar to those in rural areas, their delivery may need adjustment. Effective coverage of MDA in diverse urban populations can be supported by tailored approaches informed by mapping studies, research that identifies context-specific methods to increase MDA coverage and rigorous monitoring and evaluation.

scholarly journals The Effect of Bisoprolol on Heart Failure Preserved Ejection Fraction / Hfpef Patient’s Quality Of Life

2021 ◽  
Vol 2 (4) ◽  
pp. 25-30
Author(s):  
Ayu Asri Devi Adityawati ◽  
Anna Fuji Rahimah ◽  
Mohammad Saifur Rohman ◽  
Setyasih Anjarwani ◽  
Djanggan Sargowo
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Retrospective Cohort ◽  
Sampling Method ◽  
Preserved Ejection Fraction ◽  
Global Public Health ◽  
Public Health Burden ◽  
Heart Failure Questionnaire ◽  
Study Participants

Background: Global Public Health Burden of Heart Failure reported the growing prevalence of heart failure which is 64.3 million affected in 2020 worldwide with half of the case classified as Heart Failure Preserved Ejection Fraction (HFpEF). It is well known that someone who has been diagnosed with heart failure will have a poorer 􏰼􏰞􏰏􏰦􏰝􏰊􏰗 􏰓􏰒 􏰦􏰝􏰒􏰋􏰷􏰽􏰓􏰬􏰣 􏰾􏰘􏰖􏰦􏰓􏰩􏰿􏰋􏰑 􏰝􏰌 􏰏 􏰜􏰋􏰏􏰑􏰊 􏰑􏰏􏰊􏰋 􏰦􏰓􏰎􏰋􏰑􏰝􏰚􏰟 􏰏􏰟􏰋􏰚􏰊 􏰎􏰝􏰊􏰜 􏰏 􏰐􏰓􏰊􏰋􏰚􏰩􏰗 􏰊􏰓 􏰝􏰔􏰐􏰑􏰓􏰻􏰋 􏰊􏰜􏰋 􏰐􏰏􏰊􏰝􏰋􏰚􏰊􏱀􏰌 􏰩􏰦􏰝􏰚􏰝􏰩􏰏􏰦 outcomes, one of them is QoL. Objective􏱁 􏰥􏰜􏰝􏰌 􏰌􏰊􏰞􏰕􏰗 􏰏􏰝􏰔􏰋􏰕 􏰊􏰓 􏰓􏰖􏰌􏰋􏰑􏰻􏰋 􏰏􏰚􏰕 􏰋􏰻􏰏􏰦􏰞􏰏􏰊􏰋 􏰊􏰜􏰋 􏰋􏰒􏰒􏰋􏰩􏰊 􏰓􏰒 􏰖􏰝􏰌􏰓􏰐􏰑􏰓􏰦􏰓􏰦􏰳 􏰏 􏰊􏰗􏰐􏰋 􏰓􏰒 􏰾􏰘􏰖􏰦􏰓􏰩􏰿􏰋􏰑􏰳 􏰝􏰚 􏰊􏰜􏰋 􏰝􏰔􏰐􏰑􏰓􏰻􏰋- 􏰔􏰋􏰚􏰊 􏰓􏰒 􏱂􏱃􏰐􏰺􏱃 􏰐􏰏􏰊􏰝􏰋􏰚􏰊􏱀􏰌 􏰽􏰓􏰬􏰣 Method: This study is a retrospective cohort following HFpEF patients who received bisoprolol and HFpEF patients who did not receive bisoprolol. The study participants were selected using purposive sampling method. Result: Our study found that from all HFpEF patients who received bisoprolol 102 patients had a good QoL and 2 patients had a poor QoL (p=0.000) according to Minnesota Living With Heart Failure Questionnaire (MLHFQ). The median physical score in the patient who did not receive bisoprolol was 10 while the median score of the 􏰐􏰏􏰊􏰝􏰋􏰚􏰊 􏰎􏰜􏰓 􏰑􏰋􏰩􏰋􏰝􏰻􏰋􏰕 􏰾􏰘􏰖􏰦􏰓􏰩􏰿􏰋􏰑 􏰎􏰏􏰌 􏰲 􏰪􏰐􏰡􏰢􏰣􏰢􏰢􏰢􏰮􏰣 􏰥􏰜􏰋 􏰔􏰋􏰏􏰚 􏰋􏰔􏰓􏰊􏰝􏰓􏰚􏰏􏰦 􏰌􏰩􏰓􏰑􏰋 􏰒􏰓􏰑 􏰊􏰜􏰋 􏰐􏰏􏰊􏰝􏰋􏰚􏰊􏰌 􏰎􏰜􏰓 􏰕􏰝􏰕 􏰚􏰓􏰊 􏰑􏰋􏰩􏰋􏰝􏰻􏰋 􏰾􏰘􏰖􏰦􏰓􏰩􏰿􏰋􏰑 􏰎􏰏􏰌 􏰸 􏰎􏰜􏰝􏰦􏰋 􏰊􏰜􏰋 􏰔􏰋􏰏􏰚 􏰌􏰩􏰓􏰑􏰋 􏰓􏰒 􏰊􏰜􏰋 􏰐􏰏􏰊􏰝􏰋􏰚􏰊􏰌 􏰎􏰜􏰓 􏰑􏰋􏰩􏰋􏰝􏰻􏰋􏰕 􏰾􏰘􏰖􏰦􏰓􏰩􏰿􏰋􏰑 􏰎􏰏􏰌 􏱄 􏰪􏰐􏰡􏰢􏰣􏰢􏰢􏰢􏰮􏰣 Conclusion􏱁 􏰛􏰋 􏰩􏰓􏰚􏰩􏰦􏰞􏰕􏰋 􏰊􏰜􏰏􏰊 􏰊􏰜􏰋 􏰞􏰌􏰋 􏰓􏰒 􏰖􏰝􏰌􏰓􏰐􏰑􏰓􏰦􏰓􏰦 􏰩􏰓􏰞􏰦􏰕 􏰝􏰔􏰐􏰑􏰓􏰻􏰋 􏰊􏰜􏰋 􏱂􏱃􏰐􏰺􏱃 􏰐􏰏􏰊􏰝􏰋􏰚􏰊􏱀􏰌 􏰽􏰓􏰬 􏰋􏰻􏰏􏰦􏰞􏰏􏰊􏰋􏰕 􏰖􏰗 􏰊􏰓􏰊􏰏􏰦 score, physical score, and emotional score.

scholarly journals Two or Three Consecutive Days Albendazole Treatment Has Better Efficacy than Single-Dose Albendazole Treatment for Trichuriasis

2020 ◽  
Vol 12 (1) ◽  
pp. 45-50
Author(s):  
Dina Evalina Gultom ◽  
Muhammad Ali ◽  
Ayodhia Pitaloka Pasaribu ◽  
Syahril Pasaribu
Keyword(s):  
Single Dose ◽  
Reduction Rate ◽  
Primary School Children ◽  
Repeated Dose ◽  
Hookworm Infection ◽  
Cure Rate ◽  
Chi Square ◽  
Group Iii ◽  
Group I ◽  
Stool Samples

BACKGROUND: Soil-transmitted helminth (STH) infection is endemic in Indonesia. Singledose albendazole is routinely used to control STH infections. Some studies found that repeated-dose of albendazole showed better efficacy. There is no study in Indonesia to compare single-dose and repeated-dose albendazole for against STH infections.METHODS: A randomized, open clinical trial was conducted in July-September 2018 among primary school children. Stool samples were collected before treatment and on day 7, 14, 21, and 28 after treatment then stained using the Kato-Katz method. Group I received three consecutive days, group II received two consecutive days, and Group III received single-dose of albendazole. Cure rate (CR) and egg reduction rate (ERR) were compared using Chi-square tests, and eggs per gram (EPG) was compared using the Kruskal Wallis test (p<0.05).RESULTS: One hundred ninety-five subjects enrolled and divided into 65 subjects in each group. The CR and ERR of trichuriasis after three consecutive days (79.5% and 97.4%) and two consecutive days regimen (70.3% and 91.9%) were higher than single-dose regimen (32.2% and 74.6%) with p<0.001, but not for ascariasis or hookworm infection. The highest efficacy was found in three consecutive days regimen group. Trichuris trichiura EPG was significantly different among the three groups on day 7, 14, 21, and 28 after treatment (p<0.001).CONCLUSION: Three and two consecutive days albendazole have better efficacy than single-dose of albendazole for trichuriasis, but not for ascariasis or hookworm infection. Two consecutive days albendazole is better choice for treating trichuriasis with more adherence and less side effect than three consecutive days regimen.KEYWORDS: soil-transmitted helminth infection, albendazole, single-dose, repeated-dose

scholarly journals Validation of self-reported physical activity by accelerometry among primary school children in Kilimanjaro, Tanzania: a pilot study

2020 ◽  
Vol 3 ◽  
pp. 40
Author(s):  
Mary Vincent Mosha ◽  
Elizabeth Kasagama ◽  
Philip Ayieko ◽  
Jim Todd ◽  
Sia E. Msuya ◽  
...  
Keyword(s):  
Physical Activity ◽  
Primary School ◽  
School Children ◽  
Primary Schools ◽  
Vigorous Physical Activity ◽  
Primary School Children ◽  
Positive Correlation ◽  
Self Reports ◽  
Study Participants ◽  
Moderate Positive Correlation

Background: Self-reports are commonly used to assess physical activity in children.  Existing self-reports for physical activity have not been validated for use among primary school children in Kilimanjaro, Tanzania. In order to understand if primary school children can accurately report their physical activity, we examined the validity of self-reported physical activity against accelerometer measured physical activity. Methods: A community based cross-sectional study was conducted from May to July, 2018 among four primary schools in Moshi municipal and Moshi rural districts, Kilimanjaro, Tanzania.  A total of 51 primary school children aged 9–11 years were enrolled using a simple random sampling technique. A self-reported questionnaire was used to collect physical activity related variables. In addition, children wore accelerometers for seven consecutive days to capture physical activity movements. Spearman’s rank test and Bland Altman plots were used for assessing validity and agreement between self-reports and accelerometer moderate to vigorous physical activity (MVPA). Results: The mean age of the study participants was 10 (SD=0.8) years. Majority of the study participants were female 32 (63%). A moderate, positive correlation was found between self-reports and accelerometer MVPA (rho=0.36, p=0.009). Accelerometer had higher MVPA compared to self-reports. Children who reported walking to school had higher MVPA for both accelerometer and self- reports compared to children who use other means of transport to school, e.g. school buses (p < 0.001). Conclusions: This study found the moderate positive correlation between self-reports and accelerometers. Self-reports are prone to errors due to recall bias, and this interferes their validity.  More research is needed to develop better self-reported measures with specific activities which can easily be recalled by children. Also, researchers have to be aware of self-reports validity limitation.

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