scholarly journals Therapeutic equivalence of ivermectin 1% and two novel formulations combined of ivermectin 1% + fluazuron 12.5% for the control of Rhipicephalus (Boophilus) microplus in beef cattle from Uruguay

2021 ◽  
Vol 11 (1) ◽  
pp. 154-159
Author(s):  
Diego Robaina ◽  
Silvana Alvariza ◽  
Gonzalo Suárez

Background: Novel combinations of ivermectin (IVM) and fluazuron (FLU) are presented as an alternative for the control of ticks in cattle. Applying a combination of drugs with the aim to affect different stages of the parasite’s life cycle is established as a potential measure to achieve the control of ticks in cattle. Aim: To determine the therapeutic equivalence between two novel formulations of IVM 1% combined with FLU 12.5% tested on bovines naturally infested with Rhipicephalus (Boophilus) microplus. Methods: Forty adult beef cattle were randomized into four groups (n = 10): IVM [1% (0.2 mg/kg)], combinations groups A and B [IVM 1% (0.2 mg/kg) + FLU 12.5% (2.5 mg/kg), each], and control [untreated]). On days 14, 27, and 49 after administration, the presence of ticks was ranked as null, low, medium, and high; a cumulative link model was adjusted to evaluate treatment response. Results: Although all groups had some animals with the presence of ticks until day 27, on day 14 IVM [odds ratios (OR) 0.013, CI95%: 0.001–0.014, p < 0.01], A (OR 0.01, CI95%: 0.00–0.07, p < 0.01) and B (OR 0.01, CI95%: 0.00–0.148, p < 0.01) groups were different when compared to the control group, unlike on day 27 where only groups A (OR 0.02, CI95%: 0.00–0.17, p < 0.01) and B (OR 0.06, CI95%: 0.00–0.46, p < 0.01) remained different from the control group. On day 49 post-administration, IVM and B did not differ from the control group, with 0.95 probability (CI95% 0.92–1.02) of high parasite burden. At day 49 post-administration, group A was the only group free of ticks (OR 0.01, CI95%: 0.00–0.13, p < 0.01). Conclusions: Pharmacotechnical differences in combined formulations should be considered in therapeutic equivalence studies.

2018 ◽  
Vol 1 ◽  
pp. 00006
Author(s):  
Yanuartono Yanuartono ◽  
Alfarisa Nururrozi ◽  
Soedarmanto Indarjulianto ◽  
Hary Purnamaningsih ◽  
Nurman Haribowo ◽  
...  

<p class="Abstract">An experiment was conducted to evaluate the effects supplementation of urea-molasse multinutrient block (UMMB) on the weight gain of heifers <i>peranakan</i> <i>ongole</i> beef cattle based diets with rice straw. Urea molasse multinutrient block were made with different formulations (A and B). A total of 15 heifers <i>Peranakan Ongole</i> beef cattle were divided into 3 groups. Control group animals were daily fed rice straw as a basal diet without UMMB, group A were daily fed rice straw as a basal diet with UMMB (A), group B were daily fed rice straw as a basal diet with UMMB (B) respectively. Weight gain were measured with Lambourne method weekly. Data on the feeding trial were collected during 4 wk, and were subjected to the Paired T-test analysis of variance (ANOVA). The results of this experiment showed that the UMMB supplementation had no significantly influenced of weight gain average (P &gt; 0.05). With regard to the weight gain average of heifers, the group A showed a highest (9.52 kg), group B (9.38 kg) and control group (6.98 kg), respectively. Based on statistical analyses, it can be concluded that supplementation of UMMB had no effects on average weight gain in this study.&nbsp;<o:p></o:p></p>


2020 ◽  
Author(s):  
Yong Zhang ◽  
Yang Tao ◽  
Yun Zhong ◽  
Jacqueline Thompson ◽  
Jamal Rahmani ◽  
...  

UNSTRUCTURED Lifestyle interventions have been recognised as a line treatment of non-communicable diseases. The aimed of this study was to evaluate a bespoke mHealth approach to delivers personalised feedback to improve blood pressure and weight for hypertensive patients in community settings. A total of 307 participants, 50 from each community, were expected to be in the intervention or control group. A professional health facilitator was assigned for each of the 6 communities. The primary outcomes of the study are the reduction in blood pressure and weight at baseline and post-intervention. Of 307 recruited,192 (62.5%) participants completed the study (intervention: 104 and control: 88). There was no difference in attrition rates between the two groups (33.5%vs41.9%, p=0.291). After 6-months of intensive feedback intervention through mHealth approach, patients had better blood pressure, weight, and BMI compared with control. People who were adherent to the intervention demonstrated a clinical benefit with regards to weight and blood pressure.


2015 ◽  
Vol 3 (2) ◽  
pp. 38 ◽  
Author(s):  
Randhir S. Ranta ◽  
Vijay Kumar Sharma ◽  
Pankaj Gupta

The study pertains to the parenting stress, which is believed to be the resultant of child disability and further assesses the needs of the families across selected pockets of Himachal Himalaya. Perceived Stress Questionnaire (PSQ) and Need Assessment Scale were used for the purpose. For assessing the stress level among the parents, PQS was administered among two hundred parents having disabled children, herein called experimental group and two hundred parents with normal children, herein called control group. A three point Need assessment scale was used to measure the needs of 200 families on five different parameters. The result of t-test shows the significant difference between experimental and control groups indicating that the parents of disabled children experience more stress than their control counterpart. The study indicates that people need proper guidance and information regarding a child’s disability, nutritional requirements of a child, vocational training and child management. There is a need for proper counselling for parents suffering from stress and creating consciousness among parents of children with disabilities and in the society.


2019 ◽  
Vol 21 (2) ◽  
pp. 154-160
Author(s):  
Gianluca Villa ◽  
Rosa Giua ◽  
Timothy Amass ◽  
Lorenzo Tofani ◽  
Cosimo Chelazzi ◽  
...  

Background: In a previous trial, in-line filtration significantly prevented postoperative phlebitis associated with short peripheral venous cannulation. This study aims to describe the cost-effectiveness of in-line filtration in reducing phlebitis and examine patients’ perception of in-hospital vascular access management with and without in-line filtration. Methods: We analysed costs associated with in-line filtration: these data were prospectively recorded during the previous trial. Furthermore, we performed a follow-up for all the 268 patients enrolled in this trial. Among these, 213 patients responded and completed 6 months after hospital discharge questionnaires evaluating the perception of and satisfaction with the management of their vascular access. Results: In-line filtration group required 95.60€ more than the no-filtration group (a mean of € 0.71/patient). In terms of satisfaction with the perioperative management of their short peripheral venous cannulation, 110 (82%) and 103 (76.9%) patients, respectively, for in-line filtration and control group, completed this survey. Within in-line filtration group, 97.3% of patients were satisfied/strongly satisfied; if compared with previous experiences on short peripheral venous cannulation, 11% of them recognised in-line filtration as a relevant causative factor in determining their satisfaction. Among patients within the control group, 93.2% were satisfied/strongly satisfied, although up to 30% of them had experienced postoperative phlebitis. At the qualitative interview, they recognised no difference than previous experiences on short peripheral venous cannulation, and mentioned postoperative phlebitis as a common event that ‘normally occurs’ during a hospital stay. Conclusion: In-line filtration is cost-effective in preventing postoperative phlebitis, and it seems to contribute to increasing patient satisfaction and reducing short peripheral venous cannulation–related discomfort


2001 ◽  
Vol 46 (No. 9–10) ◽  
pp. 241-243 ◽  
Author(s):  
S. Rahman M ◽  
K. Baek B ◽  
T. Hong S ◽  
H. Lee J

The antibody responses to toxoids were measured to investigate whether&nbsp;Clostridium perfringens&nbsp;beta and epsilon toxoids induced protective humoral immune responses in buffalos. Total of 24 buffalos were divided into 4 groups (n&nbsp;= 6), beta toxoid, epsilon toxoid, combination and control groups. These buffalo groups were administered each of the designated toxoids. Immunizations in the beta and epsilon toxoid groups induced strong antibody responses. The neutralizing antibody titres from the beta and epsilon toxoid groups were equally log101.2 on day 21 after inoculation whereas there was no antibody titre detected from the control group. A statistically significant (P&nbsp;&lt; 0.01) increase in antibody titre was observed from day 0 to day 14 and 21 after inoculation. The antibody production did not vary significantly due to day of inoculation and toxoid interactions.


2021 ◽  
Vol 45 (5) ◽  
pp. 312-316
Author(s):  
Mishra Neha Sanjeev ◽  
Harsimran Kaur ◽  
Sandeep Singh Mayall ◽  
Rishika ◽  
Ramakrishna Yeluri

Objective: To evaluate the effectiveness of placing a resorbable collagen barrier in impeding the extrusion of obturation material in primary molars undergoing resorption. Study design: All the 94 canals in 47 mandibular molars were allocated to 2 groups- Group ‘A’- 47 canals with collagen barrier (Test group) and Group ‘B’- 47 canals without collagen barrier (Control group) based on randomization protocol. Pulpectomy was performed and obturation of both test and control canals were radiographically assessed. Pearson’s chi – square test was applied to analyze the results. The significance level was predetermined at p &lt; 0.05. Results: Among the test group, 93.6% of the canals showed no extrusion while, 6.4% showed visible extrusion of the material outside the apex. In the control group, 83% showed no extrusion whereas 17% of the canals showed visible extrusion outside the apex. But no significant difference was noted (p&gt;0.05). Conclusion: The placement of resorbable collagen barrier in the apical third of the canal prevented the extrusion of obturating material beyond the apex in resorbing primary molars.


2016 ◽  
Vol 13 (2) ◽  
pp. 3446
Author(s):  
Aysun Göcük ◽  
Fatma Şahin

The need for energy is increasing. If fossil fuels continue to be consumed at this rate, they will disappear after a short period of time. Therefore, it is essential to use limited energy resources consciously. How early students wins this awareness, positive outcomes will be much more. The main purpose of the study is to make students aware of the problems from early ages and the object of this study is to find out how Problem Based Learning (PBL) affect the 5th grade students literacy improvement by using knowledge tests. It is an experimental study with a controlled group applied pre-test and final- test. It was carried out with the 5th grade students on 2013-2014 education year. A total of 36 students participated in the study. The involved in the experiment and control group were selected randomly. In the experiment group, the students were taught using activities prepared by Problem Based Learning and in control group, the students were taught using traditional methods. The duration for each group was 10 lesson hours. Data of search was derived using energy literacy knowledge test         (ELKT). When researched the effect of Problem Based Learning method carried out on experiment group and traditional method carried out on control group, a significant distinction in favor of Problem Based Learning method was found out. ÖzetEnerjiye olan ihtiyaç giderek artmaktadır. Fosil yakıtlar bu hızla tüketilmeye devam ederse, kısa bir süre sonra yok olacaklar. Bu  yüzden, sınırlı olan enerji kaynaklarını bilinçli kullanmak şarttır. Öğrenciler bu bilinci ne kadar erken kazanırlarsa, olumlu sonuçları o kadar fazla olacaktır.  Bu çalışmanın temel amacı öğrencilerin erken yaşta problemin farkına varmasını sağlamaktır ve bu çalışmayla Probleme Dayalı Öğrenme (PDÖ) yaklaşımının 5. sınıf öğrencilerinin enerji okuryazarlığı üzerine etkisini bilgi testi kullanarak incelemek amaçlanmıştır.   Çalışma ön test – son test kontrol gruplu deneysel bir çalışma olarak planlanmıştır.  Araştırmanın çalışma grubunu 2013-2014 Eğitim Öğretim yılı içerisinde 5. sınıfta eğitim gören toplam 36 öğrenci oluşturmuştur. Deney ve kontrol grubunu oluşturan öğrenciler şans (random) yoluyla belirlenmiştir. Deney grubunda dersler PDÖ yöntemiyle hazırlanan ders etkinlikleriyle işlenirken, kontrol grubunda dersler mevcut programdaki etkinlikler ile işlenmiştir. Her iki grup için de çalışmanın süresi 10 ders saatidir. Araştırmanın verileri enerji okuryazarlığı bilgi testi (EOBT) ile toplanmıştır. Deney grubunda uygulanan PDÖ yöntemin mevcut programdaki etkinliklere göre enerji okuryazarlığında daha etkili olduğu tespit edilmiştir. 


Author(s):  
Fei Ha Chiew ◽  
Clotilda Petrus ◽  
Siti Zaidah Othman ◽  
Joe Davylyn Nyuin ◽  
Ung Hua Lau

This study investigated the effectiveness of a peer tutoring program that was implemented for Basic Solid Mechanics course, as an intervention program to improve students’ performance in the course. Ten tutors were chosen to provide tutoring services to an experimental group of 36 tutees. Tutees were required to answer an entry test before the intervention program, and another exit test after the program. A control group which shared the same instructor in their lecture classes was included in the study. Comparison between the performances for entry and exit tests of both experimental and control groups were made. Analyses showed an increase in the percentage of students that passed the exit test from the experimental group. The average marks for the experimental group in the exit test also increased, compared to their marks in the entry test. A Mann- Whitney U test conducted indicated a significant difference between the gain scores of the experimental group and control group. A further metaanalysis revealed a large effect size, signaling the practical significance of the results. The findings demonstrated the effectiveness of the peer tutoring intervention program on students’ performance of the course.


2017 ◽  
Vol 3 (2) ◽  
pp. 40
Author(s):  
Luluk Fajria Maulida

 One of the obstacles in breastfeeding attitude is the lack of lactation communication and counseling. Breastfeeding health education is designed to enforce healthy lifestyle of breastfeeding by delivering proof based information. Flipchart media usage can be easily understood by health counsellors and clients. The study is to investigate the influence of health education using flipchart over breastfeeding attitude in post-partum mothers. This research was used a quasi experiment design with posttest only design with control group. A random assignment sampling design was used to 42 respondents which were divided into 2 groups; intervention group and control group. The samples were randomized using numbers and were divided into intervention and control group. The intervention group was given health education after delivery and questionnaires were given in intervention and control group a week after postpartum. The average score postpartum maternal behavior in the intervention group (18,43) is higher than the control group (15,14). The results of chi square test p = 0.00; RR = 3.16; CI = 1,58-6,31. External variables related to the behavior of breastfeeding is the education level of p = 0.02. Health education using flipchart significantly affects breastfeeding behavior in postpartum mothers.


1995 ◽  
Vol 75 (4) ◽  
pp. 543-548 ◽  
Author(s):  
S. L. Aldrich ◽  
L. L. Berger ◽  
D. J. Kesler ◽  
D. B. Faulkner ◽  
J. W. Castrée

A study was conducted to evaluate the effectiveness of Synovex® H as an agent for prenatal androgenization in beef cattle. Thirty Charolais-cross heifers, exposed to a fertile bull during a 55-d spring breeding season, were randomly assigned to a control group or implanted with three times the normal dose of Synovex® H between days 20 and 75 of gestation. Serum concentrations of testosterone, estradiol, and progesterone, calving rate, and growth performance were determined in the pregnant heifers. Testosterone levels were greater (P < 0.001) in treated heifers than in control heifers. Synovex® H treatment had no affect on estradiol levels. Progesterone levels were lowered (P < 0.05) in treated heifers. Synovex® H treatment decreased (P < 0.05) calving rate and birth weight of calves born to treated heifers. Calving ease scores were not affected by Synovex® H treatment. Weight was not affected; however, average daily gain was improved 7% by Synovex® H treatment (0.88 vs. 0.82 ± 0.04 kg d−1, treated and control heifers, respectively). These results are interpreted to suggest that Synovex® H is not an appropriate androgenizing agent for cattle due to adverse effects on progesterone concentrations during pregnancy and on calving rate. Key words: Cattle, prenatal androgenization, Synovex® H, pregnancy, hormones


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