scholarly journals Protective effect of purple sweet potato leaf (Ipomoea batatas Linn Convolvulaceae) against alcohol-induced liver damage in mice

2022 ◽  
Vol 20 (2) ◽  
pp. 301-308
Author(s):  
Hyun Kang ◽  
Sung-Gyu Lee
Keyword(s):  
Sweet Potato ◽  
Liver Damage ◽  
Alanine Aminotransferase ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Treated Group ◽  
Potato Leaf ◽  
Alcohol Group ◽  
Purple Sweet Potato ◽  
Hovenia Dulcis

Purpose: To investigate the hepatoprotective effect of Ipomoea batatas extract against alcohol-induced liver damage in mice. Methods: Male C57BL/6 mice were randomly divided into 4 experimental groups (n = 10). Normal Group: The animals received distilled water 5 ml/kg for 7 days; Alcohol Group: The animals received alcohol 5 ml/kg of 40 % w/v alcohol for 7 days; Alcohol + Purple sweet potato leaf extract (PSPE) Group: PSPE 400 mg/kg was for 7 days. The animals received alcohol 5 ml/kg of 40 % w/v alcohol for 7 days; Alcohol + Hovenia dulcis Thunb extract (HDE) Group: HDE 400 mg/kg was for 7 days. To confirmed to the liver protection effect of PSPE, it was calculated, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), and total cholesterol (TC) in serum were detected. To evaluate changes of histological in alcohol-fed mice, liver tissue was determined by H&E staining. Results: Blood alcohol concentration in purple sweet potato leaf extract (PSPE) 200 mg/kg and Hovenia dulcis (H. dulcis) extract (HDE) 200 mg/kg treated group significantly decreased compared to - alcohol with water treated group (p < 0.05). Serum ALT (alanine aminotransferase) and AST (aspartate aminotransferase) were markedly reduced. Liver sections in mice stained with H&E (hematoxylin and eosin) stain to displayed the physiological changes in the liver tissue. Furthermore, the results showed that inflammatory cells increased in the alcohol group compared to the normal group, but spontaneously decreased in the PSPE or HDE-treated group. Conclusion: These results demonstrate that Ipomoea batatas may be therapeutically effective in protecting the liver from alcohol-induced hepatotoxicity and fatty liver.

scholarly journals KARAKTERISASI NANOPARTIKEL KITOSAN EKSTRAK DAUN UBIJALAR (Ipomoea batatas L.) MENGGUNAKAN METODE GELASI IONIK

Alotrop ◽  
2019 ◽  
Vol 2 (2) ◽  
Author(s):  
Ade Indriani Putri ◽  
Agus Sundaryono ◽  
I Nyoman Chandra
Keyword(s):  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Wave Number ◽  
Ammonium Ion ◽  
Leaf Extracts ◽  
Potato Leaf ◽  
Chitosan Nanoparticle ◽  
Purple Sweet Potato ◽  
Characterization Test

The purpose of this study is to determine and measure the results of the characterization of Chitosan nanoparticle synthetized from leaves of sweet potato (Ipomoea batatas l.) extracts . The methods used to make nanoparticles is made with Ionic Gelation method based on electrostatic interaction between the Hydroxyl Amine on Chitosan with cluster of negative charge from the polianion NaTPP with conditioned surfactant Tween 80 used as surfactant. Characterization test of nanoparticle morphology in this study obtained using the Fourier Transformation  Infra Red (FTIR), and Particle Size Analyzer (PSA). Results with FTIR characterization test from the obtained Chitosan-white purple sweet potato leaf extract nanoparticles has a cluster of N-H and P = O that show the occurrence of ammonium ion interaction between Chitosan with polianion from NaTPP and sweet potato leaves. The interaction seen from wave number and intensities  O-H shifting from pure Chitosan at 3425.56 cm-1 to 3427, 51 cm-1, as well as on pure Chitosan N-H absorption  undergoes a shift from 1597, 06 cm-1 to becomes 1629.85-1 cm-1, which shows that there has been a cross connective between ammonium ion on Chitosan and Posphat from NaTPP and white purple sweet potato leaf extract. The results of the analysis from the PSA, is known to the average Nanokitosan particle sizes extracts from white purple sweet potato leaf extracts with the addition of NaTPP i.e. of 302.6 nm and that the aim of the research on Chitosan nanoparticle synthesis has been successfully done.

scholarly journals PENGARUH EKSTRAK ETANOL DAUN UBI JALAR UNGU (Ipomoea batatas L.) TERHADAP LEUKOSIT DAN LIMFOSIT MENCIT JANTAN BALB/C YANG DI INDUKSI VAKSIN HEPATITIS B

2021 ◽  
Vol 4 (01) ◽  
pp. 59-71
Author(s):  
Siti Hamidatul Aliyah ◽  
Desi Sagita ◽  
Devi Kurnia
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Control Group ◽  
Immunomodulatory Activity ◽  
Potato Leaf ◽  
Group I ◽  
Purple Sweet Potato

Abstract   Background: Purple sweet potato leaves (Ipomoea batatas L.) which has been known as immunomodulatory activity, which contains chemical compounds, such as vitamins, minerals, flavonoids (anthocyanin), especially iron found in a higher proportion in the leaves. Therefore, it is necessary to study the immunomodulatory activity of the leaf extract of purple sweet potato (Ipomoea batatas L.) on the immune response in Balb/c mice who induced by hepatitis B vaccines. Method: Inducing performed at day 0 and day 15. Mice with weights ± 20 g, which has been divided into normal control group, I, II, III, IV and V (each 5 mice), respectively were given orally by the leaf extract of purple sweet potato (Ipomoea batatas L.) (doses 100 mg / kg, 200 mg / kg, 300 mg / kg, 400 mg / kg and 500 mg / kg), normal controls (CMC Na 0,5%). With the volume of giving 1% of body weight in mice, performed during the study (20th days). Blood sampling is done via the tail vein (laeralis vein), to calculate the number of leukocytes (21st days) and lymph decision to count lymphocytes (21st days). Results: The results that the leaf extract of purple sweet potato (ipomoea batatas L.), especially a dose of 500 mg / kg as immunomodulatory activity can increase the number of lymphocytes proliferation cell. Conclusion: Purple sweet potato leaf extract has activity against the increase in the number of lymphocytes cell especially on dose 500 mg/kg BW who induced by hepatitis B vaccine that can stimulated an immune response.      

scholarly journals The antihyperlipidaemic and hepatoprotective effect of Ipomoea batatas L. leaves extract in high-fat diet rats

2021 ◽  
Vol 10 (3) ◽  
pp. 558
Author(s):  
Nurkhasanah Mahfudh ◽  
Nanik Sulistyani ◽  
Muhammad Syakbani ◽  
Athifah Candra Dewi
Keyword(s):  
Sweet Potato ◽  
High Fat Diet ◽  
Ipomoea Batatas ◽  
Lipid Level ◽  
Hepatoprotective Effect ◽  
High Fat ◽  
Potato Leaf ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Liver Histopathology ◽  
Purple Sweet Potato

The administration of high-fat diets can increase the body's lipid level and damage the organs. Purple sweet potato leaf (Ipomoea batatas L.) was reported as an antioxidant against free radicals. This study aimed to observe the sweet potato leaf extract's activity on decreasing lipid profile and hepatoprotective effect in high-fat diet fed rats. The treatment animals were divided into five groups, namely normal control, high-fat diet (HFD) control, the treatment group of purple sweet potato leaf extract (SPLE) doses 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BW which fed with high-fat diet for 14 days and SPLE for 28 days. After treatment was completed, the blood was collected for the detection of cholesterol, triglyceride, serum glutamic oxaloacetic transaminase (SGOT), and serum glutamic pyruvate transaminase (SGPT). After that, the animals were sacrificed, and a liver histopathology observation was conducted using Haematoxylien and Eosin staining. The result showed a significant decrease in cholesterol and triglyceride levels (p≤0.05) compared to the negative group in all treated groups. The SGOT and SGPT enzymes in all of treatment groups were also found to decrease compared with HFD control. The result was confirmed by the histopathological observations. The finding suggested the potency of SPLE for antihyperlipidaemic and hepatoprotective agent.

scholarly journals PENGARUH JENIS PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN UBI JALAR PUTIH (Ipomoea batatas L) MENGGUNAKAN METODE MASERASI

2020 ◽  
Vol 9 (4) ◽  
pp. 438
Author(s):  
Ade Maria Kristin Gultom ◽  
Ni Made Yusa ◽  
Anak Agung Istri Sri Wiadnyani
Keyword(s):  
Antioxidant Activity ◽  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Potato Leaf ◽  
Measured Variable ◽  
Obvious Effect ◽  
Randomized Design ◽  
High Antioxidant Activity ◽  
Sweet Potato Leaves

This study aims to determine the effect of solvent types on antioxidant activity of white sweet potato leaf extract (Ipomoea batatas L) and to obtain the most appropriate type of solvent to produce white sweet potato leaf extract with high antioxidant activity. The experimental design uses in this research was Completely Randomized Design (CRD) with the treatment of solvent types methanol 80%, acetone 80%, ethanol 80% and aquades. The treatment was repeated four times so obtain 16 units of the experimental. Data were analysis of variance and followed by Duncan test if the treatment has a significant effect on measured variable. The results showed that, type of solvent had an obvious effect on antioxidant activity of white sweet potato leaves. Methanol was the best solvent in extract white sweet potato leaves with followed by yield was 32.11%, total flavonoids was 226.45 mg QE / g, total tannin was 16.58 mg TAE / g, vitamin C was 119.42 mg AAE / g and antioxidant activity was 82.42%.

scholarly journals THE EFFECT OF OFFERED FERMENTED RICE HULL IN RATION SUPPLEMENTED WITH PURPLE SWEET POTATO (Ipomoea batatas L.) LEAF ON LIPID PROFILE OF DUCK MEAT

2017 ◽  
Vol 4 (2) ◽  
pp. 184
Author(s):  
T.G. Oka Susila ◽  
T.G. Belawa Yadnya ◽  
Ni Gusti Ketut Roni
Keyword(s):  
Lipid Profile ◽  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Crude Fiber ◽  
Feed Consumption ◽  
Rice Hull ◽  
Potato Leaf ◽  
Randomized Design ◽  
Fiber Consumption ◽  
Purple Sweet Potato

This experiment was carried out to study the effect of offered fermented rice hull in ration supplemented with purple sweet potato (Ipomoea batatas L.) leaf on lipid profile of duck meat. Seven treatment rations were used in a completely randomized design (CRD) consisted of control ration A (ration   without containing rice hull and purple sweet potato leaf), ration B (ration  containing 5% rice hull), ration C (ration containing 5% fermented rice hull and purple sweet potato leaf ), ration D (ration  containing 10%  rice hull), ration E   (ration containing 10% fermented rice hull and purple sweet potato leaf), ration F (ration containing 15%  rice hull),and ration G (ration containing 15% fermented rice hull and purple sweet potato leaf). Each treatment consisted of three replicates  and each replicate consisted of five ducks. Variable observed in this study  were feed consumption, protein, crude fiber and antioxidant  consumption and lipid profile consisted cholesterol total, HDL, LDL and TGA. The results showed that feed, protein, crude fiber and antioxidant consumption on treatment A were 6414.10., 1027.70., 520.82 and 59,51g/head.  Giving  treatment B, C, D, E, F and G  decrease feed consumption (P, < 0.05), but protein consumption was increase significantly (P <0.05) except for treatment B was not significant compared with treatment A. Giving  treatments C, E and G were decrease crude fiber consumption (P<0.05).  Crude fiber consumption in treatment B increase significantly (P < 0.05), but crude fiber consumption in treatment D and F were not significantly different (P>0.05) with control (A).  Antioxidant consumption for  treatments B, C, D, E, F and G were increase significantly (P<0,05) compared with  A. Lipid profile of duck meat consisted of cholesterol total, HDL, LDL and TGA in treatment A were  75,84., 26,81., 30,04 and 100,87 mg/100g. Offered treatment B, C, E, F and G significantly decrease cholesterol total (P<0.05), but treatment D was not significantly different (P>0.05) with  treatment A . While on HDL and TGA for all treatment were not significantly different (P>0.05) except TGA for treatment C was increase significantly (P<0.05), compared treatment A. Offered  treatment C, E and G  were significantly decease LDL of  duck meat, but   treatment B, D and F   were not significantly different (P<0.05) with treatment A. Its can be concluded that offered fermented rice hull in ration supplemented with purple sweet potato (Ipomoea batatas L.) leaf improve lipid profile of  duck meat.

PENGARUH PROSES MASERASI DENGAN VARIASI KONSENTRASI PELARUT ETANOL TERHADAP KANDUNGAN SENYAWA EKSTRAK DAUN PEPAYA (Carica papaya L.) DAN DAUN UBI JALAR UNGU (Ipomoea batatas L. Lam)

2020 ◽  
Vol 6 (2) ◽  
pp. 252
Author(s):  
Herman Irawan ◽  
Sevty Syera ◽  
Nurlaili Ekawati ◽  
Djadjat Tisnadjaja
Keyword(s):  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Carica Papaya ◽  
Ethanol Extract ◽  
Hemorrhagic Fever ◽  
Total Phenol ◽  
Traditional Medicines ◽  
Purple Sweet Potato ◽  
Sweet Potato Leaves

Papaya (Carica papaya L.) and purple sweet potato (Ipomoea batatas L. Lam) are commonly used empirically as traditional medicines, including for malaria, malnutrition, fever and hemorrhagic fever. The purpose of this study was to determine the effect of differences in the concentration of ethanol solvents on the chromatogram profile and compound content. The research method began with maceration using 50%, 70%, and 96% ethanol, then thin layer chromatography test, and determination of total phenol and flavonoid levels with Elisa at λ of 750 nm and 415 nm, where the comparator used were gallic acid and quercetin . The results of total phenol levels obtained in papaya leaf extract were 3,493 mg GAE/gram and in sweet potato leaves the results were 4,786 mgGAE/mg. While the total flavonoid yield obtained from papaya leaf extract was obtained as much as 4,630 mg QE/gram and on sweetpotato which was 4,269 mgQE/mg. Characterisation of extract compound content was carried ouy by using Gas Chromatography- Mass Spectroscopy (GC-MS), where comparison of extracts used in extract combination samples are 50:50, 75:25, and 25:75. The results showed that ethanol extract contained alkaloids, flavonoids, saponins, tannins, and triterpenoids. Characterization by using GC-MS for single extract and combination extract of papaya leaves and purple sweet potato leaves obtained the main active compounds are Phytol, Neoheptadine, and n-Hexadecanoic acid.

scholarly journals RESPONS GLUKOSA DARAH BENIH IKAN JELAWAT (Leptobarbus hoeveni Blkr) DALAM MEDIA YANG DIBERI EKSTRAK DAUN UBI JALAR (Ipomoea batatas)

2020 ◽  
Vol 5 (2) ◽  
pp. 50
Author(s):  
Nur Rizki ◽  
Muhammad Sugihartono ◽  
Muarofah Ghofur
Keyword(s):  
Blood Glucose ◽  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Potato Leaf ◽  
Glucose Response ◽  
Glucose Levels ◽  
Extract Concentration ◽  
Blood Glucose Response ◽  
Blood Glucose Levels

Use of sweet potato leaf extract to determine the blood glucose response of jelawat fish       (L. hoeveni, Blkr)  seeds maintained in the media.This study aims to determine the optimal concentration of sweet potato leaf extract to reduce the stress level of Jelawat fish (L. hoeveni, Blkr) seeds by measuring blood glucose. In this study, four treatments were used with three replications using a concentration of 2ml / L sweet potato leaf extract, 4ml / L extract concentration, 6ml / L extract concentration, and control. The results showed that the 2ml / L extract concentration was the best because it was proven that the fish blood glucose response at every 1st, 6th, 12th hour, 24th hour, 168th hour fish (L. hoeveni, Blkr)  seed blood glucose levels nettle nearly close to normal blood glucose levels in fish.

scholarly journals PEMBUATAN NANOPARTIKEL-PERAK EKSTRAK DAUN UBI JALAR ORANGE (Ipomoea batatas L.) DENGAN METODE BIOREDUKSI DAN UJI AKTIVITAS TERHADAP JUMLAH TROMBOSIT Mus musculus

Alotrop ◽  
2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Ririn Trinanda ◽  
Agus Sundaryono ◽  
Dewi Handayani
Keyword(s):  
Particle Size ◽  
Silver Nanoparticles ◽  
Sweet Potato ◽  
Mus Musculus ◽  
Ipomoea Batatas ◽  
Leaf Extract ◽  
Scattering Method ◽  
Potato Leaf ◽  
Agno3 Solution ◽  
Potato Extract

This study aims to make silver nanoparticles (NPP) of orange Sweet potato extract (Ipomoea batatas L.) using bioreduction method and test the effect of giving silver nanoparticles - leaf extract of Ipomoea batatas L. orange (Ipomoea batatas L.) to the number of thrombocyte from male of  Mus musculus induced by aspirin. The precursor used is 1 mM AgNO3 solution and as bioreductor is an antioxidant compound in orange sweet potato extract (Ipomoea batatas L.). The ratio of AgNO3 1 mM solution volume and orange sweet potato leaf extract is 9: 1 with 2 hours time. The characteristic test again obtained NPP is done using FTIR and Particle Size Analyzer (PSA) using Dynamyc Light Scattering method (DLS). The results showed that from the PSA analysis is known the average size of NPP – I. Batatas, L leaf extract  is an average of 86.0 nm with a polydispersity value (PDI) of 0.17 < 1 that indicates that the  NPP-leaf extract particle size distribution It is less homogeneous and are less stable.The results show that the administration of silver nanoparticles - orange sweet potato extract (Ipomoea batatas L.) can increase the platelet count of male mice significantly Dose of 0.014 g / Kgbb of 259,600 / mm3. 

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