Modelling Total Response Rate

2019 ◽  
pp. 36-60
Author(s):  
John Goyder
Keyword(s):  
Response Rate ◽  
Total Response ◽  
Total Response Rate

Comparative Efficacy of Homoharringtonine Plus Cytarabine and Decitabine in Patients with MDS/AML

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 4340-4340
Author(s):  
Yuejian Liu ◽  
Feili Chen ◽  
Xutao Guo ◽  
Pengcheng Shi ◽  
Jie Zha ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Response Rate ◽  
Complete Response Rate ◽  
Secondary Infection ◽  
Complete Response ◽  
Total Response ◽  
Total Response Rate ◽  
Treatment Related Mortality ◽  
Related Mortality

Abstract Abstract 4340 Background: Myelodysplastic syndrome (MDS) is a malignant hematological disease that comprises a heterogeneous group of clonal hematopoietic stem and progenitor cell disorders, with peripheral cytopenias, bone marrow hypercellularity, high-risk of evolving into acute myeloid leukemia (AML). MDS/AML is a special refractory and palindromic AML characterized by poor therapeutic effects and low complete response rate, as well as high treatment-related complications and mortality. Patients with MDS/AML are often elders and represent more intolerance to routine or intensive chemotherapies. Homoharringtonine, an alkaloid found as the major active component in Chinese plants cephatotaxus fortuneif., has been widely used in AML since the 1970s in China. Decitabine, a hypomethylating agent, is active and has been approved for the treatment of myelodysplastic syndrome (MDS) in recent years. Objective: In order to compare the efficacy, toxicity and long-term prognosis of two chemotherapies HA (Homoharringtonine and cytarabine) and Decitabine regiment in MDS/AML. Methods: A total of 26 MDS/AML patients consisting of 14 males and 12 females were included in this study. They were randomly assigned to receive either HA (H 4mg.d−1,d1–3; A 100mg.m−2d−1, d1–7) or decitabine£.. 20mg.m−2d−1, d1–5£© The effect measures used were hazard ratios (HR) for overall survival (OS), progression-free survival (PFS) and freedom from first progression. Relative risks were used to analyse complete response rate, total response rate, treatment-related mortality and adverse events. A Log-rank test was used in survival analysis, and a Chi-square test was performed for other outcomes. Results: The complete remission (CR) rate with HA regimen according to MDS/AML criteria was 33% and 36% with decitabine (P>0.05). HA group had no lower total response rate than Decitabine group (53% versus 64%, P>0.05). The freedom from first progression in chemotherapy with HA regiment and decitabine was 20% and 18% (P>0.05), respectively. PFS was not statistically significantly longer for two comparators with HR was 0.41(95% confidence interval (CI) 0.09722 to 1.740). There was no statistically significant difference in OS between the HA group and decitabine group with HR was 0.799 (95% CI 0.2992 to 2.133); median survival: 300 days vs 291 days (P>0.05,95% confidence interval (CI) 0.6165 to 1.445). The treatment-related mortality was 13% with HA regimen versus 18% with decitabine at 3 weeks (P>0.05) and 40% with HA regiment versus 18% with decitabine at 3 months (P>0.05). The haematological toxicities and liver function lesion WHO grade III or IV were not significantly higher in the HA group than that in the decitabine group (P>0.05). The total secondary infection rates in all sections of chemotherapies were 58% and 19% (P=0.005) in the two groups, respectively. Secondary infection rate was significantly lower in the decitabine group than that in the HA group. Conclusions: This analysis showed that Homoharringtonine and cytarabine regiment in treating MDS/AML has a similar therapeutic effect and long-term benefit with decitabine, both regiments were associated with relatively safe and effective outcomes in patients with MDS/AML. However, HA regiment shows a higher risk of secondary infection than decitabine. Longer follow-up and further studies will evaluate prospectively the results of HA regiment versus decitabine in this setting. Disclosures: No relevant conflicts of interest to declare.

Study on external Chinese herbal medicine LC07 treating capecitabine-induced hand-foot syndrome in metastatic breast cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 1088-1088
Author(s):  
L. Jia ◽  
Y. Lou ◽  
H. Tan
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Response Rate ◽  
Metastatic Breast ◽  
Chinese Herbs ◽  
Common Side Effect ◽  
Total Response ◽  
Total Response Rate ◽  
Before And After ◽  
Hand Foot Syndrome

1088 Background: With the capecitabine being increasingly used in the treatment of metastatic breast cancer (MBC), the common side effect of capecitabine, hand-foot syndrome (HFS) has become a main problem which can distress both physicians and patients. Severe HFS such as severe pain can have a negative impact on quality of life (QOL) of these patients and cause reduced dosage or even stopping chemotherapy. No effective treatment for HFS can be available at present. Over the years we have used LC07, a kind of external agents from Chinese herbs (Herba Geranii, etc.), to treat capecitabine-induced HFS. In this study, the efficacy and safety of LC07 were evaluated in patients with MBC and HSF. Methods: Eligible patients includes patients with MBC, who had HFS (NCI-CTC grade ≥1) after receiving single capecitabine chemotherapy (1,250 mg/m2, PO, twice daily, cycled days 1–14, every 21 days). LC07 granules 10g was dissolved in 1,000mL of warm water (keep 34°C-37°C in a footbath), the patients soaked their feet and hands in this lotion for 20 minutes, twice daily for 7 days. An independent researcher assessed symptoms before and after treatment. Evaluation criteria, CR as symptom disappearing completely, PR as NCI-CTC grade for HFS decreasing by more than 1 level after treatment, the total response rate as CR+PR. The QOL of these patients were also evaluated before and after treatment using a FACT-B questionnaire (Version 4.0-Chinese). Results: 42 patients (pts) have been enrolled in this study. All of them are Asian and female. Media age 51.5 yrs (25–72). Grade 1 for HFS was seen in 8 pts, G2 in 19 pts, and G3 in 15 pts. The total response rate was 83.3% (35/42), CR 38.1% (16/42), PR 45.2% (19/42). The average time from therapy to pain relief was 1.8±0.8 days, the skin lesion of HFS including dermatitis, peeling, ulceration have been improved after treatment. The QOL scores before and after treatment were 77.24±25.69 and 109.17±20.53, respectively (p < 0.01). No side effects such as skin allergies related to LC07 was found in this study. Conclusions: In the treatment of capecitabine-induced HFS, the external Chinese medicine LC07 is fast effective for relieving pain, and it has the features of easy use and no skin allergies. Thus LC07 can improve the QOL of patients with MBC and HFS. No significant financial relationships to disclose.

scholarly journals Efficacy and Safety of the TCM Qi-Supplementing Therapy in Patients with Myasthenia Gravis: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xi-qian Yang ◽  
Ling Liu ◽  
Wen-yu Yang ◽  
Huan-huan Dong ◽  
Yi-ran Yang ◽  
...  
Keyword(s):  
Adverse Events ◽  
Myasthenia Gravis ◽  
Relapse Rate ◽  
Response Rate ◽  
Meta Analysis ◽  
Effective Rate ◽  
Efficacy And Safety ◽  
Total Response ◽  
Total Response Rate

Background. The Traditional Chinese Medicine (TCM) Qi-supplementing therapy has been used widely for treating myasthenia gravis (MG) in China. The purpose of this meta-analysis was to evaluate the efficacy and safety of Qi-supplementing therapy as an adjunctive therapy in MG patients. Methods. Seven electronic databases were searched through June 2016. Randomized controlled trials (RCTs) evaluating the add-on effect of Qi-supplementing therapy in MG patients were included. The outcome measures were the total effective rate, relapse rate, and adverse events. Results. Twenty-three RCTs involving 1,691 MG patients were included. The included studies were of low-to-moderate quality. Meta-analysis showed that Qi-supplementing therapy combined with Western medicine (WM) significantly improved the total response rate and reduced the relapse risk during 6–24 months of follow-up. Subgroup analysis showed that Qi-supplementing therapy only affected the total response rate within the first 6 months of treatment. Moreover, the rate of adverse events was lower with the addition of Qi-supplementing therapy to WM than with WM only. Conclusions. Short-term Qi-supplementing therapy combined with WM appears to be superior to WM for improving the total response rate and reducing the relapse rate. However, more high-quality RCTs are warranted owing to methodological flaws of previous trials.

scholarly journals Towards the development of a reciprocal liaison service

2000 ◽  
Vol 24 (10) ◽  
pp. 379-381 ◽  
Author(s):  
Mark Davies
Keyword(s):  
Response Rate ◽  
Psychiatric Patients ◽  
Surgical Patients ◽  
Clinical Implications ◽  
Total Response ◽  
District Health ◽  
Total Response Rate ◽  
The Mean ◽  
Equity Of Access

Aims and MethodThe aim of this survey was to determine attitudes among consultants in different specialities towards the development of a reciprocal liaison service providing access for psychiatric patients to medical and surgical liaison services equal to the access of medical and surgical patients to psychiatric liaison services. All medical, surgical and psychiatric consultants in a district health service were surveyed, with a total response rate of 48%.ResultsThe mean number of medical and surgical patients requiring a psychiatric liaison service was 6%. The mean number of psychiatric patients requiring medical and surgical liaison services was 11%. Ratings overall for various components of the two types of liaison service were generally similar, with acute assessments and follow-up being given a high priority for both types.Clinical ImplicationsAs liaison services are developed, the notion of equity of access for all patients is paramount. Commissioning of such services should thereby specify the reciprocal nature of development. This survey shows that generally there is a positive attitude to the development of such a service.

Prolonged continuous intravenous infusion interleukin-2 and lymphokine-activated killer-cell therapy for metastatic renal cell carcinoma.

1992 ◽  
Vol 10 (6) ◽  
pp. 960-968 ◽  
Author(s):  
J A Thompson ◽  
K L Shulman ◽  
M C Benyunes ◽  
C G Lindgren ◽  
C Collins ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Response Rate ◽  
Interleukin 2 ◽  
Maintenance Phase ◽  
Lak Cells ◽  
Total Response ◽  
Total Response Rate

PURPOSE Two consecutive protocols of continuous intravenous (CIV) infusion interleukin-2 (IL-2) and lymphokine-activated killer (LAK) cells were carried out in patients with metastatic renal cell carcinoma (RCC) to determine the response rate and toxicity. PATIENTS AND METHODS In both protocols, patients received induction IL-2 at 6 x 10(6) U/m2/d on days 1 to 5, and underwent leukapheresis on days 7 to 9 at the peak of rebound lymphocytosis. LAK cells were generated by a 5-day incubation with IL-2 at 1,000 U/mL, and were infused on days 12 to 14. For the first 20 patients (protocol A), maintenance IL-2 was administered at 6 x 10(6) U/m2/d on days 12 to 16. On the assumption that less IL-2 might be required to maintain rather than to induce LAK activity, and that a longer duration of maintenance IL-2 might enhance LAK survival and function in vivo, the protocol for the subsequent 22 patients (protocol B) was altered so that the maintenance phase consisted of a lower dose of IL-2 (2 x 10(6) U/m2/d) administered for a longer period of time (days 10 to 20). RESULTS In protocol A, there were two complete responses (CRs) and three partial responses (PRs), for a total response rate of 25%. One PR was surgically converted into a CR. The durations of the CRs are 36+, 18+, and 18+ months. Hypotension and capillary leak were most severe during maintenance, which limited the median duration of maintenance IL-2 to 4 days. In protocol B, no patient experienced severe hypotension, and the median duration of maintenance IL-2 was 9 days. Two patients exhibited a CR and seven a PR, for a total response rate of 41%. Two PRs were surgically converted to CRs. The durations of CR are 14+, 9+, 6+, and 5+ months. In both protocols, the CIV induction regimen resulted in marked rebound lymphocytosis (mean, 11,097/microL) and LAK-cell yield (mean, 18.1 x 10(10)). The cumulative response rate was 14 of 42 patients, or 33% (95% confidence interval, 19% to 47%). CONCLUSION These results demonstrate that both protocols of CIV IL-2 plus LAK cells have substantial antitumor activity, and that a longer maintenance phase of IL-2 at a lower dose is associated with significantly less toxicity without a loss of therapeutic efficacy.

scholarly journals A Randomized Trial of Ligustrazini Hydrochlorioi in the Treatment of Viral Encephalitis in Children

1970 ◽  
Vol 30 (2) ◽  
pp. 119-122
Author(s):  
Fuyong Jiao ◽  
Xiangyang Guo ◽  
Jin Lin ◽  
Wei Cui ◽  
Huirong Li
Keyword(s):  
Adverse Effect ◽  
Animal Studies ◽  
Conventional Treatment ◽  
Viral Encephalitis ◽  
Cerebral Oedema ◽  
Response Rate ◽  
Control Group ◽  
Total Response ◽  
Control Groups ◽  
Total Response Rate

Introduction: Chuanxiong is a herb used in traditional Chinese medicine for the Treatment of viralencephalitis. In animal studies it has shown to inhibit the synthesis and activity of Thromboxane (TXA2)and abate the imbalance between Thromboxane (TXA2) and Prostacyclin (PGI2). As a result, cerebraledema, ischemia and hypoxia could be improved. The aim of this study is to evaluate its effect in thetreatment of viral encephalitis in children. Methodology: Ninety-nine patients with viral encephalitiswere randomly divided into two groups. Ligustrazini Hydrochlorioi (LH) consisting of 51 cases (males30, females 21; age 5 years and nine month ±8 years and 2month) was given LH 4mg/kg per day in 100-300mls of 10% glucose and infused intravenously over a three to four hour period, for 7 days as a courseof treatment. A control groups of 48 cases (males 31, females 17; age 5 years and three month ±4 yearsand three month) received the conventional treatment of Vitamin C(2.0-3.0g), Coenzyme A(100u) andAdenosine Triphosphate (ATP) (40mg) in 100-300 mls of 10% glucose infused intravenously daily for 7days. Results: The total response rate in the LH group and the control group were 94.12% and 68.75%respectively (u=3.271 p<0.05). The average time to improvement was 4.29±1.41 days and 7.31±2.66days respectively. No adverse effect was observed in both groups. Conclusion: We conclude that LH isan effective, safe and well tolerated treatment for children encephalitis.Key words: Cerebral Oedema; Encephalitis; Ligustrazini HydrochlorioiDOI: 10.3126/jnps.v30i2.3451J. Nepal Paediatr. Soc. May-August, 2010 Vol 30(2) 119-122

Postgraduate Pharmacy Fellowships

1981 ◽  
Vol 15 (12) ◽  
pp. 981-985 ◽  
Author(s):  
Alan F. Kaul ◽  
Stephen H. Powell ◽  
Dale A. Cyr
Keyword(s):  
National Survey ◽  
Response Rate ◽  
Pharmacy Services ◽  
Mail Questionnaire ◽  
Total Response ◽  
Contact Person ◽  
Total Response Rate

During May 1981, the Pharmacy Services Department of the Brigham and Women's Hospital conducted a national survey by mail questionnaire regarding postgraduate pharmacy fellowships. There was a total response rate of 74 percent to the questionnaire. Fifty-eight fellowships are offered at 26 fellowship sites. Information regarding type of specialty fellowship, fellowship characteristics, fellowship location and contact person, and qualifications of applicants is reported.

Comparison of Electroacupuncture and Medical Treatment for Functional Constipation: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 35 (5) ◽  
pp. 324-331 ◽  
Author(s):  
Sheng-Li Zhou ◽  
Xiu-Lai Zhang ◽  
Jing-Hua Wang
Keyword(s):  
Systematic Review ◽  
Response Rate ◽  
Meta Analysis ◽  
Cleveland Clinic ◽  
Functional Constipation ◽  
Cochrane Library ◽  
Secondary Outcome ◽  
Total Response ◽  
Total Response Rate ◽  
Bowel Movements

Objectives To assess the effectiveness of electroacupuncture (EA) relative to conventional medication in functional constipation (FC). Design Systematic review and meta-analysis. Setting To be included, studies needed to: (1) have been randomised controlled trials; (2) have recruited adult patients diagnosed with FC according to the Rome II/III criteria or the American Gastroenterological Association guideline for chronic FC; and (3) have randomised patients to be treated with EA or anti-constipation medication. We searched Medline, the Cochrane Library and Embase databases for articles published up to 30 June 2016. Intervention EA or anti-constipation medication. Primary and secondary outcome measures The primary outcome was the change in the number of weekly spontaneous bowel movements. Secondary outcomes were total response rate (or total effective rate), symptom reduction and Cleveland Clinic constipation scores. Results The pooled results showed significantly more improvement in the frequency of spontaneous bowel movements in the EA treatment group compared with the medicine-treated group (pooled SMD 0.244, 95% CI 0.065 to 0.424, P=0.008). Deep-needling EA was significantly more effective than treatment with medication at increasing the frequency of spontaneous bowel movements (p=0.019). Significantly greater improvement was also seen for total response rates (p=0.018) and reductions in symptom score (p<0.001) in EA-treated patients. Conclusions EA was more effective than medication at improving spontaneous bowel movements and total response rate, and reducing the symptoms of FC.

Combination chemotherapy for metastatic or recurrent adenocarcinoma of the cervix.

1987 ◽  
Vol 5 (10) ◽  
pp. 1621-1623 ◽  
Author(s):  
J J Kavanagh ◽  
D Gershenson ◽  
L Copeland ◽  
W S Roberts
Keyword(s):  
Combination Chemotherapy ◽  
Response Rate ◽  
Venous Catheter ◽  
Total Response ◽  
Central Venous ◽  
Future Studies ◽  
Total Response Rate ◽  
Duration Of Response ◽  
Node Metastases ◽  
Disseminated Disease

Twenty-four patients with recurrent or widespread adenocarcinoma of the cervix were treated with combination chemotherapy. The drugs used were 5-fluorouracil (5-FU) (500 to 800 mg/m2), doxorubicin (40 to 50 mg/m2), and cisplatin (50 to 60 mg/m2). The chemotherapy was administered as a 76-hour continuous infusion via a silastic central venous catheter and repeated every 28 days. The total response rate was 42% (25% complete and 17% partial). Median duration of response was 7 months. Areas of response were usually lung and lymph node metastases. Toxicity, mainly neutropenia, was acceptable. All patients relapsed. This combination chemotherapy results in a modest response rate for a malignancy about which there is little information regarding the treatment of disseminated disease. Future studies should determine the activity of this combination administered in a bolus fashion.

scholarly journals Quality of Final Impressions and Prescriptions for Fixed Prosthodontics

2013 ◽  
Vol 3 (3) ◽  
pp. 87-91
Author(s):  
Riham N Mahmood ◽  
Neamat H Abu-bakr ◽  
Nada M Sanhouri ◽  
Yahia E Ibrahim
Keyword(s):  
Infection Control ◽  
Response Rate ◽  
Cross Infection ◽  
Total Response ◽  
Fixed Prosthodontics ◽  
Impression Materials ◽  
Total Response Rate ◽  
The Cross ◽  
Dental Schools

ABSTRACT Purpose The purpose of this study was to investigate the quality of final impressions and prescriptions for fixed restorations that were received by private and educational institute's laboratories in Sudan. Materials and methods Two hundred and seventeen questionnaires were distributed to eight private laboratories and seven dental schools in Sudan. The questionnaires were filled by the dental technicians and who were trained and instructed to complete one questionnaire per one final impression for fixed restoration immediately after it was received. Results Total response rate was 87%; the responding technicians had found evidence of obvious contamination in 23.8% of the examined impressions; blood was clear in 68.9% of these cases. Metal stock trays were used in 57.1% of the examined sample. About two-third of the impressions had been taken using condensation silicone (64.6%). Poor or no written instructions were observed in half of the sample (n = 103). Conclusion According to results of this study there was widespread use of inappropriate impression materials; the cross-infection control of sent impressions was below standard and there were poor prescriptions and communications with laboratory technicians in Sudan. How to cite this article Mahmood RN, Abu-bakr NH, Sanhouri NM, Ibrahim YE. Quality of Final Impressions and Prescriptions for Fixed Prosthodontics. Int J Prosthodont Restor Dent 2013;3(3):87-91.

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