scholarly journals A Point of Interest Data Method of Pingshan Village’s Spatial Pattern Coupling with Business Form

2021 ◽  
Vol 15 ◽  
pp. 1041-1050
Author(s):  
Li Chunta ◽  
Bi Huiyu ◽  
Chen Zhenha
Keyword(s):  
Rapid Development ◽  
Historical Record ◽  
Current Status ◽  
Optimization Strategy ◽  
Historical Building ◽  
Spatial Characteristics ◽  
Advantages And Disadvantages ◽  
Point Of Interest ◽  
Business Form ◽  
Space Layout

In the context of the rapid development of China's urbanization economy and the current situation of 'hollow villages' era., how to effectively inherit and protect the Chinese traditional villages as cultural heritage is an important issue for China’s beautiful rural construction. The economic development of villages is based on the reasonable configuration of business, as an important carrier of the layout of the format，the architectural space and street space of the village are linked together for analysis and research, so as to achieve the 'win-win' effect of high-quality business form and the rational use and protection of historical building space.This paper takes Pingshan Village, a famous historical and cultural village in Yi county, China, as the research object, collects data through historical record, on-site investigations and interviews, and uses geographic information technology, point of interest combing and spatial syntax analysis to study the spatial characteristics of the current status of the Pingshan Village’s commercial concentrated water street. Besides, this paper makes quantitative analysis of the number of business forms in JiyangXi water street, spatial analysis of the commercial layout, and fixed-point analysis of the flow of people. With the results above, this paper takes correlation analysis on the results of analyzing spatial characteristics and the layout of business forms, draws up the advantages and disadvantages of the main commercial space layout of Pingshan Village as well as the optimization strategy, thereby reaches the design suggestions on the adjustment of the business forms in different spaces in traditional village planning.

scholarly journals A Systematic Literature Review of Researches on Urban Traffic Strategy Development

2017 ◽  
Vol 3 (1) ◽  
pp. 14
Author(s):  
Zhang Lin ◽  
Cheng Wei ◽  
Wang Wei ◽  
Li Yinan ◽  
Xiao Haochen
Keyword(s):  
Traffic Signal ◽  
Urban Traffic ◽  
Current Status ◽  
Signal Control ◽  
Traffic Signal Control ◽  
Traffic Network ◽  
Optimization Strategy ◽  
Advantages And Disadvantages ◽  
Research Perspectives ◽  
Traffic Optimization

Abstract—With the advancement of computer science and the development of urban economy, the interest of human research on urban traffic strategy has been promoted. Number of vehicles in urban traffic network in a sharp increase, in order to solve the current status of China's traffic congestion, we hope to reduce urban vehicles greenhouse gas emissions and to reduce waiting time is a serious problem currently facing the city traffic. In order to solve this problem, it can be from two aspects. On the one hand, traffic signal control of traffic network, the other is to optimize the route of the vehicle. This paper respectively from tells the development of the traffic signal control strategy and vehicle routing process, and compares their advantages and disadvantages. The paper summarizes the urban traffic strategy and traffic optimization strategy in recent years, and systematically summarizes the present situation and existing problems of urban traffic optimization strategies at home and abroad, summarizes the development prospects of urban traffic optimization strategies, and provides the strategies for traffic optimization. In order to provide the strategy of scholars engaged in the transportation of new research perspectives and research data.

An old friend is better than two new ones? Approaches to market research in the context of digital transformation for the antitrust laws enforcement

2020 ◽  
pp. 37-55 ◽  
Author(s):  
A. E. Shastitko ◽  
O. A. Markova
Keyword(s):  
Business Models ◽  
Rapid Development ◽  
Digital Transformation ◽  
Market Definition ◽  
Type I ◽  
Type Ii ◽  
Digital Platforms ◽  
Advantages And Disadvantages ◽  
Pass Through ◽  
Type Ii Errors

Digital transformation has led to changes in business models of traditional players in the existing markets. What is more, new entrants and new markets appeared, in particular platforms and multisided markets. The emergence and rapid development of platforms are caused primarily by the existence of so called indirect network externalities. Regarding to this, a question arises of whether the existing instruments of competition law enforcement and market analysis are still relevant when analyzing markets with digital platforms? This paper aims at discussing advantages and disadvantages of using various tools to define markets with platforms. In particular, we define the features of the SSNIP test when being applyed to markets with platforms. Furthermore, we analyze adjustment in tests for platform market definition in terms of possible type I and type II errors. All in all, it turns out that to reduce the likelihood of type I and type II errors while applying market definition technique to markets with platforms one should consider the type of platform analyzed: transaction platforms without pass-through and non-transaction matching platforms should be tackled as players in a multisided market, whereas non-transaction platforms should be analyzed as players in several interrelated markets. However, if the platform is allowed to adjust prices, there emerges additional challenge that the regulator and companies may manipulate the results of SSNIP test by applying different models of competition.

Recent Patents on the Angular Contact Ball Bearing of High-Speed Motorized Spindle

2020 ◽  
Vol 13 ◽  
Author(s):  
Yudong Bao ◽  
Linkai Wu ◽  
Yanling Zhao ◽  
Chengyi Pan
Keyword(s):  
High Speed ◽  
Ball Bearing ◽  
Rapid Development ◽  
Ceramic Materials ◽  
Development Trend ◽  
Numerical Control ◽  
Angular Contact Ball Bearing ◽  
Practical Applications ◽  
High Speed Cutting ◽  
Advantages And Disadvantages

Background:: Angular contact ball bearings are the most popular bearing type used in the high speed spindle for machining centers, The performance of the bearing directly affects the machining efficiency of the machine tool, Obtaining a higher value is the direction of its research and development. Objective:: By analyzing the research achievements and patents of electric spindle angular contact bearings, summarizing the development trend provides a reference for the development of electric spindle bearings. Methods:: Through the analysis of the relevant technology of the electric spindle angular contact ball bearing, the advantages and disadvantages of the angular contact ball bearing are introduced, and the research results are combined with the patent analysis. Results:: With the rapid development of high-speed cutting and numerical control technology and the needs of practical applications, the spindle requires higher and higher speeds for bearings. In order to meet the requirements of use, it is necessary to improve the bearing performance by optimizing the structure size and improving the lubrication conditions. Meanwhile, reasonable processing and assembly methods will also have a beneficial effect on bearing performance. Conclusion:: With the continuous deepening of bearing technology research and the use of new structures and ceramic materials has made the bearing's limit speed repeatedly reach new highs. The future development trend of high-speed bearings for electric spindles is environmental protection, intelligence, high speed, high precision and long life.

scholarly journals Exploring Impact of Surrounding Service Facilities on Urban Vibrancy Using Tencent Location-Aware Data: A Case of Guangzhou

2021 ◽  
Vol 13 (2) ◽  
pp. 444
Author(s):  
Xucai Zhang ◽  
Yeran Sun ◽  
Ting On Chan ◽  
Ying Huang ◽  
Anyao Zheng ◽  
...  
Keyword(s):  
Rapid Development ◽  
Ordinary Least Squares ◽  
Information And Communications Technology ◽  
Time Data ◽  
Location Data ◽  
Point Of Interest ◽  
Quality Life ◽  
City Construction ◽  
The Impact ◽  
The City

Urban vibrancy contributes towards a successful city and high-quality life for people as one of its vital elements. Therefore, the association between service facilities and vibrancy is crucial for urban managers to understand and improve city construction. Moreover, the rapid development of information and communications technology (ICT) allows researchers to easily and quickly collect a large volume of real-time data generated by people in daily life. In this study, against the background of emerging multi-source big data, we utilized Tencent location data as a proxy for 24-h vibrancy and adopted point-of-interest (POI) data to represent service facilities. An analysis framework integrated with ordinary least squares (OLS) and geographically and temporally weighted regression (GTWR) models is proposed to explore the spatiotemporal relationships between urban vibrancy and POI-based variables. Empirical results show that (1) spatiotemporal variations exist in the impact of service facilities on urban vibrancy across Guangzhou, China; and (2) GTWR models exhibit a higher degree of explanatory capacity on vibrancy than the OLS models. In addition, our results can assist urban planners to understand spatiotemporal patterns of urban vibrancy in a refined resolution, and to optimize the resource allocation and functional configuration of the city.

scholarly journals Machine Learning Quantitation of Cardiovascular and Cerebrovascular Disease: A Systematic Review of Clinical Applications

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 551
Author(s):  
Chris Boyd ◽  
Greg Brown ◽  
Timothy Kleinig ◽  
Joseph Dawson ◽  
Mark D. McDonnell ◽  
...  
Keyword(s):  
Machine Learning ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Model Comparison ◽  
Disease Risk ◽  
Imaging Modalities ◽  
Current Status ◽  
Advantages And Disadvantages ◽  
Body Regions ◽  
Artery Disease

Research into machine learning (ML) for clinical vascular analysis, such as those useful for stroke and coronary artery disease, varies greatly between imaging modalities and vascular regions. Limited accessibility to large diverse patient imaging datasets, as well as a lack of transparency in specific methods, are obstacles to further development. This paper reviews the current status of quantitative vascular ML, identifying advantages and disadvantages common to all imaging modalities. Literature from the past 8 years was systematically collected from MEDLINE® and Scopus database searches in January 2021. Papers satisfying all search criteria, including a minimum of 50 patients, were further analysed and extracted of relevant data, for a total of 47 publications. Current ML image segmentation, disease risk prediction, and pathology quantitation methods have shown sensitivities and specificities over 70%, compared to expert manual analysis or invasive quantitation. Despite this, inconsistencies in methodology and the reporting of results have prevented inter-model comparison, impeding the identification of approaches with the greatest potential. The clinical potential of this technology has been well demonstrated in Computed Tomography of coronary artery disease, but remains practically limited in other modalities and body regions, particularly due to a lack of routine invasive reference measurements and patient datasets.

scholarly journals X-change symposium: status and future of modern radiation oncology—from technology to biology

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Stefanie Corradini ◽  
Maximilian Niyazi ◽  
Dirk Verellen ◽  
Vincenzo Valentini ◽  
Seán Walsh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Radiation Oncology ◽  
Trial Design ◽  
Rapid Development ◽  
Clinical Trial Design ◽  
Current Status ◽  
Treatment Modalities ◽  
Special Treatment ◽  
Image Guided Radiotherapy

AbstractFuture radiation oncology encompasses a broad spectrum of topics ranging from modern clinical trial design to treatment and imaging technology and biology. In more detail, the application of hybrid MRI devices in modern image-guided radiotherapy; the emerging field of radiomics; the role of molecular imaging using positron emission tomography and its integration into clinical routine; radiation biology with its future perspectives, the role of molecular signatures in prognostic modelling; as well as special treatment modalities such as brachytherapy or proton beam therapy are areas of rapid development. More clinically, radiation oncology will certainly find an important role in the management of oligometastasis. The treatment spectrum will also be widened by the rational integration of modern systemic targeted or immune therapies into multimodal treatment strategies. All these developments will require a concise rethinking of clinical trial design. This article reviews the current status and the potential developments in the field of radiation oncology as discussed by a panel of European and international experts sharing their vision during the “X-Change” symposium, held in July 2019 in Munich (Germany).

scholarly journals Artificial Cardiac Muscle with or without the Use of Scaffolds

2017 ◽  
Vol 2017 ◽  
pp. 1-15 ◽  
Author(s):  
Yifei Li ◽  
Donghui Zhang
Keyword(s):  
Tissue Engineering ◽  
Cardiovascular Diseases ◽  
Cardiac Tissue ◽  
Contractile Function ◽  
Rapid Development ◽  
Treatment Options ◽  
Cardiac Tissue Engineering ◽  
Hydrogel Scaffold ◽  
Fibrous Matrix ◽  
Advantages And Disadvantages

During the past several decades, major advances and improvements now promote better treatment options for cardiovascular diseases. However, these diseases still remain the single leading cause of death worldwide. The rapid development of cardiac tissue engineering has provided the opportunity to potentially restore the contractile function and retain the pumping feature of injured hearts. This conception of cardiac tissue engineering can enable researchers to produce autologous and functional biomaterials which represents a promising technique to benefit patients with cardiovascular diseases. Such an approach will ultimately reshape existing heart transplantation protocols. Notable efforts are accelerating the development of cardiac tissue engineering, particularly to create larger tissue with enhanced functionality. Decellularized scaffolds, polymer synthetics fibrous matrix, and natural materials are used to build robust cardiac tissue scaffolds to imitate the morphological and physiological patterns of natural tissue. This ultimately helps cells to implant properly to obtain endogenous biological capacity. However, newer designs such as the hydrogel scaffold-free matrix can increase the applicability of artificial tissue to engineering strategies. In this review, we summarize all the methods to produce artificial cardiac tissue using scaffold and scaffold-free technology, their advantages and disadvantages, and their relevance to clinical practice.

Professional Psychology in Portugal

1997 ◽  
Vol 81 (3_suppl) ◽  
pp. 1211-1222 ◽  
Author(s):  
Teresa Fagulha ◽  
Richard H. Dana
Keyword(s):  
Rapid Development ◽  
Well Being ◽  
Professional Psychology ◽  
Current Status ◽  
Environmental Concerns ◽  
Advanced Degrees ◽  
Professional Degree ◽  
History Of ◽  
Training Research

This paper describes the history and current status of professional psychology in Portugal where a unique perspective combines training, research, and practical contributions from Europe and the Americas with their own history of psychological tradition and expertise. Training in professional psychology includes Social Psychology and Educational and Vocational Guidance specializations in addition to Clinical Psychology and Psychotherapy and Counseling for the professional degree, Licenciatura. Advanced degrees are offered in Environmental Psychology, Career Development, Social Cognition, and other areas, primarily for academic positions. Research in all of these areas is expected to have applied outcomes that contribute to individual well being and an improved quality of life for the entire population. The result has been a rapid development of an indigenous professional psychology to address mental health, social, and environmental concerns that compel psychological attention and resources worldwide as well as those problems of local and national origins.

scholarly journals High-Throughput Quantitative Assay Technologies for Accelerating the Discovery and Optimization of Targeted Protein Degradation Therapeutics

2021 ◽  
pp. 247255522098504
Author(s):  
Jeffrey R. Simard ◽  
Linda Lee ◽  
Ellen Vieux ◽  
Reina Improgo ◽  
Trang Tieu ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Protein Degradation ◽  
Protein Interactions ◽  
Fluorescent Protein ◽  
De Novo ◽  
Rapid Development ◽  
Dependent Manner ◽  
Western Blots ◽  
Advantages And Disadvantages ◽  
Degradation Rates

The aberrant regulation of protein expression and function can drastically alter cellular physiology and lead to numerous pathophysiological conditions such as cancer, inflammatory diseases, and neurodegeneration. The steady-state expression levels of endogenous proteins are controlled by a balance of de novo synthesis rates and degradation rates. Moreover, the levels of activated proteins in signaling cascades can be further modulated by a variety of posttranslational modifications and protein–protein interactions. The field of targeted protein degradation is an emerging area for drug discovery in which small molecules are used to recruit E3 ubiquitin ligases to catalyze the ubiquitination and subsequent degradation of disease-causing target proteins by the proteasome in both a dose- and time-dependent manner. Traditional approaches for quantifying protein level changes in cells, such as Western blots, are typically low throughput with limited quantification, making it hard to drive the rapid development of therapeutics that induce selective, rapid, and sustained protein degradation. In the last decade, a number of techniques and technologies have emerged that have helped to accelerate targeted protein degradation drug discovery efforts, including the use of fluorescent protein fusions and reporter tags, flow cytometry, time-resolved fluorescence energy transfer (TR-FRET), and split luciferase systems. Here we discuss the advantages and disadvantages associated with these technologies and their application to the development and optimization of degraders as therapeutics.

MicroRNA annotation in plants: current status and challenges

2021 ◽  
Author(s):  
Yongxin Zhao ◽  
Zheng Kuang ◽  
Ying Wang ◽  
Lei Li ◽  
Xiaozeng Yang
Keyword(s):  
Small Rna ◽  
Signal To Noise Ratio ◽  
Current Status ◽  
Mirna Biogenesis ◽  
Plant Mirnas ◽  
Signal To Noise ◽  
Advantages And Disadvantages ◽  
Plant Mirna ◽  
History Of ◽  
Mirna Biogenesis Pathway

Abstract Last two decades, the studies on microRNAs (miRNAs) and the numbers of annotated miRNAs in plants and animals have surged. Herein, we reviewed the current progress and challenges of miRNA annotation in plants. Via the comparison of plant and animal miRNAs, we pinpointed out the difficulties on plant miRNA annotation and proposed potential solutions. In terms of recalling the history of methods and criteria in plant miRNA annotation, we detailed how the major progresses made and evolved. By collecting and categorizing bioinformatics tools for plant miRNA annotation, we surveyed their advantages and disadvantages, especially for ones with the principle of mimicking the miRNA biogenesis pathway by parsing deeply sequenced small RNA (sRNA) libraries. In addition, we summarized all available databases hosting plant miRNAs, and posted the potential optimization solutions such as how to increase the signal-to-noise ratio (SNR) in these databases. Finally, we discussed the challenges and perspectives of plant miRNA annotations, and indicated the possibilities offered by an all-in-one tool and platform according to the integration of artificial intelligence.

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