Does the Sea Star Discriminate Bence - Jones protein From Rat Igg as Antigens?

2020 ◽  
pp. 1-2
Author(s):  
Michel Leclerc ◽  

Immunocompetent cells were described in the sea star Asterina gibbosa: they recognize specifically various antigens as HRP (Horse-radish peroxydase) ,Alkalin phosphatase, trypsin ....On the other hand when certain Asterina gibbosa were immunized with Bence-Jones protein , other ones with Rat IGG: a crossed immune reaction occurs. The potential sea star immune system is not broad enough to detect such antigens.

Immunocompetent cells were described in the sea star Asterina gibbosa: they recognize specifically various antigens. In the present work, Asterina gibbosa were immunized with Bence-Jones protein, other ones with Rat IGG, at last certain with H.RP (Horse-radish Peroxydase) and the last ones with Alkaline Phosphatase: a crossed immune reaction occurs between Rat IGG and B.J protein, but not between B.J and H.R.P not between Rat IGG and H.R.P and not between Alkaline Phosphatase and B.J, not between Alkaline Phosphatase and Rat IGG, used as antigens.


Author(s):  
Zoran Vrucinic

The future of medicine belongs to immunology and alergology. I tried to not be too wide in description, but on the other hand to mention the most important concepts of alergology to make access to these diseases more understandable, logical and more useful for our patients, that without complex pathophysiology and mechanism of immune reaction,we gain some basic insight into immunological principles. The name allergy to medicine was introduced by Pirquet in 1906, and is of Greek origin (allos-other + ergon-act; different reaction), essentially representing the reaction of an organism to a substance that has already been in contact with it, and manifested as a specific response thatmanifests as either a heightened reaction, a hypersensitivity, or as a reduced reaction immunity. Synonyms for hypersensitivity are: altered reactivity, reaction, hypersensitivity. The word sensitization comes from the Latin (sensibilitas, atis, f.), which means sensibility,sensitivity, and has retained that meaning in medical vocabulary, while in immunology and allergology this term implies the creation of hypersensitivity to an antigen. Antigen comes from the Greek words, anti-anti + genos-genus, the opposite, anti-substance substance that causes the body to produce antibodies.


Author(s):  
Michel Leclerc

Anti-HRP (Horse-radish peroxydase) and Anti-Alkalin phosphatase immunocytochemical responses occur in Asterina gibbosa (Asterid Echinodermata) after immunizations to HRP and, on the other hand to Alkalin phosphatase enzymes. Classical TEM observations from ergastoplasmic labelling to Golgi apparatus one were done : they shown also “clasmatosis phenomenon” and recall , in a general way invertebrate antibody biosynthesis.


2020 ◽  
Vol 23 (5) ◽  
pp. 584-603
Author(s):  
Amir Hossein Ahmadi Hekmatikar ◽  
◽  
Mahdieh Molanouri Shamsi ◽  

Background and Aim: Coronavirus Disease 2019 (COVID-19), as a viral disease, has increasingly highlighted the need for lifelong exercise due to its immunological and physiological effects is necessary on health. In this review study, while examining the effects of moderate-intensity exercise on the physiological and immunological responses associated with COVID-19, appropriate exercise patterns during the COVID-19 pandemic are presented. Methods & Materials: In this study, the search was conducted in Web of Science, Scopus, ISC, PubMed, Google Scholar, MagIran, and Noor databases on related articles using the following keywords: coronavirus, COVID-19, exercise and coronavirus, exercise and immune system, high-intensity exercise and immune system. Ethical Considerations: All ethical principles in writing this article have been observed according to the instructions of the National Ethics Committee and the COPE regulations. Results: Moderate-intensity exercise can help boost the function of the immune system. On the other hand, high-intensity exercise can have negative effects on the immune system, which can be a bad strategy increasing the risk of infectious diseases. Results Moderate-intensity exercise can help boost the function of the immune system. On the other hand, high-intensity exercise can have negative effects on the immune system, which can be a bad strategy increasing the risk of infectious diseases. Conclusion: Due to the onset of the second wave of COVID-19 in the world, it is recommended to continue to exercise at home observing the hygiene rules (maintaining humidity and disinfecting environmental surfaces) and using appropriate intensity and duration.


2021 ◽  
Vol 11 ◽  
Author(s):  
Chenyu Mao ◽  
Yongfeng Ding ◽  
Nong Xu

Prostate cancer (PC) is one of the most common malignancies among men and is the second leading cause of cancer death. PC immunotherapy has taken relatively successful steps in recent years, and these treatments are still being developed and tested. Evidence suggests that immunotherapy using cytokines as essential mediators in the immune system may help treat cancer. It has been shown that cytokines play an important role in anti-tumor defense. On the other hand, other cytokines can also favor the tumor and suppress anti-tumor responses. Moreover, the dose of cytokine in cancer cytokine-based immunotherapy, as well as the side effects of high doses, can also affect the outcomes of treatment. Cytokines can also be determinative in the outcome of other immunotherapy methods used in PC. In this review, the role of cytokines in the pathogenesis of cancer and their impacts on the main types of immunotherapies in the treatment of PC are discussed.


2021 ◽  
Vol 12 (3) ◽  
pp. 286-297
Author(s):  
Diako Heidari ◽  
Aref Mehdipour

The aim of this study was to understand the role of sport on covid-19 through reviewing the published literature. This was a narrative review that used valid keywords for searching the related scholarly articles. The search for the related keywords on Pubmed, Scopus, Science Direct library and Google Scholar lead to 1158 articles in 2020. After screening 28 article found eligibility to be inclouded in the review. The result indicated that physical activity and exercise play a role in preventing novel coronavirous infection and strengthening the immune system againt the covid-19. Extended Abstract Background and Objectives Since COVID-19 virus is an unknown virus which has caused alarming death toll over the past year, researchers felt implelled to take measures through doing extensive research studies in a variety of related fields to control the virus. On the other hand, exercise is known as a useful non-pharmacological method to improve the function of the immune system, so researchers in the field of sports science have done valuable research studies in this research domain, albeit limited, which can provide us with valuable information in this regard. Hence, there is a pressing need to collect and categorize these latest findings. Therefore, the very aim of this study was to review literature on the role of exercise and physical activity against the COVID-19. Material and Methods This was a narrative review, the data was collected through searching and reteriving available articles published in information resources like Medline (PubMed), Scopus , Science Direct collection, and also Google Scholar. The keywords employed for search strategy building included: "Exercise Training", "Physical Activity", "Aerobic Exercise", "Interval Training", "Resistance Training", "Endurance Training", "COVID-19", "novel Coronavirus" and "Immune System". Based on the results of our searches conducted in databases, initially 1185 articles were selected. After screening the titles and abstracts of the retrieved articles and removal of the duplicate and irrelevant ones, 59 articles were included in the reveiew stage. Then, full text of eligible articles were put underclose scrutiny which led to the final selection of only 28 articles to be studied. Results According to our review, exercise can play a role in different ways against COVID-19 diseases and novel coronavirous, which is now recognized as a global problem. These roles include preventing some underlying diseases such as hypertension, coronary artery disease and diabetes and improving immunity. Exercise lowers cortisol levels in long term, which reduces the stress induced by COVID-19, which in turn strengthens the immune system. On the other hand, doing moderate- intensity exercise can strengthen the immune system in the long run, while low-intensity or high-intensity exercise types do not bring about similar degree of adaption. Conclusion It is necessary to pay special attention to exercise training in Covid-19 pandemic period. However, it should be noted that due to the novelty of this phenomenon, limited research has been done in this area to date and more research studies are required to be done in this regard. Practical implications of research It is best for people to stay home during Covid-19 pandemic period and to have 150 minutes of moderate-intensity regular exercise during the week to boost their immune system. Ethical considerations In this review research, the ethical issues of research and fiduciary have been observed. Conflict of interest We have no conflicts of interest to disclose. Acknowledgment No sources of funding were used to assist in the preparation of this article.


2021 ◽  
Author(s):  
Maria Abascal ◽  
Kinga Makovi ◽  
Yao Xu

Asian Americans became targets of increasingly hostile behavior during the COVID-19 pandemic. What motivated this? Fears of contagion arising from a behavioral immune system (BIS) may have motivated differential treatment towards Chinese-born US residents, especially early in the pandemic and among those vulnerable to COVID-19. On the other hand, rhetoric from right-wing media figures may have legitimated anti-Asian behavior. We explore these questions using a behavioral game with a representative sample of Americans at two points: in spring and fall 2020. Participants were partnered with a US- or Chinese-born US resident. The average American treated Chinese-born US residents worse compared to US-born residents in the spring but not the fall, when China was no longer a COVID-19 hotspot. But among Republicans, likely more receptive to right-wing rhetoric, unequal treatment was both stronger in the spring and persisted into the fall.


2021 ◽  
Vol 71 (3) ◽  
pp. 207-223
Author(s):  
Irena Živković ◽  
Lina Muhandes ◽  
Vladimir Petrušić ◽  
Rajna Minić ◽  
Ljiljana Dimitrijević

Natural, polyreactive, low-affinity antibodies are known to play an important role not only in the immediate defense against pathogens, but also in shaping the acquired immune response. On the other hand, antigen specific, high-affinity antibodies can affect the balance of natural antibodies and lead to autoimmune diseases. In this study, we have analyzed the changes that occur in the IgM and IgG pool of natural antibodies after immunization with split or whole virion influenza vaccine. For this purpose, "in-house" developed ELISAs were used. The subjects were divided, according to the vaccination status, into those who had been immunized with the influenza vaccine in previous years and those who had been immunized for the first time. The analysis indicated that the pool of natural antibodies was not impaired by the immunization, evidenced by the lack of changes in any of the groups, and that certain fluctuations were induced in order to maintain the homeostasis of the immune system.


1999 ◽  
Vol 173 ◽  
pp. 249-254
Author(s):  
A.M. Silva ◽  
R.D. Miró

AbstractWe have developed a model for theH2OandOHevolution in a comet outburst, assuming that together with the gas, a distribution of icy grains is ejected. With an initial mass of icy grains of 108kg released, theH2OandOHproductions are increased up to a factor two, and the growth curves change drastically in the first two days. The model is applied to eruptions detected in theOHradio monitorings and fits well with the slow variations in the flux. On the other hand, several events of short duration appear, consisting of a sudden rise ofOHflux, followed by a sudden decay on the second day. These apparent short bursts are frequently found as precursors of a more durable eruption. We suggest that both of them are part of a unique eruption, and that the sudden decay is due to collisions that de-excite theOHmaser, when it reaches the Cometopause region located at 1.35 × 105kmfrom the nucleus.


Author(s):  
A. V. Crewe

We have become accustomed to differentiating between the scanning microscope and the conventional transmission microscope according to the resolving power which the two instruments offer. The conventional microscope is capable of a point resolution of a few angstroms and line resolutions of periodic objects of about 1Å. On the other hand, the scanning microscope, in its normal form, is not ordinarily capable of a point resolution better than 100Å. Upon examining reasons for the 100Å limitation, it becomes clear that this is based more on tradition than reason, and in particular, it is a condition imposed upon the microscope by adherence to thermal sources of electrons.


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