scholarly journals A Double-Edged Sword Role of Cytokines in Prostate Cancer Immunotherapy

2021 ◽  
Vol 11 ◽  
Author(s):  
Chenyu Mao ◽  
Yongfeng Ding ◽  
Nong Xu
Keyword(s):  
Prostate Cancer ◽  
Immune System ◽  
Side Effects ◽  
Cancer Immunotherapy ◽  
The Other ◽  
Cancer Death ◽  
Other Hand ◽  
High Doses

Prostate cancer (PC) is one of the most common malignancies among men and is the second leading cause of cancer death. PC immunotherapy has taken relatively successful steps in recent years, and these treatments are still being developed and tested. Evidence suggests that immunotherapy using cytokines as essential mediators in the immune system may help treat cancer. It has been shown that cytokines play an important role in anti-tumor defense. On the other hand, other cytokines can also favor the tumor and suppress anti-tumor responses. Moreover, the dose of cytokine in cancer cytokine-based immunotherapy, as well as the side effects of high doses, can also affect the outcomes of treatment. Cytokines can also be determinative in the outcome of other immunotherapy methods used in PC. In this review, the role of cytokines in the pathogenesis of cancer and their impacts on the main types of immunotherapies in the treatment of PC are discussed.

scholarly journals The Role of Exercise and Physical Activity against COVID-19: A Narrative Review Study

2021 ◽  
Vol 12 (3) ◽  
pp. 286-297
Author(s):  
Diako Heidari ◽  
Aref Mehdipour
Keyword(s):  
Physical Activity ◽  
Immune System ◽  
Exercise Training ◽  
Narrative Review ◽  
The Other ◽  
Google Scholar ◽  
Moderate Intensity ◽  
Other Hand ◽  
Research Studies

The aim of this study was to understand the role of sport on covid-19 through reviewing the published literature. This was a narrative review that used valid keywords for searching the related scholarly articles. The search for the related keywords on Pubmed, Scopus, Science Direct library and Google Scholar lead to 1158 articles in 2020. After screening 28 article found eligibility to be inclouded in the review. The result indicated that physical activity and exercise play a role in preventing novel coronavirous infection and strengthening the immune system againt the covid-19. Extended Abstract Background and Objectives Since COVID-19 virus is an unknown virus which has caused alarming death toll over the past year, researchers felt implelled to take measures through doing extensive research studies in a variety of related fields to control the virus. On the other hand, exercise is known as a useful non-pharmacological method to improve the function of the immune system, so researchers in the field of sports science have done valuable research studies in this research domain, albeit limited, which can provide us with valuable information in this regard. Hence, there is a pressing need to collect and categorize these latest findings. Therefore, the very aim of this study was to review literature on the role of exercise and physical activity against the COVID-19. Material and Methods This was a narrative review, the data was collected through searching and reteriving available articles published in information resources like Medline (PubMed), Scopus , Science Direct collection, and also Google Scholar. The keywords employed for search strategy building included: "Exercise Training", "Physical Activity", "Aerobic Exercise", "Interval Training", "Resistance Training", "Endurance Training", "COVID-19", "novel Coronavirus" and "Immune System". Based on the results of our searches conducted in databases, initially 1185 articles were selected. After screening the titles and abstracts of the retrieved articles and removal of the duplicate and irrelevant ones, 59 articles were included in the reveiew stage. Then, full text of eligible articles were put underclose scrutiny which led to the final selection of only 28 articles to be studied. Results According to our review, exercise can play a role in different ways against COVID-19 diseases and novel coronavirous, which is now recognized as a global problem. These roles include preventing some underlying diseases such as hypertension, coronary artery disease and diabetes and improving immunity. Exercise lowers cortisol levels in long term, which reduces the stress induced by COVID-19, which in turn strengthens the immune system. On the other hand, doing moderate- intensity exercise can strengthen the immune system in the long run, while low-intensity or high-intensity exercise types do not bring about similar degree of adaption. Conclusion It is necessary to pay special attention to exercise training in Covid-19 pandemic period. However, it should be noted that due to the novelty of this phenomenon, limited research has been done in this area to date and more research studies are required to be done in this regard. Practical implications of research It is best for people to stay home during Covid-19 pandemic period and to have 150 minutes of moderate-intensity regular exercise during the week to boost their immune system. Ethical considerations In this review research, the ethical issues of research and fiduciary have been observed. Conflict of interest We have no conflicts of interest to disclose. Acknowledgment No sources of funding were used to assist in the preparation of this article.

BLOCKADE OF THE SURGE OF PROLACTIN AT PRO-OESTRUS BY ADMINISTRATION OF ANTI-OESTROGENIC SUBSTANCE, MER-25

1973 ◽  
Vol 74 (4) ◽  
pp. 769-774 ◽  
Author(s):  
Akira Yokoyama ◽  
Hiroshi Tomogane ◽  
Katuaki Ôta
Keyword(s):  
Strong Evidence ◽  
The Other ◽  
Other Hand

ABSTRACT A non-steroidal oestrogen antagonist, MER-25, was administered to cycling rats for elucidating the role of oestrogen in the surge of prolactin observed on the afternoon of pro-oestrus (POe). In animals injected with 20 mg of MER-25 intramuscularly on the afternoon (16.30 h) of the first day of dioestrus (D-1), the surge of prolactin was blocked while the level of prolactin on the afternoon of POe of these animals was significantly higher than that of the corresponding controls injected with oil. Ovulation was also blocked in these animals treated with the drug on the afternoon of D-l. On the other hand, treatment on the morning (10.30 h) of the 2nd day of dioestrus failed to prevent not only the surge of prolactin but also ovulation. These observations provide strong evidence for the view that oestrogen is responsible for the surge of prolactin on the afternoon of POe, and that the surge is accompanied by that of LH.

Covid-19 – rumours and facts in media

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 171-174
Author(s):  
Tarare Toshida ◽  
Chaple Jagruti
Keyword(s):  
Social Media ◽  
Preventive Measures ◽  
Vital Role ◽  
The Other ◽  
Sources Of Information ◽  
Other Hand ◽  
Corona Virus ◽  
The People ◽  
The World

The covid-19 resulted in broad range of spread throughout the world in which India has also became a prey of it and in this situation the means of media is extensively inϑluencing the mentality of the people. Media always played a role of loop between society and sources of information. In this epidemic also media is playing a vital role in shaping the reaction in ϑirst place for both good and ill by providing important facts regarding symptoms of Corona virus, preventive measures against the virus and also how to deal with any suspect of disease to overcome covid-19. On the other hand, there are endless people who spread endless rumours overs social media and are adversely affecting life of people but we always count on media because they provide us with valuable answers to our questions, facts and everything in need. Media always remains on top of the line when it comes to stop the out spread of rumours which are surely dangerous kind of information for society. So on our side we should react fairly and maturely to handle the situation to keep it in the favour of humanity and help government not only to ϑight this pandemic but also the info emic.

The Policy of the EEC on Concentrative Joint Ventures

1992 ◽  
Vol 5 (1) ◽  
pp. 53-67
Author(s):  
D.S. Nava
Keyword(s):  
Structural Change ◽  
Joint Ventures ◽  
The Other ◽  
Legal Instrument ◽  
Other Hand ◽  
Philip Morris ◽  
Competition Rules

The EEC Treaty contains no specific provisions for the control of concentrations. Only the competition rules. Articles 85 and 86 EEC, could be considered as possible legal instruments for regulating concentrations. The Commission has had to examine whether and to what extent these provisions could be used to this end.The Commission's view has been that Article 85 does not apply to operations resulting in structural change, as is the case of concentrations and concentrative joint ventures. Cooperative operations, such as cooperative joint ventures, on the other hand fall to be assessed under Article 85. The Philip Morris case has made this position uncertain. According to the extensive interpretation of this judgement Article 85 is now applicable to certain concentrations and thus to concentrative joint ventures.There is no such uncertainty regarding the role of Article 86 in controlling concentrative joint ventures, for the Court has established in the Continental Can case that concentrations can be caught by Article 86.With the adoption in 1989 of the Regulation on concentration control the Commission finally has a legal instrument specifically designed to regulate concentrations. However, only concentrations and concentrative joint ventures which comply with certain turnover thresholds (the so-called concentrations or concentrative joint ventures with a Community dimension) can be assessed by the Commission under the Regulation. This means that the provisions of the Regulation can not be applied to concentrative joint ventures beneath the threshold.Because of the difficulty in distinguishing concentrative operations from cooperative ones, the Commission published the Notice regarding the concentrative and cooperative operations under the Regulation on the control of concentrations.

scholarly journals Notes from the Editors

2014 ◽  
Vol 108 (2) ◽  
pp. iii-ix
Keyword(s):  
Basic Research ◽  
Decision Makers ◽  
The Other ◽  
Good Effect ◽  
Scholarly Journals ◽  
Other Hand ◽  
Relevant Work

We introduce this issue with a thought. There has been much made of the need for our discipline to be “policy relevant,” and much ridicule has been directed at the Review recently that comments how little the Review offers that is relevant for decision makers. But what does it mean to be policy relevant? Generally, scholarly journals publish the best in basic research, which hopefully can be used by those in positions of authority to good effect. This often means that there are no catchy titles, nor opinion-editorial pieces that are so often portrayed as the model of policy relevant work. In our view, the role of the Review is to expand knowledge on important scholarly questions, not only to publish work that is currently popular or somehow ordained as useful by pundits. There is certainly a place for such work, but not in the pages of the Review. On the other hand, we as the editors of the Review understand the need to make the Review accessible to as broad an audience as possible, and we have made great efforts to do just that.

The influence of concealing academic achievement on the self-esteem of adolescents with low achievement

2009 ◽  
Vol 37 (6) ◽  
pp. 805-810
Author(s):  
Baoshan Zhang ◽  
Jun-Yan Zhao ◽  
Guoliang Yu
Keyword(s):  
Academic Achievement ◽  
Social Interaction ◽  
Social Interactions ◽  
Self Esteem ◽  
Low Achievers ◽  
The Self ◽  
The Other ◽  
Other Hand ◽  
Positive Performance

An examination was carried out of the influences of concealing academic achievement on self-esteem in an academically relevant social interaction based on the assumption that concealing socially devalued characteristics should influence individuals' self-esteem during social interactions. An interview paradigm called for school-aged adolescents who either were or were not low (academic) achievers to play the role of students who were or were not low achievers while answering academically relevant questions. The data suggest that the performance self-esteem of low achievers who played the role of good students was more positive than that of low achievers who played the role of low achievers. On the other hand, participants who played the role of good students had more positive performance self-esteem than did participants who played the role of low achievers.

Beta-Blocker Attenuates Cardiotoxicity Related Anthracycline Usage

2021 ◽  
Vol 104 (8) ◽  
pp. 1389-1392
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Mortality Rate ◽  
Cancer Patients ◽  
Beta Blocker ◽  
The Other ◽  
Large Numbers ◽  
Therapy Effectiveness ◽  
Chemotherapy Agents

To summarize the recent trials and studies of the role of beta-blocker on the treatment for cancer patients treated with anthracycline to decrease morbidity and mortality rate. Good management of cancer will result in large numbers of cancer survivors. On the other hand, cancer therapy also has side effects, one of which is cardiotoxicity. Cardiotoxicity could reduce therapy effectiveness, hence, increase disease progression and mortality rate. Anthracyclines is one of the chemotherapy agents with cardiotoxicity as a side effect. Beta-blocker has the ability to reduce cardiotoxicity due to anthracyclines usage. Keywords: Beta-blocker; Cardiotoxicity; Anthracyclines

Analysis of the Collaborative Learning Application in Reading Material at Ninth Grade of SMPN 7 Kinali Pasaman Barat

2021 ◽  
Vol 1 (1) ◽  
pp. 71-88
Author(s):  
Sukini Sukini ◽  
Hilma Pami Putri
Keyword(s):  
Qualitative Research ◽  
Collaborative Learning ◽  
Learning Strategy ◽  
Research Question ◽  
Ninth Grade ◽  
The Other ◽  
Reading Material ◽  
Other Hand ◽  
Object Based

This research was designed to find out and analyze of the collaborative learning application in reading material at ninth grade of SMPN 7 Kinali Pasaman Barat. This research conducted due to several problems found in the field which were students make a fuss when working in groups, students do not listen to given the assignment by the teacher. It can be seen that there were students who work on group assignments that care and others were just busy talking with others. This research was done in order to answer the research question “What were the role of student and what were the role of teacher in collaborative learning at the ninth grade of SMPN 7 Kinali Pasaman Barat?” This research was a qualitative research using collaborative learning strategy. The purpose of this research was to find out and analyze the collaborative learning applicationin reading material at the ninth grade of SMPN 7 KinaliPasaman Barat by analyzing the teacher’s and students’ role in the collaborative learning. The researcher used interview and observation as the instrument of the research. The interview was directed to both students and teacher, which for the students contained 12 questions and for the teacher contained 7 questions. The researcher took 2 classes namely IX1 and IX2 as the observation object.                    Based on the finding from interview and observation of the collaborative learning in SMPN 7 Kinali Pasaman Barat, it was found that the teacher already fulfilled her role in the collaborative learning effectively, in the other hand the students still lack of the role as the cheer leader. They still laughed at their friends mistake. Besides that, the other roles that the students supposed to have were already done effectively. As the conclusion, the collaborative learning in SMPN 7 Kinali Pasaman Barat was good since the students and the teacher were doing their role effectively

Dyadic Cancer-Related Distress and The Role Of Mindfulness and Spiritual Well-Being in Couples with Cancer: An Actor-Partner Interdependence Model

2021 ◽  
Author(s):  
Afarin Rajaei ◽  
Saeideh Heshmati
Keyword(s):  
Cancer Patient ◽  
Well Being ◽  
The Other ◽  
Dyadic Data ◽  
Actor Partner Interdependence Model ◽  
Other Hand ◽  
Spiritual Well Being ◽  
Adaptive Processes ◽  
Partner Effect

The present study draws attention to the significance of considering mindfulness and spiritual well-being on cancer-related distress among couples with cancer during the pandemic. Dyadic data was analyzed among couples with cancer (80 couples; N=160) to examine the within-person (actor effects) and between-partner (partner effects) associations among links between mindfulness, spiritual well-being, and cancer-related distress through the use of the actor-partner interdependence model (APIM; Kashy & Kenny, 2000). Significant actor and/or partner effects were found for mindfulness and spiritual well-being in couples with cancer, a factor that predicted cancer-related distress. Spirituality seemed to only play an important role in patients’ own cancer-related distress (actor effect), with patients’ higher levels of spiritual well-being predicting patients’ lower levels of distress. On the other hand, mindfulness was not only significantly related to the cancer patient and partner’s own distress (actor effect), partner’s mindfulness was also significantly associated with the patient’s distress (partner effect). The findings underscore the need to adopt a systemic perspective that accounts for multiple, simultaneous adaptive processes including mindfulness and spiritual well-being as influences on cancer-related distress in the time of COVID-19.

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