scholarly journals THE RELATION BETWEEN THE CYCLE OF ADMINISTRATION OF CHEMOTHERAPY TO PSYCHOSOCIAL PROBLEMS IN BREAST CANCER PATIENTS

2021 ◽  
Vol 4 (IAHSC) ◽  
pp. 61-66
Author(s):  
Sri Handayani ◽  
Ulfah Nuraini Karim ◽  
Puji Astuti Wiratmo
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Malignant Neoplasm ◽  
Psychosocial Problems ◽  
Rank Test ◽  
P Value ◽  
Psychosocial Needs ◽  
Breast Cancer Patients ◽  
Depression Anxiety Stress Scale ◽  
The Relationship

Introduction: Breast cancer is the most common malignant neoplasm that affects women.  One of the treatments for breast cancer is chemotherapy which is carried out according to a particular schedule with a specified length of therapy to increase the patient's recovery rate.  In addition to the physiological effects, chemotherapy also has a psychological impact on the patient.  Fulfillment of psychosocial needs is important to improve the quality of life of patients caused by changes in physical, social, cognitive, spiritual, emotional and role functions.  The purpose of this study was to determine the relationship between the cycle of chemoteraphy with psychosocial problems in breast cancer patients. Method: This study is a quantitative correlational study using 54 breast cancer patients as samples by purposive sampling.  Data collection was carried out during April 2020 to June 2020 in the chemotherapy room at Koja Hospital, North Jakarta. The Depression Anxiety Stress Scale (DASS 21) questionnaire was used to identify psychosocial problems in breast cancer patients.  Statistical analysis of the Spearman rank test was carried out to analyze the relationship between chemotherapy cycles and psychosocial problems. Results: The results showed that there was a relationship between chemotherapy cycles and psychosocial problems (p value 0.001) although it showed a weak relationship between those  two variables (r 0.257).  Psychosocial problems identified included anxiety (53%), depression (9.3%), low self-esteem (16.7%) and stress (20.4%). Conclusion: Nurses need to provide comprehensive nursing care for patients undergoing chemotherapy including identifying problems related to physical complaints and psychosocial needs so that nursing interventions can be given comprehensively to breast cancer patients undergoing chemotherapy.

Correlation of AGR2 expression with the incidence of metastasis in luminal breast cancer

2021 ◽  
pp. 1-5
Author(s):  
David Samuel Kereh ◽  
John Pieter ◽  
William Hamdani ◽  
Haryasena Haryasena ◽  
Daniel Sampepajung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Mean Value ◽  
Rank Test ◽  
Luminal Breast Cancer ◽  
P Value ◽  
Strong Positive Correlation ◽  
Breast Cancer Patients ◽  
The Mean ◽  
Spearman Test

BACKGROUND: AGR2 expression is associated with luminal breast cancer. Overexpression of AGR2 is a predictor of poor prognosis. Several studies have found correlations between AGR2 in disseminated tumor cells (DTCs) in breast cancer patients. OBJECTIVE: This study aims to determine the correlation between anterior Gradient2 (AGR2) expression with the incidence of distant metastases in luminal breast cancer. METHODS: This study was an observational study using a cross-sectional method and was conducted at Wahidin Sudirohusodo Hospital and the network. ELISA methods examine AGR2 expression from blood serum of breast cancer patients. To compare the AGR2 expression in metastatic patients and the non-metastatic patient was tested with Mann Whitney test. The correlation of AGR2 expression and metastasis was tested with the Rank Spearman test. RESULTS: The mean value of AGR2 antibody expression on ELISA in this study was 2.90 ± 1.82 ng/dl, and its cut-off point was 2.1 ng/dl. Based on this cut-off point value, 14 subjects (66.7%) had overexpression of AGR2 serum ELISA, and 7 subjects (33.3%) had not. The mean value AGR2 was significantly higher in metastatic than not metastatic, 3.77 versus 1.76 (p < 0.01). The Spearman rank test obtained a p-value for the 2 tail test of 0.003 (p < 0.05), which showed a significant correlation of both, while the correlation coefficient of 0.612 showed a strong positive correlation of AGR2 overexpression and metastasis. CONCLUSIONS: AGR2 expression is correlated with metastasis in Luminal breast cancer.

scholarly journals Depression and Fatigue of Breast Cancer Patients Receiving Chemotherapy during the Covid-19

2021 ◽  
Vol 3 (3) ◽  
pp. 297-304
Author(s):  
Dwi Retnaningsih ◽  
Roudhotul Auliyak ◽  
Mariyati Mariyati ◽  
Enggar Nurnaningsih
Keyword(s):  
Breast Cancer ◽  
Data Analysis ◽  
Cancer Patients ◽  
Depression Scale ◽  
Fear Of Death ◽  
Anxiety And Depression ◽  
P Value ◽  
Breast Cancer Patients ◽  
Increased Risk ◽  
The Relationship

Depression in breast cancer patients includes mental shock, inability to accept reality, hopelessness, fear of death, and fear of the future. Depression creates long periods of sadness and worry, usually accompanied by feelings of worthlessness. Fatigue is a symptom that often appears in cancer patients undergoing chemotherapy. Associated with the conditions of the COVID-19 pandemic, cancer patients have an increased risk of transmitting COVID-19 because they have decreased endurance. This study aims to determine the relationship between depression and fatigue in breast cancer patients undergoing chemotherapy at Hospital Sultan Agung Semarang Indonesia. The instruments used in this study were questionnaire of the hospitals anxiety and Depression Scale (HADS) and questionnaire of fatigue, 30 female respondents who suffer from breast cancer and have undergone chemotherapy. Rank Spearman data analysis. P value = 0.000 and correlation coefficient value r = 0.671. There is a relationship between depression and fatigue in breast cancer patients undergoing chemotherapy which has an impact on adherence to chemotherapy for breast cancer patients. The higher the level of depression is, the more severe the level of fatigue in cancer patients.

scholarly journals Hubungan Dukungan Keluarga dengan Self Esteem pada Pasien Kanker Payudara di Poliklinik Bedah Onkologi RSUP Sanglah Denpasar

2020 ◽  
Vol 9 (2) ◽  
pp. 181
Author(s):  
Ni luh Putu Mahayani ◽  
Ni Komang Sukraandini ◽  
Ni Wayan Suniyadewi
Keyword(s):  
Breast Cancer ◽  
Family Support ◽  
Cancer Patients ◽  
Surgical Oncology ◽  
Self Esteem ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Cross Sectional Design ◽  
The Relationship

AbstractBreast cancer sufferers have a tendency to experience a decrease of self esteem that make  patients shall showing symptoms such as blaming themself for what they experienced. One way to increase self esteem in cancer patients is by increasing family participation through family support. The aim of this study is to determine the relationship between family support and self esteem in breast cancer patients. This study was using cross sectional design. The study was taken place at the Surgical Oncology Polyclinic, found samples of 188 respondents which was selected with a purposive sampling technique.The results showed that the majority of respondents were in the category of moderate self-esteem were 98 respondents (52.1%) and the category of moderate family support were 96 respondents (51.1%). The Rank Spearmen test results shows p value 0,000 (p <ɑ), means there is a relationship between self-esteem and family support in breast cancer patients with r value of 0.566 (positive relationship). It is expected that the family will always support the patient in every process of treatment, whether in the form of physical, psychological or financial support that could increase the patient's self esteem

scholarly journals Correlation of Lymphocyte-Monocyte Ratio with Grading of Breast Cancer Malignancy

2020 ◽  
Vol 4 (3) ◽  
pp. 9-18
Author(s):  
Muhartono Muhartono ◽  
Rizki Hanriko ◽  
Suharyani
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Quantitative Research ◽  
Cancer Prognosis ◽  
Rank Test ◽  
P Value ◽  
Test Results ◽  
Breast Cancer Patients ◽  
Histological Grading ◽  
Laboratory Examination

Introduction: Breast cancer cases are increase and fast becoming the leading cause of oncologic mortality among women worldwide. Delay in management will worsen the prognosis of breast cancer patients. The poor prognosis is correlate with high grade of breast cancer malignancy. Histology can be used as an indicator to assess the grade of breast cancer malignancy. In addition, a high predictive value of lymphocyte-monocyte ratio (LMR) has been suggested to indicate favorable prognosis of various cancer, and used as parameters for assessing breast cancer prognosis. Method: This study is a quantitative research, using an observational approach. Laboratory examination results are collected from 43 breast cancer patients who will conduct treatment at Urip Sumoharjo Hospital from June to September 2019. Data are processed by the Spearman rank test using SPSS 22.0. Results: Correlation test results between lymphocyte-monocyte ratio with histological grading of breast cancer obtained a P value of 0.376. Conclusions: Lymphocytes to monocytes ratio (LMR) value cannot be utilize as a parameter for evaluating prognosis of breast cancer.

scholarly journals The Relationship Between Level Anxiety And Sleeping Quality Of Breast Cancer Patients In One Day Care Chemotherapy Room

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Lucilla Suparmi ◽  
Fransisca Anjar Rina Setyani
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Patients ◽  
Day Care ◽  
P Value ◽  
Breast Cancer Patients ◽  
The Relationship ◽  
Purposive Sample ◽  
Severe Anxiety

Objective: Chemotheraphy is one of theraphy managements for breast cancer patients. Chemotherapy has some side effects like nausea, gag, alpoesia, etc. Those can increase patients’ anxiety. Then, this anxiety will give impact on sleeping quality disoeder. This research aims to identify the anxiety level of breast cancer patients in chemotheraphy ODC room.Methods: This research used crossectional design. There are 32 respondents as research sample choosen by purposive sample technic.Results: The result shows that most repondents (68,75 %) didnot feel anxiety, 15,63% got mild anxiety, 9,38% got moderate and severe anxiety, and no one got panic anxiety. Most respondents (71,87) had good sleeping quality and 28,13% had poor sleeping quality. There is no relationship between level anxiety and sleeping quality of cancer patients with P value = 0,182.Conclusion: There is no relationship between level anxiety and sleeping quality of cancer patients. Nurse should do persoal approach to patients who are still having severe anxiety and poor sleeping qualitiy.

Effects of cardioprotective medications on breast cancer survival: A retrospective study from an academic center from Southern Illinois.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e12540-e12540
Author(s):  
Manjari Rani Regmi ◽  
Priyanka Parajuli ◽  
Asad Cheema ◽  
Odalys Estefania Lara Garcia ◽  
Nitin Tandan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Beta Blocker ◽  
Hazard Ratio ◽  
Categorical Variables ◽  
Rank Test ◽  
P Value ◽  
Breast Cancer Patients ◽  
Cardiovascular Risks ◽  
Significant Difference

e12540 Background: Cardiovascular disease is one of the leading causes of deaths in breast cancer patients. Pre-existing cardiac conditions and cardiovascular risks associated with chemotherapy affect the overall mortality of these patients. Cardio protective medications like beta-blocker, ACEIs, ARBs, statin, and potassium-sparing diuretics have shown to increase the survival odds. In our study, we investigated the survival of breast cancer patients who were on cardio protective medications. Methods: Our retrospective cohort study included breast cancer patients from Simmons Cancer Institute, Springfield, Illinois from January 1st, 2014 to December 31st, 2017. The first step comprised of screening patients using ICD code of breast cancer. Next, a retrospective chart review led to selecting eligible patients with biopsy proven breast cancer diagnosis within the aforementioned dates. We excluded patients who were diagnosed outside the give time frame. Data on age, gender, medical comorbidities, medications, and survival status were also collected. Comparisons between categorical variables were compared with the Chi-Squared test. Survival curves were estimated using Kaplan-Meier methodology and analyzed with a log rank test. Predictors of survival are assessed with Cox proportional hazards regression analyses. Results: Screening using ICD codes resulted in 1618 patients. Of those, 478 had biopsy proven diagnosis within the dates mentioned. 301 out of 478 patients were on some kind of cardio protective medication (88 on beta-blockers, 73 on ACEIs, 41 on ARBs, 87 on statins, and 12 on potassium sparing diuretics). We looked into survival analysis in patients on different cardioprotective medications. ARBs and potassium sparing diuretics showed increased likelihood of survival as the hazard ratio (HR) was found to be 0.512 (95% Cl: 0.068-3.832, p-value:0.0919) and HR 0.390 (95% CI: 0.130-1.66, p-value:0.514) respectively. In contrast, other cardio protective medications showed decreased trends for survival. The HR of beta blocker was 1.734 (95% CI: 0.508-5.919, p-value: 0.379) and of ACEIs was 1.350 (95% CI: 0.395-4.613, p-value: 0.632). Similarly, statins had a hazard ratio of 1.534 (95% CI: 0.512- 4.594, p-value:0. 444). Conclusions: We found that the cardio protective medications showed no statistically significant difference in survival in breast cancer patients. Given the smaller sample size and single center study, further multi-center clinical trial is warranted to establish a stronger association.

scholarly journals Human Plasma Metabolomics for Biomarker Discovery: Targeting the Molecular Subtypes in Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 147
Author(s):  
Leticia Díaz-Beltrán ◽  
Carmen González-Olmedo ◽  
Natalia Luque-Caro ◽  
Caridad Díaz ◽  
Ariadna Martín-Blázquez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Biomarker Discovery ◽  
Molecular Subtypes ◽  
Breast Cancer Subtype ◽  
P Value ◽  
Plasma Samples ◽  
Breast Cancer Patients ◽  
Clinical Value ◽  
Molecular Phenotypes

Purpose: The aim of this study is to identify differential metabolomic signatures in plasma samples of distinct subtypes of breast cancer patients that could be used in clinical practice as diagnostic biomarkers for these molecular phenotypes and to provide a more individualized and accurate therapeutic procedure. Methods: Untargeted LC-HRMS metabolomics approach in positive and negative electrospray ionization mode was used to analyze plasma samples from LA, LB, HER2+ and TN breast cancer patients and healthy controls in order to determine specific metabolomic profiles through univariate and multivariate statistical data analysis. Results: We tentatively identified altered metabolites displaying concentration variations among the four breast cancer molecular subtypes. We found a biomarker panel of 5 candidates in LA, 7 in LB, 5 in HER2 and 3 in TN that were able to discriminate each breast cancer subtype with a false discovery range corrected p-value < 0.05 and a fold-change cutoff value > 1.3. The model clinical value was evaluated with the AUROC, providing diagnostic capacities above 0.85. Conclusion: Our study identifies metabolic profiling differences in molecular phenotypes of breast cancer. This may represent a key step towards therapy improvement in personalized medicine and prioritization of tailored therapeutic intervention strategies.

The relationship of self-acceptance with decision making duration in cancer patient to perform mastectomy

2021 ◽  
pp. 1-5
Author(s):  
Ayu Ratuati Setiawan ◽  
Feny Tunjungsari ◽  
Mochamad Aleq Sander
Keyword(s):  
Breast Cancer ◽  
Decision Making ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Abnormal Growth ◽  
Self Acceptance ◽  
Observation Method ◽  
Relationship Of ◽  
The Relationship

BACKGROUND: Cancer is a disease caused by abnormal growth of body cells that turn malignant and continue to grow uncontrollably. One of the treatments for breast cancer is mastectomy. The quickness of decision-making determines the survival rate of prognosis patients. OBJECTIVE: This study aimed to determine the relationship of self-acceptance with decision-making duration in cancer patients to perform a mastectomy. METHODS: An analytic observation method with cross-sectional design. The samples were taken by purposive sampling method with 50 samples of breast cancer patients. Data collected include age, last level of education, marital status, profession, stage of cancer during mastectomy, self-acceptance score, and decision-making duration to perform a mastectomy. RESULTS: The data analyzed with the Kruskal–Wallis test. The test showed the relationship of self-acceptance (p = 0.027) with decision-making duration in breast cancer patients to perform a mastectomy. CONCLUSION: In Conclusion, there is a relationship of self-acceptance with decision-making duration in breast cancer patients to perform a mastectomy.

Sign in / Sign up

Export Citation Format

Share Document